EA200300061A1 - Комбинированная противоопухолевая терапия, включающая применение производных замещенного акрилоилдистамицина и алкилирующих агентов - Google Patents

Комбинированная противоопухолевая терапия, включающая применение производных замещенного акрилоилдистамицина и алкилирующих агентов

Info

Publication number
EA200300061A1
EA200300061A1 EA200300061A EA200300061A EA200300061A1 EA 200300061 A1 EA200300061 A1 EA 200300061A1 EA 200300061 A EA200300061 A EA 200300061A EA 200300061 A EA200300061 A EA 200300061A EA 200300061 A1 EA200300061 A1 EA 200300061A1
Authority
EA
Eurasian Patent Office
Prior art keywords
derivatives
combined
antitument
acryloldystamicine
alkyling
Prior art date
Application number
EA200300061A
Other languages
English (en)
Other versions
EA008502B1 (ru
Inventor
Мария Кристина Роза Джерони
Паоло Коцци
Итало Берия
Original Assignee
Фармация Италия С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фармация Италия С.П.А. filed Critical Фармация Италия С.П.А.
Publication of EA200300061A1 publication Critical patent/EA200300061A1/ru
Publication of EA008502B1 publication Critical patent/EA008502B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

В данном изобретении представляют комбинированное применение производных акрилоилдистамицина, в частности производных α-бром- и α-хлоракрилоилдистамицина формулы (I), которые охарактеризованы в описании, и алкилирующего агента для лечения опухолей. Также представляют применение указанной комбинации для лечения или предупреждения метастаза или лечения опухолей ингибированием ангиогенеза.Отчет о международном поиске был опубликован 2002.05.16.
EA200300061A 2000-06-23 2001-06-20 Комбинированная противоопухолевая терапия, включающая применение производных замещенного акрилоилдистамицина и алкилирующих агентов EA008502B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0015447.6A GB0015447D0 (en) 2000-06-23 2000-06-23 Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents
PCT/EP2001/007064 WO2001097790A2 (en) 2000-06-23 2001-06-20 Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and alkylating agents

Publications (2)

Publication Number Publication Date
EA200300061A1 true EA200300061A1 (ru) 2003-04-24
EA008502B1 EA008502B1 (ru) 2007-06-29

Family

ID=9894288

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200300061A EA008502B1 (ru) 2000-06-23 2001-06-20 Комбинированная противоопухолевая терапия, включающая применение производных замещенного акрилоилдистамицина и алкилирующих агентов

Country Status (28)

Country Link
US (1) US8642580B2 (ru)
EP (1) EP1303307B1 (ru)
JP (1) JP2003535891A (ru)
KR (1) KR100869037B1 (ru)
CN (1) CN100479860C (ru)
AT (1) ATE362365T1 (ru)
AU (2) AU2001281867B2 (ru)
BR (1) BR0111740A (ru)
CA (1) CA2410160C (ru)
CY (1) CY1106713T1 (ru)
CZ (1) CZ301053B6 (ru)
DE (1) DE60128472T2 (ru)
DK (1) DK1303307T3 (ru)
EA (1) EA008502B1 (ru)
EE (1) EE05300B1 (ru)
ES (1) ES2284674T3 (ru)
GB (1) GB0015447D0 (ru)
HK (1) HK1054335B (ru)
HU (1) HUP0301234A2 (ru)
IL (2) IL152956A0 (ru)
MX (1) MXPA02012209A (ru)
NO (1) NO329782B1 (ru)
NZ (1) NZ522999A (ru)
PL (1) PL202053B1 (ru)
PT (1) PT1303307E (ru)
SK (1) SK18342002A3 (ru)
WO (1) WO2001097790A2 (ru)
ZA (1) ZA200209836B (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002352090B8 (en) * 2002-01-02 2008-06-19 Nerviano Medical Sciences S.R.L. Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and protein kinase (serine/threonine kinase) inhibitors
WO2003082267A1 (en) * 2002-04-02 2003-10-09 Pharmacia Italia Spa Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and radiotherapy
MD23Z (ru) * 2008-12-02 2010-01-31 Василе ЖОВМИР Метод дифференциального лечения неинвазивной лобулярной карциномы in situ молочной железы
MD36Z (ru) * 2008-12-02 2010-01-31 Василе ЖОВМИР Метод дифференциального лечения неинвазивной дуктальной карциномы in situ молочной железы
MD35Z (ru) * 2008-12-02 2010-01-31 Василе ЖОВМИР Метод оценки риска развития неинвазивной карциномы in situ молочной железы
MD24Z (ru) * 2008-12-02 2010-01-31 Василе ЖОВМИР Метод дифференциального лечения неинвазивной карциномы молочной железы
CN107011358B (zh) * 2012-04-05 2020-05-05 内尔维阿诺医学科学有限公司 新的烷化剂

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56154493A (en) * 1980-04-30 1981-11-30 Shionogi & Co Ltd Novel platinum complex
AT387013B (de) 1985-07-16 1988-11-25 Erba Farmitalia Verfahren zur herstellung von poly-4-aminopyrrol -2-carboxamidoderivaten
CN85103908A (zh) * 1985-07-16 1986-11-05 法米塔利·卡洛·埃尔巴有限公司 制备4′-表多克索红菌素的新方法
GB8612218D0 (en) 1986-05-20 1986-06-25 Erba Farmitalia Site specific alkylating agents
DE3768419D1 (de) 1986-10-07 1991-04-11 Boehringer Biochemia Srl Pharmazeutische zusammensetzungen mit antineoplastischer wirkung.
GB8906709D0 (en) 1989-03-23 1989-05-10 Creighton Andrew M Acryloyl substituted pyrrole derivatives
JP2919867B2 (ja) 1989-09-27 1999-07-19 千寿製薬株式会社 抗腫瘍剤
GB9000644D0 (en) * 1990-01-11 1990-03-14 Erba Carlo Spa New ureido derivatives of poly-4-amino-2-carboxy-1-methyl compounds
IT1272234B (it) 1994-05-02 1997-06-16 Consiglio Nazionale Ricerche Derivati glutationici delle antracicline e procedimento per ottenerli.
GB9416005D0 (en) 1994-08-08 1994-09-28 Erba Carlo Spa Peptidic compounds analogous to distamycin a and process for their preparation
US5880097A (en) 1996-01-04 1999-03-09 Terrapin Techologies, Inc. Tethered prodrugs
CA2244139C (en) 1996-02-02 2005-06-07 Pharmacia & Upjohn S.P.A. Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
GB9610079D0 (en) 1996-05-14 1996-07-17 Pharmacia Spa Distamycin deriratives process for preparing them and their use as antitumor and antiviral agents
GB9615692D0 (en) * 1996-07-25 1996-09-04 Pharmacia Spa Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
GB9623522D0 (en) 1996-11-11 1997-01-08 Pharmacia & Upjohn Spa Benzoheterocycle distamycin derivatives process for preparing them and their use as antitumour and antiviral agents
GB9727524D0 (en) * 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Synergistic antitumor composition containing a biologically active ureido compound
GB9806689D0 (en) 1998-03-27 1998-05-27 Pharmacia & Upjohn Spa Acryloyl derivatives analogous to distamycin,process for preparing them,and their use as antitumour and antiviral agents
GB9806692D0 (en) 1998-03-27 1998-05-27 Pharmacia & Upjohn Spa Benzoheterocyclic distamycin derivatives, process for preparing them and their use as antitumour agents
GB9816652D0 (en) 1998-07-30 1998-09-30 Pharmacia & Upjohn Spa Sulfurated distamycin derivatives process for preparing them and their use as antitumor agents
GB9816653D0 (en) 1998-07-30 1998-09-30 Pharmacia & Upjohn Spa Oxidised sulfurated distamycin derivatives process for preparing them and their use as antitumor agents
GB9928703D0 (en) 1999-12-03 2000-02-02 Pharmacia & Upjohn Spa Acryloyl peptidic derivatives,process for their preparation and their use as antitumour agents
GB0011059D0 (en) 2000-05-08 2000-06-28 Pharmacia & Upjohn Spa Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione
GB0015444D0 (en) * 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and topoisomerase I and II inhibitors
US6576612B1 (en) * 2000-10-02 2003-06-10 Pharmacia Italia S.P.A. Antitumor therapy comprising distamycin derivatives

Also Published As

Publication number Publication date
MXPA02012209A (es) 2003-06-04
ES2284674T3 (es) 2007-11-16
HK1054335B (zh) 2010-06-11
ATE362365T1 (de) 2007-06-15
SK18342002A3 (sk) 2003-06-03
HUP0301234A2 (hu) 2003-08-28
DE60128472D1 (de) 2007-06-28
EE200200660A (et) 2004-06-15
DK1303307T3 (da) 2007-07-16
WO2001097790A2 (en) 2001-12-27
NO20026077D0 (no) 2002-12-18
PL202053B1 (pl) 2009-05-29
NZ522999A (en) 2004-10-29
CA2410160A1 (en) 2001-12-27
PL365158A1 (en) 2004-12-27
BR0111740A (pt) 2003-07-08
DE60128472T2 (de) 2008-01-24
CZ20024106A3 (cs) 2003-05-14
NO20026077L (no) 2002-12-18
EP1303307A2 (en) 2003-04-23
GB0015447D0 (en) 2000-08-16
AU8186701A (en) 2002-01-02
PT1303307E (pt) 2007-07-04
AU2001281867B2 (en) 2006-02-23
WO2001097790A3 (en) 2002-05-16
EA008502B1 (ru) 2007-06-29
KR20030011105A (ko) 2003-02-06
US8642580B2 (en) 2014-02-04
CN100479860C (zh) 2009-04-22
NO329782B1 (no) 2010-12-13
JP2003535891A (ja) 2003-12-02
EE05300B1 (et) 2010-06-15
EP1303307B1 (en) 2007-05-16
ZA200209836B (en) 2003-12-04
CA2410160C (en) 2009-06-02
HK1054335A1 (en) 2003-11-28
IL152956A (en) 2010-06-30
CZ301053B6 (cs) 2009-10-21
CN1437485A (zh) 2003-08-20
IL152956A0 (en) 2003-06-24
KR100869037B1 (ko) 2008-11-17
CY1106713T1 (el) 2012-05-23
US20030180383A1 (en) 2003-09-25

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Legal Events

Date Code Title Description
PC1A Registration of transfer to a eurasian application by force of assignment
PD1A Registration of transfer to a eurasian application by order of succession in title
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU