AU772258B2 - Bicyclic heteroaromatic compounds useful as LH agonists - Google Patents

Bicyclic heteroaromatic compounds useful as LH agonists Download PDF

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Publication number
AU772258B2
AU772258B2 AU38166/00A AU3816600A AU772258B2 AU 772258 B2 AU772258 B2 AU 772258B2 AU 38166/00 A AU38166/00 A AU 38166/00A AU 3816600 A AU3816600 A AU 3816600A AU 772258 B2 AU772258 B2 AU 772258B2
Authority
AU
Australia
Prior art keywords
amino
thieno
ethyl
compound
methylthio
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU38166/00A
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English (en)
Other versions
AU3816600A (en
Inventor
Anton Egbert Peter Adang
Gerrildina Geziena Gerritsma
Nicole Corine Renee Van Straten
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme BV
Original Assignee
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel NV filed Critical Akzo Nobel NV
Publication of AU3816600A publication Critical patent/AU3816600A/en
Application granted granted Critical
Publication of AU772258B2 publication Critical patent/AU772258B2/en
Assigned to N.V. ORGANON reassignment N.V. ORGANON Alteration of Name(s) in Register under S187 Assignors: AKZO NOBEL N.V.
Assigned to MSD OSS B.V. reassignment MSD OSS B.V. Request to Amend Deed and Register Assignors: N.V. ORGANON
Assigned to MERCK SHARP & DOHME B.V. reassignment MERCK SHARP & DOHME B.V. Request to Amend Deed and Register Assignors: MSD OSS B.V.
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Public Health (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
AU38166/00A 1999-04-08 2000-04-03 Bicyclic heteroaromatic compounds useful as LH agonists Ceased AU772258B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99201152 1999-04-08
EP99201152 1999-04-08
PCT/EP2000/002865 WO2000061586A1 (en) 1999-04-08 2000-04-03 Bicyclic heteroaromatic compounds useful as lh agonists

Publications (2)

Publication Number Publication Date
AU3816600A AU3816600A (en) 2000-11-14
AU772258B2 true AU772258B2 (en) 2004-04-22

Family

ID=8240094

Family Applications (1)

Application Number Title Priority Date Filing Date
AU38166/00A Ceased AU772258B2 (en) 1999-04-08 2000-04-03 Bicyclic heteroaromatic compounds useful as LH agonists

Country Status (30)

Country Link
US (2) US6569863B1 (enExample)
EP (1) EP1171443B1 (enExample)
JP (1) JP4854856B2 (enExample)
KR (1) KR100691546B1 (enExample)
CN (1) CN1177848C (enExample)
AR (1) AR028474A1 (enExample)
AT (1) ATE299507T1 (enExample)
AU (1) AU772258B2 (enExample)
BR (1) BRPI0009558B1 (enExample)
CA (1) CA2368834C (enExample)
CO (1) CO5160348A1 (enExample)
CZ (1) CZ300832B6 (enExample)
DE (1) DE60021262T2 (enExample)
DK (1) DK1171443T3 (enExample)
ES (1) ES2245304T3 (enExample)
HK (1) HK1041266B (enExample)
HU (1) HU229002B1 (enExample)
ID (1) ID30502A (enExample)
IL (2) IL145483A0 (enExample)
MX (1) MXPA01010144A (enExample)
NO (1) NO328826B1 (enExample)
NZ (1) NZ514445A (enExample)
PE (1) PE20010030A1 (enExample)
PL (1) PL219316B1 (enExample)
PT (1) PT1171443E (enExample)
RU (1) RU2248979C2 (enExample)
TR (1) TR200102839T2 (enExample)
TW (1) TW564247B (enExample)
WO (1) WO2000061586A1 (enExample)
ZA (1) ZA200107917B (enExample)

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TWI228508B (en) * 2001-09-04 2005-03-01 Akzo Nobel Nv Thieno[2,3-d]pyrimidines with combined LH and FSH agonistic activity
CN100386329C (zh) 2002-06-06 2008-05-07 贝林格尔.英格海姆药物公司 取代的3-氨基-噻吩并[2,3-b]吡啶-2-羧酸酰胺化合物及其制备方法和用途
US6974870B2 (en) 2002-06-06 2005-12-13 Boehringer Ingelheim Phamaceuticals, Inc. Substituted 3-amino-thieno [2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses
EP1615930A2 (en) 2003-04-09 2006-01-18 Biogen Idec MA, Inc. Triazolotriazines and pyrazolotriazines useful as a2a adenosine receptor antagonists
WO2004092177A1 (en) 2003-04-09 2004-10-28 Biogen Idec Ma Inc. Triazolopyrazines and methods of making and using the same
WO2004092173A2 (en) 2003-04-09 2004-10-28 Biogen Idec Ma Inc. A2a adenosine receptor antagonists
JPWO2005019225A1 (ja) * 2003-08-21 2007-11-01 杏林製薬株式会社 Ｎｋ１受容体拮抗作用を有する化合物の製造方法及びその製造中間体
US7550485B2 (en) * 2003-10-14 2009-06-23 Wyeth Substituted N-heterocycle derivatives and methods of their use
JP4800216B2 (ja) * 2003-10-24 2011-10-26 エグゼリクシス， インコーポレイテッド ｐ７０Ｓ６キナーゼモジュレーターおよび使用方法
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
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CA2652061A1 (en) * 2006-05-17 2007-11-29 Marvin C. Gershengorn Pyrimidine low molecular weight ligands for modulating hormone receptors
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RU2444524C2 (ru) * 2006-08-21 2012-03-10 Дженентек, Инк. Азабензотиофенильные соединения и способы применения
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
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RS51660B (sr) 2007-09-14 2011-10-31 Ortho-Mcneil-Janssen Pharmaceuticals Inc. 1`,3`-disupstituisani-4-fenil-3,4,5,6-tetrahidro-2h, 1`h-[1,4`] bipiridinil-2`-oni
ATE516272T1 (de) 2007-09-14 2011-07-15 Ortho Mcneil Janssen Pharm 1,3-disubstituierte 4-(aryl-x-phenyl)-1h-pyridin- 2-one
WO2009033703A1 (en) * 2007-09-14 2009-03-19 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. 1,3-disubstituted-4-phenyl-1 h-pyridin-2-ones
EP2205608B1 (en) * 2007-10-18 2013-05-08 Boehringer Ingelheim International GmbH Preparation of dihydrothieno[3, 2-d]pyrimidines and intermediates used therein
EP2220083B1 (en) 2007-11-14 2017-07-19 Janssen Pharmaceuticals, Inc. Imidazo[1,2-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
EP2344470B1 (en) 2008-09-02 2013-11-06 Janssen Pharmaceuticals, Inc. 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
AU2009304293B2 (en) 2008-10-16 2012-04-26 Addex Pharma S.A. Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors
JP5690277B2 (ja) 2008-11-28 2015-03-25 ジャンセン ファーマシューティカルズ， インコーポレイテッド． 代謝型グルタミン酸受容体の調節因子としてのインドールおよびベンゾオキサジン誘導体
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
US8937060B2 (en) 2009-05-12 2015-01-20 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo [4,3-A] pyridine derivatives and their use for the treatment of prevention of neurological and psychiatric disorders
KR20120035158A (ko) 2009-05-12 2012-04-13 얀센 파마슈티칼즈, 인코포레이티드 1,２,４?트리아졸로［４,３?ａ］피리딘 유도체 및 ｍＧｌｕＲ２ 수용체의 양성 알로스테릭 조절자로서의 그의 용도
EP2643320B1 (en) 2010-11-08 2015-03-04 Janssen Pharmaceuticals, Inc. 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
CN103298809B (zh) 2010-11-08 2016-08-31 杨森制药公司 1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途
CA2814996C (en) 2010-11-08 2019-10-01 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
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Also Published As

Publication number Publication date
IL145483A (en) 2007-06-03
ID30502A (id) 2001-12-13
ZA200107917B (en) 2003-09-23
NO20014824L (no) 2001-10-04
BR0009558A (pt) 2002-02-19
PE20010030A1 (es) 2001-01-27
DE60021262T2 (de) 2006-01-05
HK1041266A1 (en) 2002-07-05
TR200102839T2 (tr) 2002-04-22
HUP0200653A3 (en) 2004-07-28
CN1349535A (zh) 2002-05-15
NO20014824D0 (no) 2001-10-04
US20030212081A1 (en) 2003-11-13
US6841553B2 (en) 2005-01-11
RU2248979C2 (ru) 2005-03-27
JP2002541259A (ja) 2002-12-03
NO328826B1 (no) 2010-05-25
PL350964A1 (en) 2003-02-24
TW564247B (en) 2003-12-01
US6569863B1 (en) 2003-05-27
PT1171443E (pt) 2005-11-30
HK1041266B (en) 2005-09-16
KR20010103801A (ko) 2001-11-23
WO2000061586A1 (en) 2000-10-19
HU229002B1 (en) 2013-07-29
JP4854856B2 (ja) 2012-01-18
DE60021262D1 (de) 2005-08-18
CN1177848C (zh) 2004-12-01
CA2368834C (en) 2009-11-03
DK1171443T3 (da) 2005-11-07
HUP0200653A2 (en) 2002-06-29
NZ514445A (en) 2003-07-25
EP1171443A1 (en) 2002-01-16
CZ20013605A3 (cs) 2002-03-13
ES2245304T3 (es) 2006-01-01
AU3816600A (en) 2000-11-14
PL219316B1 (pl) 2015-04-30
CZ300832B6 (cs) 2009-08-19
BRPI0009558B1 (pt) 2016-10-25
ATE299507T1 (de) 2005-07-15
IL145483A0 (en) 2002-06-30
CO5160348A1 (es) 2002-05-30
CA2368834A1 (en) 2000-10-19
MXPA01010144A (es) 2002-04-24
EP1171443B1 (en) 2005-07-13
AR028474A1 (es) 2003-05-14
KR100691546B1 (ko) 2007-03-12

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired