HK1054335B - 包含取代的丙烯酰基偏端霉素衍生物和烷基化劑的抗腫瘤聯合療法 - Google Patents

包含取代的丙烯酰基偏端霉素衍生物和烷基化劑的抗腫瘤聯合療法

Info

Publication number
HK1054335B
HK1054335B HK03106772.8A HK03106772A HK1054335B HK 1054335 B HK1054335 B HK 1054335B HK 03106772 A HK03106772 A HK 03106772A HK 1054335 B HK1054335 B HK 1054335B
Authority
HK
Hong Kong
Prior art keywords
alkylating agents
combined therapy
against tumors
therapy against
distamycin derivatives
Prior art date
Application number
HK03106772.8A
Other languages
English (en)
Other versions
HK1054335A1 (en
Inventor
M‧C‧R‧格羅尼
P‧科茲
I‧伯利亞
Original Assignee
內爾維阿諾醫學科學有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 內爾維阿諾醫學科學有限公司 filed Critical 內爾維阿諾醫學科學有限公司
Publication of HK1054335A1 publication Critical patent/HK1054335A1/xx
Publication of HK1054335B publication Critical patent/HK1054335B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK03106772.8A 2000-06-23 2003-09-22 包含取代的丙烯酰基偏端霉素衍生物和烷基化劑的抗腫瘤聯合療法 HK1054335B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0015447.6A GB0015447D0 (en) 2000-06-23 2000-06-23 Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents
PCT/EP2001/007064 WO2001097790A2 (en) 2000-06-23 2001-06-20 Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and alkylating agents

Publications (2)

Publication Number Publication Date
HK1054335A1 HK1054335A1 (en) 2003-11-28
HK1054335B true HK1054335B (zh) 2010-06-11

Family

ID=9894288

Family Applications (1)

Application Number Title Priority Date Filing Date
HK03106772.8A HK1054335B (zh) 2000-06-23 2003-09-22 包含取代的丙烯酰基偏端霉素衍生物和烷基化劑的抗腫瘤聯合療法

Country Status (28)

Country Link
US (1) US8642580B2 (zh)
EP (1) EP1303307B1 (zh)
JP (1) JP2003535891A (zh)
KR (1) KR100869037B1 (zh)
CN (1) CN100479860C (zh)
AT (1) ATE362365T1 (zh)
AU (2) AU2001281867B2 (zh)
BR (1) BR0111740A (zh)
CA (1) CA2410160C (zh)
CY (1) CY1106713T1 (zh)
CZ (1) CZ301053B6 (zh)
DE (1) DE60128472T2 (zh)
DK (1) DK1303307T3 (zh)
EA (1) EA008502B1 (zh)
EE (1) EE05300B1 (zh)
ES (1) ES2284674T3 (zh)
GB (1) GB0015447D0 (zh)
HK (1) HK1054335B (zh)
HU (1) HUP0301234A2 (zh)
IL (2) IL152956A0 (zh)
MX (1) MXPA02012209A (zh)
NO (1) NO329782B1 (zh)
NZ (1) NZ522999A (zh)
PL (1) PL202053B1 (zh)
PT (1) PT1303307E (zh)
SK (1) SK18342002A3 (zh)
WO (1) WO2001097790A2 (zh)
ZA (1) ZA200209836B (zh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA04006543A (es) * 2002-01-02 2004-10-04 Pharmacia Italia Spa Terapia combinada contra tumores, que comprende derivados de acriloildistamicina sustituida e inhibidores de serina/treonina cinasa.
KR100968657B1 (ko) * 2002-04-02 2010-07-06 네르비아노 메디칼 사이언시스 에스.알.엘. 치환된 아크릴로일 디스타마이신 유도체 및 방사선요법을포함하는 조합 종양 치료법
MD24Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de tratament diferenţiat al carcinomului neinvaziv al glandei mamare
MD35Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de apreciere a riscului dezvoltării carcinomului neinvaziv in situ al glandei mamare
MD23Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de tratament diferenţiat al carcinomului lobular in situ neinvaziv al glandei mamare
MD36Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de tratament diferenţiat al carcinomului ductal in situ neinvaziv al glandei mamare
ES2755719T3 (es) * 2012-04-05 2020-04-23 Nerviano Medical Sciences Srl Nuevos agentes alquilantes

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56154493A (en) * 1980-04-30 1981-11-30 Shionogi & Co Ltd Novel platinum complex
CN85103908A (zh) * 1985-07-16 1986-11-05 法米塔利·卡洛·埃尔巴有限公司 制备4′-表多克索红菌素的新方法
SE468642B (sv) 1985-07-16 1993-02-22 Erba Farmitalia Poly-4-aminopyrrol-2-karboxamidoderivat och foerfarande foer deras framstaellning och en farmaceutisk komposition
GB8612218D0 (en) 1986-05-20 1986-06-25 Erba Farmitalia Site specific alkylating agents
EP0265719B1 (en) 1986-10-07 1991-03-06 Boehringer Mannheim Italia S.P.A. Pharmaceutical compositions having antineoplastic activity
GB8906709D0 (en) 1989-03-23 1989-05-10 Creighton Andrew M Acryloyl substituted pyrrole derivatives
JP2919867B2 (ja) 1989-09-27 1999-07-19 千寿製薬株式会社 抗腫瘍剤
GB9000644D0 (en) * 1990-01-11 1990-03-14 Erba Carlo Spa New ureido derivatives of poly-4-amino-2-carboxy-1-methyl compounds
IT1272234B (it) 1994-05-02 1997-06-16 Consiglio Nazionale Ricerche Derivati glutationici delle antracicline e procedimento per ottenerli.
GB9416005D0 (en) 1994-08-08 1994-09-28 Erba Carlo Spa Peptidic compounds analogous to distamycin a and process for their preparation
US5880097A (en) 1996-01-04 1999-03-09 Terrapin Techologies, Inc. Tethered prodrugs
AU1596097A (en) 1996-02-02 1997-08-22 Pharmacia & Upjohn S.P.A. Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
GB9610079D0 (en) 1996-05-14 1996-07-17 Pharmacia Spa Distamycin deriratives process for preparing them and their use as antitumor and antiviral agents
GB9615692D0 (en) * 1996-07-25 1996-09-04 Pharmacia Spa Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
GB9623522D0 (en) * 1996-11-11 1997-01-08 Pharmacia & Upjohn Spa Benzoheterocycle distamycin derivatives process for preparing them and their use as antitumour and antiviral agents
GB9727524D0 (en) * 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Synergistic antitumor composition containing a biologically active ureido compound
GB9806689D0 (en) 1998-03-27 1998-05-27 Pharmacia & Upjohn Spa Acryloyl derivatives analogous to distamycin,process for preparing them,and their use as antitumour and antiviral agents
GB9806692D0 (en) * 1998-03-27 1998-05-27 Pharmacia & Upjohn Spa Benzoheterocyclic distamycin derivatives, process for preparing them and their use as antitumour agents
GB9816652D0 (en) 1998-07-30 1998-09-30 Pharmacia & Upjohn Spa Sulfurated distamycin derivatives process for preparing them and their use as antitumor agents
GB9816653D0 (en) 1998-07-30 1998-09-30 Pharmacia & Upjohn Spa Oxidised sulfurated distamycin derivatives process for preparing them and their use as antitumor agents
GB9928703D0 (en) 1999-12-03 2000-02-02 Pharmacia & Upjohn Spa Acryloyl peptidic derivatives,process for their preparation and their use as antitumour agents
GB0011059D0 (en) 2000-05-08 2000-06-28 Pharmacia & Upjohn Spa Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione
GB0015444D0 (en) * 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and topoisomerase I and II inhibitors
US6576612B1 (en) * 2000-10-02 2003-06-10 Pharmacia Italia S.P.A. Antitumor therapy comprising distamycin derivatives

Also Published As

Publication number Publication date
BR0111740A (pt) 2003-07-08
PL365158A1 (en) 2004-12-27
NO329782B1 (no) 2010-12-13
ZA200209836B (en) 2003-12-04
ES2284674T3 (es) 2007-11-16
KR20030011105A (ko) 2003-02-06
ATE362365T1 (de) 2007-06-15
NO20026077L (no) 2002-12-18
EP1303307B1 (en) 2007-05-16
IL152956A (en) 2010-06-30
EE05300B1 (et) 2010-06-15
IL152956A0 (en) 2003-06-24
EE200200660A (et) 2004-06-15
WO2001097790A3 (en) 2002-05-16
CN1437485A (zh) 2003-08-20
HUP0301234A2 (hu) 2003-08-28
PL202053B1 (pl) 2009-05-29
DE60128472T2 (de) 2008-01-24
CY1106713T1 (el) 2012-05-23
EA008502B1 (ru) 2007-06-29
CA2410160A1 (en) 2001-12-27
DK1303307T3 (da) 2007-07-16
EP1303307A2 (en) 2003-04-23
MXPA02012209A (es) 2003-06-04
AU8186701A (en) 2002-01-02
US8642580B2 (en) 2014-02-04
CZ20024106A3 (cs) 2003-05-14
EA200300061A1 (ru) 2003-04-24
NO20026077D0 (no) 2002-12-18
SK18342002A3 (sk) 2003-06-03
DE60128472D1 (de) 2007-06-28
GB0015447D0 (en) 2000-08-16
WO2001097790A2 (en) 2001-12-27
PT1303307E (pt) 2007-07-04
CZ301053B6 (cs) 2009-10-21
CN100479860C (zh) 2009-04-22
KR100869037B1 (ko) 2008-11-17
NZ522999A (en) 2004-10-29
US20030180383A1 (en) 2003-09-25
CA2410160C (en) 2009-06-02
HK1054335A1 (en) 2003-11-28
JP2003535891A (ja) 2003-12-02
AU2001281867B2 (en) 2006-02-23

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20150620