DK1171443T3 - Bicykliske, heteroaromatiske forbindelser, der er nyttige som LH-agonister - Google Patents

Bicykliske, heteroaromatiske forbindelser, der er nyttige som LH-agonister

Info

Publication number
DK1171443T3
DK1171443T3 DK00917026T DK00917026T DK1171443T3 DK 1171443 T3 DK1171443 T3 DK 1171443T3 DK 00917026 T DK00917026 T DK 00917026T DK 00917026 T DK00917026 T DK 00917026T DK 1171443 T3 DK1171443 T3 DK 1171443T3
Authority
DK
Denmark
Prior art keywords
agonists
compounds useful
heteroaromatic compounds
bicyclic heteroaromatic
bicyclic
Prior art date
Application number
DK00917026T
Other languages
English (en)
Inventor
Anton Egbert Peter Adang
Gerrildina Geziena Gerritsma
Straten Nicole Corine Rene Van
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Application granted granted Critical
Publication of DK1171443T3 publication Critical patent/DK1171443T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Public Health (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
DK00917026T 1999-04-08 2000-04-03 Bicykliske, heteroaromatiske forbindelser, der er nyttige som LH-agonister DK1171443T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99201152 1999-04-08
PCT/EP2000/002865 WO2000061586A1 (en) 1999-04-08 2000-04-03 Bicyclic heteroaromatic compounds useful as lh agonists

Publications (1)

Publication Number Publication Date
DK1171443T3 true DK1171443T3 (da) 2005-11-07

Family

ID=8240094

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00917026T DK1171443T3 (da) 1999-04-08 2000-04-03 Bicykliske, heteroaromatiske forbindelser, der er nyttige som LH-agonister

Country Status (30)

Country Link
US (2) US6569863B1 (da)
EP (1) EP1171443B1 (da)
JP (1) JP4854856B2 (da)
KR (1) KR100691546B1 (da)
CN (1) CN1177848C (da)
AR (1) AR028474A1 (da)
AT (1) ATE299507T1 (da)
AU (1) AU772258B2 (da)
BR (1) BRPI0009558B1 (da)
CA (1) CA2368834C (da)
CO (1) CO5160348A1 (da)
CZ (1) CZ300832B6 (da)
DE (1) DE60021262T2 (da)
DK (1) DK1171443T3 (da)
ES (1) ES2245304T3 (da)
HK (1) HK1041266B (da)
HU (1) HU229002B1 (da)
ID (1) ID30502A (da)
IL (2) IL145483A0 (da)
MX (1) MXPA01010144A (da)
NO (1) NO328826B1 (da)
NZ (1) NZ514445A (da)
PE (1) PE20010030A1 (da)
PL (1) PL219316B1 (da)
PT (1) PT1171443E (da)
RU (1) RU2248979C2 (da)
TR (1) TR200102839T2 (da)
TW (1) TW564247B (da)
WO (1) WO2000061586A1 (da)
ZA (1) ZA200107917B (da)

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US6974870B2 (en) 2002-06-06 2005-12-13 Boehringer Ingelheim Phamaceuticals, Inc. Substituted 3-amino-thieno [2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses
WO2004092177A1 (en) 2003-04-09 2004-10-28 Biogen Idec Ma Inc. Triazolopyrazines and methods of making and using the same
US7285550B2 (en) 2003-04-09 2007-10-23 Biogen Idec Ma Inc. Triazolotriazines and pyrazolotriazines and methods of making and using the same
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US7550485B2 (en) * 2003-10-14 2009-06-23 Wyeth Substituted N-heterocycle derivatives and methods of their use
CA2541989C (en) * 2003-10-24 2013-10-01 Exelixis, Inc. P70s6 kinase modulators and method of use
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
WO2006019832A1 (en) * 2004-07-22 2006-02-23 Ptc Therapeutics, Inc. Thienopyridines for treating hepatitis c
US8642278B2 (en) * 2005-11-22 2014-02-04 University Of South Florida Inhibition of cell proliferation
AR059898A1 (es) 2006-03-15 2008-05-07 Janssen Pharmaceutica Nv Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
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JP2009539865A (ja) 2006-06-06 2009-11-19 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 置換３−アミノ−チエノ［２，３−ｂ］ピリジン２−カルボン酸アミド化合物及び製造方法及びそれらの使用
RU2444524C2 (ru) * 2006-08-21 2012-03-10 Дженентек, Инк. Азабензотиофенильные соединения и способы применения
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200922566A (en) 2007-09-14 2009-06-01 Ortho Mcneil Janssen Pharm 1,3 disubstituted 4-(aryl-X-phenyl)-1H-pyridin-2-ones
MY152078A (en) 2007-09-14 2014-08-15 Ortho Mcneil Janssen Pharm 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h,1'h-[1,4']bipyridinyl-2'-ones
AU2008297877C1 (en) * 2007-09-14 2013-11-07 Addex Pharma S.A. 1,3-disubstituted-4-phenyl-1 H-pyridin-2-ones
US8653282B2 (en) * 2007-10-18 2014-02-18 Boehringer Ingelheim International Gmbh Preparation of dihydrothieno [3,2-D] pyrimidines and intermediates used therein
CA2704436C (en) 2007-11-14 2016-01-05 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. Imidazo[1,2-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
US8691849B2 (en) 2008-09-02 2014-04-08 Janssen Pharmaceuticals, Inc. 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
JP5656848B2 (ja) 2008-10-16 2015-01-21 ジャンセン ファーマシューティカルズ， インコーポレイテッド． 代謝型グルタミン酸受容体モジュレーターとしてのインドールおよびベンゾモルホリンの誘導体
RU2512283C2 (ru) 2008-11-28 2014-04-10 Янссен Фармасьютикалз, Инк. Производные индола и бензоксазина в качестве модуляторов метаботропных глутаматных рецепторов
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
EA020671B1 (ru) 2009-05-12 2014-12-30 Янссен Фармасьютикалз, Инк. ПРОИЗВОДНЫЕ 1,2,4-ТРИАЗОЛО[4,3-a]ПИРИДИНА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ПОЛОЖИТЕЛЬНЫХ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ mGluR2
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US9012448B2 (en) 2010-11-08 2015-04-21 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors
ES2552455T3 (es) 2010-11-08 2015-11-30 Janssen Pharmaceuticals, Inc. Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2
US8993591B2 (en) 2010-11-08 2015-03-31 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a] pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors
EP2734239A2 (en) 2011-07-18 2014-05-28 Arts Biologics A/S Long acting luteinizing hormone (lh) compound
AU2012340869B2 (en) 2011-11-23 2017-03-02 Cancer Research Technology Limited Thienopyrimidine inhibitors of atypical protein kinase C
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
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Also Published As

Publication number Publication date
US20030212081A1 (en) 2003-11-13
WO2000061586A1 (en) 2000-10-19
CZ20013605A3 (cs) 2002-03-13
PL219316B1 (pl) 2015-04-30
IL145483A0 (en) 2002-06-30
KR20010103801A (ko) 2001-11-23
CZ300832B6 (cs) 2009-08-19
HUP0200653A3 (en) 2004-07-28
TW564247B (en) 2003-12-01
ATE299507T1 (de) 2005-07-15
CN1177848C (zh) 2004-12-01
PE20010030A1 (es) 2001-01-27
RU2248979C2 (ru) 2005-03-27
BR0009558A (pt) 2002-02-19
AU3816600A (en) 2000-11-14
EP1171443A1 (en) 2002-01-16
TR200102839T2 (tr) 2002-04-22
AR028474A1 (es) 2003-05-14
DE60021262D1 (de) 2005-08-18
AU772258B2 (en) 2004-04-22
CO5160348A1 (es) 2002-05-30
CN1349535A (zh) 2002-05-15
ZA200107917B (en) 2003-09-23
PL350964A1 (en) 2003-02-24
NO20014824D0 (no) 2001-10-04
NZ514445A (en) 2003-07-25
HUP0200653A2 (en) 2002-06-29
JP4854856B2 (ja) 2012-01-18
KR100691546B1 (ko) 2007-03-12
JP2002541259A (ja) 2002-12-03
PT1171443E (pt) 2005-11-30
CA2368834C (en) 2009-11-03
ID30502A (id) 2001-12-13
BRPI0009558B1 (pt) 2016-10-25
US6841553B2 (en) 2005-01-11
NO20014824L (no) 2001-10-04
CA2368834A1 (en) 2000-10-19
HU229002B1 (en) 2013-07-29
US6569863B1 (en) 2003-05-27
ES2245304T3 (es) 2006-01-01
DE60021262T2 (de) 2006-01-05
EP1171443B1 (en) 2005-07-13
MXPA01010144A (es) 2002-04-24
HK1041266A1 (en) 2002-07-05
HK1041266B (zh) 2005-09-16
IL145483A (en) 2007-06-03
NO328826B1 (no) 2010-05-25

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