AR028474A1 - Un compuesto derivado heteroaromatico biciclico, su uso y una composicion farmaceutica que lo comprende - Google Patents
Un compuesto derivado heteroaromatico biciclico, su uso y una composicion farmaceutica que lo comprendeInfo
- Publication number
- AR028474A1 AR028474A1 ARP000101578A ARP000101578A AR028474A1 AR 028474 A1 AR028474 A1 AR 028474A1 AR P000101578 A ARP000101578 A AR P000101578A AR P000101578 A ARP000101578 A AR P000101578A AR 028474 A1 AR028474 A1 AR 028474A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- aryl
- heteroaryl
- alkynyl
- alkenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Endocrinology (AREA)
- Public Health (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
Compuestos derivados heteroaromáticos bicíclicos de acuerdo a la formula general (1), o una sal farmacéuticamente aceptable de él, en donde R1 es NR5R6, OR5, SR5 o R7; R5 y R6 se seleccionan independientemente de H, alquilo C1-8, alquenilo C2-8, alquinilo C2-8, cicloalquilo C3-8, heterocicloalquilo C2-7, alquil C1-8 carbonilo, arilcarbonilo C6-14, arilo C6-14, o heteroarilo C4-13,o R5 y R6 juntos se unen en un anillo de heterocicloalquilo C2-7; R7 es cicloalquilo C3-8, heterocicloalquilo C2-7, arilo C6-14 o heteroarilo C4-13; R2 es alquilo C1-8, alquenilo C2-8, alquinilo C2-8, o arilo C6-14 o heteroarilo C4-13, ambos opcionalmente sustituidos con uno o más sustitutos seleccionados de alquilo C1-8, alquiltio C1-8 (di)alquilamino C1-8, alcoxi C1-8, alquenilo C2-8 o alquinilo C2-8; R3 es alquilo C1-8, alquenilo C2-8, alquinilo C2-8, cicloalquilo C3-8, heterocicloalquilo C2-7, o arilo C6-14 o heteroarilo C4-13, ambos opcionalmente sustituidos con uno o más sustitutos seleccionados desde alquilo C1-8, (di) alquilamino C1-8, o alcoxi C1-8; X es S, O, o N(R4); R4 es H, alquilo C1-8, alquilcarbonilo C1-8, arilcarbonilo C6-14 o arilo C6-14 alquilo C1-8; Y es CH o N; Z es NH2 o OH; A es S, N(H), N(R9), O o un enlace; R9 puede seleccionarse de los mismos grupos como se describio para R2 y B es N(H), O o un enlace. Estos compuestos tienen actividad de activacion de receptores de LH y pueden usarse en terapias para la regulacion de la fertilidad.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99201152 | 1999-04-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR028474A1 true AR028474A1 (es) | 2003-05-14 |
Family
ID=8240094
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000101578A AR028474A1 (es) | 1999-04-08 | 2000-04-06 | Un compuesto derivado heteroaromatico biciclico, su uso y una composicion farmaceutica que lo comprende |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US6569863B1 (es) |
| EP (1) | EP1171443B1 (es) |
| JP (1) | JP4854856B2 (es) |
| KR (1) | KR100691546B1 (es) |
| CN (1) | CN1177848C (es) |
| AR (1) | AR028474A1 (es) |
| AT (1) | ATE299507T1 (es) |
| AU (1) | AU772258B2 (es) |
| BR (1) | BRPI0009558B1 (es) |
| CA (1) | CA2368834C (es) |
| CO (1) | CO5160348A1 (es) |
| CZ (1) | CZ300832B6 (es) |
| DE (1) | DE60021262T2 (es) |
| DK (1) | DK1171443T3 (es) |
| ES (1) | ES2245304T3 (es) |
| HK (1) | HK1041266B (es) |
| HU (1) | HU229002B1 (es) |
| ID (1) | ID30502A (es) |
| IL (2) | IL145483A0 (es) |
| MX (1) | MXPA01010144A (es) |
| NO (1) | NO328826B1 (es) |
| NZ (1) | NZ514445A (es) |
| PE (1) | PE20010030A1 (es) |
| PL (1) | PL219316B1 (es) |
| PT (1) | PT1171443E (es) |
| RU (1) | RU2248979C2 (es) |
| TR (1) | TR200102839T2 (es) |
| TW (1) | TW564247B (es) |
| WO (1) | WO2000061586A1 (es) |
| ZA (1) | ZA200107917B (es) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2271360C2 (ru) * | 2000-09-22 | 2006-03-10 | Акцо Нобель Н.В. | Бициклические гетероароматические соединения, фармацевтическая композиция на их основе и применение |
| GB0100622D0 (en) | 2001-01-10 | 2001-02-21 | Vernalis Res Ltd | Chemical compounds V111 |
| DE10108481A1 (de) | 2001-02-22 | 2002-10-24 | Bayer Ag | Pyridylpyrimidine |
| TWI228508B (en) * | 2001-09-04 | 2005-03-01 | Akzo Nobel Nv | Thieno[2,3-d]pyrimidines with combined LH and FSH agonistic activity |
| WO2003020727A1 (en) * | 2001-09-04 | 2003-03-13 | Akzo Nobel N.V. | GLYCINE-SUBSTITUTED THIENO [2,3-d]PYRIMIDINES WITH COMBINED LH AND FSH AGONISTIC ACTIVITY |
| US6974870B2 (en) | 2002-06-06 | 2005-12-13 | Boehringer Ingelheim Phamaceuticals, Inc. | Substituted 3-amino-thieno [2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses |
| DK1513516T3 (da) | 2002-06-06 | 2009-10-19 | Boehringer Ingelheim Pharma | Substitueret 3-amino-thieno(2,3-b)-pyridin-2-carboxylsyreamid-forbindelser og fremgangsmåder til fremstilling og deres anvendelser |
| WO2004092173A2 (en) | 2003-04-09 | 2004-10-28 | Biogen Idec Ma Inc. | A2a adenosine receptor antagonists |
| US7285550B2 (en) | 2003-04-09 | 2007-10-23 | Biogen Idec Ma Inc. | Triazolotriazines and pyrazolotriazines and methods of making and using the same |
| US7674791B2 (en) | 2003-04-09 | 2010-03-09 | Biogen Idec Ma Inc. | Triazolopyrazines and methods of making and using the same |
| JPWO2005019225A1 (ja) * | 2003-08-21 | 2007-11-01 | 杏林製薬株式会社 | Ｎｋ１受容体拮抗作用を有する化合物の製造方法及びその製造中間体 |
| US7550485B2 (en) * | 2003-10-14 | 2009-06-23 | Wyeth | Substituted N-heterocycle derivatives and methods of their use |
| AU2004283751B2 (en) * | 2003-10-24 | 2011-05-19 | Exelixis, Inc. | p70S6 kinase modulators and method of use |
| US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| CN101022802A (zh) * | 2004-07-22 | 2007-08-22 | Ptc医疗公司 | 用于治疗丙型肝炎的噻吩并吡啶化合物 |
| CA2630920A1 (en) * | 2005-11-22 | 2007-05-31 | University Of South Florida | Inhibition of cell proliferation |
| TWI417095B (zh) | 2006-03-15 | 2013-12-01 | Janssen Pharmaceuticals Inc | １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途 |
| WO2007136776A2 (en) * | 2006-05-17 | 2007-11-29 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Pyrimidine low molecular weight ligands for modulating hormone receptors |
| JP2009539865A (ja) | 2006-06-06 | 2009-11-19 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 置換３−アミノ−チエノ［２，３−ｂ］ピリジン２−カルボン酸アミド化合物及び製造方法及びそれらの使用 |
| RU2444524C2 (ru) * | 2006-08-21 | 2012-03-10 | Дженентек, Инк. | Азабензотиофенильные соединения и способы применения |
| TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| WO2009033702A1 (en) | 2007-09-14 | 2009-03-19 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | 1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones |
| PT2203439E (pt) | 2007-09-14 | 2011-02-11 | Ortho Mcneil Janssen Pharm | 4-fenil-3,4,5,6-tetra-hidro-2h,1'h-[1,4']bipiridinil-2'- onas 1',3'-dissubstituídas |
| TW200927731A (en) * | 2007-09-14 | 2009-07-01 | Ortho Mcneil Janssen Pharm | 1,3-disubstituted-4-phenyl-1H-pyridin-2-ones |
| MX2010003826A (es) * | 2007-10-18 | 2010-04-21 | Boehringer Ingelheim Int | Preparacion de dihidrotieno [3,2-d] pirimidinas e intermedios usados en la misma. |
| EP2220083B1 (en) | 2007-11-14 | 2017-07-19 | Janssen Pharmaceuticals, Inc. | Imidazo[1,2-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| EP2344470B1 (en) | 2008-09-02 | 2013-11-06 | Janssen Pharmaceuticals, Inc. | 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors |
| AU2009304293B2 (en) | 2008-10-16 | 2012-04-26 | Addex Pharma S.A. | Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors |
| CN102232074B (zh) | 2008-11-28 | 2014-12-03 | 奥梅-杨森制药有限公司 | 作为代谢性谷氨酸盐受体调节剂的吲哚和苯并噁嗪衍生物 |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| ES2409006T3 (es) | 2009-05-12 | 2013-06-24 | Janssen Pharmaceuticals Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de los receptores mGluR2 |
| CA2760741C (en) | 2009-05-12 | 2018-05-01 | Addex Pharma S.A. | 1,2,4-triazolo [4,3-a] pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders |
| JP5852665B2 (ja) | 2010-11-08 | 2016-02-03 | ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド | １，２，４−トリアゾロ［４，３−ａ］ピリジン誘導体およびｍＧｌｕＲ２受容体のポジティブアロステリックモジュレーターとしてのそれらの使用 |
| CA2815002C (en) | 2010-11-08 | 2019-10-22 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| CN103298810B (zh) | 2010-11-08 | 2016-03-16 | 杨森制药公司 | 1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途 |
| KR20140053991A (ko) | 2011-07-18 | 2014-05-08 | 아츠 바이올로직스 에이/에스 | 장기간 작용하는 황체 형성 호르몬 (ｌｈ) 화합물 |
| WO2013078126A1 (en) | 2011-11-23 | 2013-05-30 | Cancer Research Technology Limited | Thienopyrimidine inhibitors of atypical protein kinase c |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
| JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
| KR20200036063A (ko) | 2014-01-21 | 2020-04-06 | 얀센 파마슈티카 엔.브이. | 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도 |
| JP6629740B2 (ja) | 2014-01-21 | 2020-01-15 | ヤンセン ファーマシューティカ エヌ．ベー． | 代謝型グルタミン酸作動性受容体サブタイプ２の正のアロステリック調節因子またはオルトステリックアゴニストを含む組み合わせ、およびそれらの使用 |
| CN107602585A (zh) * | 2017-10-23 | 2018-01-19 | 遵义医学院 | 噻吩并吡啶双杂环化合物的制备工艺 |
| BR102019022529A2 (pt) * | 2019-10-25 | 2021-05-04 | Anhanguera Educacional Ltda. | Processo para obtenção de composições farmacêuticas antitumorais através de butadienos push-pull, compostos e seus usos |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993013664A2 (en) * | 1992-01-11 | 1993-07-22 | Schering Agrochemicals Limited | Biheterocyclic fungicidal compounds |
| TW449600B (en) | 1994-04-19 | 2001-08-11 | Takeda Chemical Industries Ltd | Condensed-ring thiophene derivatives, their production and use |
| JP3854648B2 (ja) * | 1994-04-19 | 2006-12-06 | 武田薬品工業株式会社 | 縮合チオフェン誘導体、その製造法及び用途 |
| HUT77348A (hu) * | 1994-11-08 | 1998-03-30 | Takeda Chemical Industries, Ltd. | Tienopiridin- és tienopirimidinszármazékok, eljárás előállításukra és az ezeket tartalmazó gyógyszerkészítmények |
| JPH09169767A (ja) * | 1995-10-19 | 1997-06-30 | Takeda Chem Ind Ltd | 複素環化合物、その製造法および用途 |
| CN1063446C (zh) * | 1995-10-19 | 2001-03-21 | 武田药品工业株式会社 | 作为促性腺激素释放激素拮抗剂的噻吩并吡啶衍生物 |
| JPH09169766A (ja) * | 1995-10-19 | 1997-06-30 | Takeda Chem Ind Ltd | チエノピリジン誘導体，その製造法および用途 |
| CA2250895A1 (en) * | 1996-04-26 | 1997-11-06 | Takeda Chemical Industries, Ltd. | Thienopyridine derivatives, their production and use |
-
2000
- 2000-03-23 TW TW089105361A patent/TW564247B/zh not_active IP Right Cessation
- 2000-04-03 BR BRPI0009558A patent/BRPI0009558B1/pt not_active IP Right Cessation
- 2000-04-03 AT AT00917026T patent/ATE299507T1/de active
- 2000-04-03 CZ CZ20013605A patent/CZ300832B6/cs not_active IP Right Cessation
- 2000-04-03 HU HU0200653A patent/HU229002B1/hu not_active IP Right Cessation
- 2000-04-03 CN CNB008069077A patent/CN1177848C/zh not_active Expired - Fee Related
- 2000-04-03 EP EP00917026A patent/EP1171443B1/en not_active Expired - Lifetime
- 2000-04-03 PT PT00917026T patent/PT1171443E/pt unknown
- 2000-04-03 PL PL350964A patent/PL219316B1/pl unknown
- 2000-04-03 TR TR2001/02839T patent/TR200102839T2/xx unknown
- 2000-04-03 NZ NZ514445A patent/NZ514445A/en not_active IP Right Cessation
- 2000-04-03 KR KR1020017012792A patent/KR100691546B1/ko not_active IP Right Cessation
- 2000-04-03 AU AU38166/00A patent/AU772258B2/en not_active Ceased
- 2000-04-03 WO PCT/EP2000/002865 patent/WO2000061586A1/en active IP Right Grant
- 2000-04-03 US US09/937,416 patent/US6569863B1/en not_active Expired - Lifetime
- 2000-04-03 MX MXPA01010144A patent/MXPA01010144A/es active IP Right Grant
- 2000-04-03 IL IL14548300A patent/IL145483A0/xx active IP Right Grant
- 2000-04-03 RU RU2001130051/04A patent/RU2248979C2/ru not_active IP Right Cessation
- 2000-04-03 CA CA002368834A patent/CA2368834C/en not_active Expired - Fee Related
- 2000-04-03 ES ES00917026T patent/ES2245304T3/es not_active Expired - Lifetime
- 2000-04-03 DE DE60021262T patent/DE60021262T2/de not_active Expired - Lifetime
- 2000-04-03 ID IDW00200102449A patent/ID30502A/id unknown
- 2000-04-03 DK DK00917026T patent/DK1171443T3/da active
- 2000-04-03 JP JP2000610857A patent/JP4854856B2/ja not_active Expired - Fee Related
- 2000-04-06 AR ARP000101578A patent/AR028474A1/es not_active Application Discontinuation
- 2000-04-06 PE PE2000000312A patent/PE20010030A1/es not_active Application Discontinuation
- 2000-04-07 CO CO00025852A patent/CO5160348A1/es unknown
-
2001
- 2001-09-16 IL IL145483A patent/IL145483A/en not_active IP Right Cessation
- 2001-09-26 ZA ZA200107917A patent/ZA200107917B/xx unknown
- 2001-10-04 NO NO20014824A patent/NO328826B1/no not_active IP Right Cessation
-
2002
- 2002-04-23 HK HK02103025.1A patent/HK1041266B/zh not_active IP Right Cessation
-
2003
- 2003-04-11 US US10/411,960 patent/US6841553B2/en not_active Expired - Lifetime
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