FR2123632A6 - Prepn of 5-azacytosines and 5-azacytidines - from bis trimethylsilyl-5-azacytosine - Google Patents

Prepn of 5-azacytosines and 5-azacytidines - from bis trimethylsilyl-5-azacytosine

Info

Publication number
FR2123632A6
FR2123632A6 FR7102441A FR7102441A FR2123632A6 FR 2123632 A6 FR2123632 A6 FR 2123632A6 FR 7102441 A FR7102441 A FR 7102441A FR 7102441 A FR7102441 A FR 7102441A FR 2123632 A6 FR2123632 A6 FR 2123632A6
Authority
FR
France
Prior art keywords
azacytosine
azacytosines
azacytidines
prepn
iii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR7102441A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Czech Academy of Sciences CAS
Original Assignee
Czech Academy of Sciences CAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Czech Academy of Sciences CAS filed Critical Czech Academy of Sciences CAS
Priority to FR7102441A priority Critical patent/FR2123632A6/en
Application granted granted Critical
Publication of FR2123632A6 publication Critical patent/FR2123632A6/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals

Abstract

The prepns. of the following are described: 2',3',5'-tri-O-benzoyl-5-azacytidine (I), 5-azacytidine (II), 1,(3,5-di-O-tolyl-2-desoxy-alpha-D-ribofuranosyl)-5-azacytosine (III) and 1-(2-desoxy-alpha-D-ribofuranosyl)-5-azacytosine (IV). (I) and (III) are prepd. by condensation of bis(trimethyl silyl)-5-azacytosine (V) with dry acetonitrile and the appropriate acid chloride. (II) and (IV) are prepd. from (I) and (III) by treatment with sodium methoxide.
FR7102441A 1971-01-26 1971-01-26 Prepn of 5-azacytosines and 5-azacytidines - from bis trimethylsilyl-5-azacytosine Expired FR2123632A6 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7102441A FR2123632A6 (en) 1971-01-26 1971-01-26 Prepn of 5-azacytosines and 5-azacytidines - from bis trimethylsilyl-5-azacytosine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7102441A FR2123632A6 (en) 1971-01-26 1971-01-26 Prepn of 5-azacytosines and 5-azacytidines - from bis trimethylsilyl-5-azacytosine

Publications (1)

Publication Number Publication Date
FR2123632A6 true FR2123632A6 (en) 1972-09-15

Family

ID=9070878

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7102441A Expired FR2123632A6 (en) 1971-01-26 1971-01-26 Prepn of 5-azacytosines and 5-azacytidines - from bis trimethylsilyl-5-azacytosine

Country Status (1)

Country Link
FR (1) FR2123632A6 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7700770B2 (en) 2003-03-17 2010-04-20 Celgene Corporation Methods for isolating crystalline form I of 5-azacytidine
US7772199B2 (en) 2003-03-17 2010-08-10 Celgene Corporation Forms of 5-azacytidine
US7858774B2 (en) 2003-03-17 2010-12-28 Pharmion Llc Synthesis of 5-azacytidine
US8846628B2 (en) 2008-05-15 2014-09-30 Celgene Corporation Oral formulations of cytidine analogs and methods of use thereof
US9951098B2 (en) 2011-03-31 2018-04-24 Pharmion Llc Synthesis of 5-azacytidine

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8779117B2 (en) 2003-03-17 2014-07-15 Pharmion Llc Pharmaceutical compositions comprising 5-azacytidine monohydrate
US8211862B2 (en) 2003-03-17 2012-07-03 Pharmion Llc Pharmaceutical compositions comprising crystal forms of 5-azacytidine
US7700770B2 (en) 2003-03-17 2010-04-20 Celgene Corporation Methods for isolating crystalline form I of 5-azacytidine
US8058424B2 (en) 2003-03-17 2011-11-15 Pharmion Llc Synthesis of 5-azacytidine
US9192620B2 (en) 2003-03-17 2015-11-24 Pharmion Llc Pharmaceutical compositions comprising forms of 5-azacytidine
US8481715B2 (en) 2003-03-17 2013-07-09 Pharmion Llc Methods for isolating crystalline form I of 5-azacytidine
US8513406B2 (en) 2003-03-17 2013-08-20 Pharmion Llc Pharmaceutical compositions comprising forms of 5-azacytidine
US8975392B2 (en) 2003-03-17 2015-03-10 Pharmion Llc Methods for isolating crystalline form I of 5-azacytidine
US7858774B2 (en) 2003-03-17 2010-12-28 Pharmion Llc Synthesis of 5-azacytidine
US7772199B2 (en) 2003-03-17 2010-08-10 Celgene Corporation Forms of 5-azacytidine
US8614313B2 (en) 2003-03-17 2013-12-24 Pharmion Llc Pharmaceutical compositions comprising forms of 5-azacytidine
US8846628B2 (en) 2008-05-15 2014-09-30 Celgene Corporation Oral formulations of cytidine analogs and methods of use thereof
US10220050B2 (en) 2008-05-15 2019-03-05 Celgene Corporation Isotopologues of 5-azacytidine
US10463683B2 (en) 2008-05-15 2019-11-05 Celgene Corporation Isotopologues of 5-azacytidine
US10646503B2 (en) 2008-05-15 2020-05-12 Celgene Corporation Isotopologues of 5-azacytidine
US11571436B2 (en) 2008-05-15 2023-02-07 Celgene Corporation Oral formulations of cytidine analogs and methods of use thereof
US9951098B2 (en) 2011-03-31 2018-04-24 Pharmion Llc Synthesis of 5-azacytidine

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