GB1433507A - Pharmaceutically active 2-substituted adenosine-3,5-cyclic monophosphates - Google Patents

Pharmaceutically active 2-substituted adenosine-3,5-cyclic monophosphates

Info

Publication number
GB1433507A
GB1433507A GB2303573A GB2303573A GB1433507A GB 1433507 A GB1433507 A GB 1433507A GB 2303573 A GB2303573 A GB 2303573A GB 2303573 A GB2303573 A GB 2303573A GB 1433507 A GB1433507 A GB 1433507A
Authority
GB
United Kingdom
Prior art keywords
alkyl
salt
cycloalkyl
alkenyl
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2303573A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of GB1433507A publication Critical patent/GB1433507A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Abstract

1433507 Pharmaceutically active cyclic nucleotides TAKEDA YAKUHIN KOGYO KK 15 May 1973 [15 May 1972] 23035/73 Heading C2P [Also in Division A5] Novel nucleotides of Formula I and pharmaceutically acceptable salts thereof, where R is C 1-6 alkyl, C 2-6 alkenyl, C 3-6 cycloalkyl, aryl, aralkyl, di-(C 1-6 alkyl) amino, heterocyclic, halogen or R<SP>1</SP>A- where R<SP>1</SP> is C 1-6 alkyl, C 2-6 alkenyl, C 3-6 cycloalkyl, aryl or aralkyl and A is S, O or NH and R (except when halogen) and R<SP>1</SP> may have one or more substituents selected from C 1-6 alkyl and alkoxy, C 2-6 alkenyl and alkenyloxy and C 3-6 cycloalkyl and cycloalkoxy, may be prepared by cyclizing the corresponding 5<SP>1</SP>-monoester (or an ester thereof which may be de-esterified by a base) and optionally forming a salt. The 5<SP>1</SP>-monoesters required as starting materials may be prepared by reacting the corresponding 2-substituted nucleoside with pyrophosphoryl chloride and optionally forming a salt. 2-n-Butylaminoadenosine-5<SP>1</SP>-monophosphate ammonium salt is prepared by reacting 2 - chloroadenosine - 5<SP>1</SP> - monophosphate ammonium salt with n-butylamine. The nitrophenyl esters of 2-methyl- and 2-chloroadenosine - 5<SP>1</SP> - monophosphate tributylammonium salt are obtained by esterification with nitrophenol. The compounds of Formula I may be used as the active ingredients in conventional pharmaceutical compositions, optionally together with inositol.
GB2303573A 1972-05-15 1973-05-15 Pharmaceutically active 2-substituted adenosine-3,5-cyclic monophosphates Expired GB1433507A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP47048372A JPS4911896A (en) 1972-05-15 1972-05-15

Publications (1)

Publication Number Publication Date
GB1433507A true GB1433507A (en) 1976-04-28

Family

ID=12801489

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2303573A Expired GB1433507A (en) 1972-05-15 1973-05-15 Pharmaceutically active 2-substituted adenosine-3,5-cyclic monophosphates

Country Status (9)

Country Link
JP (1) JPS4911896A (en)
AT (1) AT331998B (en)
AU (1) AU5567573A (en)
CA (1) CA1000696A (en)
DE (1) DE2324130A1 (en)
FR (1) FR2184813B1 (en)
GB (1) GB1433507A (en)
HU (1) HU169628B (en)
NL (1) NL7306790A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0929218A2 (en) * 1996-10-30 1999-07-21 University Of North Carolina At Chapel Hill P2y receptor antagonists

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR205247A1 (en) * 1973-02-07 1976-04-21 Icn Pharmaceuticals PROCEDURE FOR PREPARING 2-SUBSTITUTED AMP DERIVATIVES
JPS54103891A (en) * 1978-01-28 1979-08-15 Kikkoman Corp Novel 2-fluoro-adenosine-3',5'-cyclic phosphoric acid and its preparation
CA2049977A1 (en) * 1989-03-24 1990-09-25 Hirofumi Kitaoka Nootropic agent
MXPA01013323A (en) * 1999-06-22 2003-10-15 Cv Therapeutics Inc Thiophene a2a receptor agonists.
CA2465264C (en) 2001-10-25 2010-09-07 King Pharmaceuticals Research & Development, Inc. Synthesis of 2-aralkoxyadenosines and 2-alkoxyadenosines
US7342003B2 (en) 2001-10-25 2008-03-11 King Pharmaceuticals Research And Development, Inc. Synthesis of 2-aralkyloxyadenosines, 2-alkoxyadenosines, and their analogs

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2068728A1 (en) * 1969-10-10 1971-09-03 Anvar Cyclic (iso)adenosine-3' 5'-monophosphoric - acid derivs
GB1336441A (en) * 1969-10-10 1973-11-07 Anvar Derivatives of cyclo adenosine-3,5-phosphoric acid and their preparation

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0929218A2 (en) * 1996-10-30 1999-07-21 University Of North Carolina At Chapel Hill P2y receptor antagonists
EP0929218A4 (en) * 1996-10-30 2001-05-16 Univ North Carolina P2y receptor antagonists

Also Published As

Publication number Publication date
FR2184813B1 (en) 1976-07-02
AT331998B (en) 1976-09-10
JPS4911896A (en) 1974-02-01
AU5567573A (en) 1974-11-14
DE2324130A1 (en) 1973-11-29
HU169628B (en) 1976-12-28
CA1000696A (en) 1976-11-30
FR2184813A1 (en) 1973-12-28
NL7306790A (en) 1973-11-19
ATA424373A (en) 1975-12-15

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees