OA10896A - Indole derivatives useful as endothelin receptor antagonists - Google Patents

Indole derivatives useful as endothelin receptor antagonists Download PDF

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Publication number
OA10896A
OA10896A OA9800192A OA9800192A OA10896A OA 10896 A OA10896 A OA 10896A OA 9800192 A OA9800192 A OA 9800192A OA 9800192 A OA9800192 A OA 9800192A OA 10896 A OA10896 A OA 10896A
Authority
OA
OAPI
Prior art keywords
compound
iii
alkyl
formula
nmr
Prior art date
Application number
OA9800192A
Other languages
English (en)
Inventor
David James Rawson
Kevin Neil Dack
Roger Peter Dickinson
Kim James
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of OA10896A publication Critical patent/OA10896A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
OA9800192A 1996-05-09 1998-10-09 Indole derivatives useful as endothelin receptor antagonists OA10896A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9609641.7A GB9609641D0 (en) 1996-05-09 1996-05-09 Compounds useful in therapy

Publications (1)

Publication Number Publication Date
OA10896A true OA10896A (en) 2001-10-11

Family

ID=10793387

Family Applications (1)

Application Number Title Priority Date Filing Date
OA9800192A OA10896A (en) 1996-05-09 1998-10-09 Indole derivatives useful as endothelin receptor antagonists

Country Status (43)

Country Link
US (4) US6017945A (pt)
EP (1) EP0901470B1 (pt)
JP (1) JP3245179B2 (pt)
KR (1) KR100331217B1 (pt)
CN (1) CN1124262C (pt)
AP (1) AP830A (pt)
AR (1) AR007030A1 (pt)
AT (1) ATE263151T1 (pt)
AU (1) AU717849B2 (pt)
BG (1) BG102873A (pt)
BR (1) BR9709072A (pt)
CA (1) CA2253876A1 (pt)
CO (1) CO4650036A1 (pt)
CZ (1) CZ292928B6 (pt)
DE (1) DE69728392T2 (pt)
DK (1) DK0901470T3 (pt)
DZ (1) DZ2227A1 (pt)
EA (1) EA001471B1 (pt)
ES (1) ES2218675T3 (pt)
GB (1) GB9609641D0 (pt)
HK (1) HK1019149A1 (pt)
HN (1) HN1997000058A (pt)
HR (1) HRP970249B1 (pt)
HU (1) HUP9901245A3 (pt)
ID (1) ID16878A (pt)
IL (1) IL125903A0 (pt)
IS (1) IS1856B (pt)
MA (1) MA26428A1 (pt)
NO (1) NO312547B1 (pt)
NZ (1) NZ332640A (pt)
OA (1) OA10896A (pt)
PE (1) PE65098A1 (pt)
PL (1) PL329725A1 (pt)
PT (1) PT901470E (pt)
SI (1) SI0901470T1 (pt)
SK (1) SK150398A3 (pt)
TN (1) TNSN97078A1 (pt)
TR (1) TR199802269T2 (pt)
TW (1) TW491838B (pt)
UA (1) UA50767C2 (pt)
UY (1) UY24546A1 (pt)
WO (1) WO1997043260A1 (pt)
ZA (1) ZA973963B (pt)

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GB9722287D0 (en) * 1997-10-22 1997-12-17 Pfizer Ltd Compounds useful in therapy
PL199802B1 (pl) 1999-02-10 2008-10-31 Astrazeneca Ab Pochodne chinazoliny, sposoby ich wytwarzania, ich kompozycje farmaceutyczne i ich zastosowania
US20050203166A1 (en) * 2000-06-30 2005-09-15 Cancer Research Technology Limited Indole-3-acetic acid derivatives
GB0016162D0 (en) * 2000-06-30 2000-08-23 Cancer Res Campaign Tech Indole-3-acetic acid derivatives
WO2003000253A1 (en) 2001-06-20 2003-01-03 Wyeth Substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)
TWI224101B (en) 2001-06-20 2004-11-21 Wyeth Corp Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1)
AR037097A1 (es) 2001-10-05 2004-10-20 Novartis Ag Compuestos acilsulfonamidas, composiciones farmaceuticas y el uso de dichos compuestos para la preparacion de un medicamento
CN1726190A (zh) 2002-12-10 2006-01-25 惠氏公司 作为纤溶酶原激活物抑制剂－1(pai－1)的抑制剂的取代3－羰基－1h－吲哚－1－基乙酸衍生物
UA80453C2 (en) 2002-12-10 2007-09-25 Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1)
MXPA05006287A (es) 2002-12-10 2005-09-08 Wyeth Corp Derivados de acido indoloxo-acetilaminoacetico sustituidos como inhibidores del inhibidor del activador de plasminogeno 1 (pai-1).
WO2004052853A2 (en) 2002-12-10 2004-06-24 Wyeth Substituted 3-alkyl and 3-arylalkyl 1h-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)
CA2509191A1 (en) 2002-12-10 2004-06-24 Wyeth Aryl, aryloxy, and alkyloxy substituted 1h-indol-3-yl glyoxylic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)
CA2511806A1 (en) * 2003-01-22 2004-08-12 Eli Lilly And Company Indole-derivative modulators of steroid hormone nuclear receptors
US7342039B2 (en) 2003-09-25 2008-03-11 Wyeth Substituted indole oximes
US7442805B2 (en) 2003-09-25 2008-10-28 Wyeth Substituted sulfonamide-indoles
US7446201B2 (en) 2003-09-25 2008-11-04 Wyeth Substituted heteroaryl benzofuran acids
US7265148B2 (en) 2003-09-25 2007-09-04 Wyeth Substituted pyrrole-indoles
US7268159B2 (en) 2003-09-25 2007-09-11 Wyeth Substituted indoles
US7411083B2 (en) 2003-09-25 2008-08-12 Wyeth Substituted acetic acid derivatives
US7420083B2 (en) 2003-09-25 2008-09-02 Wyeth Substituted aryloximes
US7351726B2 (en) 2003-09-25 2008-04-01 Wyeth Substituted oxadiazolidinediones
US7582773B2 (en) 2003-09-25 2009-09-01 Wyeth Substituted phenyl indoles
US7163954B2 (en) 2003-09-25 2007-01-16 Wyeth Substituted naphthyl benzothiophene acids
US7332521B2 (en) 2003-09-25 2008-02-19 Wyeth Substituted indoles
US7141592B2 (en) 2003-09-25 2006-11-28 Wyeth Substituted oxadiazolidinediones
JP2005109006A (ja) * 2003-09-29 2005-04-21 Tdk Corp 高電圧貫通型コンデンサ及びマグネトロン
HN2004000536A (es) 2003-12-16 2009-02-18 Wyeth Corp Un procediemiento de sintesis para la alquilacion reductiva de la posicon c-3 de indoles
RU2007106868A (ru) 2004-08-23 2008-09-27 Вайет (Us) Оксазол-нафтиловые кислоты и их применение в качестве модуляторов ингибитора активатора плазминогена-1 (pai) для лечения тромбоза и сердечно-сосудистых заболеваний
EP1919866A2 (en) 2005-08-17 2008-05-14 Wyeth a Corporation of the State of Delaware Substituted indoles and use thereof
BRPI0709950A2 (pt) * 2006-04-13 2011-08-02 Actelion Pharmaceuticals Ltd uso de bosentan na preparação de um medicamento para o tratamento de fibrose pulmonar idiopática em estágio precoce e uso de antagonista do receptor endotelin
DE102008030207A1 (de) 2008-06-25 2009-12-31 Bayer Schering Pharma Aktiengesellschaft Substituierte 7-Sulfanylmethyl-, 7-Sulfinylmethyl- und 7-Sulfonylmethyl-Indole und ihre Verwendung
DE102008030206A1 (de) 2008-06-25 2009-12-31 Bayer Schering Pharma Aktiengesellschaft 3-Cyanoalky- und 3-Hydroxyalkyl-Indole und ihre Verwendung
CN106674065A (zh) * 2016-12-07 2017-05-17 贵州大学 一种5‑卤代‑2‑烷氧基‑4‑甲苯磺酰氯制备方法
GB201817038D0 (en) * 2018-10-19 2018-12-05 Inflazome Ltd Novel processes
KR20210134689A (ko) 2019-02-27 2021-11-10 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 뇌 장애를 치료하기 위한 아제피노-인돌 및 다른 헤테로사이클

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BE638840A (pt) * 1962-09-14
GB1255518A (en) * 1968-10-08 1971-12-01 Sumitomo Chemical Co 2-indolylacetic acid derivatives and process for production thereof
US4397079A (en) * 1981-03-30 1983-08-09 International Business Machines Corp. Process for improving the yield of integrated devices including Schottky barrier diodes
US5245046A (en) * 1988-11-14 1993-09-14 The Upjohn Company α-amino-indole-3-acetic acids useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents
CA2091257A1 (en) * 1990-09-10 1992-03-11 Fu-Chih Huang Substituted bicyclic aryl compounds exhibiting selective leukotriene b4 antagonists activity
ZA939516B (en) * 1992-12-22 1994-06-06 Smithkline Beecham Corp Endothelin receptor antagonists
DE69422742T2 (de) * 1993-03-19 2000-08-17 Merck & Co Inc Phenoxyphenylessigsäurederivate
GB9317096D0 (en) * 1993-08-17 1993-09-29 Pfizer Ltd Indoles

Also Published As

Publication number Publication date
AP9700982A0 (en) 1997-07-31
HRP970249B1 (en) 2003-06-30
JPH11508285A (ja) 1999-07-21
PE65098A1 (es) 1998-10-29
IS1856B (is) 2003-02-21
JP3245179B2 (ja) 2002-01-07
CO4650036A1 (es) 1998-09-03
UY24546A1 (es) 2000-09-29
TR199802269T2 (xx) 2001-12-21
KR100331217B1 (ko) 2002-05-09
BR9709072A (pt) 1999-08-03
CN1216531A (zh) 1999-05-12
US6136843A (en) 2000-10-24
AR007030A1 (es) 1999-10-13
EP0901470B1 (en) 2004-03-31
BG102873A (en) 1999-11-30
NO985225D0 (no) 1998-11-09
HN1997000058A (es) 1997-06-26
AU717849B2 (en) 2000-04-06
EA001471B1 (ru) 2001-04-23
US6384070B2 (en) 2002-05-07
PL329725A1 (en) 1999-04-12
ES2218675T3 (es) 2004-11-16
DZ2227A1 (fr) 2002-12-25
US20010014677A1 (en) 2001-08-16
DE69728392T2 (de) 2005-01-13
IS4838A (is) 1998-08-28
TNSN97078A1 (fr) 2005-03-15
EA199800908A1 (ru) 1999-06-24
HK1019149A1 (en) 2000-01-14
WO1997043260A1 (en) 1997-11-20
DE69728392D1 (de) 2004-05-06
PT901470E (pt) 2004-07-30
HUP9901245A3 (en) 2002-01-28
SI0901470T1 (en) 2004-08-31
CN1124262C (zh) 2003-10-15
IL125903A0 (en) 1999-04-11
NO985225L (no) 1998-11-09
US6306852B1 (en) 2001-10-23
AP830A (en) 2000-05-03
HRP970249A2 (en) 1998-06-30
HUP9901245A2 (hu) 1999-08-30
ID16878A (id) 1997-11-20
DK0901470T3 (da) 2004-07-12
GB9609641D0 (en) 1996-07-10
EP0901470A1 (en) 1999-03-17
CA2253876A1 (en) 1997-11-20
UA50767C2 (uk) 2002-11-15
NZ332640A (en) 2001-03-30
TW491838B (en) 2002-06-21
AU2697897A (en) 1997-12-05
ZA973963B (en) 1998-11-09
CZ358298A3 (cs) 1999-08-11
ATE263151T1 (de) 2004-04-15
SK150398A3 (en) 1999-03-12
CZ292928B6 (cs) 2004-01-14
NO312547B1 (no) 2002-05-27
KR20000010879A (ko) 2000-02-25
US6017945A (en) 2000-01-25
MA26428A1 (fr) 2004-12-20

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