NO20014824D0 - Bicykliske heteroaromatiske forbindelser anvendelige som LH- agonister - Google Patents

Bicykliske heteroaromatiske forbindelser anvendelige som LH- agonister

Info

Publication number
NO20014824D0
NO20014824D0 NO20014824A NO20014824A NO20014824D0 NO 20014824 D0 NO20014824 D0 NO 20014824D0 NO 20014824 A NO20014824 A NO 20014824A NO 20014824 A NO20014824 A NO 20014824A NO 20014824 D0 NO20014824 D0 NO 20014824D0
Authority
NO
Norway
Prior art keywords
agonists
compounds useful
heteroaromatic compounds
bicyclic heteroaromatic
bicyclic
Prior art date
Application number
NO20014824A
Other languages
English (en)
Other versions
NO328826B1 (no
NO20014824L (no
Inventor
Gerrildina Geziena Gerritsma
Nicole Corine Renee Va Straten
Anton Egbert Peter Adang
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of NO20014824L publication Critical patent/NO20014824L/no
Publication of NO20014824D0 publication Critical patent/NO20014824D0/no
Publication of NO328826B1 publication Critical patent/NO328826B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Diabetes (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
NO20014824A 1999-04-08 2001-10-04 Bicykliske heteroaromatiske forbindelser anvendelige som LH-agonister samt farmasoytiske preparater inneholdende slike NO328826B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99201152 1999-04-08
PCT/EP2000/002865 WO2000061586A1 (en) 1999-04-08 2000-04-03 Bicyclic heteroaromatic compounds useful as lh agonists

Publications (3)

Publication Number Publication Date
NO20014824L NO20014824L (no) 2001-10-04
NO20014824D0 true NO20014824D0 (no) 2001-10-04
NO328826B1 NO328826B1 (no) 2010-05-25

Family

ID=8240094

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20014824A NO328826B1 (no) 1999-04-08 2001-10-04 Bicykliske heteroaromatiske forbindelser anvendelige som LH-agonister samt farmasoytiske preparater inneholdende slike

Country Status (30)

Country Link
US (2) US6569863B1 (no)
EP (1) EP1171443B1 (no)
JP (1) JP4854856B2 (no)
KR (1) KR100691546B1 (no)
CN (1) CN1177848C (no)
AR (1) AR028474A1 (no)
AT (1) ATE299507T1 (no)
AU (1) AU772258B2 (no)
BR (1) BRPI0009558B1 (no)
CA (1) CA2368834C (no)
CO (1) CO5160348A1 (no)
CZ (1) CZ300832B6 (no)
DE (1) DE60021262T2 (no)
DK (1) DK1171443T3 (no)
ES (1) ES2245304T3 (no)
HK (1) HK1041266B (no)
HU (1) HU229002B1 (no)
ID (1) ID30502A (no)
IL (2) IL145483A0 (no)
MX (1) MXPA01010144A (no)
NO (1) NO328826B1 (no)
NZ (1) NZ514445A (no)
PE (1) PE20010030A1 (no)
PL (1) PL219316B1 (no)
PT (1) PT1171443E (no)
RU (1) RU2248979C2 (no)
TR (1) TR200102839T2 (no)
TW (1) TW564247B (no)
WO (1) WO2000061586A1 (no)
ZA (1) ZA200107917B (no)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0113987A (pt) * 2000-09-22 2003-08-12 Akzo Nobel Nv Composto heteromático bicìclico, ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso de derivados heteroaromáticos bicìclicos ou de um sal ou solvato farmaceuticamente aceitável dos mesmos
GB0100622D0 (en) 2001-01-10 2001-02-21 Vernalis Res Ltd Chemical compounds V111
DE10108481A1 (de) * 2001-02-22 2002-10-24 Bayer Ag Pyridylpyrimidine
TWI228508B (en) * 2001-09-04 2005-03-01 Akzo Nobel Nv Thieno[2,3-d]pyrimidines with combined LH and FSH agonistic activity
CN1261437C (zh) * 2001-09-04 2006-06-28 阿克佐诺贝尔公司 具有LH与FSH联合激动活性的甘氨酸－取代的噻吩并[2,3－d]嘧啶
US6974870B2 (en) 2002-06-06 2005-12-13 Boehringer Ingelheim Phamaceuticals, Inc. Substituted 3-amino-thieno [2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses
CN100386329C (zh) 2002-06-06 2008-05-07 贝林格尔.英格海姆药物公司 取代的3-氨基-噻吩并[2,3-b]吡啶-2-羧酸酰胺化合物及其制备方法和用途
DE602004018637D1 (de) 2003-04-09 2009-02-05 Biogen Idec Inc A2a-adenosinrezeptorantagonisten
EP1615930A2 (en) 2003-04-09 2006-01-18 Biogen Idec MA, Inc. Triazolotriazines and pyrazolotriazines useful as a2a adenosine receptor antagonists
US7674791B2 (en) 2003-04-09 2010-03-09 Biogen Idec Ma Inc. Triazolopyrazines and methods of making and using the same
WO2005019225A1 (ja) * 2003-08-21 2005-03-03 Kyorin Pharmaceutical Co., Ltd. Ｎｋ１受容体拮抗作用を有する化合物の製造方法及びその製造中間体
US7550485B2 (en) * 2003-10-14 2009-06-23 Wyeth Substituted N-heterocycle derivatives and methods of their use
CA2541989C (en) * 2003-10-24 2013-10-01 Exelixis, Inc. P70s6 kinase modulators and method of use
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
AU2005275182A1 (en) * 2004-07-22 2006-02-23 Ptc Therapeutics, Inc. Thienopyridines for treating Hepatitis C
CA2630920A1 (en) * 2005-11-22 2007-05-31 University Of South Florida Inhibition of cell proliferation
TWI417095B (zh) 2006-03-15 2013-12-01 Janssen Pharmaceuticals Inc １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途
CA2652061A1 (en) * 2006-05-17 2007-11-29 Marvin C. Gershengorn Pyrimidine low molecular weight ligands for modulating hormone receptors
WO2007146602A1 (en) 2006-06-06 2007-12-21 Boehringer Ingelheim International Gmbh Substituted 3-amino-thieno[2,3-b] pyridine-2-carboxamide compounds, their preparation and use
RU2444524C2 (ru) * 2006-08-21 2012-03-10 Дженентек, Инк. Азабензотиофенильные соединения и способы применения
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
JP5433579B2 (ja) * 2007-09-14 2014-03-05 ジャンセン ファーマシューティカルズ， インコーポレイテッド． １，３−二置換−４−フェニル−１ｈ−ピリジン−２−オン
PT2200985E (pt) 2007-09-14 2011-07-21 Ortho Mcneil Janssen Pharm 4-(aril-x-fenil)-1h-piridin-2-onas 1,3-dissubstituídas
UA100126C2 (en) 2007-09-14 2012-11-26 Аддекс Фарма С.А. 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h, 1'h-[1, 4'] bipyridinyl-2'-ones
CA2702500A1 (en) * 2007-10-18 2009-04-23 Boehringer Ingelheim International Gmbh Preparation of dihydrothieno [3, 2-d] pyrimidines and intermediates used therein
CN101861316B (zh) 2007-11-14 2013-08-21 奥梅-杨森制药有限公司 咪唑并[1,2-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途
AU2009289784B2 (en) 2008-09-02 2012-03-22 Addex Pharma S.A. 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
RU2517181C2 (ru) 2008-10-16 2014-05-27 Орто-Макнейл-Янссен Фармасьютикалз, Инк. Производные индола и бензоморфолина в качестве модулятора метаботропных глутаматных рецепторов
BRPI0921333A2 (pt) 2008-11-28 2015-12-29 Addex Pharmaceuticals Sa derivados de indol e benzoxazina como moduladores de receptores de glutamato metabotrópicos
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
BRPI1010831A2 (pt) 2009-05-12 2016-04-05 Addex Pharmaceuticals Sa derivados de 1,2,4-triazolo[4,3-a]piridina e seu como moduladores alostéricos positivos de receptores de mglur2
KR101753826B1 (ko) 2009-05-12 2017-07-04 얀센 파마슈티칼즈, 인코포레이티드 1,２,４―트리아졸로［４,３―ａ］피리딘 유도체 및 신경정신 질환의 치료 또는 예방을 위한 이들의 용도
ES2536433T3 (es) 2010-11-08 2015-05-25 Janssen Pharmaceuticals, Inc. Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2
EP2649069B1 (en) 2010-11-08 2015-08-26 Janssen Pharmaceuticals, Inc. 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
AU2011328203B2 (en) 2010-11-08 2015-03-19 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
KR20140053991A (ko) 2011-07-18 2014-05-08 아츠 바이올로직스 에이/에스 장기간 작용하는 황체 형성 호르몬 (ｌｈ) 화합물
AU2012340869B2 (en) 2011-11-23 2017-03-02 Cancer Research Technology Limited Thienopyrimidine inhibitors of atypical protein kinase C
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
MX2016009471A (es) 2014-01-21 2016-10-13 Janssen Pharmaceutica Nv Combinaciones que comprenden agonistas ortostericos o moduladores alostericos positivos del receptor glutamatergico metabotropico de subtipo 2 y su uso.
HUE045610T2 (hu) 2014-01-21 2020-01-28 Janssen Pharmaceutica Nv 2-es altípusú metabotróp glutamáterg receptor pozitív allosztérikus modulátorait vagy ortosztérikus agonistáit tartalmazó kombinációk és alkalmazásuk
CN107602585A (zh) * 2017-10-23 2018-01-19 遵义医学院 噻吩并吡啶双杂环化合物的制备工艺
BR102019022529A2 (pt) * 2019-10-25 2021-05-04 Anhanguera Educacional Ltda. Processo para obtenção de composições farmacêuticas antitumorais através de butadienos push-pull, compostos e seus usos

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3262593A (en) 1992-01-11 1993-08-03 Schering Agrochemicals Limited Biheterocyclic fungicidal compounds
JP3854648B2 (ja) * 1994-04-19 2006-12-06 武田薬品工業株式会社 縮合チオフェン誘導体、その製造法及び用途
TW449600B (en) 1994-04-19 2001-08-11 Takeda Chemical Industries Ltd Condensed-ring thiophene derivatives, their production and use
WO1996014319A1 (en) 1994-11-08 1996-05-17 Takeda Chemical Industries, Ltd. Thienopyridine or thienopyrimidine derivatives and their use
JPH09169767A (ja) * 1995-10-19 1997-06-30 Takeda Chem Ind Ltd 複素環化合物、その製造法および用途
JPH09169766A (ja) * 1995-10-19 1997-06-30 Takeda Chem Ind Ltd チエノピリジン誘導体，その製造法および用途
WO1997014697A1 (en) * 1995-10-19 1997-04-24 Takeda Chemical Industries, Ltd. Thienopyridine derivatives as gonadotropin releasing hormone antagonists
AU2406597A (en) 1996-04-26 1997-11-19 Takeda Chemical Industries Ltd. Thienopyridine derivatives, their production and use

Also Published As

Publication number Publication date
CA2368834A1 (en) 2000-10-19
TW564247B (en) 2003-12-01
ATE299507T1 (de) 2005-07-15
PL350964A1 (en) 2003-02-24
PE20010030A1 (es) 2001-01-27
HUP0200653A2 (en) 2002-06-29
ES2245304T3 (es) 2006-01-01
CN1349535A (zh) 2002-05-15
DK1171443T3 (da) 2005-11-07
HU229002B1 (en) 2013-07-29
CO5160348A1 (es) 2002-05-30
PL219316B1 (pl) 2015-04-30
PT1171443E (pt) 2005-11-30
AR028474A1 (es) 2003-05-14
KR100691546B1 (ko) 2007-03-12
CZ20013605A3 (cs) 2002-03-13
JP2002541259A (ja) 2002-12-03
CA2368834C (en) 2009-11-03
RU2248979C2 (ru) 2005-03-27
ID30502A (id) 2001-12-13
BR0009558A (pt) 2002-02-19
KR20010103801A (ko) 2001-11-23
MXPA01010144A (es) 2002-04-24
EP1171443B1 (en) 2005-07-13
EP1171443A1 (en) 2002-01-16
CZ300832B6 (cs) 2009-08-19
US6569863B1 (en) 2003-05-27
IL145483A0 (en) 2002-06-30
NO328826B1 (no) 2010-05-25
US20030212081A1 (en) 2003-11-13
DE60021262D1 (de) 2005-08-18
ZA200107917B (en) 2003-09-23
AU772258B2 (en) 2004-04-22
DE60021262T2 (de) 2006-01-05
US6841553B2 (en) 2005-01-11
AU3816600A (en) 2000-11-14
CN1177848C (zh) 2004-12-01
WO2000061586A1 (en) 2000-10-19
NO20014824L (no) 2001-10-04
JP4854856B2 (ja) 2012-01-18
IL145483A (en) 2007-06-03
HK1041266B (zh) 2005-09-16
BRPI0009558B1 (pt) 2016-10-25
TR200102839T2 (tr) 2002-04-22
HUP0200653A3 (en) 2004-07-28
HK1041266A1 (en) 2002-07-05
NZ514445A (en) 2003-07-25

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Legal Events

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CHAD Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: MERCK SHARP & DOHME BV, NL

MM1K Lapsed by not paying the annual fees