BR112021018947A2 - Compostos macrocíclicos como agonistas de sting - Google Patents
Compostos macrocíclicos como agonistas de stingInfo
- Publication number
- BR112021018947A2 BR112021018947A2 BR112021018947A BR112021018947A BR112021018947A2 BR 112021018947 A2 BR112021018947 A2 BR 112021018947A2 BR 112021018947 A BR112021018947 A BR 112021018947A BR 112021018947 A BR112021018947 A BR 112021018947A BR 112021018947 A2 BR112021018947 A2 BR 112021018947A2
- Authority
- BR
- Brazil
- Prior art keywords
- macrocyclic compounds
- sting agonists
- compounds
- disclosed
- macrocyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/16—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
compostos macrocíclicos como agonistas de sting. são divulgados os compostos macrocíclicos de fórmula geral (i) e suas formas tautoméricas, estereoisômeros, sais farmaceuticamente aceitáveis e combinação dos mesmos com medicamentos adequados, processos correspondentes para a síntese e composições farmacêuticas e usos dos compostos aqui divulgados.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN201921012258 | 2019-03-28 | ||
| IN201921046194 | 2019-11-13 | ||
| PCT/IB2020/052654 WO2020194160A1 (en) | 2019-03-28 | 2020-03-21 | Macrocyclic compounds as sting agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112021018947A2 true BR112021018947A2 (pt) | 2022-02-08 |
Family
ID=70293003
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112021018947A BR112021018947A2 (pt) | 2019-03-28 | 2020-03-21 | Compostos macrocíclicos como agonistas de sting |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20220144852A1 (pt) |
| EP (1) | EP3946610A1 (pt) |
| JP (1) | JP2022527306A (pt) |
| KR (1) | KR20210146370A (pt) |
| CN (1) | CN113631228B (pt) |
| AU (1) | AU2020245263A1 (pt) |
| BR (1) | BR112021018947A2 (pt) |
| CA (1) | CA3132508A1 (pt) |
| CL (1) | CL2021002480A1 (pt) |
| CO (1) | CO2021012559A2 (pt) |
| CR (1) | CR20210495A (pt) |
| EC (1) | ECSP21071644A (pt) |
| IL (1) | IL286526A (pt) |
| MA (1) | MA55517A (pt) |
| MX (1) | MX2021011686A (pt) |
| PE (1) | PE20220169A1 (pt) |
| SG (1) | SG11202109191SA (pt) |
| WO (1) | WO2020194160A1 (pt) |
| ZA (1) | ZA202106629B (pt) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20220937A1 (es) * | 2019-07-22 | 2022-05-31 | Lupin Ltd | Compuestos macrociclicos como agonistas de sting y metodos y usos de los mismos |
| US11155567B2 (en) | 2019-08-02 | 2021-10-26 | Mersana Therapeutics, Inc. | Sting agonist compounds and methods of use |
| KR20220167275A (ko) | 2020-04-10 | 2022-12-20 | 오노 야꾸힝 고교 가부시키가이샤 | 암 치료 방법 |
| CA3207893A1 (en) * | 2021-01-15 | 2022-07-21 | Seagen Inc. | Immunomodulatory antibody-drug conjugates |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104513253A (zh) * | 2013-10-01 | 2015-04-15 | 南京波尔泰药业科技有限公司 | 用于治疗增殖性疾病的大环化合物 |
| KR20170109546A (ko) * | 2015-02-05 | 2017-09-29 | 메르크 파텐트 게엠베하 | Irak1/4 억제제로서의 매크로시클릭 화합물 및 이들의 용도 |
| EP3325473A4 (en) | 2015-07-22 | 2019-06-26 | The Royal Institution for the Advancement of Learning / McGill University | Compounds and uses thereof in the treatment of cancer and other medical disorders |
| AR107032A1 (es) | 2015-12-09 | 2018-03-14 | Padlock Therapeutics Inc | Inhibidores bicíclicos de pad4 |
| JP6746712B2 (ja) | 2016-04-07 | 2020-08-26 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ | タンパク質調節因子として有用な複素環式アミド |
| SG11201808708RA (en) | 2016-04-07 | 2018-11-29 | Glaxosmithkline Ip Dev Ltd | Heterocyclic amides useful as protein modulators |
| WO2018234805A1 (en) * | 2017-06-22 | 2018-12-27 | Curadev Pharma Limited | SMALL MOLECULAR MODULATORS OF HUMAN STING |
| WO2018234807A1 (en) | 2017-06-22 | 2018-12-27 | Curadev Pharma Limited | HETEROCYCLIC MODULATORS WITH SMALL MOLECULES OF HUMAN STING |
| CA3067257A1 (en) | 2017-06-22 | 2018-12-27 | Curadev Pharma Limited | Small molecule modulators of human sting |
| US10689376B2 (en) | 2017-07-27 | 2020-06-23 | Stingray Therapeutics, Inc. | Substituted-3H-imidazo [4,5-c] pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) and stimulator for interferon genes (STING) modulators as cancer immunotherapeutics |
| AU2018311966A1 (en) | 2017-08-04 | 2020-02-13 | Merck Sharp & Dohme Llc | Benzo[b]thiophene sting agonists for cancer treatment |
| RU2020109328A (ru) * | 2017-08-04 | 2021-09-06 | Мерк Шарп И Доум Корп. | Комбинации антагонистов pd-1 и бензо[b]тиофеновых агонистов sting для лечения рака |
-
2020
- 2020-03-21 WO PCT/IB2020/052654 patent/WO2020194160A1/en active Application Filing
- 2020-03-21 US US17/598,524 patent/US20220144852A1/en active Pending
- 2020-03-21 MX MX2021011686A patent/MX2021011686A/es unknown
- 2020-03-21 KR KR1020217035108A patent/KR20210146370A/ko unknown
- 2020-03-21 MA MA055517A patent/MA55517A/fr unknown
- 2020-03-21 PE PE2021001577A patent/PE20220169A1/es unknown
- 2020-03-21 CA CA3132508A patent/CA3132508A1/en active Pending
- 2020-03-21 JP JP2021557830A patent/JP2022527306A/ja active Pending
- 2020-03-21 CN CN202080025785.1A patent/CN113631228B/zh active Active
- 2020-03-21 CR CR20210495A patent/CR20210495A/es unknown
- 2020-03-21 BR BR112021018947A patent/BR112021018947A2/pt unknown
- 2020-03-21 SG SG11202109191SA patent/SG11202109191SA/en unknown
- 2020-03-21 EP EP20719719.5A patent/EP3946610A1/en active Pending
- 2020-03-21 AU AU2020245263A patent/AU2020245263A1/en active Pending
-
2021
- 2021-09-08 ZA ZA2021/06629A patent/ZA202106629B/en unknown
- 2021-09-19 IL IL286526A patent/IL286526A/en unknown
- 2021-09-24 CO CONC2021/0012559A patent/CO2021012559A2/es unknown
- 2021-09-24 EC ECSENADI202171644A patent/ECSP21071644A/es unknown
- 2021-09-24 CL CL2021002480A patent/CL2021002480A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20210146370A (ko) | 2021-12-03 |
| CN113631228B (zh) | 2023-10-13 |
| CL2021002480A1 (es) | 2022-04-29 |
| CN113631228A (zh) | 2021-11-09 |
| SG11202109191SA (en) | 2021-09-29 |
| JP2022527306A (ja) | 2022-06-01 |
| CA3132508A1 (en) | 2020-10-01 |
| WO2020194160A1 (en) | 2020-10-01 |
| CO2021012559A2 (es) | 2021-09-30 |
| MX2021011686A (es) | 2021-10-22 |
| CR20210495A (es) | 2021-10-18 |
| US20220144852A1 (en) | 2022-05-12 |
| ECSP21071644A (es) | 2021-12-30 |
| MA55517A (fr) | 2022-02-09 |
| EP3946610A1 (en) | 2022-02-09 |
| PE20220169A1 (es) | 2022-01-28 |
| ZA202106629B (en) | 2022-07-27 |
| IL286526A (en) | 2021-10-31 |
| AU2020245263A1 (en) | 2021-10-07 |
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