ES8802382A1 - Un procedimiento para preparar derivados de vinilisoquinolina - Google Patents

Un procedimiento para preparar derivados de vinilisoquinolina

Info

Publication number
ES8802382A1
ES8802382A1 ES554635A ES554635A ES8802382A1 ES 8802382 A1 ES8802382 A1 ES 8802382A1 ES 554635 A ES554635 A ES 554635A ES 554635 A ES554635 A ES 554635A ES 8802382 A1 ES8802382 A1 ES 8802382A1
Authority
ES
Spain
Prior art keywords
containing heterocyclic
heterocyclic compounds
nitrogen containing
compounds
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES554635A
Other languages
English (en)
Other versions
ES554635A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of ES8802382A1 publication Critical patent/ES8802382A1/es
Publication of ES554635A0 publication Critical patent/ES554635A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Materials For Medical Uses (AREA)
  • Dental Preparations (AREA)
  • Quinoline Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

LOS DERIVADOS DE VINILISOQUINOLINA (I), DONDE NO EXCLUSIVAMENTE, LA LINEA DE PUNTOS REPRESENTA UN ENLACE SIMPLE O DOBLE, SEGUN SEA M 1 O O, R ES CH2R10, R1 METOXI O METILO, R2, R3 Y R4 SON UN GRUPO R10-ACON R10 HIDROCARBILO C1-16, R5A Y R5B SON ALQUILO C1-4, R6A Y R6B HIDROCARBILO C1-12, R7 HIDROGENO, R8 CUANO O NITRO Y R9 ES -(CHFCH)NR11, CON N DE 0 A 2 Y R11 ALQUILO C1-8; SE IBTIENEN CICLIZANDO COMPUESTO (II), POR CALENTAMIENTO A REFLUJO EN UN DISOLVENTE COMO BENCENO, TOLUENO O ACIDO ACETICO, EN PRESENCIA DE UN REACTIVO ACIDO COMO EL OXICLORURO DE FOSFORO. POSEEN ACTIVIDAD CONTRA LOS PROTOZOOS, PARTICULARMENTE CONTRA LOS TRICHONOMAS, COMO EL TRICHONOMAS VAGINALES Y OTROS COMO LOS DEL GENERO COCCIDIA, LEISHMANIA, ETC. SON ANTIFUNGICOS DE AMPLIO ESPECTRO, APLICABLES EN EL TRATAMIENTO DE INFECCIONES PRODUCIDAS EN LOS SERES HUMANOS Y LAS PLANTAS POR: CANDIDA ALBICANS, CRYPTOCOCCUS NETORMANS, SACCHAROMYCES CEREVISIAE Y OTROS.
ES554635A 1984-08-01 1986-05-03 Un procedimiento para preparar derivados de vinilisoquinolina Expired ES8802382A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848419658A GB8419658D0 (en) 1984-08-01 1984-08-01 Nitrogen containing heterocyclic compounds

Publications (2)

Publication Number Publication Date
ES8802382A1 true ES8802382A1 (es) 1988-05-16
ES554635A0 ES554635A0 (es) 1988-05-16

Family

ID=10564801

Family Applications (3)

Application Number Title Priority Date Filing Date
ES545775A Expired ES8701730A1 (es) 1984-08-01 1985-07-31 Un procedimiento para preparar un derivado de vinilisoquino-linas
ES554635A Expired ES8802382A1 (es) 1984-08-01 1986-05-03 Un procedimiento para preparar derivados de vinilisoquinolina
ES554636A Expired ES8802222A1 (es) 1984-08-01 1986-05-03 Un procedimiento para preparar derivados de vinilisoquinolina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES545775A Expired ES8701730A1 (es) 1984-08-01 1985-07-31 Un procedimiento para preparar un derivado de vinilisoquino-linas

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES554636A Expired ES8802222A1 (es) 1984-08-01 1986-05-03 Un procedimiento para preparar derivados de vinilisoquinolina

Country Status (25)

Country Link
US (2) US4968698A (es)
EP (1) EP0170524B1 (es)
JP (2) JPH0688903B2 (es)
KR (1) KR920004484B1 (es)
CN (1) CN85106609A (es)
AT (1) ATE78163T1 (es)
AU (1) AU597564B2 (es)
CA (1) CA1291993C (es)
CS (1) CS266332B2 (es)
DD (1) DD236525A5 (es)
DE (1) DE3586340T2 (es)
DK (1) DK347685A (es)
ES (3) ES8701730A1 (es)
FI (1) FI86848C (es)
GB (1) GB8419658D0 (es)
GR (1) GR851879B (es)
HU (1) HU194834B (es)
IE (1) IE58661B1 (es)
IL (1) IL75978A (es)
MC (1) MC1693A1 (es)
NZ (1) NZ212929A (es)
PH (1) PH27347A (es)
PL (1) PL147636B1 (es)
PT (1) PT80893B (es)
ZA (1) ZA855800B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8717374D0 (en) * 1987-07-22 1987-08-26 Smith Kline French Lab Pharmaceutically active compounds
WO1995007275A1 (de) * 1993-09-10 1995-03-16 Ciba-Geigy Ag Photochrome verbindungen, verfahren und zwischenprodukte zu deren hestellung und deren verwendung
EP1200410A1 (en) * 1999-07-29 2002-05-02 Egis Gyogyszergyar Rt. Isoquinoline derivatives, pharmaceutical compositions containing the same, and a process for the preparation of the active substance
ES2260202T3 (es) * 2000-02-23 2006-11-01 Ciba Specialty Chemicals Holding Inc. Empleo de derivados de feniletilamina para el tratamiento antimicrobiano de superficies.
US6846492B2 (en) 2000-02-23 2005-01-25 Ciba Specialty Chemicals Corporation Use of phenylethylamine derivatives for the antimicrobial treatment of surfaces
WO2003040402A2 (en) * 2001-11-09 2003-05-15 The Regents Of The University Of California Alpha-helix mimicry by a class of organic molecules
DE10229762A1 (de) * 2002-07-03 2004-01-22 Aventis Pharma Deutschland Gmbh Pyrazoloisoquinolinenderivaten zur Inhibierung von NFkappaB-induzierende Kinase
CN100386319C (zh) * 2005-12-05 2008-05-07 中国人民解放军第二军医大学 具有抗生育和抗真菌活性的四氢异喹啉类化合物或其盐类
EP2345642A1 (en) * 2009-12-29 2011-07-20 Polichem S.A. Secondary 8-hydroxyquinoline-7-carboxamide derivatives for use as antifungal agents
CZ302637B6 (cs) * 2010-01-05 2011-08-10 Zentiva, K. S Zpusob prípravy 6,7-dimethoxy-1-[2-(4-trifluormethylfenyl)ethyl]-3,4-dihydroisochinolinu

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3067203A (en) * 1962-12-04 Tetrahybroisqquinoline derivatives
GB862052A (en) * 1958-09-04 1961-03-01 Hoffmann La Roche Novel isoquinoline derivatives and salts thereof and a process for the manufacture of same
US3146266A (en) * 1959-08-25 1964-08-25 Hoffmann La Roche Novel ketone compounds
GB1181959A (en) * 1969-01-30 1970-02-18 Dresden Arzneimittel 6,7-Dimethoxy-3,4-Dihydroisoquinoline Derivatives
GB1386076A (en) * 1971-06-03 1975-03-05 Wyeth John & Brother Ltd Isoquinoline derivatives

Also Published As

Publication number Publication date
EP0170524A2 (en) 1986-02-05
FI852959L (fi) 1986-02-02
DE3586340T2 (de) 1993-03-04
PH27347A (en) 1993-06-08
JPS6187665A (ja) 1986-05-06
CN85106609A (zh) 1987-03-25
ES554636A0 (es) 1988-04-16
IE58661B1 (en) 1993-11-03
IL75978A (en) 1989-09-10
GB8419658D0 (en) 1984-09-05
EP0170524B1 (en) 1992-07-15
IL75978A0 (en) 1985-12-31
ES8701730A1 (es) 1986-12-01
KR860001791A (ko) 1986-03-22
ES545775A0 (es) 1986-12-01
JPH0688903B2 (ja) 1994-11-09
AU597564B2 (en) 1990-06-07
DD236525A5 (de) 1986-06-11
AU4566285A (en) 1986-02-06
ES8802222A1 (es) 1988-04-16
GR851879B (es) 1985-12-02
US4968698A (en) 1990-11-06
PT80893A (en) 1985-08-01
MC1693A1 (fr) 1986-07-18
PT80893B (pt) 1987-11-30
ES554635A0 (es) 1988-05-16
ATE78163T1 (de) 1992-08-15
PL254779A1 (en) 1986-12-30
NZ212929A (en) 1989-05-29
HUT40084A (en) 1986-11-28
EP0170524A3 (en) 1988-05-25
ZA855800B (en) 1987-03-25
DE3586340D1 (de) 1992-08-20
KR920004484B1 (ko) 1992-06-05
JPH07252154A (ja) 1995-10-03
DK347685D0 (da) 1985-07-31
CS266332B2 (en) 1989-12-13
CS558285A2 (en) 1989-02-10
US4963562A (en) 1990-10-16
FI86848C (fi) 1992-10-26
CA1291993C (en) 1991-11-12
HU194834B (en) 1988-03-28
FI852959A0 (fi) 1985-07-31
DK347685A (da) 1986-02-02
IE851903L (en) 1986-02-01
FI86848B (fi) 1992-07-15
PL147636B1 (en) 1989-07-31

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970612