PT2268666E - Recombinante fsh incluindo sialilação alfa 2,3 e alfa 2,6 - Google Patents

Recombinante fsh incluindo sialilação alfa 2,3 e alfa 2,6 Download PDF

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Publication number
PT2268666E
PT2268666E PT97334973T PT09733497T PT2268666E PT 2268666 E PT2268666 E PT 2268666E PT 97334973 T PT97334973 T PT 97334973T PT 09733497 T PT09733497 T PT 09733497T PT 2268666 E PT2268666 E PT 2268666E
Authority
PT
Portugal
Prior art keywords
alpha
sialilation
recombinant fsh
fsh including
including alpha
Prior art date
Application number
PT97334973T
Other languages
English (en)
Portuguese (pt)
Inventor
Ian Cottingham
Daniel Plaksin
Richard Boyd White
Original Assignee
Ferring Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39717519&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2268666(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ferring Bv filed Critical Ferring Bv
Publication of PT2268666E publication Critical patent/PT2268666E/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1081—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C12Y204/99006—N-Acetyllactosaminide alpha-2,3-sialyltransferase (2.4.99.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PT97334973T 2008-04-16 2009-04-16 Recombinante fsh incluindo sialilação alfa 2,3 e alfa 2,6 PT2268666E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4542408P 2008-04-16 2008-04-16
EP08251528 2008-04-25

Publications (1)

Publication Number Publication Date
PT2268666E true PT2268666E (pt) 2014-06-25

Family

ID=39717519

Family Applications (6)

Application Number Title Priority Date Filing Date
PT97334973T PT2268666E (pt) 2008-04-16 2009-04-16 Recombinante fsh incluindo sialilação alfa 2,3 e alfa 2,6
PT161791215T PT3098234T (pt) 2008-04-25 2009-04-16 Fsh recombinante incluindo alfa 2,3- e alfa 2,6- sialilação
PT161581418T PT3045471T (pt) 2008-04-16 2009-04-16 Resumo
PT161949250T PT3144318T (pt) 2008-04-25 2009-04-16 Fsh recombinante incluindo sialilação alfa 2,3 e alfa 2,6
PT141787291T PT2808340T (pt) 2008-04-16 2009-04-16 Resumo
PT212128730T PT4015527T (pt) 2008-04-25 2009-04-16 Fsh recombinante incluindo alfa 2,3- e alfa 2,6- sialilação

Family Applications After (5)

Application Number Title Priority Date Filing Date
PT161791215T PT3098234T (pt) 2008-04-25 2009-04-16 Fsh recombinante incluindo alfa 2,3- e alfa 2,6- sialilação
PT161581418T PT3045471T (pt) 2008-04-16 2009-04-16 Resumo
PT161949250T PT3144318T (pt) 2008-04-25 2009-04-16 Fsh recombinante incluindo sialilação alfa 2,3 e alfa 2,6
PT141787291T PT2808340T (pt) 2008-04-16 2009-04-16 Resumo
PT212128730T PT4015527T (pt) 2008-04-25 2009-04-16 Fsh recombinante incluindo alfa 2,3- e alfa 2,6- sialilação

Country Status (29)

Country Link
US (6) US8951967B2 (enExample)
EP (7) EP3144318B1 (enExample)
JP (7) JP2011519359A (enExample)
KR (5) KR20170110741A (enExample)
CN (3) CN102066414A (enExample)
AR (1) AR071479A1 (enExample)
AU (5) AU2009237479B2 (enExample)
BR (1) BRPI0910461B8 (enExample)
CA (1) CA2725257A1 (enExample)
CY (1) CY1115413T1 (enExample)
DK (6) DK3045471T3 (enExample)
ES (5) ES2610277T3 (enExample)
FI (4) FI3098234T3 (enExample)
FR (3) FR17C1020I2 (enExample)
HR (5) HRP20241187T1 (enExample)
HU (9) HUE068565T2 (enExample)
IL (2) IL208538A (enExample)
LT (8) LT3045471T (enExample)
MX (3) MX355457B (enExample)
NO (4) NO2017025I1 (enExample)
NZ (1) NZ588381A (enExample)
PL (6) PL2808340T3 (enExample)
PT (6) PT2268666E (enExample)
RU (3) RU2537268C2 (enExample)
SA (1) SA109300228B1 (enExample)
SI (6) SI2808340T1 (enExample)
TW (1) TWI488640B (enExample)
WO (1) WO2009127826A1 (enExample)
ZA (1) ZA201007373B (enExample)

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TWI604850B (zh) * 2009-10-05 2017-11-11 菲瑞茵國際中心股份有限公司 藥學製劑
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WO2012016576A1 (en) * 2010-08-04 2012-02-09 Glycotope Gmbh Improved recombinant human follicle-stimulating hormone
RS54214B2 (sr) 2010-09-29 2024-02-29 Ferring Bv Smeša za upotrebu u lečenju infertiliteta
WO2012050175A1 (ja) 2010-10-15 2012-04-19 日本ケミカルリサーチ株式会社 糖鎖の非還元末端がマンノース残基である糖蛋白質の製造方法
CN103619358B (zh) * 2011-03-31 2017-02-15 辉凌公司 药物制剂
AR090095A1 (es) 2011-06-06 2014-10-22 Ferring Bv Preparacion farmaceutica que comprende hormona estimulante del foliculo recombinante
JO3092B1 (ar) 2011-08-08 2017-03-15 Ferring Bv مركب لتحفيز مسيطر عليه للمبيض
WO2013093760A2 (en) * 2011-12-19 2013-06-27 Grifols, S.A. Compositions, methods, and kits for preparing sialylated recombinant proteins
JP6279466B2 (ja) * 2012-04-27 2018-02-14 Ｊｃｒファーマ株式会社 新規な発現ベクター
EP2824176A1 (en) 2013-07-11 2015-01-14 Siamed'xpress Methods for producing sialylated therapeutic proteins
JP6652334B2 (ja) 2014-05-31 2020-02-19 Ｊｃｒファーマ株式会社 ウリジンとｎ−アセチル−ｄ−マンノサミンとを含有する培地
CN107429237B (zh) * 2014-12-22 2021-09-28 豪夫迈·罗氏有限公司 Cmp依赖性的唾液酸酶活性
PL3662925T3 (pl) 2015-04-17 2021-10-25 Ferring B.V. Kompozycja zawierająca FSH do leczenia niepłodności
JP6845813B2 (ja) 2015-06-26 2021-03-24 フェリング ベスローテン フェンノートシャップ 精製および／またはウイルス不活性化の方法
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EP3441471A1 (en) 2017-08-08 2019-02-13 CEVEC Pharmaceuticals GmbH Use of constitutively active variants of growth factor receptors as selection makers for the generation of stable producer cell lines
DK3973982T3 (da) 2017-09-01 2024-09-23 Ferring Bv Sammensætning til kontrolleret ovariestimulation
PL3787667T3 (pl) 2018-04-30 2025-07-28 Ferring B.V. Kompozycja do kontrolowanej stymulacji jajników
TWI846743B (zh) 2018-10-17 2024-07-01 荷蘭商菲林公司 用於控制性卵巢刺激之組成物及方法
US20220380785A1 (en) * 2019-11-01 2022-12-01 The University Of British Columbia Compositions and methods for sialylated mucin-type o-glycosylation of therapeutic proteins
TW202237173A (zh) 2020-12-09 2022-10-01 荷蘭商菲林公司 用於受控的卵巢刺激之組成物及方法
JP2025511129A (ja) 2022-04-01 2025-04-15 フェリング ベスローテン フェンノートシャップ 不妊症の治療のための混合プロトコル
US20250333466A1 (en) 2022-05-26 2025-10-30 Ferring B.V. Compositions and methods for treatment of infertility in males
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AR133300A1 (es) 2023-07-20 2025-09-17 Ferring Bv Micropartículas cargadas con fármaco de liberación prolongada

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TWI604850B (zh) * 2009-10-05 2017-11-11 菲瑞茵國際中心股份有限公司 藥學製劑
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WO2012016576A1 (en) * 2010-08-04 2012-02-09 Glycotope Gmbh Improved recombinant human follicle-stimulating hormone
RS54214B2 (sr) 2010-09-29 2024-02-29 Ferring Bv Smeša za upotrebu u lečenju infertiliteta
CN103619358B (zh) 2011-03-31 2017-02-15 辉凌公司 药物制剂
AR090095A1 (es) 2011-06-06 2014-10-22 Ferring Bv Preparacion farmaceutica que comprende hormona estimulante del foliculo recombinante
JO3092B1 (ar) 2011-08-08 2017-03-15 Ferring Bv مركب لتحفيز مسيطر عليه للمبيض
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Also Published As

Publication number Publication date
RU2682270C2 (ru) 2019-03-18
TW200948378A (en) 2009-12-01
LTPA2025525I1 (enExample) 2025-07-25
PT3144318T (pt) 2020-11-04
EP3098234B1 (en) 2024-07-31
LT4015527T (lt) 2025-04-10
AU2017225020B2 (en) 2019-11-14
NZ588381A (en) 2012-05-25
BRPI0910461A2 (pt) 2018-03-27
EP2268666B1 (en) 2014-03-12
PT4015527T (pt) 2025-04-10
PT2808340T (pt) 2016-11-21
PT3098234T (pt) 2024-10-21
US20210332099A1 (en) 2021-10-28
CN105906703A (zh) 2016-08-31
HUS1700025I1 (hu) 2017-06-28
FR25C1003I1 (fr) 2025-02-28
RU2010141908A (ru) 2012-05-27
LTPA2017018I1 (lt) 2017-06-26
NO2025032I1 (no) 2025-07-14
EP2268666A1 (en) 2011-01-05
HUE030652T2 (en) 2017-05-29
JP2018021037A (ja) 2018-02-08
KR20160056960A (ko) 2016-05-20
JP2024038000A (ja) 2024-03-19
LT3045471T (lt) 2017-07-10
EP3098234A1 (en) 2016-11-30
HRP20241187T1 (hr) 2024-12-06
MX348622B (es) 2017-06-22
SI3098234T1 (sl) 2024-10-30
US20160347811A1 (en) 2016-12-01
AU2009237479A1 (en) 2009-10-22
ES2629392T3 (es) 2017-08-09
BRPI0910461B8 (pt) 2021-05-25
FR17C1020I1 (enExample) 2020-04-10
HUE033830T2 (en) 2018-01-29
LTPA2017029I1 (lt) 2017-10-10
PL2808340T3 (pl) 2017-02-28
HUS1700036I1 (hu) 2017-10-30
KR20190092608A (ko) 2019-08-07
CN105906702A (zh) 2016-08-31
KR20110005863A (ko) 2011-01-19
LT3098234T (lt) 2024-09-10
EP4015527A1 (en) 2022-06-22
ES2468318T3 (es) 2014-06-16
FIC20250003I1 (fi) 2025-01-15
AU2009237479B2 (en) 2014-05-15
US20180079794A1 (en) 2018-03-22
FI3098234T3 (fi) 2024-10-31
HUS2500029I1 (hu) 2025-07-28
HK1146284A1 (en) 2011-05-20
PL3098234T3 (pl) 2025-01-07
EP2722339A1 (en) 2014-04-23
DK2808340T3 (en) 2016-12-05
DK3098234T3 (da) 2024-10-21
CA2725257A1 (en) 2009-10-22
FR17C1020I2 (fr) 2020-04-10
DK3045471T3 (en) 2017-06-26
JP6762916B2 (ja) 2020-09-30
EP3045471B1 (en) 2017-03-29
SI2268666T1 (sl) 2014-07-31
SI4015527T1 (sl) 2025-05-30
AU2014203277B2 (en) 2017-04-06
RU2745557C1 (ru) 2021-03-29
JP2022031652A (ja) 2022-02-22
AU2017225020A1 (en) 2017-09-28
JP6486310B2 (ja) 2019-03-20
JP7316905B2 (ja) 2023-07-28
LT2808340T (lt) 2016-11-10
MX2010011343A (es) 2011-01-20
PL4015527T3 (pl) 2025-05-26
NO2025006I1 (no) 2025-01-16
AU2014203277C1 (en) 2017-07-27
PL3144318T3 (pl) 2021-02-08
SI3144318T1 (sl) 2020-12-31
EP2808340B1 (en) 2016-08-17
AU2017204259A1 (en) 2017-07-20
US9771407B2 (en) 2017-09-26
RU2745557C3 (ru) 2021-12-10
HRP20161520T1 (hr) 2016-12-30
PL2268666T3 (pl) 2014-08-29
NO2017050I1 (no) 2017-09-28
ES2989729T3 (es) 2024-11-27
EP2808340A1 (en) 2014-12-03
AR071479A1 (es) 2010-06-23
BRPI0910461B1 (pt) 2021-02-23
SA109300228B1 (ar) 2014-04-08
IL230571A (en) 2015-11-30
WO2009127826A1 (en) 2009-10-22
BRPI0910461A8 (pt) 2018-10-16
DK4015527T3 (da) 2025-04-14
PT3045471T (pt) 2017-06-14
KR20170110741A (ko) 2017-10-11
JP2020040956A (ja) 2020-03-19
HUS2500008I1 (hu) 2025-02-28
SI2808340T1 (sl) 2016-12-30
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HUE068565T2 (hu) 2025-01-28
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SI3045471T1 (sl) 2017-07-31
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KR101622944B1 (ko) 2016-05-23
FR25C1025I1 (fr) 2025-09-19
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HK1199039A1 (en) 2015-06-19

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