BR112022023834A2 - Composto duplo-agonista para os receptores de glp-1 e gip e aplicação do mesmo - Google Patents

Composto duplo-agonista para os receptores de glp-1 e gip e aplicação do mesmo

Info

Publication number
BR112022023834A2
BR112022023834A2 BR112022023834A BR112022023834A BR112022023834A2 BR 112022023834 A2 BR112022023834 A2 BR 112022023834A2 BR 112022023834 A BR112022023834 A BR 112022023834A BR 112022023834 A BR112022023834 A BR 112022023834A BR 112022023834 A2 BR112022023834 A2 BR 112022023834A2
Authority
BR
Brazil
Prior art keywords
glp
application
agonist compound
gip
double
Prior art date
Application number
BR112022023834A
Other languages
English (en)
Inventor
Wu Fangzhou
Wang Lei
Huang Xuchao
Wu Ran
Liu Renzhi
Hua Haiqing
Original Assignee
Beijing Tuo Jie Biopharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beijing Tuo Jie Biopharmaceutical Co Ltd filed Critical Beijing Tuo Jie Biopharmaceutical Co Ltd
Publication of BR112022023834A2 publication Critical patent/BR112022023834A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

COMPOSTO DUPLO-AGONISTA PARA OS RECEPTORES DE GLP-1 E GIP E APLICAÇÃO DO MESMO. A presente invenção se refere a um composto duplo-agonista para os receptores do peptídeo semelhante ao glucagon 1 (GLP-1) e polipeptídeo insulinotrópico dependente de glicose (GIP), e aplicação do mesmo. Em particular, são fornecidos um análogo de polipeptídeo derivado de GLP-1 e um sal farmaceuticamente aceitável do mesmo, que tem um efeito agonista sobre o receptor GLP-1 humano e receptor GIP humano e podem ser usados para o tratamento de doenças metabólicas, como obesidade, diabetes tipo II e doença hepática gordurosa não alcoólica.
BR112022023834A 2020-05-29 2021-05-28 Composto duplo-agonista para os receptores de glp-1 e gip e aplicação do mesmo BR112022023834A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN202010472577 2020-05-29
CN202110335100 2021-03-29
PCT/CN2021/096568 WO2021239082A1 (zh) 2020-05-29 2021-05-28 Glp-1和gip受体双重激动剂化合物及其应用

Publications (1)

Publication Number Publication Date
BR112022023834A2 true BR112022023834A2 (pt) 2022-12-27

Family

ID=78745631

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022023834A BR112022023834A2 (pt) 2020-05-29 2021-05-28 Composto duplo-agonista para os receptores de glp-1 e gip e aplicação do mesmo

Country Status (11)

Country Link
US (1) US20230190879A1 (pt)
EP (1) EP4159750A4 (pt)
JP (1) JP2023526973A (pt)
KR (1) KR20230018395A (pt)
CN (1) CN114222755A (pt)
AU (1) AU2021278157A1 (pt)
BR (1) BR112022023834A2 (pt)
CA (1) CA3180215A1 (pt)
MX (1) MX2022014368A (pt)
TW (1) TW202144393A (pt)
WO (1) WO2021239082A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3204051A1 (en) 2021-01-20 2022-07-28 Brian Lian Compositions and methods for the treatment of metabolic and liver disorders
WO2023083301A1 (zh) * 2021-11-12 2023-05-19 福建盛迪医药有限公司 Glp-1受体和gip受体双重激动剂的药物组合物及其用途
CN116970063A (zh) * 2022-04-29 2023-10-31 苏州星洲生物科技有限公司 Glp-1/gip受体共激动剂、包含其的药物组合物及其用途
WO2024012472A1 (zh) * 2022-07-13 2024-01-18 杭州中美华东制药有限公司 Glp-1/gip双激动剂及其制备方法和用途
CN115806593B (zh) * 2022-09-23 2023-09-05 成都普康生物科技有限公司 一种脂肪酸链修饰的双受体激动剂及其用途
CN116496361B (zh) * 2023-06-25 2023-09-15 北京科翔中升医药科技有限公司 氘代模拟肽gip和glp-1双受体激动剂药物及用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6006118B2 (ja) * 2009-12-16 2016-10-12 ノヴォ ノルディスク アー／エス Ｇｌｐ−１アナログ及び誘導体
CN103764673A (zh) * 2011-06-10 2014-04-30 北京韩美药品有限公司 葡萄糖依赖性促胰岛素多肽类似物、其药物组合物及应用
UA116553C2 (uk) * 2012-12-21 2018-04-10 Санофі Пептидна сполука - агоніст рецептора glp-1 i glp
TW201625672A (zh) * 2014-10-24 2016-07-16 默沙東藥廠 升糖素及ｇｌｐ－１受體之共促效劑
ES2835033T3 (es) * 2016-03-03 2021-06-21 Novo Nordisk As Derivados de GLP-1 y sus usos
JP2022527803A (ja) * 2019-04-11 2022-06-06 ジエンス ハンセン ファーマセウティカル グループ カンパニー リミテッド マルチ受容体刺激剤及びその医療上の使用
CN111825758A (zh) * 2019-04-19 2020-10-27 上海翰森生物医药科技有限公司 Glp-1和gip共激动剂化合物

Also Published As

Publication number Publication date
US20230190879A1 (en) 2023-06-22
MX2022014368A (es) 2022-12-15
JP2023526973A (ja) 2023-06-26
EP4159750A4 (en) 2023-10-18
CN114222755A (zh) 2022-03-22
AU2021278157A1 (en) 2022-11-24
KR20230018395A (ko) 2023-02-07
CA3180215A1 (en) 2021-12-02
TW202144393A (zh) 2021-12-01
EP4159750A1 (en) 2023-04-05
WO2021239082A1 (zh) 2021-12-02

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