KR100691546B1 - Ｌｈ 작용약으로서 유용한 비시클릭 헤테로방향족 화합물 - Google Patents

Ｌｈ 작용약으로서 유용한 비시클릭 헤테로방향족 화합물 Download PDF

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Publication number
KR100691546B1
KR100691546B1 KR1020017012792A KR20017012792A KR100691546B1 KR 100691546 B1 KR100691546 B1 KR 100691546B1 KR 1020017012792 A KR1020017012792 A KR 1020017012792A KR 20017012792 A KR20017012792 A KR 20017012792A KR 100691546 B1 KR100691546 B1 KR 100691546B1
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South Korea
Prior art keywords
aryl
amino
thieno
alkyl
pyrimidine
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Expired - Fee Related
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KR1020017012792A
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English (en)
Korean (ko)
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KR20010103801A (ko
Inventor
게리트스마게릴디나게지에나
반슈트라텐니콜코린르네
아당안톤에그베르트페터
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엔.브이.오가논
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Publication of KR100691546B1 publication Critical patent/KR100691546B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Public Health (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
KR1020017012792A 1999-04-08 2000-04-03 Ｌｈ 작용약으로서 유용한 비시클릭 헤테로방향족 화합물 Expired - Fee Related KR100691546B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99201152.8 1999-04-08
EP99201152 1999-04-08
PCT/EP2000/002865 WO2000061586A1 (en) 1999-04-08 2000-04-03 Bicyclic heteroaromatic compounds useful as lh agonists

Publications (2)

Publication Number Publication Date
KR20010103801A KR20010103801A (ko) 2001-11-23
KR100691546B1 true KR100691546B1 (ko) 2007-03-12

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KR1020017012792A Expired - Fee Related KR100691546B1 (ko) 1999-04-08 2000-04-03 Ｌｈ 작용약으로서 유용한 비시클릭 헤테로방향족 화합물

Country Status (30)

Country Link
US (2) US6569863B1 (enExample)
EP (1) EP1171443B1 (enExample)
JP (1) JP4854856B2 (enExample)
KR (1) KR100691546B1 (enExample)
CN (1) CN1177848C (enExample)
AR (1) AR028474A1 (enExample)
AT (1) ATE299507T1 (enExample)
AU (1) AU772258B2 (enExample)
BR (1) BRPI0009558B1 (enExample)
CA (1) CA2368834C (enExample)
CO (1) CO5160348A1 (enExample)
CZ (1) CZ300832B6 (enExample)
DE (1) DE60021262T2 (enExample)
DK (1) DK1171443T3 (enExample)
ES (1) ES2245304T3 (enExample)
HK (1) HK1041266B (enExample)
HU (1) HU229002B1 (enExample)
ID (1) ID30502A (enExample)
IL (2) IL145483A0 (enExample)
MX (1) MXPA01010144A (enExample)
NO (1) NO328826B1 (enExample)
NZ (1) NZ514445A (enExample)
PE (1) PE20010030A1 (enExample)
PL (1) PL219316B1 (enExample)
PT (1) PT1171443E (enExample)
RU (1) RU2248979C2 (enExample)
TR (1) TR200102839T2 (enExample)
TW (1) TW564247B (enExample)
WO (1) WO2000061586A1 (enExample)
ZA (1) ZA200107917B (enExample)

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TWI228508B (en) * 2001-09-04 2005-03-01 Akzo Nobel Nv Thieno[2,3-d]pyrimidines with combined LH and FSH agonistic activity
UY27834A1 (es) 2002-06-06 2003-12-31 Boehringer Ingelheim Pharma Compuestos de amidas de acido 3-amino-tieno(2,3-b) piiridino-2-carboxilico sustituido y procedimientos para prepararlos y sus usos.
US6974870B2 (en) 2002-06-06 2005-12-13 Boehringer Ingelheim Phamaceuticals, Inc. Substituted 3-amino-thieno [2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses
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US7674791B2 (en) 2003-04-09 2010-03-09 Biogen Idec Ma Inc. Triazolopyrazines and methods of making and using the same
US7285550B2 (en) 2003-04-09 2007-10-23 Biogen Idec Ma Inc. Triazolotriazines and pyrazolotriazines and methods of making and using the same
JPWO2005019225A1 (ja) * 2003-08-21 2007-11-01 杏林製薬株式会社 Ｎｋ１受容体拮抗作用を有する化合物の製造方法及びその製造中間体
US7550485B2 (en) * 2003-10-14 2009-06-23 Wyeth Substituted N-heterocycle derivatives and methods of their use
WO2005039506A2 (en) * 2003-10-24 2005-05-06 Exelixis, Inc. P70s6 kinase modulators and method of use
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
NZ553329A (en) * 2004-07-22 2010-09-30 Ptc Therapeutics Inc Thienopyridines for treating hepatitis C
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AR059898A1 (es) 2006-03-15 2008-05-07 Janssen Pharmaceutica Nv Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
AU2007254165A1 (en) * 2006-05-17 2007-11-29 Forschungsverbund Berlin E.V. Pyrimidine low molecular weight ligands for modulating hormone receptors
EP2029608A1 (en) 2006-06-06 2009-03-04 Boehringer Ingelheim International GmbH Substituted 3-amino-thieno[2,3-b] pyridine-2-carboxamide compounds, their preparation and use
RU2444524C2 (ru) * 2006-08-21 2012-03-10 Дженентек, Инк. Азабензотиофенильные соединения и способы применения
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CN103497201A (zh) * 2007-10-18 2014-01-08 贝林格尔.英格海姆国际有限公司 二氢噻吩并[3,2-d]嘧啶的制备中使用的中间体及其制备
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EA020672B1 (ru) 2009-05-12 2014-12-30 Янссен Фармасьютикалс, Инк. Производные 1,2,4-триазоло[4,3-a]пиридина и их применение для лечения или предупреждения неврологических и психиатрических расстройств
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Also Published As

Publication number Publication date
PL350964A1 (en) 2003-02-24
AU3816600A (en) 2000-11-14
CN1349535A (zh) 2002-05-15
US20030212081A1 (en) 2003-11-13
TW564247B (en) 2003-12-01
HUP0200653A3 (en) 2004-07-28
CO5160348A1 (es) 2002-05-30
NO20014824D0 (no) 2001-10-04
ID30502A (id) 2001-12-13
HUP0200653A2 (en) 2002-06-29
JP2002541259A (ja) 2002-12-03
RU2248979C2 (ru) 2005-03-27
CZ300832B6 (cs) 2009-08-19
WO2000061586A1 (en) 2000-10-19
BR0009558A (pt) 2002-02-19
AR028474A1 (es) 2003-05-14
AU772258B2 (en) 2004-04-22
IL145483A0 (en) 2002-06-30
NO328826B1 (no) 2010-05-25
JP4854856B2 (ja) 2012-01-18
DK1171443T3 (da) 2005-11-07
KR20010103801A (ko) 2001-11-23
IL145483A (en) 2007-06-03
DE60021262T2 (de) 2006-01-05
CA2368834C (en) 2009-11-03
CN1177848C (zh) 2004-12-01
NO20014824L (no) 2001-10-04
CZ20013605A3 (cs) 2002-03-13
US6569863B1 (en) 2003-05-27
TR200102839T2 (tr) 2002-04-22
US6841553B2 (en) 2005-01-11
HK1041266A1 (en) 2002-07-05
NZ514445A (en) 2003-07-25
CA2368834A1 (en) 2000-10-19
BRPI0009558B1 (pt) 2016-10-25
ES2245304T3 (es) 2006-01-01
ZA200107917B (en) 2003-09-23
HK1041266B (en) 2005-09-16
EP1171443B1 (en) 2005-07-13
PL219316B1 (pl) 2015-04-30
ATE299507T1 (de) 2005-07-15
HU229002B1 (en) 2013-07-29
MXPA01010144A (es) 2002-04-24
PT1171443E (pt) 2005-11-30
PE20010030A1 (es) 2001-01-27
EP1171443A1 (en) 2002-01-16
DE60021262D1 (de) 2005-08-18

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