PT2513140E - Compostos derivados de glp-1 duplamente acilados - Google Patents
Compostos derivados de glp-1 duplamente acilados Download PDFInfo
- Publication number
- PT2513140E PT2513140E PT107880957T PT10788095T PT2513140E PT 2513140 E PT2513140 E PT 2513140E PT 107880957 T PT107880957 T PT 107880957T PT 10788095 T PT10788095 T PT 10788095T PT 2513140 E PT2513140 E PT 2513140E
- Authority
- PT
- Portugal
- Prior art keywords
- derivatives
- double
- acylated glp
- glp
- acylated
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors (Somatomedins), e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/575—Hormones
- G01N2333/605—Glucagons
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09179390 | 2009-12-16 | ||
US28860109P | 2009-12-21 | 2009-12-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT2513140E true PT2513140E (pt) | 2016-03-11 |
Family
ID=41800497
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT107880957T PT2513140E (pt) | 2009-12-16 | 2010-12-16 | Compostos derivados de glp-1 duplamente acilados |
Country Status (19)
Country | Link |
---|---|
US (4) | US20120329711A1 (pt) |
EP (4) | EP2513141B1 (pt) |
JP (5) | JP2013514322A (pt) |
KR (1) | KR101817607B1 (pt) |
CN (6) | CN102791731B (pt) |
AU (1) | AU2010338387B2 (pt) |
BR (1) | BR112012014475A8 (pt) |
CA (1) | CA2784757A1 (pt) |
DK (1) | DK2513140T3 (pt) |
ES (2) | ES2625735T3 (pt) |
HU (1) | HUE027229T2 (pt) |
IL (1) | IL219945A (pt) |
MX (1) | MX2012006634A (pt) |
PL (1) | PL2513140T3 (pt) |
PT (1) | PT2513140E (pt) |
RU (1) | RU2559540C2 (pt) |
TW (1) | TWI484974B (pt) |
WO (3) | WO2011080103A1 (pt) |
ZA (1) | ZA201204436B (pt) |
Families Citing this family (114)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2240155B1 (en) | 2008-02-13 | 2012-06-06 | Intarcia Therapeutics, Inc | Devices, formulations, and methods for delivery of multiple beneficial agents |
AP3329A (en) | 2009-07-13 | 2015-06-30 | Zealand Pharma As | Acylated glucagon analogues |
SI2462246T1 (en) | 2009-09-28 | 2018-01-31 | Intarcia Therapeutics, Inc. | Fast-setting and / or cessation of substantially unchanged delivery of the product |
CA2784757A1 (en) | 2009-12-16 | 2011-07-07 | Novo Nordisk A/S | Double-acylated glp-1 derivatives |
WO2012062803A1 (en) | 2010-11-09 | 2012-05-18 | Novo Nordisk A/S | Double-acylated glp-1 derivatives |
BR112013014942B1 (pt) | 2010-12-16 | 2020-01-28 | Novo Nordisk As | composições sólidas para administração, e seus usos |
US20120208755A1 (en) * | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
ES2612278T3 (es) | 2011-04-12 | 2017-05-16 | Novo Nordisk A/S | Derivados de GLP-1 doble-acilados |
KR20140053991A (ko) | 2011-07-18 | 2014-05-08 | 아츠 바이올로직스 에이/에스 | 장기간 작용하는 황체 형성 호르몬 (lh) 화합물 |
ES2626013T3 (es) * | 2011-09-06 | 2017-07-21 | Novo Nordisk A/S | Derivados de GLP-1 |
CA2861000A1 (en) | 2011-12-29 | 2013-07-04 | Novo Nordisk A/S | Dipeptide comprising a non-proteogenic amino acid |
ES2810153T3 (es) | 2012-03-01 | 2021-03-08 | Novo Nordisk As | Profármacos de GLP-1 |
HUE042757T2 (hu) | 2012-03-22 | 2019-07-29 | Novo Nordisk As | Szállító szert tartalmazó készítmények és elõállításuk |
KR102072202B1 (ko) | 2012-03-22 | 2020-01-31 | 노보 노르디스크 에이/에스 | Glp-1 펩티드의 조성물 및 그것의 제조 |
AR090937A1 (es) | 2012-05-03 | 2014-12-17 | Zealand Pharma As | Compuestos agonista duales de gip-glp-1 y metodos para usarlos |
US10000542B2 (en) | 2012-05-08 | 2018-06-19 | Novo Nordisk A/S | Double-acylated GLP-1 derivatives |
US11274135B2 (en) * | 2012-05-08 | 2022-03-15 | Novo Nordisk A/S | Double-acylated GLP-1 derivatives |
WO2013170636A1 (zh) | 2012-05-18 | 2013-11-21 | 爱德迪安(北京)生物技术有限公司 | 用于糖尿病治疗的蛋白、蛋白缀合物及其应用 |
ES2871328T3 (es) | 2012-06-20 | 2021-10-28 | Novo Nordisk As | Formulación de comprimido que comprende un péptido y un agente de suministro |
AU2013286177B2 (en) * | 2012-07-01 | 2018-04-26 | Novo Nordisk A/S | Use of long-acting GLP-1 peptides |
CN109456400A (zh) | 2012-07-23 | 2019-03-12 | 西兰制药公司 | 胰高血糖素类似物 |
FR2994848B1 (fr) | 2012-08-30 | 2014-08-22 | Univ Paris Curie | Traitement de l'arthrose par les hormones incretines ou leurs analogues |
TWI608013B (zh) | 2012-09-17 | 2017-12-11 | 西蘭製藥公司 | 升糖素類似物 |
UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
EP2915817B1 (en) * | 2012-10-31 | 2018-06-20 | Hybio Pharmaceutical Co., Ltd. | Method for preparing exenatide |
WO2014096150A1 (en) | 2012-12-21 | 2014-06-26 | Sanofi | Dual glp1/gip or trigonal glp1/gip/glucagon agonists |
PT2991671T (pt) * | 2013-05-02 | 2018-11-05 | Novo Nordisk As | Dosagem oral de compostos de glp-1 |
JP6475233B2 (ja) * | 2013-06-20 | 2019-02-27 | ノヴォ ノルディスク アー/エス | Glp−1誘導体及びその使用 |
EP3016975B1 (en) | 2013-07-04 | 2019-01-16 | Novo Nordisk A/S | Derivatives of glp-1 like peptides, and uses thereof |
JP6599863B2 (ja) | 2013-08-15 | 2019-10-30 | ノヴォ ノルディスク アー/エス | Glp−1誘導体及びその使用 |
WO2015038938A1 (en) | 2013-09-13 | 2015-03-19 | The California Institute For Biomedical Research | Modified therapeutic agents and compositions thereof |
PT3057984T (pt) | 2013-10-17 | 2018-10-24 | Boehringer Ingelheim Int | Análogos de glucagon acilados |
US9988429B2 (en) | 2013-10-17 | 2018-06-05 | Zealand Pharma A/S | Glucagon analogues |
CN105849122B (zh) | 2013-11-06 | 2021-04-30 | 西兰制药公司 | Gip-glp-1双重激动剂化合物及方法 |
CA2929107C (en) | 2013-11-06 | 2023-09-26 | Zealand Pharma A/S | Glucagon-glp-1-gip triple agonist compounds |
CN112043835B (zh) | 2013-12-06 | 2022-10-21 | 韩捷 | 用于含氮和羟基的药物的生物可逆引入基团 |
EP3080154B1 (en) | 2013-12-13 | 2018-02-07 | Sanofi | Dual glp-1/gip receptor agonists |
WO2015086733A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Dual glp-1/glucagon receptor agonists |
WO2015086730A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Non-acylated exendin-4 peptide analogues |
TW201609795A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 作為雙重glp-1/gip受體促效劑的艾塞那肽-4(exendin-4)胜肽類似物 |
EP4212180A1 (en) | 2013-12-18 | 2023-07-19 | The Scripps Research Institute | Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof |
TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重glp-1/昇糖素受體激動劑之艾塞那肽-4衍生物 |
TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自exendin-4之雙重glp-1/升糖素受體促效劑 |
WO2015155151A1 (en) * | 2014-04-07 | 2015-10-15 | Novo Nordisk A/S | Double-acylated glp-1 compounds |
TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽-4(Exendin-4)之肽類雙重GLP-1/升糖素受體促效劑 |
PT3628680T (pt) | 2014-06-12 | 2021-10-07 | Ra Pharmaceuticals Inc | Modulação da atividade do complemento |
US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
EP3985016A1 (en) | 2014-10-29 | 2022-04-20 | Zealand Pharma A/S | Gip agonist compounds and methods |
JP6730278B2 (ja) * | 2014-11-27 | 2020-07-29 | ノヴォ ノルディスク アー/エス | Glp−1誘導体及びその使用 |
CN107108714B (zh) | 2014-12-17 | 2022-02-08 | 诺和诺德股份有限公司 | Glp-1衍生物及其用途 |
JP6640229B2 (ja) | 2015-01-28 | 2020-02-05 | ラ ファーマシューティカルズ インコーポレイテッドRa Pharmaceuticals,Inc. | 補体活性の変調剤 |
CN107205949A (zh) * | 2015-01-29 | 2017-09-26 | 诺和诺德股份有限公司 | 包含片芯和立即释放包衣的用于口服glp‑1给药的药物组合物 |
JP7211704B2 (ja) * | 2015-01-29 | 2023-01-24 | ノヴォ ノルディスク アー/エス | Glp-1アゴニスト及び腸溶コーティングを含む錠剤 |
US10336802B2 (en) | 2015-04-16 | 2019-07-02 | Zealand Pharma A/S | Acylated glucagon analogue |
KR20240042548A (ko) | 2015-06-03 | 2024-04-02 | 인타르시아 세라퓨틱스 인코포레이티드 | 임플란트 배치 및 제거 시스템들 |
WO2016197009A1 (en) | 2015-06-05 | 2016-12-08 | Vertex Pharmaceuticals Incorporated | Triazoles for the treatment of demyelinating diseases |
AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
LT3319959T (lt) | 2015-07-06 | 2021-12-27 | Alkermes, Inc. | Histono deacetilazės hetero-halogeno inhibitoriai |
WO2017007755A1 (en) | 2015-07-06 | 2017-01-12 | Rodin Therapeutics, Inc. | Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase |
TW201706291A (zh) | 2015-07-10 | 2017-02-16 | 賽諾菲公司 | 作為選擇性肽雙重glp-1/升糖素受體促效劑之新毒蜥外泌肽(exendin-4)衍生物 |
CN106496322A (zh) * | 2015-09-07 | 2017-03-15 | 江苏恒瑞医药股份有限公司 | 人胰岛素或其类似物的酰化衍生物的制备方法 |
WO2017075505A2 (en) * | 2015-10-28 | 2017-05-04 | Tufts University | Novel polypeptides with improved proteolytic stability, and methods of preparing and using same |
MX2018007352A (es) | 2015-12-16 | 2019-05-16 | Ra Pharmaceuticals Inc | Moduladores de la actividad del complemento. |
GB2551945B (en) * | 2015-12-18 | 2021-09-08 | Heptares Therapeutics Ltd | Novel GLP-1 receptor agonist peptides |
ES2835033T3 (es) | 2016-03-03 | 2021-06-21 | Novo Nordisk As | Derivados de GLP-1 y sus usos |
MA53353A (fr) | 2016-05-16 | 2021-06-09 | Intarcia Therapeutics Inc | Polypeptides sélectifs pour le récepteur du glucagon et méthodes pour leur utilisation |
USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
CN107561168A (zh) * | 2016-06-30 | 2018-01-09 | 山东新时代药业有限公司 | 一种聚乙二醇化促胰岛素分泌肽类似物的分析检测方法 |
WO2018083335A1 (en) | 2016-11-07 | 2018-05-11 | Novo Nordisk A/S | Dchbs-active esters of peg compounds and their use |
WO2018106643A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Heterocyclic azoles for the treatment of demyelinating diseases |
WO2018106646A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Aminotriazoles for the treatment of demyelinating diseases |
WO2018106641A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Pyrazoles for the treatment of demyelinating diseases |
MX2019006527A (es) | 2016-12-07 | 2019-08-01 | Ra Pharmaceuticals Inc | Moduladores de la actividad del complemento. |
EP3565580B1 (en) | 2017-01-03 | 2024-03-06 | i2o Therapeutics, Inc. | Continuous administration of exenatide and co-adminstration of acetaminophen, ethinylestradiol or levonorgestrel |
SG11201906164RA (en) | 2017-01-11 | 2019-08-27 | Rodin Therapeutics Inc | Bicyclic inhibitors of histone deacetylase |
FR3061715B1 (fr) * | 2017-01-12 | 2021-07-30 | Institut National Univ Jean Francois Champollion | Peptide immunomodulateur |
EP3592376A1 (en) * | 2017-03-08 | 2020-01-15 | Intarcia Therapeutics, Inc | Apparatus and methods for administration of a nauseogenic compound from a drug delivery device |
AR112015A1 (es) | 2017-06-09 | 2019-09-11 | Novo Nordisk As | Composiciones sólidas para administración oral |
JP7152471B2 (ja) | 2017-08-07 | 2022-10-12 | ロダン・セラピューティクス,インコーポレーテッド | ヒストン脱アセチル化酵素の二環阻害剤 |
PE20211202A1 (es) | 2017-08-24 | 2021-07-05 | Novo Nordisk As | Composiciones de glp-1 y sus usos |
EP3684414A4 (en) * | 2017-09-19 | 2021-06-09 | Immunwork Inc. | PHARMACEUTICAL CONSTRUCTIONS WITH IMPROVED BINDING AFFINITY WITH ALBUMIN |
PL3746111T3 (pl) | 2018-02-02 | 2024-01-15 | Novo Nordisk A/S | Stałe kompozycje zawierające agonistę glp-1 i sól kwasu n-(8-(2- hydroksybenzoilo)amino kaprylowego i substancję poślizgową |
PL3774862T3 (pl) | 2018-04-05 | 2022-10-03 | Sun Pharmaceutical Industries Limited | Nowe analogi glp-1 |
KR102379958B1 (ko) * | 2018-05-04 | 2022-04-01 | 노보 노르디스크 에이/에스 | Gip 유도체 및 이의 용도 |
TWI829687B (zh) | 2018-05-07 | 2024-01-21 | 丹麥商諾佛 儂迪克股份有限公司 | 包含glp-1促效劑與n-(8-(2-羥基苯甲醯基)胺基)辛酸之鹽的固體組成物 |
CN109111361A (zh) * | 2018-10-08 | 2019-01-01 | 扬州工业职业技术学院 | 一种一步法高效制备十二烷基二酸单叔丁酯的方法 |
CN109134257A (zh) * | 2018-10-08 | 2019-01-04 | 扬州工业职业技术学院 | 一种两步法制备高纯度十二烷基二酸单叔丁酯的方法 |
WO2020118843A1 (zh) * | 2018-12-12 | 2020-06-18 | 四川利通科创生物医药科技有限公司 | 一种glp-1突变体及其制备方法和用途 |
WO2020152304A1 (en) | 2019-01-24 | 2020-07-30 | Novo Nordisk A/S | Roller compactor and method of dry granulation using a roller compactor |
EP3930757A1 (en) | 2019-03-01 | 2022-01-05 | President And Fellows Of Harvard College | Methods and compositions for protein delivery |
US20220257767A1 (en) | 2019-04-03 | 2022-08-18 | President And Fellows Of Harvard College | Ionic liquids for drug delivery |
WO2021070202A1 (en) * | 2019-10-09 | 2021-04-15 | Prasad Alaparthi Lakshmi | A method for preparing glp-1 analogue by solid-phase peptide synthesis |
WO2021089678A1 (en) | 2019-11-06 | 2021-05-14 | Novo Nordisk A/S | Glp-1 receptor agonists in dementia |
EP4054536A1 (en) | 2019-11-07 | 2022-09-14 | Novo Nordisk A/S | Solid compositions comprising a glp-1 agonist, an sglt2 inhibitor and a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid |
JP2023503899A (ja) | 2019-11-22 | 2023-02-01 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 薬物送達のためのイオン液体 |
CN116925237A (zh) | 2019-12-31 | 2023-10-24 | 北京质肽生物医药科技有限公司 | Glp-1和gdf15的融合蛋白以及其缀合物 |
PE20221575A1 (es) | 2020-02-18 | 2022-10-06 | Novo Nordisk As | Formulaciones farmaceuticas |
US20230165939A1 (en) | 2020-04-29 | 2023-06-01 | Novo Nordisk A/S | Solid compositions comprising a glp-1 agonist and histidine |
BR112022023834A2 (pt) * | 2020-05-29 | 2022-12-27 | Beijing Tuo Jie Biopharmaceutical Co Ltd | Composto duplo-agonista para os receptores de glp-1 e gip e aplicação do mesmo |
EP4181946A1 (en) * | 2020-07-18 | 2023-05-24 | Dr. Reddy's Laboratories Ltd. | Improved purification process of semaglutide |
MX2023000303A (es) | 2020-07-22 | 2023-02-09 | Novo Nordisk As | Coagonistas de los receptores del peptido 1 similar al glucagon (glp-1) y del polipeptido insulinotropico dependiente de glucosa (gip) adecuados para el suministro oral. |
CN115925994B (zh) * | 2020-09-30 | 2023-09-22 | 北京质肽生物医药科技有限公司 | 多肽缀合物和使用方法 |
IL302159A (en) | 2020-11-06 | 2023-06-01 | Novo Nordisk As | GLP-1 drug inhibitors and uses thereof |
TW202227474A (zh) * | 2020-12-18 | 2022-07-16 | 丹麥商諾佛 儂迪克股份有限公司 | Glp-1及澱粉素受體之共促效劑 |
CN114685644A (zh) * | 2020-12-29 | 2022-07-01 | 苏州康宁杰瑞生物科技有限公司 | 一种人glp-1多肽变体及其应用 |
WO2022175384A1 (en) * | 2021-02-17 | 2022-08-25 | Fundación Universidad Católica De Valencia San Vicente Mártir | Small-molecule agents with antiviral activity against rna viruses |
WO2023012263A1 (en) | 2021-08-04 | 2023-02-09 | Novo Nordisk A/S | Solid oral peptide formulations |
CA3233824A1 (en) | 2021-10-08 | 2023-04-13 | Samir Mitragotri | Ionic liquids for drug delivery |
TW202330584A (zh) | 2022-01-20 | 2023-08-01 | 丹麥商諾佛 儂迪克股份有限公司 | 前藥及其用途 |
WO2023217744A1 (en) | 2022-05-10 | 2023-11-16 | Novo Nordisk A/S | Prodrugs of glp-1 polypeptide and uses thereof |
WO2024003313A1 (en) | 2022-06-30 | 2024-01-04 | Sanofi | New peptides as selective il-23 receptor antagonists |
CN116514952B (zh) * | 2022-10-13 | 2024-02-02 | 江苏师范大学 | 一类glp-1类似物及其应用 |
Family Cites Families (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5545618A (en) | 1990-01-24 | 1996-08-13 | Buckley; Douglas I. | GLP-1 analogs useful for diabetes treatment |
JP3262329B2 (ja) * | 1990-01-24 | 2002-03-04 | アイ. バックレイ,ダグラス | 糖尿病治療に有用なglp―1アナログ |
US5336782A (en) | 1991-04-24 | 1994-08-09 | Kuraray Co., Ltd. | Long chain carboxylic acid imide ester |
US5512549A (en) | 1994-10-18 | 1996-04-30 | Eli Lilly And Company | Glucagon-like insulinotropic peptide analogs, compositions, and methods of use |
US5869602A (en) | 1995-03-17 | 1999-02-09 | Novo Nordisk A/S | Peptide derivatives |
US6458924B2 (en) | 1996-08-30 | 2002-10-01 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
UA72181C2 (uk) | 1996-08-30 | 2005-02-15 | Ново Нордіск А/С | Похідна глюкагоноподібного пептиду-1 (варіанти), фармацевтична композиція та спосіб одержання лікувального засобу (варіанти), спосіб лікування діабету (варіанти) і ожиріння |
EP1062240B1 (en) * | 1998-02-27 | 2010-04-28 | Novo Nordisk A/S | N-terminally modified glp-1 derivatives |
ATE466027T1 (de) | 1998-02-27 | 2010-05-15 | Novo Nordisk As | Abkömmlinge von glp-1 analogen |
EP1056774A1 (en) | 1998-02-27 | 2000-12-06 | Novo Nordisk A/S | N-terminally truncated glp-1 derivatives |
AU5027299A (en) | 1998-07-31 | 2000-02-28 | Novo Nordisk A/S | Use of glp-1 and analogues for preventing type ii diabetes |
MY155270A (en) * | 1998-09-24 | 2015-09-30 | Lilly Co Eli | Use of glp-1 or analogs in treatment of stroke |
ES2614603T3 (es) | 2002-02-20 | 2017-06-01 | Emisphere Technologies, Inc. | Procedimiento de administración de moléculas GLP-1 |
US20050059605A1 (en) * | 2003-01-31 | 2005-03-17 | Krishna Peri | Chemically modified metabolites of regulatory peptides and methods of producing and using same |
CA2518336A1 (en) | 2003-03-19 | 2004-11-04 | Eli Lilly And Company | Polyethelene glycol link glp-1 compounds |
US20070161087A1 (en) | 2003-05-29 | 2007-07-12 | Wolfgang Glaesner | Glp-1 fusion proteins |
JP2007501812A (ja) * | 2003-08-08 | 2007-02-01 | ノボ ノルディスク アクティーゼルスカブ | ペプチドのための結合剤として新しい構造上十分に定義された枝分れしたポリマーの合成および適用 |
EP2932981B1 (en) | 2003-09-19 | 2021-06-16 | Novo Nordisk A/S | Albumin-binding derivatives of GLP-1 |
BRPI0417684A (pt) | 2003-12-18 | 2007-03-20 | Novo Nordisk As | composto, composição farmacêutica, e, uso de um composto |
MXPA06006745A (es) | 2003-12-18 | 2006-08-18 | Novo Nordisk As | Compuestos glp-1 novedosos. |
US20060286129A1 (en) | 2003-12-19 | 2006-12-21 | Emisphere Technologies, Inc. | Oral GLP-1 formulations |
WO2005121090A1 (en) | 2004-06-02 | 2005-12-22 | Abbott Laboratories | Substituted piperidines that have antiangiogenic activity |
WO2006005667A2 (en) | 2004-07-08 | 2006-01-19 | Novo Nordisk A/S | Polypeptide protracting tags comprising a tetrazole moiety |
US8067362B2 (en) | 2005-02-02 | 2011-11-29 | Novo Nordisk As | Insulin derivatives |
JP2008531059A (ja) * | 2005-03-04 | 2008-08-14 | バイオレクシス ファーマシューティカル コーポレーション | 改変トランスフェリン融合タンパク質 |
TWI362392B (en) | 2005-03-18 | 2012-04-21 | Novo Nordisk As | Acylated glp-1 compounds |
JP5755398B2 (ja) | 2005-03-18 | 2015-07-29 | ノヴォ ノルディスク アー/エス | 伸長されたglp−1化合物 |
PT1881850E (pt) | 2005-05-13 | 2010-11-26 | Lilly Co Eli | Compostos peguilados de glp-1 |
AR053495A1 (es) * | 2005-05-26 | 2007-05-09 | Bristol Myers Squibb Co | Moduladores del peptido 1 similar al glucagon humano y su uso en el tratamiento de la diabetes y condiciones relacionadas |
CA2649751A1 (en) | 2006-04-20 | 2007-11-01 | Amgen Inc. | Glp-1 compound/glucagon antibody compositions |
ES2553154T3 (es) | 2006-05-09 | 2015-12-04 | Novo Nordisk A/S | Derivado de la insulina |
MX2008014061A (es) | 2006-05-09 | 2008-11-14 | Novo Nordisk As | Derivado de insulina. |
US20090098130A1 (en) * | 2007-01-05 | 2009-04-16 | Bradshaw Curt W | Glucagon-like protein-1 receptor (glp-1r) agonist compounds |
JP2011504871A (ja) | 2007-06-01 | 2011-02-17 | ノボ・ノルデイスク・エー/エス | 固体又は半固体担体中にペプチド薬剤を含む自然に分散可能なプレコンセントレイト |
JP2010530962A (ja) | 2007-06-12 | 2010-09-16 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 血漿においてタンパク質を検出する方法 |
EP2679597A1 (en) * | 2007-09-05 | 2014-01-01 | Novo Nordisk A/S | Glucagon-like peptide-1 derivatives and their pharmaceutical use |
EP2190460B1 (en) * | 2007-09-05 | 2014-12-17 | Novo Nordisk A/S | Peptides derivatized with a-b-c-d- and their therapeutical use |
US20100317057A1 (en) | 2007-12-28 | 2010-12-16 | Novo Nordisk A/S | Semi-recombinant preparation of glp-1 analogues |
EP2340049B1 (en) | 2008-09-12 | 2015-11-11 | Novo Nordisk A/S | Method of acylating a peptide or protein |
PL2386203T3 (pl) | 2008-10-15 | 2014-05-30 | Bayer Ip Gmbh | Zastosowanie ditiino-tetrakarboksyimidów do zwalczania fitopatogennych grzybów |
CN101463081B (zh) | 2009-01-12 | 2012-07-04 | 华东师范大学 | 一种glp-1衍生物 |
AR077956A1 (es) | 2009-09-14 | 2011-10-05 | Bayer Cropscience Ag | Combinaciones de compuestos activos |
CA2784757A1 (en) | 2009-12-16 | 2011-07-07 | Novo Nordisk A/S | Double-acylated glp-1 derivatives |
ES2612278T3 (es) | 2011-04-12 | 2017-05-16 | Novo Nordisk A/S | Derivados de GLP-1 doble-acilados |
-
2010
- 2010-12-16 CA CA2784757A patent/CA2784757A1/en not_active Withdrawn
- 2010-12-16 TW TW099144174A patent/TWI484974B/zh not_active IP Right Cessation
- 2010-12-16 CN CN201080057110.1A patent/CN102791731B/zh active Active
- 2010-12-16 DK DK10788095.7T patent/DK2513140T3/en active
- 2010-12-16 JP JP2012543757A patent/JP2013514322A/ja not_active Withdrawn
- 2010-12-16 CN CN201080057056.0A patent/CN102686607B/zh active Active
- 2010-12-16 JP JP2012543758A patent/JP6006118B2/ja active Active
- 2010-12-16 JP JP2012543759A patent/JP5411366B2/ja active Active
- 2010-12-16 AU AU2010338387A patent/AU2010338387B2/en not_active Ceased
- 2010-12-16 US US13/516,311 patent/US20120329711A1/en not_active Abandoned
- 2010-12-16 PL PL10788095T patent/PL2513140T3/pl unknown
- 2010-12-16 KR KR1020127015873A patent/KR101817607B1/ko active IP Right Grant
- 2010-12-16 HU HUE10788095A patent/HUE027229T2/en unknown
- 2010-12-16 WO PCT/EP2010/069932 patent/WO2011080103A1/en active Application Filing
- 2010-12-16 CN CN201410482902.3A patent/CN104311657B/zh active Active
- 2010-12-16 BR BR112012014475A patent/BR112012014475A8/pt active Search and Examination
- 2010-12-16 ES ES10790788.3T patent/ES2625735T3/es active Active
- 2010-12-16 WO PCT/EP2010/069929 patent/WO2011073328A1/en active Application Filing
- 2010-12-16 ES ES10788095.7T patent/ES2561658T3/es active Active
- 2010-12-16 EP EP10790788.3A patent/EP2513141B1/en active Active
- 2010-12-16 MX MX2012006634A patent/MX2012006634A/es active IP Right Grant
- 2010-12-16 PT PT107880957T patent/PT2513140E/pt unknown
- 2010-12-16 EP EP10788095.7A patent/EP2513140B1/en active Active
- 2010-12-16 CN CN2010800570823A patent/CN102655883A/zh active Pending
- 2010-12-16 WO PCT/EP2010/069931 patent/WO2011080102A2/en active Application Filing
- 2010-12-16 EP EP10793244A patent/EP2512518A1/en not_active Withdrawn
- 2010-12-16 CN CN202010234195.1A patent/CN111560060A/zh not_active Withdrawn
- 2010-12-16 CN CN201410482563.9A patent/CN104327182B/zh active Active
- 2010-12-16 US US13/516,312 patent/US8815802B2/en active Active
- 2010-12-16 EP EP15188731.2A patent/EP3000482B1/en active Active
- 2010-12-16 RU RU2012128547/10A patent/RU2559540C2/ru not_active IP Right Cessation
- 2010-12-16 US US12/970,196 patent/US8648041B2/en active Active
-
2012
- 2012-05-23 IL IL219945A patent/IL219945A/en not_active IP Right Cessation
- 2012-06-15 ZA ZA2012/04436A patent/ZA201204436B/en unknown
-
2013
- 2013-02-20 JP JP2013030695A patent/JP6194176B2/ja active Active
- 2013-12-10 US US14/101,618 patent/US9556250B2/en active Active
-
2016
- 2016-02-08 JP JP2016021671A patent/JP2016094473A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA201204436B (en) | Double-acylated glp-1 derivatives | |
HK1173142A1 (en) | N1-sulfonyl-5-fluoropyrimidinone derivatives n1--5- | |
HK1172893A1 (en) | 5-fluoropyrimidinone derivatives 5- | |
ZA201203205B (en) | Benzimidazole-imidazole derivatives | |
IL216007A0 (en) | Isoxazole-pyridine derivatives | |
EP2397480A4 (en) | DIAZEPINEDIONE DERIVATIVE | |
ZA201106855B (en) | Oxasiazole derivatives | |
IL215109A0 (en) | Isoxazole-pyridazine derivatives | |
IL214941A0 (en) | Isoxazole-pyrazole derivatives | |
ZA201104991B (en) | Deoxyactagardine derivatives | |
HK1172894A1 (en) | N1-acyl-5-fluoropyrimidinone derivatives n1--5- | |
HK1169623A1 (en) | Pyrazinooxazepine derivatives | |
EP2512482A4 (en) | DERIVATIVES OF 2-ALDOXIMINO-5-FLUOROPYRIMIDINE | |
GB0921967D0 (en) | Novel Aryloxyanilide Derivatives | |
HK1173134A1 (en) | Substituted halophenoxybenzamide derivatives | |
ZA201104279B (en) | Tetrahydronaphthalen-2-ol derivatives | |
GB0912499D0 (en) | Indopyl-pyridone derivatives |