FR2112084A1 - Cyclic (iso)adenosine-3' 5'-monophosphoric - acid derivs - Google Patents

Cyclic (iso)adenosine-3' 5'-monophosphoric - acid derivs

Info

Publication number
FR2112084A1
FR2112084A1 FR7035682A FR7035682A FR2112084A1 FR 2112084 A1 FR2112084 A1 FR 2112084A1 FR 7035682 A FR7035682 A FR 7035682A FR 7035682 A FR7035682 A FR 7035682A FR 2112084 A1 FR2112084 A1 FR 2112084A1
Authority
FR
France
Prior art keywords
cpds
prepd
iso
monophosphoric
cyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7035682A
Other languages
French (fr)
Other versions
FR2112084B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bpifrance Financement SA
Original Assignee
Agence National de Valorisation de la Recherche ANVAR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agence National de Valorisation de la Recherche ANVAR filed Critical Agence National de Valorisation de la Recherche ANVAR
Priority to FR7035682A priority Critical patent/FR2112084A1/en
Priority to GB4773170A priority patent/GB1336441A/en
Priority to GB1340270A priority patent/GB1336444A/en
Priority to GB1336443D priority patent/GB1336443A/en
Priority to GB1336442D priority patent/GB1336442A/en
Priority to CH1500570A priority patent/CH531009A/en
Priority to CA095,217A priority patent/CA979890A/en
Priority to DE19702065809 priority patent/DE2065809A1/en
Priority to DE19702049638 priority patent/DE2049638A1/en
Priority to CH1596771A priority patent/CH535791A/en
Priority to SE7013709A priority patent/SE400296B/en
Priority to JP45089620A priority patent/JPS5022559B1/ja
Priority to US00080223A priority patent/US3856776A/en
Publication of FR2112084A1 publication Critical patent/FR2112084A1/en
Application granted granted Critical
Publication of FR2112084B1 publication Critical patent/FR2112084B1/fr
Priority to SE7314163A priority patent/SE412240B/en
Priority to CA194,485A priority patent/CA980343A/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Abstract

Isomeric cyclic (iso)adnosine-3',5'-monophosphoric acids of general formula (I) and (II) possess hypophysis-stimulating activity, in creasing thyroid hormone secretion, replacing ACTH and increasing corticosteroid prodn. Cpds. (II) are prepd. by reaction of 6-Cl-9-(ribo-beta-furanosyl-2',3'-isopropylidene)-purine with amines NHXY and phosphorylating the product with POCl3 in Me phosphate. Cpds. (I) are prepd. by cyclisation of cpds. (II) by refluxing with dicyclohexylcarbodiimide in DMF anhyd. pyridine 1 : 1 mixture. Cpds. with R' = Br are prepd. by direct bromination with aq. Br. Other R' cpds. are prepd. from the Br cpd. in known manner. (where NXY = NH2, NHMe, NMe2, NHBun, NHBut; R' = H, BR, SMe, opt. substd. NH2; R" = H or opt. substd. NH2; R = H or butyryl).
FR7035682A 1969-10-10 1970-10-02 Cyclic (iso)adenosine-3' 5'-monophosphoric - acid derivs Granted FR2112084A1 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
FR7035682A FR2112084A1 (en) 1970-10-02 1970-10-02 Cyclic (iso)adenosine-3' 5'-monophosphoric - acid derivs
GB1340270A GB1336444A (en) 1969-10-10 1970-10-07 Adenosine-5,-monophosphoric acids
GB1336443D GB1336443A (en) 1969-10-10 1970-10-07 Preparation of ,3,5-nucleotides
GB1336442D GB1336442A (en) 1969-10-10 1970-10-07 Preparation of adenosine-3,5-monophosphoric acid derivatives
GB4773170A GB1336441A (en) 1969-10-10 1970-10-07 Derivatives of cyclo adenosine-3,5-phosphoric acid and their preparation
DE19702049638 DE2049638A1 (en) 1969-10-10 1970-10-09 Isomeric nucleoside derivatives and processes for their preparation
CA095,217A CA979890A (en) 1969-10-10 1970-10-09 Derives d'acide adenosine -3',5'-phosphorique cyclique et leur preparation
DE19702065809 DE2065809A1 (en) 1969-10-10 1970-10-09 8-Substd. adenosine monophosphoric acids - inters for (di)butyroyl cyclic AMP derivs
CH1500570A CH531009A (en) 1969-10-10 1970-10-09 Process for the preparation of novel adenosine-3 ', 5'-cyclic phosphoric acid derivatives and their use
CH1596771A CH535791A (en) 1969-10-10 1970-10-09 Cyclic (iso)adenosine-3' 5'-monophosphoric - acid derivs
SE7013709A SE400296B (en) 1969-10-10 1970-10-09 PROCEDURE FOR THE PREPARATION OF CYCLIC ADENOSIN-3 ', 5'-MONOPHOSPHIC ACID DERIVATIVES
JP45089620A JPS5022559B1 (en) 1969-10-10 1970-10-12
US00080223A US3856776A (en) 1969-10-10 1970-10-12 Derivatives of cyclo adenosine-3 -,5 -phosphoric acid and their preparation
SE7314163A SE412240B (en) 1969-10-10 1973-10-18 PROCEDURE FOR THE PREPARATION OF CYCLIC ADENOSINE PHOSPHORIC ACID DERIVATIVES
CA194,485A CA980343A (en) 1969-10-10 1974-03-08 Adenosine-5'-monophosphoric acids

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7035682A FR2112084A1 (en) 1970-10-02 1970-10-02 Cyclic (iso)adenosine-3' 5'-monophosphoric - acid derivs

Publications (2)

Publication Number Publication Date
FR2112084A1 true FR2112084A1 (en) 1972-06-16
FR2112084B1 FR2112084B1 (en) 1973-06-08

Family

ID=9062195

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7035682A Granted FR2112084A1 (en) 1969-10-10 1970-10-02 Cyclic (iso)adenosine-3' 5'-monophosphoric - acid derivs

Country Status (1)

Country Link
FR (1) FR2112084A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54103891A (en) * 1978-01-28 1979-08-15 Kikkoman Corp Novel 2-fluoro-adenosine-3',5'-cyclic phosphoric acid and its preparation

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54103891A (en) * 1978-01-28 1979-08-15 Kikkoman Corp Novel 2-fluoro-adenosine-3',5'-cyclic phosphoric acid and its preparation
JPS5728720B2 (en) * 1978-01-28 1982-06-18

Also Published As

Publication number Publication date
FR2112084B1 (en) 1973-06-08

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