PT1171443E - Compostos heteroaromaticos biciclicos uteis como agonistas de lh - Google Patents

Compostos heteroaromaticos biciclicos uteis como agonistas de lh

Info

Publication number
PT1171443E
PT1171443E PT00917026T PT00917026T PT1171443E PT 1171443 E PT1171443 E PT 1171443E PT 00917026 T PT00917026 T PT 00917026T PT 00917026 T PT00917026 T PT 00917026T PT 1171443 E PT1171443 E PT 1171443E
Authority
PT
Portugal
Prior art keywords
uht
agonists
heteroaromatic compounds
bicyclic heteroaromatic
bicyclic
Prior art date
Application number
PT00917026T
Other languages
English (en)
Portuguese (pt)
Inventor
Anton Egbert Peter Adang
Gerritsma Gerrildina Geziena
Straten Nicole Corine Va Renee
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of PT1171443E publication Critical patent/PT1171443E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Public Health (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
PT00917026T 1999-04-08 2000-04-03 Compostos heteroaromaticos biciclicos uteis como agonistas de lh PT1171443E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99201152 1999-04-08

Publications (1)

Publication Number Publication Date
PT1171443E true PT1171443E (pt) 2005-11-30

Family

ID=8240094

Family Applications (1)

Application Number Title Priority Date Filing Date
PT00917026T PT1171443E (pt) 1999-04-08 2000-04-03 Compostos heteroaromaticos biciclicos uteis como agonistas de lh

Country Status (30)

Country Link
US (2) US6569863B1 (enExample)
EP (1) EP1171443B1 (enExample)
JP (1) JP4854856B2 (enExample)
KR (1) KR100691546B1 (enExample)
CN (1) CN1177848C (enExample)
AR (1) AR028474A1 (enExample)
AT (1) ATE299507T1 (enExample)
AU (1) AU772258B2 (enExample)
BR (1) BRPI0009558B1 (enExample)
CA (1) CA2368834C (enExample)
CO (1) CO5160348A1 (enExample)
CZ (1) CZ300832B6 (enExample)
DE (1) DE60021262T2 (enExample)
DK (1) DK1171443T3 (enExample)
ES (1) ES2245304T3 (enExample)
HK (1) HK1041266B (enExample)
HU (1) HU229002B1 (enExample)
ID (1) ID30502A (enExample)
IL (2) IL145483A0 (enExample)
MX (1) MXPA01010144A (enExample)
NO (1) NO328826B1 (enExample)
NZ (1) NZ514445A (enExample)
PE (1) PE20010030A1 (enExample)
PL (1) PL219316B1 (enExample)
PT (1) PT1171443E (enExample)
RU (1) RU2248979C2 (enExample)
TR (1) TR200102839T2 (enExample)
TW (1) TW564247B (enExample)
WO (1) WO2000061586A1 (enExample)
ZA (1) ZA200107917B (enExample)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4977940B2 (ja) 2000-09-22 2012-07-18 エム・エス・ディー・オス・ベー・フェー 二環式ヘテロ芳香族化合物
GB0100622D0 (en) 2001-01-10 2001-02-21 Vernalis Res Ltd Chemical compounds V111
DE10108481A1 (de) 2001-02-22 2002-10-24 Bayer Ag Pyridylpyrimidine
EP1427734B1 (en) * 2001-09-04 2005-11-09 Akzo Nobel N.V. GLYCINE-SUBSTITUTED THIENO[2,3-d]PYRIMIDINES WITH COMBINED LH AND FSH AGONISTIC ACTIVITY
TWI228508B (en) * 2001-09-04 2005-03-01 Akzo Nobel Nv Thieno[2,3-d]pyrimidines with combined LH and FSH agonistic activity
UY27834A1 (es) 2002-06-06 2003-12-31 Boehringer Ingelheim Pharma Compuestos de amidas de acido 3-amino-tieno(2,3-b) piiridino-2-carboxilico sustituido y procedimientos para prepararlos y sus usos.
US6974870B2 (en) 2002-06-06 2005-12-13 Boehringer Ingelheim Phamaceuticals, Inc. Substituted 3-amino-thieno [2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses
WO2004092173A2 (en) 2003-04-09 2004-10-28 Biogen Idec Ma Inc. A2a adenosine receptor antagonists
US7674791B2 (en) 2003-04-09 2010-03-09 Biogen Idec Ma Inc. Triazolopyrazines and methods of making and using the same
US7285550B2 (en) 2003-04-09 2007-10-23 Biogen Idec Ma Inc. Triazolotriazines and pyrazolotriazines and methods of making and using the same
JPWO2005019225A1 (ja) * 2003-08-21 2007-11-01 杏林製薬株式会社 Ｎｋ１受容体拮抗作用を有する化合物の製造方法及びその製造中間体
US7550485B2 (en) * 2003-10-14 2009-06-23 Wyeth Substituted N-heterocycle derivatives and methods of their use
WO2005039506A2 (en) * 2003-10-24 2005-05-06 Exelixis, Inc. P70s6 kinase modulators and method of use
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
NZ553329A (en) * 2004-07-22 2010-09-30 Ptc Therapeutics Inc Thienopyridines for treating hepatitis C
CA2630920A1 (en) * 2005-11-22 2007-05-31 University Of South Florida Inhibition of cell proliferation
AR059898A1 (es) 2006-03-15 2008-05-07 Janssen Pharmaceutica Nv Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
AU2007254165A1 (en) * 2006-05-17 2007-11-29 Forschungsverbund Berlin E.V. Pyrimidine low molecular weight ligands for modulating hormone receptors
EP2029608A1 (en) 2006-06-06 2009-03-04 Boehringer Ingelheim International GmbH Substituted 3-amino-thieno[2,3-b] pyridine-2-carboxamide compounds, their preparation and use
RU2444524C2 (ru) * 2006-08-21 2012-03-10 Дженентек, Инк. Азабензотиофенильные соединения и способы применения
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
KR20100065191A (ko) 2007-09-14 2010-06-15 오르토-맥닐-얀센 파마슈티칼스 인코포레이티드 １,３-이치환된 ４-(아릴-ｘ-페닐)-１ｈ-피리딘-２-온
MX2010002536A (es) 2007-09-14 2010-08-10 Ortho Mcneil Janssen Pharm 4-fenil-3,4,5,6-tetrahidro-2h, 1'h-[1,4]bipiridinil-2'-onas 1',3'-disubstituidas.
EP2205565B1 (en) * 2007-09-14 2013-04-17 Janssen Pharmaceuticals, Inc. 1,3-disubstituted-4-phenyl-1 h-pyridin-2-ones
CN103497201A (zh) * 2007-10-18 2014-01-08 贝林格尔.英格海姆国际有限公司 二氢噻吩并[3,2-d]嘧啶的制备中使用的中间体及其制备
EP2220083B1 (en) 2007-11-14 2017-07-19 Janssen Pharmaceuticals, Inc. Imidazo[1,2-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
MX2011002042A (es) 2008-09-02 2011-06-20 Ortho Mcneil Janssen Pharm Derivados de 3-azabiciclo[3.1.o]hexilo como moduladores de los receptores del glutamato metabotropico.
AU2009304293B2 (en) 2008-10-16 2012-04-26 Addex Pharma S.A. Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors
CN102232074B (zh) 2008-11-28 2014-12-03 奥梅-杨森制药有限公司 作为代谢性谷氨酸盐受体调节剂的吲哚和苯并噁嗪衍生物
EA020672B1 (ru) 2009-05-12 2014-12-30 Янссен Фармасьютикалс, Инк. Производные 1,2,4-триазоло[4,3-a]пиридина и их применение для лечения или предупреждения неврологических и психиатрических расстройств
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
SG176018A1 (en) 2009-05-12 2011-12-29 Janssen Pharmaceuticals Inc 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
CA2815002C (en) 2010-11-08 2019-10-22 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
ES2552455T3 (es) 2010-11-08 2015-11-30 Janssen Pharmaceuticals, Inc. Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2
US9012448B2 (en) 2010-11-08 2015-04-21 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors
RU2014103185A (ru) 2011-07-18 2015-08-27 Артс Байолоджикс А/С Биологически активное соединение на основе лютеинизирующего гормона (lh) с пролонгированным действием
MX355088B (es) 2011-11-23 2018-04-04 Cancer Research Tech Ltd Inhibidores de tienopirimidina de proteina cinasa c atipica.
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
UA121965C2 (uk) 2014-01-21 2020-08-25 Янссен Фармацевтика Нв Комбінації, які містять позитивні алостеричні модулятори або ортостеричні агоністи метаботропного глутаматергічного рецептора 2 підтипу, та їх застосування
KR102502485B1 (ko) 2014-01-21 2023-02-21 얀센 파마슈티카 엔.브이. 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도
CN107602585A (zh) * 2017-10-23 2018-01-19 遵义医学院 噻吩并吡啶双杂环化合物的制备工艺
BR102019022529A2 (pt) * 2019-10-25 2021-05-04 Anhanguera Educacional Ltda. Processo para obtenção de composições farmacêuticas antitumorais através de butadienos push-pull, compostos e seus usos

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993013664A2 (en) * 1992-01-11 1993-07-22 Schering Agrochemicals Limited Biheterocyclic fungicidal compounds
TW449600B (en) 1994-04-19 2001-08-11 Takeda Chemical Industries Ltd Condensed-ring thiophene derivatives, their production and use
JP3854648B2 (ja) * 1994-04-19 2006-12-06 武田薬品工業株式会社 縮合チオフェン誘導体、その製造法及び用途
HUT77348A (hu) * 1994-11-08 1998-03-30 Takeda Chemical Industries, Ltd. Tienopiridin- és tienopirimidinszármazékok, eljárás előállításukra és az ezeket tartalmazó gyógyszerkészítmények
EP0862573A1 (en) * 1995-10-19 1998-09-09 Takeda Chemical Industries, Ltd. Thienopyridine derivatives as gonadotropin releasing hormone antagonists
JPH09169767A (ja) * 1995-10-19 1997-06-30 Takeda Chem Ind Ltd 複素環化合物、その製造法および用途
JPH09169766A (ja) * 1995-10-19 1997-06-30 Takeda Chem Ind Ltd チエノピリジン誘導体，その製造法および用途
EP0900222A1 (en) * 1996-04-26 1999-03-10 Takeda Chemical Industries, Ltd. Thienopyridine derivatives, their production and use

Also Published As

Publication number Publication date
PL350964A1 (en) 2003-02-24
AU3816600A (en) 2000-11-14
CN1349535A (zh) 2002-05-15
US20030212081A1 (en) 2003-11-13
TW564247B (en) 2003-12-01
HUP0200653A3 (en) 2004-07-28
CO5160348A1 (es) 2002-05-30
NO20014824D0 (no) 2001-10-04
ID30502A (id) 2001-12-13
HUP0200653A2 (en) 2002-06-29
JP2002541259A (ja) 2002-12-03
RU2248979C2 (ru) 2005-03-27
CZ300832B6 (cs) 2009-08-19
WO2000061586A1 (en) 2000-10-19
BR0009558A (pt) 2002-02-19
AR028474A1 (es) 2003-05-14
AU772258B2 (en) 2004-04-22
IL145483A0 (en) 2002-06-30
NO328826B1 (no) 2010-05-25
JP4854856B2 (ja) 2012-01-18
DK1171443T3 (da) 2005-11-07
KR20010103801A (ko) 2001-11-23
IL145483A (en) 2007-06-03
DE60021262T2 (de) 2006-01-05
CA2368834C (en) 2009-11-03
CN1177848C (zh) 2004-12-01
KR100691546B1 (ko) 2007-03-12
NO20014824L (no) 2001-10-04
CZ20013605A3 (cs) 2002-03-13
US6569863B1 (en) 2003-05-27
TR200102839T2 (tr) 2002-04-22
US6841553B2 (en) 2005-01-11
HK1041266A1 (en) 2002-07-05
NZ514445A (en) 2003-07-25
CA2368834A1 (en) 2000-10-19
BRPI0009558B1 (pt) 2016-10-25
ES2245304T3 (es) 2006-01-01
ZA200107917B (en) 2003-09-23
HK1041266B (en) 2005-09-16
EP1171443B1 (en) 2005-07-13
PL219316B1 (pl) 2015-04-30
ATE299507T1 (de) 2005-07-15
HU229002B1 (en) 2013-07-29
MXPA01010144A (es) 2002-04-24
PE20010030A1 (es) 2001-01-27
EP1171443A1 (en) 2002-01-16
DE60021262D1 (de) 2005-08-18

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