EP0929218A4 - R2y rezeptor antagonisten - Google Patents

R2y rezeptor antagonisten

Info

Publication number
EP0929218A4
EP0929218A4 EP97952172A EP97952172A EP0929218A4 EP 0929218 A4 EP0929218 A4 EP 0929218A4 EP 97952172 A EP97952172 A EP 97952172A EP 97952172 A EP97952172 A EP 97952172A EP 0929218 A4 EP0929218 A4 EP 0929218A4
Authority
EP
European Patent Office
Prior art keywords
receptor antagonists
antagonists
receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97952172A
Other languages
English (en)
French (fr)
Other versions
EP0929218A2 (de
Inventor
Jose L Boyer
T Kendall Harden
Kenneth A Jacobson
Emidio Camaioni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of North Carolina at Chapel Hill
University of North Carolina System
Original Assignee
University of North Carolina at Chapel Hill
University of North Carolina System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of North Carolina at Chapel Hill, University of North Carolina System filed Critical University of North Carolina at Chapel Hill
Publication of EP0929218A2 publication Critical patent/EP0929218A2/de
Publication of EP0929218A4 publication Critical patent/EP0929218A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
EP97952172A 1996-10-30 1997-10-23 R2y rezeptor antagonisten Withdrawn EP0929218A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2985596P 1996-10-30 1996-10-30
US29855P 1996-10-30
PCT/US1997/019922 WO1998018430A2 (en) 1996-10-30 1997-10-23 P2y receptor antagonists

Publications (2)

Publication Number Publication Date
EP0929218A2 EP0929218A2 (de) 1999-07-21
EP0929218A4 true EP0929218A4 (de) 2001-05-16

Family

ID=21851254

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97952172A Withdrawn EP0929218A4 (de) 1996-10-30 1997-10-23 R2y rezeptor antagonisten

Country Status (5)

Country Link
EP (1) EP0929218A4 (de)
JP (1) JP2001504097A (de)
AU (1) AU5584698A (de)
CA (1) CA2241687A1 (de)
WO (1) WO1998018430A2 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9908270A (pt) 1998-02-25 2004-06-29 Univ Emory 2-fluoro-nucleosìdeos, composições farmacêuticas e seus usos
SE9802574D0 (sv) * 1998-07-17 1998-07-17 Astra Pharma Prod Novel compounds
AU6234000A (en) * 1999-07-22 2001-02-13 Supergen, Inc. Methods for treating autoimmune diseases
US7115585B2 (en) * 2000-08-21 2006-10-03 Inspire Pharmaceuticals, Inc. Compositions for treating epithelial and retinal tissue diseases
WO2002062816A1 (en) * 2001-02-07 2002-08-15 Celltech R & D Limited Non-natural nucleotides and dinucleotides
US7256183B2 (en) * 2001-11-06 2007-08-14 Inspire Pharmaceuticals, Inc. Method for treating or preventing inflammatory diseases
NZ541651A (en) * 2003-02-03 2009-01-31 Cv Therapeutics Inc Partial and full agonists of A1 adenosine receptors
US7388021B2 (en) 2004-05-12 2008-06-17 Bristol Myers Squibb Company Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
US7550499B2 (en) * 2004-05-12 2009-06-23 Bristol-Myers Squibb Company Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
AU2006206611A1 (en) 2005-01-19 2006-07-27 Bristol-Myers Squibb Company 2-phenoxy-N- (1, 3 , 4-thiadizol-2-yl) pyridin-3-amine derivatives and related compounds as P2Y1 receptor inhibitors for the treatment of thromboembolic disorders
KR20080027890A (ko) 2005-06-27 2008-03-28 브리스톨-마이어스 스큅 컴퍼니 혈전성 증상의 치료에 유용한 ｐ2ｙ1 수용체의 ｎ-연결헤테로시클릭 길항제
ATE502924T1 (de) 2005-06-27 2011-04-15 Bristol Myers Squibb Co Lineare harnstoffmimetika-antagonisten des p2y1- rezeptors zur behandlung von thromboseleiden
WO2007002634A1 (en) 2005-06-27 2007-01-04 Bristol-Myers Squibb Company Carbocycle and heterocycle antagonists of p2y1 receptor useful in the treatment of thrombotic conditions
ES2352796T3 (es) 2005-06-27 2011-02-23 Bristol-Myers Squibb Company Antagonistas cíclicos unidos a c del receptor p2y1 útiles en el tratamiento de afecciones trombóticas.
US7960569B2 (en) 2006-10-17 2011-06-14 Bristol-Myers Squibb Company Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
CL2007003305A1 (es) 2006-11-17 2008-07-04 Epix Delaware Inc Compuestos analogos de adenosina; compuestos intermediarios; composicion farmaceutica; y uso en el tratamiento de enfermdades tales como fibrosis quistica, otitis media, asma, ulcera peptica, entre otras.

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2331223A1 (de) * 1972-06-19 1974-01-17 Kohjin Co S-substituierte-2-thioadenosine
US3846402A (en) * 1971-05-06 1974-11-05 Max Planck Gesellschaft Thiophosphate analogues of the nucleoside diphosphates and triphosphates and a method for the preparation thereof
GB1433507A (en) * 1972-05-15 1976-04-28 Takeda Chemical Industries Ltd Pharmaceutically active 2-substituted adenosine-3,5-cyclic monophosphates
US4266048A (en) * 1977-10-11 1981-05-05 The United States Of America As Represented By The Department Of Health, Education And Welfare Synthesis of analogs of 3'-phosphoadenosine 5'-phosphosulfate (PAPS)
US4719295A (en) * 1985-12-31 1988-01-12 Warner-Lambert Company Compound 2-iodo-2'-deoxyadenosine
US4828979A (en) * 1984-11-08 1989-05-09 Life Technologies, Inc. Nucleotide analogs for nucleic acid labeling and detection
WO1992017488A1 (en) * 1991-04-06 1992-10-15 Fisons Plc Atp analogues
WO1994018216A1 (en) * 1993-02-10 1994-08-18 Astra Pharmaceuticals Limited N-alkyl-2-substituted atp analogues
WO1995010287A1 (en) * 1993-10-15 1995-04-20 Wisconsin Alumni Research Foundation Substituted purine nucleoside analogs and method for treating endotoxin shock
WO1996029345A1 (en) * 1995-03-23 1996-09-26 The Trustees Of The University Of Pennsylvania Novel inotropic agents

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4788181A (en) * 1986-09-29 1988-11-29 The United States Of America As Represented By The Department Of Health And Human Services 5-substituted-2',3'-dideoxycytidine compounds with anti-HTLV-III activity
US5620676A (en) * 1994-03-08 1997-04-15 The United States Of America As Represented By The Department Of Health And Human Services Biologically active ATP analogs

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3846402A (en) * 1971-05-06 1974-11-05 Max Planck Gesellschaft Thiophosphate analogues of the nucleoside diphosphates and triphosphates and a method for the preparation thereof
GB1433507A (en) * 1972-05-15 1976-04-28 Takeda Chemical Industries Ltd Pharmaceutically active 2-substituted adenosine-3,5-cyclic monophosphates
DE2331223A1 (de) * 1972-06-19 1974-01-17 Kohjin Co S-substituierte-2-thioadenosine
US4266048A (en) * 1977-10-11 1981-05-05 The United States Of America As Represented By The Department Of Health, Education And Welfare Synthesis of analogs of 3'-phosphoadenosine 5'-phosphosulfate (PAPS)
US4828979A (en) * 1984-11-08 1989-05-09 Life Technologies, Inc. Nucleotide analogs for nucleic acid labeling and detection
US4719295A (en) * 1985-12-31 1988-01-12 Warner-Lambert Company Compound 2-iodo-2'-deoxyadenosine
WO1992017488A1 (en) * 1991-04-06 1992-10-15 Fisons Plc Atp analogues
WO1994018216A1 (en) * 1993-02-10 1994-08-18 Astra Pharmaceuticals Limited N-alkyl-2-substituted atp analogues
WO1995010287A1 (en) * 1993-10-15 1995-04-20 Wisconsin Alumni Research Foundation Substituted purine nucleoside analogs and method for treating endotoxin shock
WO1996029345A1 (en) * 1995-03-23 1996-09-26 The Trustees Of The University Of Pennsylvania Novel inotropic agents

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BOYER, J.L. ET AL.: "Identification of competitive antagonists of the P2Y1 receptor", MOL. PHARMACOL., vol. 50, 1996, pages 1323 - 9, XP000944991 *
BRENNAN, C.A. AND GUMPORT, R. I.: "T4 RNA ligase catalyzed synthesis of base analogue-containing oligodeoxyribonucleotides and a characterization of thermal stabilities", NUCLEIC ACIDS RES., vol. 13, 1985, pages 8665 - 84, XP000944971 *
FISCHER, B. ET AL.: "Identification of potent, selective P2Y-purinoreceptor antagonists: relationship or 2-thioether derivatives of adenosine 5'-triphosphate", J. MED. CHEM., vol. 36, 1993, pages 3937 - 46, XP002155543 *
See also references of WO9818430A3 *
VAN RHEE, A.M. ET AL.: "Novel competitive antagonists for P2 purinoreceptors", EUR. J. PHARMACOL. MOL. PHARMACOL. SECT., vol. 268, 1994, pages 1 - 7, XP000944973 *

Also Published As

Publication number Publication date
CA2241687A1 (en) 1998-05-07
EP0929218A2 (de) 1999-07-21
AU5584698A (en) 1998-05-22
WO1998018430A2 (en) 1998-05-07
WO1998018430A3 (en) 1998-06-18
JP2001504097A (ja) 2001-03-27

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