YU12399A - Jedinjenje i njegova upotreba - Google Patents
Jedinjenje i njegova upotrebaInfo
- Publication number
- YU12399A YU12399A YU12399A YU12399A YU12399A YU 12399 A YU12399 A YU 12399A YU 12399 A YU12399 A YU 12399A YU 12399 A YU12399 A YU 12399A YU 12399 A YU12399 A YU 12399A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- lamotrigin
- dichlorophenyl
- triazine
- regard
- amino
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/90—Plate chromatography, e.g. thin layer or paper chromatography
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/145555—Hetero-N
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/145555—Hetero-N
- Y10T436/147777—Plural nitrogen in the same ring [e.g., barbituates, creatinine, etc.]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Plural Heterocyclic Compounds (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Abstract
Metoda za odredjivanje čistoće ili stabilnosti u odnosu na degradaciju uzorka lamotrigina ili farmaceutskog oblika doziranja koji sadrži lamotrigin obuhvata ispitivanje rečnog uzorka u pogledu prisustva jedinjenja odabranog izmedju 3-amino-6-(2,3-dihlorofenil)-1,2,4-triazin-5-(4H)-ona (jedinjenje A) i N-[5-amino-6-(2,3-dihlorofenil)-1,2,4-triazin-3-il]-2,3-dihlorobenzamida (jedinjenje B). Postupak za dobijanje jedinjenja B, koji je nov, takodje je pokazan.[Method for determining purity or stability with regard to the degeneration of samples of lamotrigin or pharmaceutical form of dosing containing lamotrigin encompassing the mentioned sample with regard to the presence of compound chosen between 3- amino-6 (2,3-dichlorophenyl)-1,2,4-triazine- 5(4H)-ones (compounds A) and N-(5-amino-6-2,3 dichlorophenyl)-1,2,4-triazine -3-il)-2,3-dichloro benzamides (compunds B). Procedure for obtaining compund B, that is new, is also demonstrated.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9812413.4A GB9812413D0 (en) | 1998-06-10 | 1998-06-10 | Compound and its use |
Publications (1)
Publication Number | Publication Date |
---|---|
YU12399A true YU12399A (sh) | 2002-08-12 |
Family
ID=10833464
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU12399A YU12399A (sh) | 1998-06-10 | 1999-03-10 | Jedinjenje i njegova upotreba |
Country Status (31)
Country | Link |
---|---|
US (1) | US6333198B1 (sh) |
EP (2) | EP0963980B1 (sh) |
JP (1) | JP2989189B1 (sh) |
KR (1) | KR100322354B1 (sh) |
CN (2) | CN1238454A (sh) |
AP (3) | AP0102286A0 (sh) |
AR (1) | AR014074A1 (sh) |
AT (1) | ATE218552T1 (sh) |
AU (1) | AU2031999A (sh) |
BR (1) | BR9900984A (sh) |
CA (1) | CA2265194C (sh) |
DE (1) | DE69901656T2 (sh) |
DK (1) | DK0963980T3 (sh) |
EA (1) | EA000666B1 (sh) |
ES (1) | ES2178342T3 (sh) |
GB (1) | GB9812413D0 (sh) |
HR (1) | HRP990074A2 (sh) |
HU (1) | HUP9900592A3 (sh) |
ID (1) | ID22957A (sh) |
MA (1) | MA24777A1 (sh) |
NO (2) | NO991151L (sh) |
NZ (1) | NZ334590A (sh) |
PE (1) | PE20000332A1 (sh) |
PL (1) | PL331870A1 (sh) |
PT (1) | PT963980E (sh) |
SG (1) | SG85628A1 (sh) |
SI (1) | SI0963980T1 (sh) |
TR (1) | TR199900520A3 (sh) |
UY (1) | UY25946A1 (sh) |
YU (1) | YU12399A (sh) |
ZA (1) | ZA991951B (sh) |
Families Citing this family (92)
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WO2002053541A1 (en) | 2000-12-29 | 2002-07-11 | Pfizer Limited | Amide derivative of amlodipine |
MXPA03005882A (es) | 2000-12-29 | 2005-04-19 | Pfizer Ltd | Derivado amida de amlodipina. |
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US6653481B2 (en) | 2000-12-29 | 2003-11-25 | Synthon Bv | Process for making amlodipine |
WO2002053538A1 (en) | 2000-12-29 | 2002-07-11 | Pfizer Limited | Amlodipine fumarate |
BR0116552A (pt) | 2000-12-29 | 2004-02-03 | Pfizer Ltd | Hemi-maleato de amlodipina, processo, método para o tratamento ou prevenção de angina ou hipertensão, composição farmacêutica, para uso no tratamento e/ou de angina ou da hipertensão |
AT5874U1 (de) | 2000-12-29 | 2003-01-27 | Bioorg Bv | Pharmazeutische zubereitungen enthaltend amlodipinmaleat |
GB2371862B (en) * | 2000-12-29 | 2004-07-14 | Bioorg Bv | Reference standards for determining the purity or stability of amlodipine maleate and processes therefor |
WO2002053542A1 (en) | 2000-12-29 | 2002-07-11 | Pfizer Limited | Process for making amlodipine maleate |
DE10134980C2 (de) * | 2001-07-17 | 2003-05-28 | Helm Ag | Verfahren zur Herstellung von Lamotrigin |
CA2366521C (en) | 2001-12-24 | 2007-03-06 | Brantford Chemicals Inc. | A new and efficient process for the preparation of lamotrigine and related 3,5-diamino-6-substituted-1,2,4-triazines |
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ES2209639B1 (es) | 2002-10-31 | 2005-08-01 | Vita Cientifica, S.L. | Procedimiento para la obtencion de un compuesto farmaceuticamente activo y obtencion de su intermedio. |
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US7683188B2 (en) * | 2004-04-26 | 2010-03-23 | TEVA Gyógyszergyár Zártkōrūen Mūkōdō Részvénytársaság | Process for preparation of mycophenolic acid and ester derivatives thereof |
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WO2015092819A2 (en) | 2013-12-21 | 2015-06-25 | Nektar Therapeutics (India) Pvt. Ltd. | Derivatives of 6-(2,3-dichlorophenyl)-1,2,4-triazin-5- amine |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GR68380B (sh) | 1979-06-01 | 1981-12-28 | Wellcome Found | |
EP0021120B1 (en) | 1979-06-01 | 1983-04-06 | The Wellcome Foundation Limited | 3,5-diamino-1,2,4-triazine derivatives, process for preparing such compounds and pharmaceutical compositions containing them |
GB8613183D0 (en) | 1986-05-30 | 1986-07-02 | Wellcome Found | Triazine salt |
JPH11501007A (ja) * | 1994-12-30 | 1999-01-26 | ザ、ウェルカム、ファンデーション、リミテッド | ラモトリジンの製造法 |
GB9426448D0 (en) * | 1994-12-30 | 1995-03-01 | Wellcome Found | Process |
GB9512854D0 (en) * | 1995-06-23 | 1995-08-23 | Wellcome Found | Novel formulation |
-
1998
- 1998-06-10 GB GBGB9812413.4A patent/GB9812413D0/en not_active Ceased
-
1999
- 1999-02-24 EA EA199900159A patent/EA000666B1/ru not_active IP Right Cessation
- 1999-02-25 SG SG9901252A patent/SG85628A1/en unknown
- 1999-03-09 KR KR1019990007632A patent/KR100322354B1/ko active IP Right Review Request
- 1999-03-09 HR HR990074A patent/HRP990074A2/hr not_active Application Discontinuation
- 1999-03-10 PT PT99200695T patent/PT963980E/pt unknown
- 1999-03-10 ES ES99200695T patent/ES2178342T3/es not_active Expired - Lifetime
- 1999-03-10 CN CN99103445A patent/CN1238454A/zh active Pending
- 1999-03-10 TR TR1999/00520A patent/TR199900520A3/tr unknown
- 1999-03-10 PE PE1999000190A patent/PE20000332A1/es not_active Application Discontinuation
- 1999-03-10 DK DK99200695T patent/DK0963980T3/da active
- 1999-03-10 AU AU20319/99A patent/AU2031999A/en not_active Abandoned
- 1999-03-10 SI SI9930088T patent/SI0963980T1/xx unknown
- 1999-03-10 AT AT99200695T patent/ATE218552T1/de not_active IP Right Cessation
- 1999-03-10 PL PL99331870A patent/PL331870A1/xx not_active Application Discontinuation
- 1999-03-10 US US09/265,670 patent/US6333198B1/en not_active Expired - Fee Related
- 1999-03-10 ID IDP990201D patent/ID22957A/id unknown
- 1999-03-10 JP JP11063792A patent/JP2989189B1/ja not_active Expired - Fee Related
- 1999-03-10 CA CA002265194A patent/CA2265194C/en not_active Expired - Fee Related
- 1999-03-10 HU HU9900592A patent/HUP9900592A3/hu unknown
- 1999-03-10 AP APAP/P/2001/002286A patent/AP0102286A0/en unknown
- 1999-03-10 YU YU12399A patent/YU12399A/sh unknown
- 1999-03-10 DE DE69901656T patent/DE69901656T2/de not_active Expired - Fee Related
- 1999-03-10 NO NO991151A patent/NO991151L/no unknown
- 1999-03-10 NZ NZ334590A patent/NZ334590A/xx unknown
- 1999-03-10 BR BR9900984-6A patent/BR9900984A/pt not_active IP Right Cessation
- 1999-03-10 MA MA25489A patent/MA24777A1/fr unknown
- 1999-03-10 AR ARP990101018A patent/AR014074A1/es not_active Application Discontinuation
- 1999-03-10 EP EP99200695A patent/EP0963980B1/en not_active Expired - Lifetime
- 1999-03-10 EP EP01203376A patent/EP1170588A1/en not_active Withdrawn
- 1999-03-10 ZA ZA9901951A patent/ZA991951B/xx unknown
- 1999-03-10 AP APAP/P/1999/001481A patent/AP9901481A0/en unknown
-
2000
- 2000-01-17 UY UY25946A patent/UY25946A1/es unknown
- 2000-07-25 CN CN00122208A patent/CN1306210A/zh active Pending
-
2001
- 2001-09-06 AP AP2001002286A patent/AP2001002286A0/xx unknown
-
2003
- 2003-06-17 NO NO20032753A patent/NO20032753D0/no unknown
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