EA200702057A1 - Новые антиаритмические и применяемые при сердечной недостаточности лекарственные средства, которые направлены против "просачивания" рецептора рианодина (ryr2) - Google Patents

Новые антиаритмические и применяемые при сердечной недостаточности лекарственные средства, которые направлены против "просачивания" рецептора рианодина (ryr2)

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Publication number
EA200702057A1
EA200702057A1 EA200702057A EA200702057A EA200702057A1 EA 200702057 A1 EA200702057 A1 EA 200702057A1 EA 200702057 A EA200702057 A EA 200702057A EA 200702057 A EA200702057 A EA 200702057A EA 200702057 A1 EA200702057 A1 EA 200702057A1
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EA
Eurasian Patent Office
Prior art keywords
heart failure
methods
ryr2
present
rianodyn
Prior art date
Application number
EA200702057A
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English (en)
Inventor
Эндрю Р. Маркс
Дональд В. Лэндри
Шисянь Дэн
Чжэн Чжуан Чэн
Original Assignee
Дзе Трастиз Оф Коламбия Юниверсити Ин Дзе Сити Оф Нью Йорк
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37024084&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200702057(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Дзе Трастиз Оф Коламбия Юниверсити Ин Дзе Сити Оф Нью Йорк filed Critical Дзе Трастиз Оф Коламбия Юниверсити Ин Дзе Сити Оф Нью Йорк
Publication of EA200702057A1 publication Critical patent/EA200702057A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G01N2800/325—Heart failure or cardiac arrest, e.g. cardiomyopathy, congestive heart failure
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G01N2800/326—Arrhythmias, e.g. ventricular fibrillation, tachycardia, atrioventricular block, torsade de pointes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Настоящее изобретение предлагает новые 1,4-бензотиазепиновые промежуточные соединения и производные, способы их получения и способы их испытания. Настоящее изобретение предлагает также способы применения указанных новых соединений для ограничения или предотвращения снижения уровня RyR2-связанного FKBP12.6 у субъекта; для предотвращения вызванной физической нагрузкой скоропостижной смерти субъекта от сердечной недостаточности, для лечения или профилактики сердечной недостаточности, фибрилляции предсердий и вызванной физической нагрузкой сердечной аритмии у субъекта. Настоящее изобретение предлагает также способы идентификации агента, который повышает связывание RyR2 и FKBP12.6, и агенты, идентифицированные указанными способами. Кроме того, настоящее изобретение предлагает способы идентификации агентов для применения при лечении или профилактике сердечной недостаточности, фибрилляции предсердий или вызванной физической нагрузкой сердечной аритмии и при предотвращении вызванной физической нагрузкой скоропостижной смерти от сердечной недостаточности. Предложены также агенты, идентифицированные такими способами.
EA200702057A 2005-03-23 2005-03-24 Новые антиаритмические и применяемые при сердечной недостаточности лекарственные средства, которые направлены против "просачивания" рецептора рианодина (ryr2) EA200702057A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/088,058 US7544678B2 (en) 2002-11-05 2005-03-23 Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2)
PCT/US2005/010055 WO2006101496A1 (en) 2005-03-23 2005-03-24 Novel anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (ryr2)

Publications (1)

Publication Number Publication Date
EA200702057A1 true EA200702057A1 (ru) 2008-04-28

Family

ID=37024084

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200702057A EA200702057A1 (ru) 2005-03-23 2005-03-24 Новые антиаритмические и применяемые при сердечной недостаточности лекарственные средства, которые направлены против "просачивания" рецептора рианодина (ryr2)

Country Status (15)

Country Link
US (2) US7544678B2 (ru)
EP (1) EP1861385A1 (ru)
JP (1) JP2008534497A (ru)
KR (1) KR20070116900A (ru)
CN (1) CN101146785A (ru)
AU (1) AU2005329398A1 (ru)
BR (1) BRPI0520160A2 (ru)
CA (1) CA2601541A1 (ru)
EA (1) EA200702057A1 (ru)
IL (1) IL185668A0 (ru)
MA (1) MA30440B1 (ru)
MX (1) MX2007011528A (ru)
NO (1) NO20075386L (ru)
WO (1) WO2006101496A1 (ru)
ZA (1) ZA200707573B (ru)

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US7718644B2 (en) 2004-01-22 2010-05-18 The Trustees Of Columbia University In The City Of New York Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof
US8022058B2 (en) * 2000-05-10 2011-09-20 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
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US8710045B2 (en) 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
US7704990B2 (en) 2005-08-25 2010-04-27 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
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EP1861385A1 (en) 2007-12-05
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US20050187386A1 (en) 2005-08-25
US20100152440A1 (en) 2010-06-17
AU2005329398A1 (en) 2006-09-28
MA30440B1 (fr) 2009-06-01
ZA200707573B (en) 2008-07-30
US7544678B2 (en) 2009-06-09
IL185668A0 (en) 2008-01-06
WO2006101496A1 (en) 2006-09-28
MX2007011528A (es) 2007-12-12
KR20070116900A (ko) 2007-12-11
BRPI0520160A2 (pt) 2009-04-22
CA2601541A1 (en) 2006-09-28

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