NL7002128A - Substd phenacrylquanidines - Google Patents
Substd phenacrylquanidinesInfo
- Publication number
- NL7002128A NL7002128A NL7002128A NL7002128A NL7002128A NL 7002128 A NL7002128 A NL 7002128A NL 7002128 A NL7002128 A NL 7002128A NL 7002128 A NL7002128 A NL 7002128A NL 7002128 A NL7002128 A NL 7002128A
- Authority
- NL
- Netherlands
- Prior art keywords
- phenacrylquanidines
- substd
- alkyl
- cyanostyenes
- acylguanidines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/48—Nitrogen atoms not forming part of a nitro radical with acyclic hydrocarbon or substituted acyclic hydrocarbon radicals, attached to said nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/12—Nitrogen atoms not forming part of a nitro radical
- C07D239/16—Nitrogen atoms not forming part of a nitro radical acylated on said nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Acylguanidines of formula (I): where R' = H, Cl or Me, R2 = Cl or Me, and R3, R4 and R5 = H or (1-6C) alkyl opt. subst. by OH or o-alkyl, or R3 + R4 = (CH2)n where n = 2 or 3 and R5 = H, are active as antihypertensives. (I) are prepd. by hydrolysis and rearrangement of the corresp. guanidino - alpha-cyanostyenes.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH285869A CH511816A (en) | 1969-02-26 | 1969-02-26 | Substd phenacrylquanidines |
CH1694769A CH518910A (en) | 1969-10-31 | 1969-11-14 | Substd phenacrylquanidines |
Publications (1)
Publication Number | Publication Date |
---|---|
NL7002128A true NL7002128A (en) | 1970-08-28 |
Family
ID=25691576
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NL7002128A NL7002128A (en) | 1969-02-26 | 1970-02-16 | Substd phenacrylquanidines |
Country Status (6)
Country | Link |
---|---|
AT (1) | AT316575B (en) |
BR (1) | BR7016960D0 (en) |
CA (1) | CA958016A (en) |
CS (1) | CS158267B2 (en) |
NL (1) | NL7002128A (en) |
SE (1) | SE372948B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103058890A (en) * | 2012-12-27 | 2013-04-24 | 郑州大明药物科技有限公司 | Method for preparing guanfacine hydrochloride |
-
1970
- 1970-02-16 NL NL7002128A patent/NL7002128A/en unknown
- 1970-02-24 CA CA075,689A patent/CA958016A/en not_active Expired
- 1970-02-24 BR BR21696070A patent/BR7016960D0/en unknown
- 1970-02-24 CS CS124670A patent/CS158267B2/cs unknown
- 1970-02-25 AT AT173370A patent/AT316575B/en active
- 1970-02-25 SE SE243070A patent/SE372948B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
BR7016960D0 (en) | 1973-02-13 |
CS158267B2 (en) | 1974-10-15 |
AT316575B (en) | 1974-07-25 |
CA958016A (en) | 1974-11-19 |
SE372948B (en) | 1975-01-20 |
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