PE20131116A1 - Compuestos heterociclicos potenciadores de ampa - Google Patents
Compuestos heterociclicos potenciadores de ampaInfo
- Publication number
- PE20131116A1 PE20131116A1 PE2013000244A PE2013000244A PE20131116A1 PE 20131116 A1 PE20131116 A1 PE 20131116A1 PE 2013000244 A PE2013000244 A PE 2013000244A PE 2013000244 A PE2013000244 A PE 2013000244A PE 20131116 A1 PE20131116 A1 PE 20131116A1
- Authority
- PE
- Peru
- Prior art keywords
- thadiazine
- dihydropyride
- ring
- ampa
- enhancing
- Prior art date
Links
- MGRVRXRGTBOSHW-UHFFFAOYSA-N (aminomethyl)phosphonic acid Chemical compound NCP(O)(O)=O MGRVRXRGTBOSHW-UHFFFAOYSA-N 0.000 title 1
- 230000002708 enhancing effect Effects 0.000 title 1
- 150000002391 heterocyclic compounds Chemical class 0.000 title 1
- -1 4-PHENOXYPHENYL Chemical class 0.000 abstract 3
- 206010020772 Hypertension Diseases 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- UUDAMDVQRQNNHZ-UHFFFAOYSA-N (S)-AMPA Chemical compound CC=1ONC(=O)C=1CC(N)C(O)=O UUDAMDVQRQNNHZ-UHFFFAOYSA-N 0.000 abstract 1
- KEIFWROAQVVDBN-UHFFFAOYSA-N 1,2-dihydronaphthalene Chemical compound C1=CC=C2C=CCCC2=C1 KEIFWROAQVVDBN-UHFFFAOYSA-N 0.000 abstract 1
- 102000003678 AMPA Receptors Human genes 0.000 abstract 1
- 108090000078 AMPA Receptors Proteins 0.000 abstract 1
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- 150000001924 cycloalkanes Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000003334 potential effect Effects 0.000 abstract 1
- 239000004576 sand Substances 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010179577 | 2010-08-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20131116A1 true PE20131116A1 (es) | 2013-10-24 |
Family
ID=44534564
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2013000244A PE20131116A1 (es) | 2010-08-10 | 2011-08-09 | Compuestos heterociclicos potenciadores de ampa |
Country Status (39)
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT2603513T (lt) * | 2010-08-10 | 2020-05-25 | Takeda Pharmaceutical Company Limited | Heterociklinis junginys ir jo panaudojimas kaip ampa receptoriaus teigiamo alosterinio moduliatoriaus |
| EP2694472B1 (en) * | 2011-04-05 | 2020-03-11 | Takeda Pharmaceutical Company Limited | Sulfonamide derivative and use thereof |
| JP6134654B2 (ja) * | 2012-02-08 | 2017-05-24 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
| EP3008167A4 (en) * | 2013-06-13 | 2017-06-07 | VeroScience LLC | Compositions and methods for treating metabolic disorders |
| SG11201509186TA (en) | 2013-06-27 | 2016-01-28 | Pfizer | Heteroaromatic compounds and their use as dopamine d1 ligands |
| US11589583B2 (en) | 2013-12-03 | 2023-02-28 | Fmc Corporation | Pyrrolidinones herbicides |
| CA2931961C (en) | 2013-12-03 | 2023-10-31 | Andrew Duncan Satterfield | Pyrrolidinones as herbicides |
| SG11201610720VA (en) | 2014-07-02 | 2017-01-27 | Du Pont | Piperidinone herbicides |
| CN107001260B (zh) | 2014-12-08 | 2020-11-10 | Fmc公司 | 3-氧基-3-(芳氨基)丙酸酯、其制备方法、以及其在制备吡咯烷酮中的用途 |
| EP3280709B1 (en) | 2015-04-10 | 2021-05-26 | FMC Corporation | Substituted cyclic amides as herbicides |
| BR112017020094B1 (pt) | 2015-04-27 | 2022-01-11 | Fmc Corporation | Composto, composições herbicidas, mistura de herbicida e método para controlar o crescimento de vegetação indesejada |
| RS61688B1 (sr) | 2015-04-29 | 2021-05-31 | Janssen Pharmaceutica Nv | Azabenzimidazoli i njihiova upotreba kao modulatori ampa receptora |
| WO2016176457A1 (en) * | 2015-04-29 | 2016-11-03 | Janssen Pharmaceutica Nv | Imidazopyrazines and pyrazolopyrimidines and their use as ampa receptor modulators |
| JP7000160B2 (ja) | 2015-05-12 | 2022-01-19 | エフ エム シー コーポレーション | 除草剤としてのアリール置換二環式化合物 |
| JP6869192B2 (ja) | 2015-05-29 | 2021-05-12 | エフ エム シー コーポレーションＦｍｃ Ｃｏｒｐｏｒａｔｉｏｎ | 除草剤としての置換環状アミド |
| CN107709310B (zh) | 2015-06-02 | 2021-09-24 | Fmc公司 | 取代的环酰胺及其作为除草剂的用途 |
| JP6937290B2 (ja) | 2015-07-31 | 2021-09-22 | エフ エム シー コーポレーションＦｍｃ Ｃｏｒｐｏｒａｔｉｏｎ | 除草剤として有用な環状ｎ−カルボキサミド化合物 |
| CA2982825C (en) * | 2015-08-06 | 2023-10-17 | F. Hoffmann-La Roche Ag | Processes for the preparation of galnac acid derivatives |
| US20170181292A1 (en) * | 2015-12-16 | 2017-06-22 | Rohm And Haas Electronic Materials Llc | Method for forming organic coating on nickel surface |
| CN105669731B (zh) * | 2016-01-10 | 2017-06-30 | 沧州普瑞东方科技有限公司 | 一种4‑(4‑烷基环己氧基)苯硼酸的合成方法 |
| RU2019122791A (ru) | 2016-12-21 | 2021-01-25 | Фмк Корпорейшн | Гербициды на основе нитрона |
| CN107892697B (zh) | 2016-12-26 | 2020-11-03 | 郑州泰基鸿诺医药股份有限公司 | 一种[1,3]噻嗪-2-胺类化合物及应用，药物组合物 |
| MX2019010969A (es) | 2017-03-21 | 2019-12-02 | Fmc Corp | Pirrolidinonas y proceso para prepararlas. |
| CN110740646B (zh) | 2017-03-21 | 2022-05-10 | Fmc公司 | 除草剂混合物、组合物和方法 |
| AR111967A1 (es) | 2017-05-30 | 2019-09-04 | Fmc Corp | Amidas herbicidas |
| AR111839A1 (es) | 2017-05-30 | 2019-08-21 | Fmc Corp | Lactamas 3-sustituidas herbicidas |
| ES2970624T3 (es) | 2017-10-06 | 2024-05-29 | Takeda Pharmaceuticals Co | Compuesto heterocíclico |
| EP3693360B1 (en) * | 2017-10-06 | 2023-12-13 | Takeda Pharmaceutical Company Limited | Heterocyclic compounds |
| AU2020348675B2 (en) | 2019-09-16 | 2025-11-20 | Takeda Pharmaceutical Company Limited | Azole-fused pyridazin-3(2H)-one derivatives |
| US20230338391A1 (en) * | 2020-05-15 | 2023-10-26 | Takeda Pharmaceutical Company Limited | Treatment for depression |
| CN113943294A (zh) * | 2020-07-15 | 2022-01-18 | 成都海博为药业有限公司 | 一种作为btk抑制剂的化合物及其制备方法与用途 |
| WO2025224508A1 (en) | 2024-04-22 | 2025-10-30 | Takeda Pharmaceutical Company Limited | Pharmaceutical composition for treating depressive disorders |
| WO2026050231A1 (en) | 2024-08-27 | 2026-03-05 | Neurocrine Biosciences, Inc. | Method of treating a bipolar disorder |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0437742Y2 (https=) | 1986-10-22 | 1992-09-04 | ||
| JPH0285851A (ja) * | 1988-09-22 | 1990-03-27 | Konica Corp | 新規な写真用カプラー |
| JPH037742A (ja) | 1989-06-05 | 1991-01-14 | Toyo Tire & Rubber Co Ltd | ラバーチエーン用ゴム組成物 |
| JP2874960B2 (ja) * | 1990-06-03 | 1999-03-24 | コニカ株式会社 | 新規な染料を含有するハロゲン化銀写真感光材料 |
| JPH04119890A (ja) * | 1990-09-11 | 1992-04-21 | Konica Corp | ピラゾロチアジアジン系色素 |
| JP3430375B2 (ja) * | 1993-11-12 | 2003-07-28 | コニカ株式会社 | 感熱転写材料及び該材料に好適な色素 |
| DE19704923A1 (de) | 1997-02-10 | 1998-08-13 | Hoechst Schering Agrevo Gmbh | Klebstoffhaltige Schädlingsbekämpfungsmittel |
| EP1229786A1 (en) | 1999-11-04 | 2002-08-14 | Colorado State University | Method and device for attracting insects |
| FR2801587B1 (fr) | 1999-11-30 | 2002-01-11 | Adir | Nouveaux derives de benzothiadiazines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| JP2005508352A (ja) * | 2001-10-10 | 2005-03-31 | ニューロサーチ、アクティーゼルスカブ | 新規ベンゾチアジン誘導体、その製造方法及びその使用方法 |
| FR2833955B1 (fr) * | 2001-12-21 | 2004-01-30 | Servier Lab | Nouveaux derives de benzothiazine et de benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2854634B1 (fr) | 2003-05-05 | 2005-07-08 | Servier Lab | Nouveaux derives de thiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2865474B1 (fr) | 2004-01-26 | 2008-06-13 | Servier Lab | Nouveaux derives de benzothiazines fluorees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2879201B1 (fr) | 2004-12-10 | 2007-02-16 | Servier Lab | Nouveaux derives de benzothiazine et benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| CA2655376A1 (en) | 2006-06-23 | 2007-12-27 | Nufarm Australia Limited | Phenoxy alkanoate herbicidal composition and method of preparation and use |
| US8097652B2 (en) | 2006-12-11 | 2012-01-17 | Eli Lilly And Company | AMPA receptor potentiators |
| US20080167374A1 (en) | 2007-01-09 | 2008-07-10 | Loveland Products, Inc. | Pesticide composition and method of use |
| US8487099B2 (en) * | 2007-11-05 | 2013-07-16 | Merck Sharp & Dohme Corp. | Gamma secretase modulators |
| CA2709784A1 (en) * | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| WO2009119088A1 (ja) | 2008-03-25 | 2009-10-01 | 武田薬品工業株式会社 | 複素環化合物 |
| JP2009248543A (ja) * | 2008-04-11 | 2009-10-29 | Fujifilm Corp | 光情報記録媒体および情報記録方法 |
| TW201012803A (en) | 2008-06-06 | 2010-04-01 | Organon Nv | Heterocyclic derivatives |
| EP2356115A1 (en) * | 2008-11-06 | 2011-08-17 | Schering Corporation | Gamma secretase modulators |
| TW201030002A (en) | 2009-01-16 | 2010-08-16 | Bristol Myers Squibb Co | Bicyclic compounds for the reduction of beta-amyloid production |
| JP2012051806A (ja) | 2009-02-26 | 2012-03-15 | Eisai R & D Management Co Ltd | イミダゾリルピラジン誘導体 |
| FR2943342B1 (fr) | 2009-03-20 | 2011-03-04 | Servier Lab | Nouveaux derives de benzothiadiazepines,leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| WO2010140339A1 (ja) | 2009-06-01 | 2010-12-09 | 武田薬品工業株式会社 | 複素環化合物 |
| EP2455380A4 (en) | 2009-07-13 | 2012-11-28 | Takeda Pharmaceutical | HETEROCYCLIC COMPOUND AND USE THEREOF |
| WO2011036885A1 (ja) | 2009-09-25 | 2011-03-31 | 武田薬品工業株式会社 | 複素環化合物 |
| WO2011036889A1 (ja) | 2009-09-25 | 2011-03-31 | 武田薬品工業株式会社 | 複素環化合物 |
| LT2603513T (lt) * | 2010-08-10 | 2020-05-25 | Takeda Pharmaceutical Company Limited | Heterociklinis junginys ir jo panaudojimas kaip ampa receptoriaus teigiamo alosterinio moduliatoriaus |
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2011
- 2011-08-09 LT LTEP11749944.2T patent/LT2603513T/lt unknown
- 2011-08-09 SG SG2013007463A patent/SG187656A1/en unknown
- 2011-08-09 MX MX2013001614A patent/MX349470B/es active IP Right Grant
- 2011-08-09 MA MA35708A patent/MA34509B1/fr unknown
- 2011-08-09 BR BR112013002250-7A patent/BR112013002250B1/pt active IP Right Grant
- 2011-08-09 CN CN201180048970.3A patent/CN103180326B/zh active Active
- 2011-08-09 RS RS20200574A patent/RS60311B1/sr unknown
- 2011-08-09 PL PL11749944T patent/PL2603513T3/pl unknown
- 2011-08-09 TW TW100128311A patent/TWI504604B/zh active
- 2011-08-09 NZ NZ607593A patent/NZ607593A/en unknown
- 2011-08-09 CN CN201510259936.0A patent/CN104926837A/zh active Pending
- 2011-08-09 CA CA2807460A patent/CA2807460C/en active Active
- 2011-08-09 HU HUE11749944A patent/HUE049460T2/hu unknown
- 2011-08-09 DK DK11749944.2T patent/DK2603513T3/da active
- 2011-08-09 PT PT117499442T patent/PT2603513T/pt unknown
- 2011-08-09 EA EA201390222A patent/EA022078B1/ru not_active IP Right Cessation
- 2011-08-09 GE GEAP201113021A patent/GEP20156216B/en unknown
- 2011-08-09 HR HRP20200844TT patent/HRP20200844T1/hr unknown
- 2011-08-09 MY MYPI2013000428A patent/MY165908A/en unknown
- 2011-08-09 PH PH1/2013/500247A patent/PH12013500247A1/en unknown
- 2011-08-09 KR KR1020137006113A patent/KR101852215B1/ko active Active
- 2011-08-09 EP EP11749944.2A patent/EP2603513B1/en active Active
- 2011-08-09 US US13/206,113 patent/US8575154B2/en active Active
- 2011-08-09 WO PCT/JP2011/068497 patent/WO2012020848A1/en not_active Ceased
- 2011-08-09 ES ES11749944T patent/ES2793723T3/es active Active
- 2011-08-09 SI SI201131887T patent/SI2603513T1/sl unknown
- 2011-08-09 UY UY0001033551A patent/UY33551A/es not_active Application Discontinuation
- 2011-08-09 PE PE2013000244A patent/PE20131116A1/es active IP Right Grant
- 2011-08-09 JP JP2013506362A patent/JP5788496B2/ja active Active
- 2011-08-09 AU AU2011290126A patent/AU2011290126B2/en active Active
- 2011-08-09 AR ARP110102905A patent/AR082618A1/es active IP Right Grant
- 2011-08-09 US US13/816,137 patent/US9150591B2/en active Active
- 2011-09-08 UA UAA201302884A patent/UA111594C2/uk unknown
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2013
- 2013-01-28 IL IL224452A patent/IL224452A/en active IP Right Grant
- 2013-02-05 DO DO2013000030A patent/DOP2013000030A/es unknown
- 2013-02-07 CL CL2013000380A patent/CL2013000380A1/es unknown
- 2013-02-12 ZA ZA2013/01120A patent/ZA201301120B/en unknown
- 2013-02-18 CR CR20130066A patent/CR20130066A/es unknown
- 2013-02-22 US US13/774,707 patent/US8916551B2/en active Active
- 2013-02-22 US US13/774,635 patent/US8778934B2/en active Active
- 2013-03-06 EC ECSP13012478 patent/ECSP13012478A/es unknown
- 2013-03-07 CO CO13046020A patent/CO6680700A2/es active IP Right Grant
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2014
- 2014-11-13 US US14/540,699 patent/US20150073137A1/en not_active Abandoned
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2015
- 2015-07-21 US US14/804,935 patent/US9499568B2/en active Active
- 2015-07-29 JP JP2015149216A patent/JP6113789B2/ja active Active
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2016
- 2016-10-10 US US15/289,650 patent/US9884875B2/en active Active
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2017
- 2017-12-18 US US15/845,621 patent/US20180162875A1/en not_active Abandoned
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2019
- 2019-01-24 US US16/256,773 patent/US10654874B2/en active Active
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2020
- 2020-03-23 US US16/827,316 patent/US11279713B2/en active Active
- 2020-05-25 CY CY20201100475T patent/CY1123507T1/el unknown
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2024
- 2024-03-01 US US18/592,897 patent/US20240360156A1/en active Pending
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