PE20000332A1 - Metodo de valoracion de lamotrigina - Google Patents
Metodo de valoracion de lamotriginaInfo
- Publication number
- PE20000332A1 PE20000332A1 PE1999000190A PE00019099A PE20000332A1 PE 20000332 A1 PE20000332 A1 PE 20000332A1 PE 1999000190 A PE1999000190 A PE 1999000190A PE 00019099 A PE00019099 A PE 00019099A PE 20000332 A1 PE20000332 A1 PE 20000332A1
- Authority
- PE
- Peru
- Prior art keywords
- triazine
- amino
- lamotrigine
- chromatogram
- compound
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/90—Plate chromatography, e.g. thin layer or paper chromatography
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/145555—Hetero-N
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/145555—Hetero-N
- Y10T436/147777—Plural nitrogen in the same ring [e.g., barbituates, creatinine, etc.]
Abstract
SE REFIERE A UN METODO DE VALORACION DE LA PUREZA O ESTABILIDAD A LA DEGRADACION DE LAMOTRIGINA, QUE SE CARACTERIZA POR LA PRESENCIA DE 3-AMINO-6-(2,3-DICLOROFENIL)1,2,4-TRIAZINA-5-(4H)-ONA (COMPUESTO A) Y N-[5-AMINO-6-(2,3-DICLOROFENIL)-1,2,4-TRIAZINA-3-IL]-2,3-DICLOROBENZAMIDA (COMPUESTO B); QUE COMPRENDE a) DISOLVER LAMOTRIGINA EN UN SOLVENTE; b) DISOLVER 3-AMINO-6-(2,3-DICLOROFENIL)-1,2,4-TRIAZINA-5-(4H)-ONA, N-(5-AMINO-6-(2,3-DICLOROFENIL)-1,2,4-TRIAZINA-3-IL]-2,3-DICLOROBENZAMIDA EN UN SOLVENTE, FORMANDO UNA SOLUCION ESTANDAR DEL MARCADOR DE REFERENCIA; c) SOMETER LA SOLUCION DE MUESTRA Y LA SOLUCION ESTANDAR A CROMATOGRAFIA DE CAPA DELGADA O EN COLUMNA HPLC PARA OBTENER UN CROMATOGRAMA; d) ESTIMAR LA INTENSIDAD DE CUALQUIER MANCHA SECUNDARIA OBTENIDA EN EL CROMATOGRAMA DE LA SOLUCION DE MUESTRA, LA CUAL CORRESPONDE EN VALOR DE Rf AL MARCADOR DE REFERENCIA, CONTRA LA MANCHA DEBIDO AL MARCADOR DE REFERENCIA EN EL CROMATOGRAMA DE LA SOLUCION ESTANDAR O ESTIMAR EL AREA DEL PICO CORRESPONDIENTE. TAMBIEN SE REFIERE AL COMPUESTO B Y A UN PROCEDIMIENTO PARA LA PREPARACION
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9812413.4A GB9812413D0 (en) | 1998-06-10 | 1998-06-10 | Compound and its use |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20000332A1 true PE20000332A1 (es) | 2000-04-10 |
Family
ID=10833464
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE1999000190A PE20000332A1 (es) | 1998-06-10 | 1999-03-10 | Metodo de valoracion de lamotrigina |
Country Status (31)
Country | Link |
---|---|
US (1) | US6333198B1 (es) |
EP (2) | EP0963980B1 (es) |
JP (1) | JP2989189B1 (es) |
KR (1) | KR100322354B1 (es) |
CN (2) | CN1238454A (es) |
AP (3) | AP9901481A0 (es) |
AR (1) | AR014074A1 (es) |
AT (1) | ATE218552T1 (es) |
AU (1) | AU2031999A (es) |
BR (1) | BR9900984A (es) |
CA (1) | CA2265194C (es) |
DE (1) | DE69901656T2 (es) |
DK (1) | DK0963980T3 (es) |
EA (1) | EA000666B1 (es) |
ES (1) | ES2178342T3 (es) |
GB (1) | GB9812413D0 (es) |
HR (1) | HRP990074A2 (es) |
HU (1) | HUP9900592A3 (es) |
ID (1) | ID22957A (es) |
MA (1) | MA24777A1 (es) |
NO (2) | NO991151L (es) |
NZ (1) | NZ334590A (es) |
PE (1) | PE20000332A1 (es) |
PL (1) | PL331870A1 (es) |
PT (1) | PT963980E (es) |
SG (1) | SG85628A1 (es) |
SI (1) | SI0963980T1 (es) |
TR (1) | TR199900520A2 (es) |
UY (1) | UY25946A1 (es) |
YU (1) | YU12399A (es) |
ZA (1) | ZA991951B (es) |
Families Citing this family (92)
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KR102270026B1 (ko) * | 2020-01-31 | 2021-06-28 | 현대약품 주식회사 | (3s)-3-(4-(3-(1,4-다이옥사스파이로[4,5]데스-7-엔-8-일)벤질옥시)페닐)헥스-4-이노익산의 품질 평가 방법 |
CN113156009B (zh) * | 2021-04-20 | 2023-12-22 | 三金集团湖南三金制药有限责任公司 | 高效液相色谱分析拉莫三嗪的方法 |
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Publication number | Priority date | Publication date | Assignee | Title |
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DK153787C (da) | 1979-06-01 | 1989-01-16 | Wellcome Found | Analogifremgangsmaade til fremstilling af substituerede 3,5-diamino-6-phenyl-1,2,4-triaziner og alfa-cyanobenzyliden-aminoguanidinforbindelser til anvendelse som mellemprodukter herved |
EP0021120B1 (en) | 1979-06-01 | 1983-04-06 | The Wellcome Foundation Limited | 3,5-diamino-1,2,4-triazine derivatives, process for preparing such compounds and pharmaceutical compositions containing them |
GB8613183D0 (en) | 1986-05-30 | 1986-07-02 | Wellcome Found | Triazine salt |
GB9426448D0 (en) * | 1994-12-30 | 1995-03-01 | Wellcome Found | Process |
WO1996020934A1 (en) * | 1994-12-30 | 1996-07-11 | The Wellcome Foundation Limited | Process for the preparation of lamotrigine |
GB9512854D0 (en) * | 1995-06-23 | 1995-08-23 | Wellcome Found | Novel formulation |
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1998
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