JP2019525936A5 - - Google Patents
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- JP2019525936A5 JP2019525936A5 JP2019504110A JP2019504110A JP2019525936A5 JP 2019525936 A5 JP2019525936 A5 JP 2019525936A5 JP 2019504110 A JP2019504110 A JP 2019504110A JP 2019504110 A JP2019504110 A JP 2019504110A JP 2019525936 A5 JP2019525936 A5 JP 2019525936A5
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662367389P | 2016-07-27 | 2016-07-27 | |
| US62/367,389 | 2016-07-27 | ||
| PCT/US2017/044194 WO2018022897A1 (en) | 2016-07-27 | 2017-07-27 | Covalent inhibitors of pad4 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019525936A JP2019525936A (ja) | 2019-09-12 |
| JP2019525936A5 true JP2019525936A5 (https=) | 2020-09-03 |
| JP6987843B2 JP6987843B2 (ja) | 2022-01-05 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019504110A Active JP6987843B2 (ja) | 2016-07-27 | 2017-07-27 | Ｐａｄ４の共有結合性阻害剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10703741B2 (https=) |
| EP (1) | EP3490989B1 (https=) |
| JP (1) | JP6987843B2 (https=) |
| KR (1) | KR102398941B1 (https=) |
| CN (1) | CN109790162B (https=) |
| ES (1) | ES2828623T3 (https=) |
| WO (1) | WO2018022897A1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3015482A1 (en) * | 2016-02-23 | 2017-08-31 | Padlock Therapeutics, Inc. | Heteroaryl inhibitors of pad4 |
| US11026937B2 (en) | 2016-09-12 | 2021-06-08 | Padlock Therapeutics, Inc. | Heteroaryl inhibitors of PAD4 |
| MX2021001471A (es) * | 2018-08-08 | 2021-04-28 | Bristol Myers Squibb Co | Benzimidazoles sustituidos como inhibidores de peptidil arginina deiminasa 4 (pad4). |
| US20220348562A1 (en) * | 2018-08-08 | 2022-11-03 | Bristol-Myers Squibb Company | Benzimidazole inhibitors of pad enzymes |
| JP7447080B2 (ja) | 2018-08-08 | 2024-03-11 | ブリストル－マイヤーズ スクイブ カンパニー | Ｐａｄ４阻害剤としての置換チエノピロール |
| MX2021001565A (es) | 2018-08-08 | 2021-04-19 | Bristol Myers Squibb Co | Inhibidores tipo indol y azaindol de enzimas peptidil arginina deiminasas (pad). |
| WO2020085504A1 (ja) | 2018-10-26 | 2020-04-30 | 大鵬薬品工業株式会社 | 光照射ザンドマイヤー反応を用いたクロロアゾールカルボキシレート誘導体の製造方法 |
| UA129778C2 (uk) | 2019-10-28 | 2025-07-30 | Мерк Шарп Енд Доум Елелсі | Низькомолекулярні інгібітори g12c-мутантного kras |
| WO2021084765A1 (en) * | 2019-10-31 | 2021-05-06 | Taiho Pharmaceutical Co., Ltd | 4-aminobut-2-enamide derivatives and salts thereof |
| BR112022009881A2 (pt) * | 2019-11-22 | 2022-10-11 | Univ California | Inibidores de caspase 6 e usos dos mesmos |
| EP4067343A4 (en) | 2019-11-29 | 2024-01-03 | Taiho Pharmaceutical Co., Ltd. | NEW PHENOLIC COMPOUND OR SALT THEREOF |
| WO2021158840A1 (en) * | 2020-02-06 | 2021-08-12 | Bristol-Myers Squibb Company | Macrocyclic pad4 inhibitors useful as immunosuppressant |
| TW202140477A (zh) | 2020-02-12 | 2021-11-01 | 美商必治妥美雅史谷比公司 | 雜環ｐａｄ４抑制劑 |
| WO2021222353A1 (en) | 2020-04-30 | 2021-11-04 | Gilead Sciences, Inc. | Macrocyclic inhibitors of peptidylarginine deiminases |
| TW202233174A (zh) | 2020-12-22 | 2022-09-01 | 美商基利科學股份有限公司 | 肽基精胺酸去亞胺酶之抑制劑 |
| WO2022140390A1 (en) | 2020-12-22 | 2022-06-30 | Gilead Sciences, Inc. | Inhibitors of peptidylarginine deiminases |
| US20240246968A1 (en) * | 2021-04-27 | 2024-07-25 | Merck Sharp & Dohme Llc | Small molecule inhibitors of kras g12c mutant |
| CN119604287A (zh) * | 2022-05-26 | 2025-03-11 | 细胞基因公司 | 杂环pad4抑制剂 |
| KR20260041867A (ko) | 2023-07-21 | 2026-03-27 | 브리스톨-마이어스 스큅 컴퍼니 | Pad4 조정제의 시트룰린화 및 활성을 평가하는 방법 |
| AU2024361909A1 (en) | 2023-10-20 | 2026-03-26 | Merck Sharp & Dohme Llc | Small molecule inhibitors of kras proteins |
| WO2026020127A2 (en) | 2024-07-19 | 2026-01-22 | Bristol-Myers Squibb Company | Methods of assessing citrullination and activity of pad2 modulators |
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| EP1264037A2 (en) | 2000-02-09 | 2002-12-11 | Akzo Nobel N.V. | Pulping process |
| CA2555199A1 (en) * | 2004-02-04 | 2005-08-18 | Yokohama City University | Peptidylarginine deiminase 4 inhibitor |
| CN101479249B (zh) * | 2006-06-29 | 2012-10-10 | 霍夫曼-拉罗奇有限公司 | 苯并咪唑衍生物、其制备方法、它们作为fxr激动剂的用途及含有它们的药物制剂 |
| BRPI0714299A2 (pt) * | 2006-07-20 | 2013-04-24 | Genelabs Tech Inc | inibidores virais policÍclicos |
| KR101916443B1 (ko) | 2012-07-26 | 2018-11-08 | 글락소 그룹 리미티드 | Pad4 억제제로서의 2-(아자인돌-2-일) 벤즈이미다졸 |
| CA2908098A1 (en) * | 2013-03-15 | 2014-09-25 | Celgene Avilomics Research, Inc. | Mk2 inhibitors and uses thereof |
| KR20180005250A (ko) * | 2015-05-21 | 2018-01-15 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | Pad4 억제제로서의 벤조이미다졸 유도체 |
| AR107032A1 (es) | 2015-12-09 | 2018-03-14 | Padlock Therapeutics Inc | Inhibidores bicíclicos de pad4 |
| AR107030A1 (es) | 2015-12-09 | 2018-03-14 | Padlock Therapeutics Inc | Inhibidores aza-bencimidazol de pad4 |
| CA3015482A1 (en) | 2016-02-23 | 2017-08-31 | Padlock Therapeutics, Inc. | Heteroaryl inhibitors of pad4 |
| US11026937B2 (en) | 2016-09-12 | 2021-06-08 | Padlock Therapeutics, Inc. | Heteroaryl inhibitors of PAD4 |
-
2017
- 2017-07-27 WO PCT/US2017/044194 patent/WO2018022897A1/en not_active Ceased
- 2017-07-27 JP JP2019504110A patent/JP6987843B2/ja active Active
- 2017-07-27 CN CN201780059309.XA patent/CN109790162B/zh active Active
- 2017-07-27 EP EP17749074.5A patent/EP3490989B1/en active Active
- 2017-07-27 US US16/319,006 patent/US10703741B2/en active Active
- 2017-07-27 ES ES17749074T patent/ES2828623T3/es active Active
- 2017-07-27 KR KR1020197005300A patent/KR102398941B1/ko active Active
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