ATE263151T1 - Indolderivate verwendbar als endothelinrezeptorantagonisten - Google Patents
Indolderivate verwendbar als endothelinrezeptorantagonistenInfo
- Publication number
- ATE263151T1 ATE263151T1 AT97920690T AT97920690T ATE263151T1 AT E263151 T1 ATE263151 T1 AT E263151T1 AT 97920690 T AT97920690 T AT 97920690T AT 97920690 T AT97920690 T AT 97920690T AT E263151 T1 ATE263151 T1 AT E263151T1
- Authority
- AT
- Austria
- Prior art keywords
- receptor antagonists
- indole derivatives
- endothelin receptor
- derivatives usable
- usable
- Prior art date
Links
- 229940118365 Endothelin receptor antagonist Drugs 0.000 title 1
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical class C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
- 229940054051 antipsychotic indole derivative Drugs 0.000 title 1
- 239000002308 endothelin receptor antagonist Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9609641.7A GB9609641D0 (en) | 1996-05-09 | 1996-05-09 | Compounds useful in therapy |
| PCT/EP1997/001882 WO1997043260A1 (en) | 1996-05-09 | 1997-04-11 | Indole derivatives useful as endothelin receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE263151T1 true ATE263151T1 (de) | 2004-04-15 |
Family
ID=10793387
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97920690T ATE263151T1 (de) | 1996-05-09 | 1997-04-11 | Indolderivate verwendbar als endothelinrezeptorantagonisten |
Country Status (42)
| Country | Link |
|---|---|
| US (4) | US6017945A (de) |
| EP (1) | EP0901470B1 (de) |
| JP (1) | JP3245179B2 (de) |
| KR (1) | KR100331217B1 (de) |
| CN (1) | CN1124262C (de) |
| AP (1) | AP830A (de) |
| AR (1) | AR007030A1 (de) |
| AT (1) | ATE263151T1 (de) |
| AU (1) | AU717849B2 (de) |
| BG (1) | BG102873A (de) |
| BR (1) | BR9709072A (de) |
| CA (1) | CA2253876A1 (de) |
| CO (1) | CO4650036A1 (de) |
| CZ (1) | CZ292928B6 (de) |
| DE (1) | DE69728392T2 (de) |
| DK (1) | DK0901470T3 (de) |
| DZ (1) | DZ2227A1 (de) |
| EA (1) | EA001471B1 (de) |
| ES (1) | ES2218675T3 (de) |
| GB (1) | GB9609641D0 (de) |
| HN (1) | HN1997000058A (de) |
| HR (1) | HRP970249B1 (de) |
| HU (1) | HUP9901245A3 (de) |
| ID (1) | ID16878A (de) |
| IL (1) | IL125903A0 (de) |
| IS (1) | IS1856B (de) |
| MA (1) | MA26428A1 (de) |
| NO (1) | NO312547B1 (de) |
| NZ (1) | NZ332640A (de) |
| OA (1) | OA10896A (de) |
| PE (1) | PE65098A1 (de) |
| PL (1) | PL329725A1 (de) |
| PT (1) | PT901470E (de) |
| SI (1) | SI0901470T1 (de) |
| SK (1) | SK150398A3 (de) |
| TN (1) | TNSN97078A1 (de) |
| TR (1) | TR199802269T2 (de) |
| TW (1) | TW491838B (de) |
| UA (1) | UA50767C2 (de) |
| UY (1) | UY24546A1 (de) |
| WO (1) | WO1997043260A1 (de) |
| ZA (1) | ZA973963B (de) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9722287D0 (en) * | 1997-10-22 | 1997-12-17 | Pfizer Ltd | Compounds useful in therapy |
| MXPA01008182A (es) | 1999-02-10 | 2003-08-20 | Astrazeneca Ab | Derivados de quinazolina como inhibidores de angiotensina. |
| GB0016162D0 (en) * | 2000-06-30 | 2000-08-23 | Cancer Res Campaign Tech | Indole-3-acetic acid derivatives |
| US20050203166A1 (en) * | 2000-06-30 | 2005-09-15 | Cancer Research Technology Limited | Indole-3-acetic acid derivatives |
| TWI224101B (en) | 2001-06-20 | 2004-11-21 | Wyeth Corp | Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) |
| DK1397130T3 (da) | 2001-06-20 | 2007-11-12 | Wyeth Corp | Substituerede indolsyrederivater som inhibitorer af plasminogenaktivatorinhibitor-1 (PAI-1) |
| AR037097A1 (es) | 2001-10-05 | 2004-10-20 | Novartis Ag | Compuestos acilsulfonamidas, composiciones farmaceuticas y el uso de dichos compuestos para la preparacion de un medicamento |
| ATE430731T1 (de) | 2002-12-10 | 2009-05-15 | Wyeth Corp | Substituierte indoloxoacetylaminoessigsäurederivate als inhibitoren des plasminogenaktivatorinhibitors-1 (pai-1) |
| DK1569899T3 (da) | 2002-12-10 | 2006-10-23 | Wyeth Corp | Substituerede 3-alkyl- og 3-arylalkyl-1H-indol-1-yl-eddikesyrederivater som inhibitorer af plasminogenaktivator-inhibitor-1 (PAI-1) |
| DE60324183D1 (en) | 2002-12-10 | 2008-11-27 | Wyeth Corp | Aryl-, aryloxy- und alkyloxysubstituierte 1h-indol-3-yl-glyoxylsäurederivateals inhibitoren des plasminogenaktivatorinhibitors-1 (pai-1) |
| JP2006514637A (ja) | 2002-12-10 | 2006-05-11 | ワイス | プラスミノーゲン活性化因子の阻害因子−１（ｐａｉ−１）の阻害剤としての置換３−カルボニル−１ｈ−インドール−１−イル酢酸誘導体 |
| UA80453C2 (en) | 2002-12-10 | 2007-09-25 | Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1) | |
| JP2007500253A (ja) * | 2003-01-22 | 2007-01-11 | イーライ リリー アンド カンパニー | ステロイドホルモン核内受容体のインドール誘導体モジュレーター |
| US7163954B2 (en) | 2003-09-25 | 2007-01-16 | Wyeth | Substituted naphthyl benzothiophene acids |
| US7446201B2 (en) | 2003-09-25 | 2008-11-04 | Wyeth | Substituted heteroaryl benzofuran acids |
| US7141592B2 (en) | 2003-09-25 | 2006-11-28 | Wyeth | Substituted oxadiazolidinediones |
| US7420083B2 (en) | 2003-09-25 | 2008-09-02 | Wyeth | Substituted aryloximes |
| US7351726B2 (en) | 2003-09-25 | 2008-04-01 | Wyeth | Substituted oxadiazolidinediones |
| US7534894B2 (en) | 2003-09-25 | 2009-05-19 | Wyeth | Biphenyloxy-acids |
| US7411083B2 (en) | 2003-09-25 | 2008-08-12 | Wyeth | Substituted acetic acid derivatives |
| US7442805B2 (en) | 2003-09-25 | 2008-10-28 | Wyeth | Substituted sulfonamide-indoles |
| US7582773B2 (en) | 2003-09-25 | 2009-09-01 | Wyeth | Substituted phenyl indoles |
| US7265148B2 (en) | 2003-09-25 | 2007-09-04 | Wyeth | Substituted pyrrole-indoles |
| US7342039B2 (en) | 2003-09-25 | 2008-03-11 | Wyeth | Substituted indole oximes |
| US7332521B2 (en) | 2003-09-25 | 2008-02-19 | Wyeth | Substituted indoles |
| US7268159B2 (en) | 2003-09-25 | 2007-09-11 | Wyeth | Substituted indoles |
| JP2005109006A (ja) * | 2003-09-29 | 2005-04-21 | Tdk Corp | 高電圧貫通型コンデンサ及びマグネトロン |
| HN2004000536A (es) * | 2003-12-16 | 2009-02-18 | Wyeth Corp | Un procediemiento de sintesis para la alquilacion reductiva de la posicon c-3 de indoles |
| CN101044127A (zh) | 2004-08-23 | 2007-09-26 | 惠氏公司 | 用作纤溶酶原激活剂抑制剂－1的噻唑基－萘基酸 |
| BRPI0514544A (pt) | 2004-08-23 | 2008-06-17 | Wyeth Corp | ácidos de oxazol-naftila como moduladores de inibidor tipo-1 de ativador de plasminogênio (pai-1) |
| US7186749B2 (en) | 2004-08-23 | 2007-03-06 | Wyeth | Pyrrolo-naphthyl acids and methods for using them |
| WO2007022321A2 (en) | 2005-08-17 | 2007-02-22 | Wyeth | Substituted indoles and use thereof |
| AU2007237874A1 (en) * | 2006-04-13 | 2007-10-25 | Actelion Pharmaceuticals Ltd | Endothelin receptor antagonists for early stage idiopathic pulmonary fibrosis |
| DE102008030206A1 (de) | 2008-06-25 | 2009-12-31 | Bayer Schering Pharma Aktiengesellschaft | 3-Cyanoalky- und 3-Hydroxyalkyl-Indole und ihre Verwendung |
| DE102008030207A1 (de) | 2008-06-25 | 2009-12-31 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 7-Sulfanylmethyl-, 7-Sulfinylmethyl- und 7-Sulfonylmethyl-Indole und ihre Verwendung |
| WO2018064465A1 (en) | 2016-09-29 | 2018-04-05 | The Regents Of The University Of California | Compounds for increasing neural plasticity |
| CN106674065A (zh) * | 2016-12-07 | 2017-05-17 | 贵州大学 | 一种5‑卤代‑2‑烷氧基‑4‑甲苯磺酰氯制备方法 |
| GB201817038D0 (en) * | 2018-10-19 | 2018-12-05 | Inflazome Ltd | Novel processes |
| AU2020229779B9 (en) | 2019-02-27 | 2025-09-18 | The Regents Of The University Of California | Azepino-indoles and other heterocycles for treating brain disorders |
| MX2024007221A (es) | 2021-12-15 | 2024-08-27 | Delix Therapeutics Inc | Psicoplastogenos sustituidos con fenoxi y benciloxi y sus usos. |
| CN117263832B (zh) * | 2023-08-18 | 2026-02-03 | 辽宁龙田化工科技有限公司 | 一种2-氯-4-甲磺酰基苯甲酸合成方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE637352A (de) * | 1962-09-14 | |||
| GB1255518A (en) * | 1968-10-08 | 1971-12-01 | Sumitomo Chemical Co | 2-indolylacetic acid derivatives and process for production thereof |
| US4397079A (en) * | 1981-03-30 | 1983-08-09 | International Business Machines Corp. | Process for improving the yield of integrated devices including Schottky barrier diodes |
| US5245046A (en) * | 1988-11-14 | 1993-09-14 | The Upjohn Company | α-amino-indole-3-acetic acids useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents |
| ATE136026T1 (de) * | 1990-09-10 | 1996-04-15 | Rhone Poulenc Rorer Int | Substituierte bizyklische arylderivate mit selektiver leukotrien b4 antagonistischer wirkung |
| ZA939516B (en) * | 1992-12-22 | 1994-06-06 | Smithkline Beecham Corp | Endothelin receptor antagonists |
| DK0617001T3 (da) * | 1993-03-19 | 2000-04-17 | Merck & Co Inc | Phenoxyphenyleddikesyrederivater |
| GB9317096D0 (en) * | 1993-08-17 | 1993-09-29 | Pfizer Ltd | Indoles |
-
1996
- 1996-05-09 GB GBGB9609641.7A patent/GB9609641D0/en active Pending
-
1997
- 1997-04-01 TW TW086104171A patent/TW491838B/zh not_active IP Right Cessation
- 1997-04-11 JP JP54042397A patent/JP3245179B2/ja not_active Expired - Fee Related
- 1997-04-11 CA CA002253876A patent/CA2253876A1/en not_active Abandoned
- 1997-04-11 CZ CZ19983582A patent/CZ292928B6/cs not_active IP Right Cessation
- 1997-04-11 SI SI9730646T patent/SI0901470T1/xx unknown
- 1997-04-11 IL IL12590397A patent/IL125903A0/xx unknown
- 1997-04-11 US US09/147,096 patent/US6017945A/en not_active Expired - Fee Related
- 1997-04-11 UA UA98115906A patent/UA50767C2/uk unknown
- 1997-04-11 HU HU9901245A patent/HUP9901245A3/hu unknown
- 1997-04-11 AU AU26978/97A patent/AU717849B2/en not_active Ceased
- 1997-04-11 BR BR9709072A patent/BR9709072A/pt active Search and Examination
- 1997-04-11 AT AT97920690T patent/ATE263151T1/de not_active IP Right Cessation
- 1997-04-11 PL PL97329725A patent/PL329725A1/xx unknown
- 1997-04-11 WO PCT/EP1997/001882 patent/WO1997043260A1/en not_active Ceased
- 1997-04-11 TR TR1998/02269T patent/TR199802269T2/xx unknown
- 1997-04-11 DK DK97920690T patent/DK0901470T3/da active
- 1997-04-11 NZ NZ332640A patent/NZ332640A/en unknown
- 1997-04-11 KR KR1019980709023A patent/KR100331217B1/ko not_active Expired - Fee Related
- 1997-04-11 CN CN97194016A patent/CN1124262C/zh not_active Expired - Fee Related
- 1997-04-11 SK SK1503-98A patent/SK150398A3/sk unknown
- 1997-04-11 PT PT97920690T patent/PT901470E/pt unknown
- 1997-04-11 ES ES97920690T patent/ES2218675T3/es not_active Expired - Lifetime
- 1997-04-11 DE DE1997628392 patent/DE69728392T2/de not_active Expired - Fee Related
- 1997-04-11 EA EA199800908A patent/EA001471B1/ru not_active IP Right Cessation
- 1997-04-11 EP EP97920690A patent/EP0901470B1/de not_active Expired - Lifetime
- 1997-04-29 HN HN1997000058A patent/HN1997000058A/es unknown
- 1997-05-02 PE PE1997000345A patent/PE65098A1/es not_active Application Discontinuation
- 1997-05-07 DZ DZ970074A patent/DZ2227A1/fr active
- 1997-05-07 ID IDP971517A patent/ID16878A/id unknown
- 1997-05-07 MA MA24599A patent/MA26428A1/fr unknown
- 1997-05-07 UY UY24546A patent/UY24546A1/es not_active IP Right Cessation
- 1997-05-07 AR ARP970101888A patent/AR007030A1/es not_active Application Discontinuation
- 1997-05-07 TN TNTNSN97078A patent/TNSN97078A1/fr unknown
- 1997-05-07 CO CO97024471A patent/CO4650036A1/es unknown
- 1997-05-08 AP APAP/P/1997/000982A patent/AP830A/en active
- 1997-05-08 ZA ZA973963A patent/ZA973963B/xx unknown
- 1997-05-09 HR HR970249A patent/HRP970249B1/xx not_active IP Right Cessation
-
1998
- 1998-08-28 IS IS4838A patent/IS1856B/is unknown
- 1998-10-09 OA OA9800192A patent/OA10896A/en unknown
- 1998-10-27 BG BG102873A patent/BG102873A/xx unknown
- 1998-11-09 NO NO19985225A patent/NO312547B1/no not_active IP Right Cessation
-
1999
- 1999-10-07 US US09/414,361 patent/US6136843A/en not_active Expired - Fee Related
-
2000
- 2000-04-24 US US09/556,651 patent/US6306852B1/en not_active Expired - Fee Related
-
2001
- 2001-01-09 US US09/756,835 patent/US6384070B2/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0901470 Country of ref document: EP |
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| REN | Ceased due to non-payment of the annual fee |