FR2068728A1 - Cyclic (iso)adenosine-3' 5'-monophosphoric - acid derivs - Google Patents
Cyclic (iso)adenosine-3' 5'-monophosphoric - acid derivsInfo
- Publication number
- FR2068728A1 FR2068728A1 FR6934747A FR6934747A FR2068728A1 FR 2068728 A1 FR2068728 A1 FR 2068728A1 FR 6934747 A FR6934747 A FR 6934747A FR 6934747 A FR6934747 A FR 6934747A FR 2068728 A1 FR2068728 A1 FR 2068728A1
- Authority
- FR
- France
- Prior art keywords
- cpds
- prepd
- iso
- monophosphoric
- cyclic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Isomeric cyclic (iso)adnosine-3',5'-monophosphoric acids of general formula (I) and (II) possess hypophysis-stimulating activity, in creasing thyroid hormone secretion, replacing ACTH and increasing corticosteroid prodn. Cpds. (II) are prepd. by reaction of 6-Cl-9-(ribo-beta-furanosyl-2',3'-isopropylidene)-purine with amines NHXY and phosphorylating the product with POCl3 in Me phosphate. Cpds. (I) are prepd. by cyclisation of cpds. (II) by refluxing with dicyclohexylcarbodiimide in DMF anhyd. pyridine 1 : 1 mixture. Cpds. with R' = Br are prepd. by direct bromination with aq. Br. Other R' cpds. are prepd. from the Br cpd. in known manner. (where NXY = NH2, NHMe, NMe2, NHBun, NHBut; R' = H, BR, SMe, opt. substd. NH2; R" = H or opt. substd. NH2; R = H or butyryl).
Priority Applications (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR6934747A FR2068728A1 (en) | 1969-10-10 | 1969-10-10 | Cyclic (iso)adenosine-3' 5'-monophosphoric - acid derivs |
GB1336442D GB1336442A (en) | 1969-10-10 | 1970-10-07 | Preparation of adenosine-3,5-monophosphoric acid derivatives |
GB4773170A GB1336441A (en) | 1969-10-10 | 1970-10-07 | Derivatives of cyclo adenosine-3,5-phosphoric acid and their preparation |
GB1340270A GB1336444A (en) | 1969-10-10 | 1970-10-07 | Adenosine-5,-monophosphoric acids |
GB1336443D GB1336443A (en) | 1969-10-10 | 1970-10-07 | Preparation of ,3,5-nucleotides |
CA095,217A CA979890A (en) | 1969-10-10 | 1970-10-09 | Derives d'acide adenosine -3',5'-phosphorique cyclique et leur preparation |
CH1596771A CH535791A (en) | 1969-10-10 | 1970-10-09 | Cyclic (iso)adenosine-3' 5'-monophosphoric - acid derivs |
CH1500570A CH531009A (en) | 1969-10-10 | 1970-10-09 | Process for the preparation of novel adenosine-3 ', 5'-cyclic phosphoric acid derivatives and their use |
SE7013709A SE400296B (en) | 1969-10-10 | 1970-10-09 | PROCEDURE FOR THE PREPARATION OF CYCLIC ADENOSIN-3 ', 5'-MONOPHOSPHIC ACID DERIVATIVES |
DE19702065809 DE2065809A1 (en) | 1969-10-10 | 1970-10-09 | 8-Substd. adenosine monophosphoric acids - inters for (di)butyroyl cyclic AMP derivs |
DE19702049638 DE2049638A1 (en) | 1969-10-10 | 1970-10-09 | Isomeric nucleoside derivatives and processes for their preparation |
JP45089620A JPS5022559B1 (en) | 1969-10-10 | 1970-10-12 | |
US00080223A US3856776A (en) | 1969-10-10 | 1970-10-12 | Derivatives of cyclo adenosine-3 -,5 -phosphoric acid and their preparation |
SE7314163A SE412240B (en) | 1969-10-10 | 1973-10-18 | PROCEDURE FOR THE PREPARATION OF CYCLIC ADENOSINE PHOSPHORIC ACID DERIVATIVES |
CA194,485A CA980343A (en) | 1969-10-10 | 1974-03-08 | Adenosine-5'-monophosphoric acids |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR6934747A FR2068728A1 (en) | 1969-10-10 | 1969-10-10 | Cyclic (iso)adenosine-3' 5'-monophosphoric - acid derivs |
Publications (1)
Publication Number | Publication Date |
---|---|
FR2068728A1 true FR2068728A1 (en) | 1971-09-03 |
Family
ID=9041340
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR6934747A Withdrawn FR2068728A1 (en) | 1969-10-10 | 1969-10-10 | Cyclic (iso)adenosine-3' 5'-monophosphoric - acid derivs |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2068728A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4911896A (en) * | 1972-05-15 | 1974-02-01 |
-
1969
- 1969-10-10 FR FR6934747A patent/FR2068728A1/en not_active Withdrawn
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4911896A (en) * | 1972-05-15 | 1974-02-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |