NZ570494A - Malate salts, and polymorphs of (3S,5S)-7-[3-amino-5-methyl-piperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid - Google Patents
Malate salts, and polymorphs of (3S,5S)-7-[3-amino-5-methyl-piperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acidInfo
- Publication number
- NZ570494A NZ570494A NZ570494A NZ57049407A NZ570494A NZ 570494 A NZ570494 A NZ 570494A NZ 570494 A NZ570494 A NZ 570494A NZ 57049407 A NZ57049407 A NZ 57049407A NZ 570494 A NZ570494 A NZ 570494A
- Authority
- NZ
- New Zealand
- Prior art keywords
- malate
- salt
- compound
- reaction
- hydrate
- Prior art date
Links
- 150000004701 malic acid derivatives Chemical class 0.000 title claims abstract description 28
- AVPQPGFLVZTJOR-RYUDHWBXSA-N nemonoxacin Chemical compound COC1=C(N2C[C@@H](N)C[C@H](C)C2)C=CC(C(C(C(O)=O)=C2)=O)=C1N2C1CC1 AVPQPGFLVZTJOR-RYUDHWBXSA-N 0.000 title claims abstract 3
- 150000003839 salts Chemical class 0.000 claims abstract description 73
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims abstract description 30
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- 241001465754 Metazoa Species 0.000 claims abstract description 8
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- 238000002441 X-ray diffraction Methods 0.000 claims description 16
- BJEPYKJPYRNKOW-UWTATZPHSA-N (R)-malic acid Chemical compound OC(=O)[C@H](O)CC(O)=O BJEPYKJPYRNKOW-UWTATZPHSA-N 0.000 claims description 12
- 238000002329 infrared spectrum Methods 0.000 claims description 12
- QSVWKBUDZWXCAX-HSHFZTNMSA-N (2R)-2-hydroxybutanedioic acid hydrate Chemical compound O.C([C@H](O)CC(=O)O)(=O)O QSVWKBUDZWXCAX-HSHFZTNMSA-N 0.000 claims description 11
- QSVWKBUDZWXCAX-DKWTVANSSA-N O.O[C@@H](CC(O)=O)C(O)=O Chemical compound O.O[C@@H](CC(O)=O)C(O)=O QSVWKBUDZWXCAX-DKWTVANSSA-N 0.000 claims description 11
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- 230000008025 crystallization Effects 0.000 description 24
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- 230000015572 biosynthetic process Effects 0.000 description 15
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- DTYLXDLAOLOTKT-UHFFFAOYSA-N 1,4-dihydroquinoline-3-carboxylic acid Chemical compound C1=CC=C2CC(C(=O)O)=CNC2=C1 DTYLXDLAOLOTKT-UHFFFAOYSA-N 0.000 description 10
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- 238000001644 13C nuclear magnetic resonance spectroscopy Methods 0.000 description 7
- 101150041968 CDC13 gene Proteins 0.000 description 7
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- 238000000746 purification Methods 0.000 description 7
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- 230000001225 therapeutic effect Effects 0.000 description 5
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 4
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 description 4
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- OCQSDUSXODQMAY-WDSKDSINSA-N [(3s,5s)-5-methylpiperidin-3-yl]carbamic acid Chemical compound C[C@@H]1CNC[C@@H](NC(O)=O)C1 OCQSDUSXODQMAY-WDSKDSINSA-N 0.000 description 3
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78648306P | 2006-03-28 | 2006-03-28 | |
| PCT/IB2007/051055 WO2007110834A2 (fr) | 2006-03-28 | 2007-03-26 | Malates et formes polymorphes de l'acide (3s,5s)-7-[3-amino-5-méthyl-pipéridinyl]-1-cyclopropyl-1,4-dihydro-8-méthoxy-4-oxo-3-quinoléine-carboxylique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ570494A true NZ570494A (en) | 2011-09-30 |
Family
ID=38441484
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ570494A NZ570494A (en) | 2006-03-28 | 2007-03-26 | Malate salts, and polymorphs of (3S,5S)-7-[3-amino-5-methyl-piperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US8039485B2 (fr) |
| EP (1) | EP2001862B1 (fr) |
| JP (1) | JP5097967B2 (fr) |
| KR (1) | KR101102288B1 (fr) |
| AR (2) | AR060189A1 (fr) |
| AT (1) | ATE507219T1 (fr) |
| AU (1) | AU2007230630B2 (fr) |
| BR (1) | BRPI0709772B8 (fr) |
| CA (1) | CA2647346C (fr) |
| CY (1) | CY1111683T1 (fr) |
| DE (1) | DE602007014191D1 (fr) |
| DK (1) | DK2001862T3 (fr) |
| ES (1) | ES2366150T3 (fr) |
| HR (1) | HRP20110558T1 (fr) |
| IL (1) | IL193990A (fr) |
| MA (1) | MA30554B1 (fr) |
| MX (1) | MX2008012328A (fr) |
| MY (1) | MY148393A (fr) |
| NZ (1) | NZ570494A (fr) |
| PE (1) | PE20080175A1 (fr) |
| PL (1) | PL2001862T3 (fr) |
| PT (1) | PT2001862E (fr) |
| SI (1) | SI2001862T1 (fr) |
| SM (1) | SMP200800058B (fr) |
| TW (1) | TWI364419B (fr) |
| WO (1) | WO2007110834A2 (fr) |
| ZA (1) | ZA200807158B (fr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007110835A2 (fr) * | 2006-03-28 | 2007-10-04 | The Procter & Gamble Company | Procede de couplage pour preparer des intermediaires quinolone |
| US8658183B2 (en) * | 2007-08-09 | 2014-02-25 | Taigen Biotechnology Company, Ltd. | Antimicrobial parenteral formulation |
| WO2010002415A1 (fr) * | 2008-07-01 | 2010-01-07 | Taigen Biotechnology Co., Ltd. | Traitement d'une infection par des bactéries résistantes aux antibiotiques |
| CN101618039B (zh) * | 2008-07-02 | 2012-04-11 | 太景生物科技股份有限公司 | 肺炎的治疗药物 |
| US8553466B2 (en) | 2010-03-04 | 2013-10-08 | Samsung Electronics Co., Ltd. | Non-volatile memory device, erasing method thereof, and memory system including the same |
| CZ304984B6 (cs) | 2012-10-12 | 2015-03-11 | Zentiva, K.S. | Zlepšený způsob výroby a nové intermediáty syntézy elvitegraviru |
| CZ304983B6 (cs) * | 2012-10-12 | 2015-03-11 | Zentiva, K.S. | Způsob výroby a nové intermediáty syntézy elvitegraviru |
| CN103145615B (zh) * | 2013-03-20 | 2015-07-29 | 浙江医药股份有限公司 | 一种奈诺沙星螯合物的后处理方法 |
| CN114437026A (zh) * | 2021-10-26 | 2022-05-06 | 浙江医药股份有限公司新昌制药厂 | 一种低组合物杂质的苹果酸奈诺沙星原料药及其制备方法 |
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