JP2019525936A5 - - Google Patents
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- JP2019525936A5 JP2019525936A5 JP2019504110A JP2019504110A JP2019525936A5 JP 2019525936 A5 JP2019525936 A5 JP 2019525936A5 JP 2019504110 A JP2019504110 A JP 2019504110A JP 2019504110 A JP2019504110 A JP 2019504110A JP 2019525936 A5 JP2019525936 A5 JP 2019525936A5
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662367389P | 2016-07-27 | 2016-07-27 | |
| US62/367,389 | 2016-07-27 | ||
| PCT/US2017/044194 WO2018022897A1 (en) | 2016-07-27 | 2017-07-27 | Covalent inhibitors of pad4 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019525936A JP2019525936A (ja) | 2019-09-12 |
| JP2019525936A5 true JP2019525936A5 (https=) | 2020-09-03 |
| JP6987843B2 JP6987843B2 (ja) | 2022-01-05 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019504110A Active JP6987843B2 (ja) | 2016-07-27 | 2017-07-27 | Ｐａｄ４の共有結合性阻害剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10703741B2 (https=) |
| EP (1) | EP3490989B1 (https=) |
| JP (1) | JP6987843B2 (https=) |
| KR (1) | KR102398941B1 (https=) |
| CN (1) | CN109790162B (https=) |
| ES (1) | ES2828623T3 (https=) |
| WO (1) | WO2018022897A1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6926126B2 (ja) | 2016-02-23 | 2021-08-25 | パドロック・セラピューティクス・インコーポレイテッドＰａｄｌｏｃｋ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | Ｐａｄ４のヘテロアリール阻害剤 |
| JP7118951B2 (ja) | 2016-09-12 | 2022-08-16 | パドロック・セラピューティクス・インコーポレイテッド | Ｐａｄ４のヘテロアリール阻害剤 |
| WO2020033488A1 (en) * | 2018-08-08 | 2020-02-13 | Bristol-Myers Squibb Company | Substituted benzimidazoles as pad4 inhibitors |
| CN112789087B (zh) * | 2018-08-08 | 2024-08-13 | 百时美施贵宝公司 | Pad酶的苯并咪唑抑制剂 |
| EP3833671B1 (en) | 2018-08-08 | 2022-08-24 | Bristol-Myers Squibb Company | Substituted thienopyrroles as pad4 inhibitors |
| AU2019319835A1 (en) | 2018-08-08 | 2021-03-25 | Bristol-Myers Squibb Company | Indole and azaindole inhibitors of PAD enzymes |
| WO2020085504A1 (ja) | 2018-10-26 | 2020-04-30 | 大鵬薬品工業株式会社 | 光照射ザンドマイヤー反応を用いたクロロアゾールカルボキシレート誘導体の製造方法 |
| CN114867726B (zh) | 2019-10-28 | 2023-11-28 | 默沙东有限责任公司 | Kras g12c突变体的小分子抑制剂 |
| WO2021084765A1 (en) * | 2019-10-31 | 2021-05-06 | Taiho Pharmaceutical Co., Ltd | 4-aminobut-2-enamide derivatives and salts thereof |
| MX2022006052A (es) * | 2019-11-22 | 2022-08-15 | Univ California | Inhibidores de la caspasa 6 y usos de los mismos. |
| US12479834B2 (en) | 2019-11-29 | 2025-11-25 | Taiho Pharmaceutical Co., Ltd. | Phenol compound or salt thereof |
| EP4100405A1 (en) * | 2020-02-06 | 2022-12-14 | Bristol-Myers Squibb Company | Macrocyclic pad4 inhibitors useful as immunosuppressant |
| TW202140477A (zh) | 2020-02-12 | 2021-11-01 | 美商必治妥美雅史谷比公司 | 雜環ｐａｄ４抑制劑 |
| EP4143189A1 (en) * | 2020-04-30 | 2023-03-08 | Gilead Sciences, Inc. | Macrocyclic inhibitors of peptidylarginine deiminases |
| TW202241884A (zh) | 2020-12-22 | 2022-11-01 | 美商基利科學股份有限公司 | 肽基精胺酸去亞胺酶之抑制劑 |
| WO2022140428A2 (en) | 2020-12-22 | 2022-06-30 | Gilead Sciences, Inc. | Inhibitors of peptidylarginine deiminases |
| EP4329750A4 (en) * | 2021-04-27 | 2025-06-18 | Merck Sharp & Dohme LLC | Small-molecule inhibitors of the KRAS G12C mutant |
| US20250346592A1 (en) * | 2022-05-26 | 2025-11-13 | Celgene Corporation | Heterocyclic pad4 inhibitors |
| WO2025024265A1 (en) | 2023-07-21 | 2025-01-30 | Bristol-Myers Squibb Company | Methods of assessing citrullination and activity of pad4 modulators |
| WO2025085748A1 (en) | 2023-10-20 | 2025-04-24 | Merck Sharp & Dohme Llc | Small molecule inhibitors of kras proteins |
| WO2026020127A2 (en) | 2024-07-19 | 2026-01-22 | Bristol-Myers Squibb Company | Methods of assessing citrullination and activity of pad2 modulators |
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| CA2399723A1 (en) | 2000-02-09 | 2001-08-16 | Akzo Nobel N.V. | Pulping process |
| WO2005075414A1 (ja) * | 2004-02-04 | 2005-08-18 | Yokohama City University | ぺプチジルアルギニンデイミナーゼ４阻害剤 |
| RU2424233C2 (ru) * | 2006-06-29 | 2011-07-20 | Ф.Хоффманн-Ля Рош Аг | Производные бензимидазола, методы их получения, применение их в качестве агонистов фарнезоид-х-рецептора (fxr) и содержащие их фармацевтические препараты |
| AR062827A1 (es) * | 2006-07-20 | 2008-12-10 | Genelabs Tech Inc | Inhibidores virales policiclicos, una composicion farmaceutica que los comprende y su uso en la preparacion de medicamentos para el tratamiento de una infeccion viral mediada porl el virus de la hepatitis c |
| RS55684B1 (sr) * | 2012-07-26 | 2017-07-31 | Glaxo Group Ltd | 2-(azaindol-2-il)benzimidazoli kao pad4 inhibitori |
| JP2016518316A (ja) * | 2013-03-15 | 2016-06-23 | セルジーン アビロミクス リサーチ， インコーポレイテッド | Ｍｋ２阻害剤およびそれらの使用 |
| US10407407B2 (en) * | 2015-05-21 | 2019-09-10 | Glaxosmithkline Intellectual Property Development Limited | Benzoimidazole derivatives as PAD4 inhibitors |
| AR107032A1 (es) | 2015-12-09 | 2018-03-14 | Padlock Therapeutics Inc | Inhibidores bicíclicos de pad4 |
| AR107030A1 (es) | 2015-12-09 | 2018-03-14 | Padlock Therapeutics Inc | Inhibidores aza-bencimidazol de pad4 |
| JP6926126B2 (ja) | 2016-02-23 | 2021-08-25 | パドロック・セラピューティクス・インコーポレイテッドＰａｄｌｏｃｋ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | Ｐａｄ４のヘテロアリール阻害剤 |
| JP7118951B2 (ja) | 2016-09-12 | 2022-08-16 | パドロック・セラピューティクス・インコーポレイテッド | Ｐａｄ４のヘテロアリール阻害剤 |
-
2017
- 2017-07-27 KR KR1020197005300A patent/KR102398941B1/ko active Active
- 2017-07-27 JP JP2019504110A patent/JP6987843B2/ja active Active
- 2017-07-27 US US16/319,006 patent/US10703741B2/en active Active
- 2017-07-27 EP EP17749074.5A patent/EP3490989B1/en active Active
- 2017-07-27 CN CN201780059309.XA patent/CN109790162B/zh active Active
- 2017-07-27 WO PCT/US2017/044194 patent/WO2018022897A1/en not_active Ceased
- 2017-07-27 ES ES17749074T patent/ES2828623T3/es active Active
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