UY25946A1 - Un método para probar la pureza o estabilidad a la degradación de una muestra de lamotrigina o una formulación farmacéutica en dosis que incluya lamotrigina - Google Patents
Un método para probar la pureza o estabilidad a la degradación de una muestra de lamotrigina o una formulación farmacéutica en dosis que incluya lamotriginaInfo
- Publication number
- UY25946A1 UY25946A1 UY25946A UY25946A UY25946A1 UY 25946 A1 UY25946 A1 UY 25946A1 UY 25946 A UY25946 A UY 25946A UY 25946 A UY25946 A UY 25946A UY 25946 A1 UY25946 A1 UY 25946A1
- Authority
- UY
- Uruguay
- Prior art keywords
- sample
- lamotrigine
- compound
- triazine
- amino
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/90—Plate chromatography, e.g. thin layer or paper chromatography
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/145555—Hetero-N
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/145555—Hetero-N
- Y10T436/147777—Plural nitrogen in the same ring [e.g., barbituates, creatinine, etc.]
Abstract
Un método para probar la pureza o estabilidad a la degradación de una muestra de lamotrigina o una formulación farmacéutica en dosis que incluya lamotrigina, comprende la realización de ensayos con dicha muestra para detectar la presencia de un compuesto seleccionado de 3-amino-6-(2,3-diclorofenil)-1,2,4-triazina-5-(4h)-ona y N-[5-amino-6-(2,3-diclorofeni)-1,2.4-triazina-3-il]-2.3-diclorobenzamida (fórmula l) asimismo, también se revela un proceso, para la producción del compuesto de fórmula l. Un método para probar la pureza de una muestra de lamotrigina, que incluye estos pasos: 1- disolver una muestra de lamotrigina en un solvente para producir una solución de muestra; 2- disolver una muestra de uno-3-amino-6-(2,3-diclorofenil)-1,2,4-triazina-5-(4H) o N-[5-amino-6-(2,3-diclorofeni)-1,2.4-triazina-3-il]-2.3-diclorobenzamida en un solvente para producir una solución estandar como marcador de referencia; 3- someter la solución de muestra y la solución estandar a cromatografía en capa fina para obtener un cromatograma TLC para cada una; y 4- estimar la intensidad de cualquier mancha secundaria obtenida en el cromatograma de la solución de muestra, que corresponde en valor de respuesta, al marcador de referencia, en contraposición a la mancha debida al marcador de referencia en el cromatograma de la solución estandar. Un proceso para producir el compuesto b, cuyo proceso comprende: 1- la reacción de dos equivalentes de cloruro de 2,3-diclorobenzoilo con 1 equivalente de lamotrigina disuelta en piridina a una temp. de menos de 35sC; o 2- ciclizar un compuesto de fórmula l en propan 1-ol bajo reflujo. Un proceso en donde en el paso 2 el compuesto de fórmula l se produce haciendo juntos a los compuestos de la formulas ll y lll en presencia de ácido mineral.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9812413.4A GB9812413D0 (en) | 1998-06-10 | 1998-06-10 | Compound and its use |
Publications (1)
Publication Number | Publication Date |
---|---|
UY25946A1 true UY25946A1 (es) | 2000-12-29 |
Family
ID=10833464
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY25946A UY25946A1 (es) | 1998-06-10 | 2000-01-17 | Un método para probar la pureza o estabilidad a la degradación de una muestra de lamotrigina o una formulación farmacéutica en dosis que incluya lamotrigina |
Country Status (31)
Country | Link |
---|---|
US (1) | US6333198B1 (es) |
EP (2) | EP0963980B1 (es) |
JP (1) | JP2989189B1 (es) |
KR (1) | KR100322354B1 (es) |
CN (2) | CN1238454A (es) |
AP (3) | AP9901481A0 (es) |
AR (1) | AR014074A1 (es) |
AT (1) | ATE218552T1 (es) |
AU (1) | AU2031999A (es) |
BR (1) | BR9900984A (es) |
CA (1) | CA2265194C (es) |
DE (1) | DE69901656T2 (es) |
DK (1) | DK0963980T3 (es) |
EA (1) | EA000666B1 (es) |
ES (1) | ES2178342T3 (es) |
GB (1) | GB9812413D0 (es) |
HR (1) | HRP990074A2 (es) |
HU (1) | HUP9900592A3 (es) |
ID (1) | ID22957A (es) |
MA (1) | MA24777A1 (es) |
NO (2) | NO991151L (es) |
NZ (1) | NZ334590A (es) |
PE (1) | PE20000332A1 (es) |
PL (1) | PL331870A1 (es) |
PT (1) | PT963980E (es) |
SG (1) | SG85628A1 (es) |
SI (1) | SI0963980T1 (es) |
TR (1) | TR199900520A2 (es) |
UY (1) | UY25946A1 (es) |
YU (1) | YU12399A (es) |
ZA (1) | ZA991951B (es) |
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CN102766104A (zh) * | 2012-08-20 | 2012-11-07 | 三金集团湖南三金制药有限责任公司 | 一种治疗双向情感障碍及癫痫病药物拉莫三嗪的合成方法 |
WO2015092819A2 (en) * | 2013-12-21 | 2015-06-25 | Nektar Therapeutics (India) Pvt. Ltd. | Derivatives of 6-(2,3-dichlorophenyl)-1,2,4-triazin-5- amine |
CN110467560A (zh) | 2018-05-09 | 2019-11-19 | 深圳微芯生物科技股份有限公司 | 一种苯基氨基丙酸钠衍生物、其制备方法和应用 |
KR102270026B1 (ko) * | 2020-01-31 | 2021-06-28 | 현대약품 주식회사 | (3s)-3-(4-(3-(1,4-다이옥사스파이로[4,5]데스-7-엔-8-일)벤질옥시)페닐)헥스-4-이노익산의 품질 평가 방법 |
CN113156009B (zh) * | 2021-04-20 | 2023-12-22 | 三金集团湖南三金制药有限责任公司 | 高效液相色谱分析拉莫三嗪的方法 |
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DK153787C (da) | 1979-06-01 | 1989-01-16 | Wellcome Found | Analogifremgangsmaade til fremstilling af substituerede 3,5-diamino-6-phenyl-1,2,4-triaziner og alfa-cyanobenzyliden-aminoguanidinforbindelser til anvendelse som mellemprodukter herved |
EP0021120B1 (en) | 1979-06-01 | 1983-04-06 | The Wellcome Foundation Limited | 3,5-diamino-1,2,4-triazine derivatives, process for preparing such compounds and pharmaceutical compositions containing them |
GB8613183D0 (en) | 1986-05-30 | 1986-07-02 | Wellcome Found | Triazine salt |
GB9426448D0 (en) * | 1994-12-30 | 1995-03-01 | Wellcome Found | Process |
WO1996020934A1 (en) * | 1994-12-30 | 1996-07-11 | The Wellcome Foundation Limited | Process for the preparation of lamotrigine |
GB9512854D0 (en) * | 1995-06-23 | 1995-08-23 | Wellcome Found | Novel formulation |
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