PL1689233T3 - Bicykliczne inhibitory MEK - Google Patents
Bicykliczne inhibitory MEKInfo
- Publication number
- PL1689233T3 PL1689233T3 PL04811728T PL04811728T PL1689233T3 PL 1689233 T3 PL1689233 T3 PL 1689233T3 PL 04811728 T PL04811728 T PL 04811728T PL 04811728 T PL04811728 T PL 04811728T PL 1689233 T3 PL1689233 T3 PL 1689233T3
- Authority
- PL
- Poland
- Prior art keywords
- compounds
- mek
- mammals
- treatment
- disclosed
- Prior art date
Links
- 125000002619 bicyclic group Chemical group 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 241000124008 Mammalia Species 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000003463 hyperproliferative effect Effects 0.000 abstract 2
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000004968 inflammatory condition Effects 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
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- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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|---|---|---|---|
| US52327003P | 2003-11-19 | 2003-11-19 | |
| PCT/US2004/039061 WO2005051302A2 (en) | 2003-11-19 | 2004-11-18 | Bicyclic inhibitors of mek and methods of use thereof |
| EP04811728A EP1689233B1 (en) | 2003-11-19 | 2004-11-18 | Bicyclic inhibitors of mek |
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| PL04811728T PL1689233T3 (pl) | 2003-11-19 | 2004-11-18 | Bicykliczne inhibitory MEK |
| PL10008429T PL2251327T3 (pl) | 2003-11-19 | 2004-11-18 | Heterocykliczne inhibitory MEK |
| PL04811726T PL1689387T3 (pl) | 2003-11-19 | 2004-11-18 | Bicykliczne inhibitory MEK i sposoby ich otrzymywania |
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| PL10008429T PL2251327T3 (pl) | 2003-11-19 | 2004-11-18 | Heterocykliczne inhibitory MEK |
| PL04811726T PL1689387T3 (pl) | 2003-11-19 | 2004-11-18 | Bicykliczne inhibitory MEK i sposoby ich otrzymywania |
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