EP0929218A4 - P2y receptor antagonists - Google Patents

P2y receptor antagonists

Info

Publication number
EP0929218A4
EP0929218A4 EP19970952172 EP97952172A EP0929218A4 EP 0929218 A4 EP0929218 A4 EP 0929218A4 EP 19970952172 EP19970952172 EP 19970952172 EP 97952172 A EP97952172 A EP 97952172A EP 0929218 A4 EP0929218 A4 EP 0929218A4
Authority
EP
Grant status
Application
Patent type
Prior art keywords
receptor antagonists
p2y receptor
p2y
antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19970952172
Other languages
German (de)
French (fr)
Other versions
EP0929218A2 (en )
Inventor
Jose L Boyer
T Kendall Harden
Kenneth A Jacobson
Emidio Camaioni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of North Carolina at Chapel Hill
University of North Carolina
Original Assignee
University of North Carolina at Chapel Hill
University of North Carolina
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals
    • C07H19/20Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
EP19970952172 1996-10-30 1997-10-23 P2y receptor antagonists Withdrawn EP0929218A4 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US2985596 true 1996-10-30 1996-10-30
US29855P 1996-10-30
PCT/US1997/019922 WO1998018430A3 (en) 1996-10-30 1997-10-23 P2y receptor antagonists

Publications (2)

Publication Number Publication Date
EP0929218A2 true EP0929218A2 (en) 1999-07-21
EP0929218A4 true true EP0929218A4 (en) 2001-05-16

Family

ID=21851254

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19970952172 Withdrawn EP0929218A4 (en) 1996-10-30 1997-10-23 P2y receptor antagonists

Country Status (4)

Country Link
EP (1) EP0929218A4 (en)
JP (1) JP2001504097A (en)
CA (1) CA2241687A1 (en)
WO (1) WO1998018430A3 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69933860T2 (en) 1998-02-25 2007-05-31 Choi, Yongseok 2'-fluoronukleoside
US7115585B2 (en) * 2000-08-21 2006-10-03 Inspire Pharmaceuticals, Inc. Compositions for treating epithelial and retinal tissue diseases
WO2002062816A1 (en) * 2001-02-07 2002-08-15 Celltech R & D Limited Non-natural nucleotides and dinucleotides
CA2465894A1 (en) * 2001-11-06 2003-05-15 Inspire Pharmaceuticals, Inc. Method for treating or preventing inflammatory diseases
EP1590359A2 (en) * 2003-02-03 2005-11-02 CV Therapeutics Inc. PARTIAL AND FULL AGONISTS OF A sb 1 /sb ADENOSINE RECEPTORS
US7550499B2 (en) 2004-05-12 2009-06-23 Bristol-Myers Squibb Company Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
WO2005113511A9 (en) * 2004-05-12 2006-02-02 Squibb Bristol Myers Co Urea antagonists of p2y1 receptor useful in the treatment of thrombotic conditions
WO2007002634A1 (en) 2005-06-27 2007-01-04 Bristol-Myers Squibb Company Carbocycle and heterocycle antagonists of p2y1 receptor useful in the treatment of thrombotic conditions
KR20080027890A (en) * 2005-06-27 2008-03-28 브리스톨-마이어스 스큅 컴퍼니 N-linked heterocyclic antagonists of p2y1 receptor useful in the treatment of thrombotic conditions
DE602006020871D1 (en) 2005-06-27 2011-05-05 Bristol Myers Squibb Co Linear harnstoffmimetika antagonists of thrombosis suffer P2Y1 receptor for treatment of
US7960569B2 (en) 2006-10-17 2011-06-14 Bristol-Myers Squibb Company Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2331223A1 (en) * 1972-06-19 1974-01-17 Kohjin Co S-substd 2-thioadenosines - as coronary vasodilators and blood platelet aggregation inhibitors
US3846402A (en) * 1971-05-06 1974-11-05 Max Planck Gesellschaft Thiophosphate analogues of the nucleoside diphosphates and triphosphates and a method for the preparation thereof
GB1433507A (en) * 1972-05-15 1976-04-28 Takeda Chemical Industries Ltd Pharmaceutically active 2-substituted adenosine-3,5-cyclic monophosphates
US4266048A (en) * 1977-10-11 1981-05-05 The United States Of America As Represented By The Department Of Health, Education And Welfare Synthesis of analogs of 3'-phosphoadenosine 5'-phosphosulfate (PAPS)
US4719295A (en) * 1985-12-31 1988-01-12 Warner-Lambert Company Compound 2-iodo-2'-deoxyadenosine
US4828979A (en) * 1984-11-08 1989-05-09 Life Technologies, Inc. Nucleotide analogs for nucleic acid labeling and detection
WO1992017488A1 (en) * 1991-04-06 1992-10-15 Fisons Plc Atp analogues
WO1994018216A1 (en) * 1993-02-10 1994-08-18 Astra Pharmaceuticals Limited N-alkyl-2-substituted atp analogues
WO1995010287A1 (en) * 1993-10-15 1995-04-20 Wisconsin Alumni Research Foundation Substituted purine nucleoside analogs and method for treating endotoxin shock
WO1996029345A1 (en) * 1995-03-23 1996-09-26 The Trustees Of The University Of Pennsylvania Novel inotropic agents

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4788181A (en) * 1986-09-29 1988-11-29 The United States Of America As Represented By The Department Of Health And Human Services 5-substituted-2',3'-dideoxycytidine compounds with anti-HTLV-III activity
US5620676A (en) * 1994-03-08 1997-04-15 The United States Of America As Represented By The Department Of Health And Human Services Biologically active ATP analogs

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3846402A (en) * 1971-05-06 1974-11-05 Max Planck Gesellschaft Thiophosphate analogues of the nucleoside diphosphates and triphosphates and a method for the preparation thereof
GB1433507A (en) * 1972-05-15 1976-04-28 Takeda Chemical Industries Ltd Pharmaceutically active 2-substituted adenosine-3,5-cyclic monophosphates
DE2331223A1 (en) * 1972-06-19 1974-01-17 Kohjin Co S-substd 2-thioadenosines - as coronary vasodilators and blood platelet aggregation inhibitors
US4266048A (en) * 1977-10-11 1981-05-05 The United States Of America As Represented By The Department Of Health, Education And Welfare Synthesis of analogs of 3'-phosphoadenosine 5'-phosphosulfate (PAPS)
US4828979A (en) * 1984-11-08 1989-05-09 Life Technologies, Inc. Nucleotide analogs for nucleic acid labeling and detection
US4719295A (en) * 1985-12-31 1988-01-12 Warner-Lambert Company Compound 2-iodo-2'-deoxyadenosine
WO1992017488A1 (en) * 1991-04-06 1992-10-15 Fisons Plc Atp analogues
WO1994018216A1 (en) * 1993-02-10 1994-08-18 Astra Pharmaceuticals Limited N-alkyl-2-substituted atp analogues
WO1995010287A1 (en) * 1993-10-15 1995-04-20 Wisconsin Alumni Research Foundation Substituted purine nucleoside analogs and method for treating endotoxin shock
WO1996029345A1 (en) * 1995-03-23 1996-09-26 The Trustees Of The University Of Pennsylvania Novel inotropic agents

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BOYER, J.L. ET AL.: "Identification of competitive antagonists of the P2Y1 receptor", MOL. PHARMACOL., vol. 50, 1996, pages 1323 - 9, XP000944991 *
BRENNAN, C.A. AND GUMPORT, R. I.: "T4 RNA ligase catalyzed synthesis of base analogue-containing oligodeoxyribonucleotides and a characterization of thermal stabilities", NUCLEIC ACIDS RES., vol. 13, 1985, pages 8665 - 84, XP000944971 *
FISCHER, B. ET AL.: "Identification of potent, selective P2Y-purinoreceptor antagonists: relationship or 2-thioether derivatives of adenosine 5'-triphosphate", J. MED. CHEM., vol. 36, 1993, pages 3937 - 46, XP002155543 *
See also references of WO9818430A3 *
VAN RHEE, A.M. ET AL.: "Novel competitive antagonists for P2 purinoreceptors", EUR. J. PHARMACOL. MOL. PHARMACOL. SECT., vol. 268, 1994, pages 1 - 7, XP000944973 *

Also Published As

Publication number Publication date Type
JP2001504097A (en) 2001-03-27 application
WO1998018430A2 (en) 1998-05-07 application
WO1998018430A3 (en) 1998-06-18 application
CA2241687A1 (en) 1998-05-07 application
EP0929218A2 (en) 1999-07-21 application

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