ID30502A - Senyawa heteroaromatik bisiklik yang berguna sebagai agonis lh - Google Patents

Senyawa heteroaromatik bisiklik yang berguna sebagai agonis lh

Info

Publication number
ID30502A
ID30502A IDW00200102449A ID20012449A ID30502A ID 30502 A ID30502 A ID 30502A ID W00200102449 A IDW00200102449 A ID W00200102449A ID 20012449 A ID20012449 A ID 20012449A ID 30502 A ID30502 A ID 30502A
Authority
ID
Indonesia
Prior art keywords
agonists
heteroaromatic compounds
combined
combined heteroaromatic
compounds
Prior art date
Application number
IDW00200102449A
Other languages
English (en)
Indonesian (id)
Inventor
Gerilldina Geziena Gerritsma
Nicole Corine Renee Va Straten
Anton Egbert Peter Adang
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of ID30502A publication Critical patent/ID30502A/id

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Public Health (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
IDW00200102449A 1999-04-08 2000-04-03 Senyawa heteroaromatik bisiklik yang berguna sebagai agonis lh ID30502A (id)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99201152 1999-04-08

Publications (1)

Publication Number Publication Date
ID30502A true ID30502A (id) 2001-12-13

Family

ID=8240094

Family Applications (1)

Application Number Title Priority Date Filing Date
IDW00200102449A ID30502A (id) 1999-04-08 2000-04-03 Senyawa heteroaromatik bisiklik yang berguna sebagai agonis lh

Country Status (30)

Country Link
US (2) US6569863B1 (no)
EP (1) EP1171443B1 (no)
JP (1) JP4854856B2 (no)
KR (1) KR100691546B1 (no)
CN (1) CN1177848C (no)
AR (1) AR028474A1 (no)
AT (1) ATE299507T1 (no)
AU (1) AU772258B2 (no)
BR (1) BRPI0009558B1 (no)
CA (1) CA2368834C (no)
CO (1) CO5160348A1 (no)
CZ (1) CZ300832B6 (no)
DE (1) DE60021262T2 (no)
DK (1) DK1171443T3 (no)
ES (1) ES2245304T3 (no)
HK (1) HK1041266B (no)
HU (1) HU229002B1 (no)
ID (1) ID30502A (no)
IL (2) IL145483A0 (no)
MX (1) MXPA01010144A (no)
NO (1) NO328826B1 (no)
NZ (1) NZ514445A (no)
PE (1) PE20010030A1 (no)
PL (1) PL219316B1 (no)
PT (1) PT1171443E (no)
RU (1) RU2248979C2 (no)
TR (1) TR200102839T2 (no)
TW (1) TW564247B (no)
WO (1) WO2000061586A1 (no)
ZA (1) ZA200107917B (no)

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RU2271360C2 (ru) * 2000-09-22 2006-03-10 Акцо Нобель Н.В. Бициклические гетероароматические соединения, фармацевтическая композиция на их основе и применение
GB0100622D0 (en) 2001-01-10 2001-02-21 Vernalis Res Ltd Chemical compounds V111
DE10108481A1 (de) 2001-02-22 2002-10-24 Bayer Ag Pyridylpyrimidine
TWI228508B (en) * 2001-09-04 2005-03-01 Akzo Nobel Nv Thieno[2,3-d]pyrimidines with combined LH and FSH agonistic activity
WO2003020727A1 (en) * 2001-09-04 2003-03-13 Akzo Nobel N.V. GLYCINE-SUBSTITUTED THIENO [2,3-d]PYRIMIDINES WITH COMBINED LH AND FSH AGONISTIC ACTIVITY
US6974870B2 (en) 2002-06-06 2005-12-13 Boehringer Ingelheim Phamaceuticals, Inc. Substituted 3-amino-thieno [2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses
DK1513516T3 (da) 2002-06-06 2009-10-19 Boehringer Ingelheim Pharma Substitueret 3-amino-thieno(2,3-b)-pyridin-2-carboxylsyreamid-forbindelser og fremgangsmåder til fremstilling og deres anvendelser
WO2004092173A2 (en) 2003-04-09 2004-10-28 Biogen Idec Ma Inc. A2a adenosine receptor antagonists
US7285550B2 (en) 2003-04-09 2007-10-23 Biogen Idec Ma Inc. Triazolotriazines and pyrazolotriazines and methods of making and using the same
US7674791B2 (en) 2003-04-09 2010-03-09 Biogen Idec Ma Inc. Triazolopyrazines and methods of making and using the same
JPWO2005019225A1 (ja) * 2003-08-21 2007-11-01 杏林製薬株式会社 Ｎｋ１受容体拮抗作用を有する化合物の製造方法及びその製造中間体
US7550485B2 (en) * 2003-10-14 2009-06-23 Wyeth Substituted N-heterocycle derivatives and methods of their use
AU2004283751B2 (en) * 2003-10-24 2011-05-19 Exelixis, Inc. p70S6 kinase modulators and method of use
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
CN101022802A (zh) * 2004-07-22 2007-08-22 Ptc医疗公司 用于治疗丙型肝炎的噻吩并吡啶化合物
CA2630920A1 (en) * 2005-11-22 2007-05-31 University Of South Florida Inhibition of cell proliferation
TWI417095B (zh) 2006-03-15 2013-12-01 Janssen Pharmaceuticals Inc １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途
WO2007136776A2 (en) * 2006-05-17 2007-11-29 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Pyrimidine low molecular weight ligands for modulating hormone receptors
JP2009539865A (ja) 2006-06-06 2009-11-19 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 置換３−アミノ−チエノ［２，３−ｂ］ピリジン２−カルボン酸アミド化合物及び製造方法及びそれらの使用
RU2444524C2 (ru) * 2006-08-21 2012-03-10 Дженентек, Инк. Азабензотиофенильные соединения и способы применения
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
WO2009033702A1 (en) 2007-09-14 2009-03-19 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. 1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones
PT2203439E (pt) 2007-09-14 2011-02-11 Ortho Mcneil Janssen Pharm 4-fenil-3,4,5,6-tetra-hidro-2h,1'h-[1,4']bipiridinil-2'- onas 1',3'-dissubstituídas
TW200927731A (en) * 2007-09-14 2009-07-01 Ortho Mcneil Janssen Pharm 1,3-disubstituted-4-phenyl-1H-pyridin-2-ones
MX2010003826A (es) * 2007-10-18 2010-04-21 Boehringer Ingelheim Int Preparacion de dihidrotieno [3,2-d] pirimidinas e intermedios usados en la misma.
EP2220083B1 (en) 2007-11-14 2017-07-19 Janssen Pharmaceuticals, Inc. Imidazo[1,2-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
EP2344470B1 (en) 2008-09-02 2013-11-06 Janssen Pharmaceuticals, Inc. 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
AU2009304293B2 (en) 2008-10-16 2012-04-26 Addex Pharma S.A. Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors
CN102232074B (zh) 2008-11-28 2014-12-03 奥梅-杨森制药有限公司 作为代谢性谷氨酸盐受体调节剂的吲哚和苯并噁嗪衍生物
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
ES2409006T3 (es) 2009-05-12 2013-06-24 Janssen Pharmaceuticals Inc. Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de los receptores mGluR2
CA2760741C (en) 2009-05-12 2018-05-01 Addex Pharma S.A. 1,2,4-triazolo [4,3-a] pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders
JP5852665B2 (ja) 2010-11-08 2016-02-03 ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド １，２，４−トリアゾロ［４，３−ａ］ピリジン誘導体およびｍＧｌｕＲ２受容体のポジティブアロステリックモジュレーターとしてのそれらの使用
CA2815002C (en) 2010-11-08 2019-10-22 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
CN103298810B (zh) 2010-11-08 2016-03-16 杨森制药公司 1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途
KR20140053991A (ko) 2011-07-18 2014-05-08 아츠 바이올로직스 에이/에스 장기간 작용하는 황체 형성 호르몬 (ｌｈ) 화합물
WO2013078126A1 (en) 2011-11-23 2013-05-30 Cancer Research Technology Limited Thienopyrimidine inhibitors of atypical protein kinase c
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
KR20200036063A (ko) 2014-01-21 2020-04-06 얀센 파마슈티카 엔.브이. 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도
JP6629740B2 (ja) 2014-01-21 2020-01-15 ヤンセン ファーマシューティカ エヌ．ベー． 代謝型グルタミン酸作動性受容体サブタイプ２の正のアロステリック調節因子またはオルトステリックアゴニストを含む組み合わせ、およびそれらの使用
CN107602585A (zh) * 2017-10-23 2018-01-19 遵义医学院 噻吩并吡啶双杂环化合物的制备工艺
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Also Published As

Publication number Publication date
AR028474A1 (es) 2003-05-14
HU229002B1 (en) 2013-07-29
CZ20013605A3 (cs) 2002-03-13
CO5160348A1 (es) 2002-05-30
HUP0200653A2 (en) 2002-06-29
US6569863B1 (en) 2003-05-27
CN1349535A (zh) 2002-05-15
NZ514445A (en) 2003-07-25
WO2000061586A1 (en) 2000-10-19
AU772258B2 (en) 2004-04-22
NO20014824D0 (no) 2001-10-04
MXPA01010144A (es) 2002-04-24
DE60021262T2 (de) 2006-01-05
PL219316B1 (pl) 2015-04-30
AU3816600A (en) 2000-11-14
HK1041266B (zh) 2005-09-16
EP1171443A1 (en) 2002-01-16
RU2248979C2 (ru) 2005-03-27
IL145483A0 (en) 2002-06-30
CA2368834C (en) 2009-11-03
PE20010030A1 (es) 2001-01-27
TW564247B (en) 2003-12-01
ATE299507T1 (de) 2005-07-15
NO328826B1 (no) 2010-05-25
TR200102839T2 (tr) 2002-04-22
KR20010103801A (ko) 2001-11-23
HUP0200653A3 (en) 2004-07-28
KR100691546B1 (ko) 2007-03-12
NO20014824L (no) 2001-10-04
CN1177848C (zh) 2004-12-01
CZ300832B6 (cs) 2009-08-19
DK1171443T3 (da) 2005-11-07
BR0009558A (pt) 2002-02-19
JP2002541259A (ja) 2002-12-03
CA2368834A1 (en) 2000-10-19
ES2245304T3 (es) 2006-01-01
JP4854856B2 (ja) 2012-01-18
BRPI0009558B1 (pt) 2016-10-25
PT1171443E (pt) 2005-11-30
HK1041266A1 (en) 2002-07-05
US6841553B2 (en) 2005-01-11
DE60021262D1 (de) 2005-08-18
PL350964A1 (en) 2003-02-24
IL145483A (en) 2007-06-03
US20030212081A1 (en) 2003-11-13
EP1171443B1 (en) 2005-07-13
ZA200107917B (en) 2003-09-23

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