JP2019505597A5 - - Google Patents
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- JP2019505597A5 JP2019505597A5 JP2018563393A JP2018563393A JP2019505597A5 JP 2019505597 A5 JP2019505597 A5 JP 2019505597A5 JP 2018563393 A JP2018563393 A JP 2018563393A JP 2018563393 A JP2018563393 A JP 2018563393A JP 2019505597 A5 JP2019505597 A5 JP 2019505597A5
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662298726P | 2016-02-23 | 2016-02-23 | |
| US62/298,726 | 2016-02-23 | ||
| PCT/US2017/018790 WO2017147102A1 (en) | 2016-02-23 | 2017-02-22 | Heteroaryl inhibitors of pad4 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019505597A JP2019505597A (ja) | 2019-02-28 |
| JP2019505597A5 true JP2019505597A5 (https=) | 2020-04-02 |
| JP6926126B2 JP6926126B2 (ja) | 2021-08-25 |
Family
ID=58191708
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018563393A Active JP6926126B2 (ja) | 2016-02-23 | 2017-02-22 | Ｐａｄ４のヘテロアリール阻害剤 |
Country Status (17)
| Country | Link |
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| US (2) | US11198681B2 (https=) |
| EP (1) | EP3419969B1 (https=) |
| JP (1) | JP6926126B2 (https=) |
| KR (1) | KR102759005B1 (https=) |
| CN (1) | CN109071497B (https=) |
| AR (1) | AR107694A1 (https=) |
| AU (1) | AU2017223416A1 (https=) |
| BR (1) | BR112018016433A2 (https=) |
| CA (1) | CA3015482A1 (https=) |
| EA (1) | EA201891910A1 (https=) |
| ES (1) | ES2770102T3 (https=) |
| IL (1) | IL261167A (https=) |
| MX (1) | MX2018009773A (https=) |
| SG (1) | SG11201807021UA (https=) |
| TW (1) | TW201825476A (https=) |
| UY (1) | UY37134A (https=) |
| WO (1) | WO2017147102A1 (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6926126B2 (ja) | 2016-02-23 | 2021-08-25 | パドロック・セラピューティクス・インコーポレイテッドＰａｄｌｏｃｋ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | Ｐａｄ４のヘテロアリール阻害剤 |
| KR102398941B1 (ko) | 2016-07-27 | 2022-05-17 | 패들락 테라퓨틱스, 인코포레이티드 | Pad4의 공유결합성 억제제 |
| JP7118951B2 (ja) | 2016-09-12 | 2022-08-16 | パドロック・セラピューティクス・インコーポレイテッド | Ｐａｄ４のヘテロアリール阻害剤 |
| WO2019059202A1 (ja) * | 2017-09-19 | 2019-03-28 | 三菱瓦斯化学株式会社 | 半導体リソグラフィー膜形成組成物、並びにレジストパターン形成方法及びデバイス |
| MX2020003242A (es) | 2017-09-22 | 2020-09-18 | Jubilant Epipad LLC | Compuestos heterociclicos como inhibidores de pad. |
| AU2018352142B2 (en) | 2017-10-18 | 2022-08-25 | Jubilant Epipad LLC | Imidazo-pyridine compounds as PAD inhibitors |
| KR20200085836A (ko) | 2017-11-06 | 2020-07-15 | 주빌런트 프로델 엘엘씨 | Pd1/pd-l1 활성화 억제제로서의 피리미딘 유도체 |
| BR112020010322A2 (pt) | 2017-11-24 | 2020-11-17 | Jubilant Episcribe Llc | composto da fórmula i; composto da fórmula ia; composto da fórmula ib; processo de preparação de compostos da fórmula i; composição farmacêutica; método para o tratamento e/ou prevenção de várias doenças; uso dos compostos; método para o tratamento de câncer; e método para o tratamento e/ou prevenção de uma afecção mediada por prmt5 ou um distúrbio proliferativo ou câncer |
| WO2019122202A1 (en) * | 2017-12-20 | 2019-06-27 | Ecole Polytechnique Federale De Lausanne (Epfl) | Sting inhibitors |
| SG11202008950PA (en) | 2018-03-13 | 2020-10-29 | Jubilant Prodel LLC | Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation |
| EP3833671B1 (en) * | 2018-08-08 | 2022-08-24 | Bristol-Myers Squibb Company | Substituted thienopyrroles as pad4 inhibitors |
| AU2019319835A1 (en) | 2018-08-08 | 2021-03-25 | Bristol-Myers Squibb Company | Indole and azaindole inhibitors of PAD enzymes |
| CN112789087B (zh) * | 2018-08-08 | 2024-08-13 | 百时美施贵宝公司 | Pad酶的苯并咪唑抑制剂 |
| AU2020337720B2 (en) * | 2019-08-30 | 2024-02-15 | Tsd Life Sciences Co., Ltd. | Imidazopyridine derivative and pharmaceutical composition comprising same as active ingredient |
| TW202115083A (zh) * | 2019-09-27 | 2021-04-16 | 大陸商南京藥捷安康生物科技有限公司 | 肽醯精胺酸脫亞胺酶抑制劑及其用途 |
| CA3166630A1 (en) | 2020-01-03 | 2021-07-08 | Berg Llc | Polycyclic amides as ube2k modulators for treating cancer |
| EP4100405A1 (en) | 2020-02-06 | 2022-12-14 | Bristol-Myers Squibb Company | Macrocyclic pad4 inhibitors useful as immunosuppressant |
| CN113248507A (zh) * | 2020-02-09 | 2021-08-13 | 上海茂晟康慧科技有限公司 | 瑞德西韦关键中间体7-卤代吡咯并[1,2-f][1,2,4]三嗪-4-胺的合成方法 |
| TW202140477A (zh) | 2020-02-12 | 2021-11-01 | 美商必治妥美雅史谷比公司 | 雜環ｐａｄ４抑制劑 |
| EP4143189A1 (en) * | 2020-04-30 | 2023-03-08 | Gilead Sciences, Inc. | Macrocyclic inhibitors of peptidylarginine deiminases |
| CN112618546B (zh) * | 2020-12-22 | 2022-03-01 | 陈昊 | Pad4抑制剂在制备放射治疗增敏药物方面的应用 |
| TW202241884A (zh) | 2020-12-22 | 2022-11-01 | 美商基利科學股份有限公司 | 肽基精胺酸去亞胺酶之抑制劑 |
| WO2022140428A2 (en) | 2020-12-22 | 2022-06-30 | Gilead Sciences, Inc. | Inhibitors of peptidylarginine deiminases |
| KR20220122879A (ko) * | 2021-02-26 | 2022-09-05 | 주식회사 티에스디라이프사이언스 | 이미다조피리딘 유도체 및 이를 유효성분으로 함유하는 약학적 조성물 |
| CN121399122A (zh) | 2023-04-18 | 2026-01-23 | 卡尔优普公司 | Nk3调节剂及其用途 |
| WO2025006962A1 (en) | 2023-06-30 | 2025-01-02 | Bristol-Myers Squibb Company | Kras inhibitors |
| WO2025024265A1 (en) | 2023-07-21 | 2025-01-30 | Bristol-Myers Squibb Company | Methods of assessing citrullination and activity of pad4 modulators |
| WO2025080781A1 (en) * | 2023-10-12 | 2025-04-17 | Kallyope, Inc. | Nk3 modulators and uses thereof |
| WO2026020127A2 (en) | 2024-07-19 | 2026-01-22 | Bristol-Myers Squibb Company | Methods of assessing citrullination and activity of pad2 modulators |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS55684B1 (sr) * | 2012-07-26 | 2017-07-31 | Glaxo Group Ltd | 2-(azaindol-2-il)benzimidazoli kao pad4 inhibitori |
| US10407407B2 (en) | 2015-05-21 | 2019-09-10 | Glaxosmithkline Intellectual Property Development Limited | Benzoimidazole derivatives as PAD4 inhibitors |
| AR107032A1 (es) * | 2015-12-09 | 2018-03-14 | Padlock Therapeutics Inc | Inhibidores bicíclicos de pad4 |
| AR107030A1 (es) | 2015-12-09 | 2018-03-14 | Padlock Therapeutics Inc | Inhibidores aza-bencimidazol de pad4 |
| JP6926126B2 (ja) | 2016-02-23 | 2021-08-25 | パドロック・セラピューティクス・インコーポレイテッドＰａｄｌｏｃｋ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | Ｐａｄ４のヘテロアリール阻害剤 |
| KR102398941B1 (ko) * | 2016-07-27 | 2022-05-17 | 패들락 테라퓨틱스, 인코포레이티드 | Pad4의 공유결합성 억제제 |
| JP7118951B2 (ja) | 2016-09-12 | 2022-08-16 | パドロック・セラピューティクス・インコーポレイテッド | Ｐａｄ４のヘテロアリール阻害剤 |
-
2017
- 2017-02-22 JP JP2018563393A patent/JP6926126B2/ja active Active
- 2017-02-22 AU AU2017223416A patent/AU2017223416A1/en not_active Abandoned
- 2017-02-22 SG SG11201807021UA patent/SG11201807021UA/en unknown
- 2017-02-22 ES ES17708142T patent/ES2770102T3/es active Active
- 2017-02-22 KR KR1020187027136A patent/KR102759005B1/ko active Active
- 2017-02-22 TW TW106105844A patent/TW201825476A/zh unknown
- 2017-02-22 US US16/078,376 patent/US11198681B2/en active Active
- 2017-02-22 MX MX2018009773A patent/MX2018009773A/es unknown
- 2017-02-22 WO PCT/US2017/018790 patent/WO2017147102A1/en not_active Ceased
- 2017-02-22 EP EP17708142.9A patent/EP3419969B1/en active Active
- 2017-02-22 CN CN201780025089.9A patent/CN109071497B/zh active Active
- 2017-02-22 CA CA3015482A patent/CA3015482A1/en not_active Abandoned
- 2017-02-22 EA EA201891910A patent/EA201891910A1/ru unknown
- 2017-02-22 UY UY0001037134A patent/UY37134A/es unknown
- 2017-02-22 BR BR112018016433-0A patent/BR112018016433A2/pt not_active IP Right Cessation
- 2017-02-22 AR ARP170100442A patent/AR107694A1/es unknown
-
2018
- 2018-08-15 IL IL261167A patent/IL261167A/en unknown
-
2021
- 2021-11-09 US US17/522,348 patent/US11897866B2/en active Active
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