NO914292L - Forbedret innkapslingsprosess, samt produkter fra denne prosess - Google Patents

Forbedret innkapslingsprosess, samt produkter fra denne prosess

Info

Publication number
NO914292L
NO914292L NO91914292A NO914292A NO914292L NO 914292 L NO914292 L NO 914292L NO 91914292 A NO91914292 A NO 91914292A NO 914292 A NO914292 A NO 914292A NO 914292 L NO914292 L NO 914292L
Authority
NO
Norway
Prior art keywords
encapping
products
improved
agent
effective amount
Prior art date
Application number
NO91914292A
Other languages
English (en)
Other versions
NO302683B1 (no
NO914292D0 (no
Inventor
Thomas R Tice
Richard M Gilley
Original Assignee
Southern Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23363857&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO914292(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Southern Res Inst filed Critical Southern Res Inst
Publication of NO914292L publication Critical patent/NO914292L/no
Publication of NO914292D0 publication Critical patent/NO914292D0/no
Publication of NO302683B1 publication Critical patent/NO302683B1/no

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/12—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)
  • Extrusion Moulding Of Plastics Or The Like (AREA)
  • Glass Compositions (AREA)
  • Surgical Instruments (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Electron Tubes For Measurement (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Injection Moulding Of Plastics Or The Like (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Press Drives And Press Lines (AREA)
  • Separation By Low-Temperature Treatments (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
NO914292A 1989-05-04 1991-11-01 Emulsjonsbasert fremgangsmåte for mikroinnkapsling av et middel NO302683B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34747689A 1989-05-04 1989-05-04
PCT/US1990/002439 WO1990013361A1 (en) 1989-05-04 1990-05-02 Improved encapsulation process and products therefrom

Publications (3)

Publication Number Publication Date
NO914292L true NO914292L (no) 1991-11-01
NO914292D0 NO914292D0 (no) 1991-11-01
NO302683B1 NO302683B1 (no) 1998-04-14

Family

ID=23363857

Family Applications (1)

Application Number Title Priority Date Filing Date
NO914292A NO302683B1 (no) 1989-05-04 1991-11-01 Emulsjonsbasert fremgangsmåte for mikroinnkapsling av et middel

Country Status (21)

Country Link
US (1) US5407609A (no)
EP (1) EP0471036B2 (no)
JP (1) JP2582186B2 (no)
KR (1) KR0162660B1 (no)
CN (1) CN1047223A (no)
AT (1) ATE133087T1 (no)
AU (1) AU5741590A (no)
CA (1) CA2050911C (no)
DE (1) DE69024953T3 (no)
DK (1) DK0471036T4 (no)
ES (1) ES2084698T5 (no)
FI (1) FI103183B1 (no)
GR (1) GR1000614B (no)
HK (1) HK30897A (no)
IE (1) IE69313B1 (no)
IL (1) IL94296A (no)
MX (1) MX20594A (no)
NO (1) NO302683B1 (no)
NZ (1) NZ233570A (no)
WO (1) WO1990013361A1 (no)
ZA (1) ZA903411B (no)

Families Citing this family (317)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5693343A (en) 1984-03-16 1997-12-02 The United States Of America As Represented By The Secretary Of The Army Microparticle carriers of maximal uptake capacity by both M cells and non-M cells
US20030161889A1 (en) * 1984-03-16 2003-08-28 Reid Robert H. Vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres
US6217911B1 (en) 1995-05-22 2001-04-17 The United States Of America As Represented By The Secretary Of The Army sustained release non-steroidal, anti-inflammatory and lidocaine PLGA microspheres
USRE40786E1 (en) 1984-03-16 2009-06-23 The United States Of America As Represented By The Secretary Of The Army Vaccines against intracellular pathogens using antigens encapsulated within biodegradable-biocompatible microspheres
US6309669B1 (en) 1984-03-16 2001-10-30 The United States Of America As Represented By The Secretary Of The Army Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix
US6410056B1 (en) 1984-03-16 2002-06-25 The United States Of America As Represented By The Secretary Of The Army Chemotherapeutic treatment of bacterial infections with an antibiotic encapsulated within a biodegradable polymeric matrix
US5985354A (en) 1995-06-07 1999-11-16 Brown University Research Foundation Preparation of multiwall polymeric microcapsules from hydrophilic polymers
US5840293A (en) * 1988-11-16 1998-11-24 Advanced Polymer Systems, Inc. Ionic beads for controlled release and adsorption
WO1992019263A1 (en) 1991-04-24 1992-11-12 The United States Of America, As Represented By The Secretary Of The Army Oral-intestinal vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres
CH683149A5 (fr) * 1991-07-22 1994-01-31 Debio Rech Pharma Sa Procédé pour la préparation de microsphères en matériau polymère biodégradable.
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
ZA93929B (en) * 1992-02-18 1993-09-10 Akzo Nv A process for the preparation of biologically active materialcontaining polymeric microcapsules.
US5922340A (en) 1992-09-10 1999-07-13 Children's Medical Center Corporation High load formulations and methods for providing prolonged local anesthesia
US6251920B1 (en) 1993-05-13 2001-06-26 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US5346738A (en) * 1992-11-04 1994-09-13 X-Cal Corporation Identification label with micro-encapsulated etchant
DE4244122C1 (de) * 1992-12-24 1994-06-01 Sanol Arznei Schwarz Gmbh Lyophilisierte, wirkstoffhaltige Emulsion zur intravenösen Applikation
US6663881B2 (en) 1993-01-28 2003-12-16 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6939546B2 (en) 1993-05-21 2005-09-06 The United States Of America As Represented By The Secretary Of The Army Model for testing immunogenicity of peptides
US5650173A (en) * 1993-11-19 1997-07-22 Alkermes Controlled Therapeutics Inc. Ii Preparation of biodegradable microparticles containing a biologically active agent
CA2176716C (en) * 1993-11-19 2009-04-07 Ramstack, J. Michael Preparation of biodegradable microparticles containing a biologically active agent
KR100354270B1 (ko) 1993-11-19 2003-02-11 알커메스 컨트롤드 테라포이틱스 인코퍼레이티드 Ii 마이크로캡슐화된3-피페리디닐-치환된1,2-벤즈이속사졸및1,2-벤즈이소티아졸
IT1265290B1 (it) * 1993-12-17 1996-10-31 Dox Al Italia Spa Miscele ad elevato contenuto di sostanze attive idonee ad essere distribuite in modo omogeneo nei mangimi per animali.
US6447796B1 (en) 1994-05-16 2002-09-10 The United States Of America As Represented By The Secretary Of The Army Sustained release hydrophobic bioactive PLGA microspheres
US6855331B2 (en) 1994-05-16 2005-02-15 The United States Of America As Represented By The Secretary Of The Army Sustained release hydrophobic bioactive PLGA microspheres
US5622723A (en) * 1995-02-03 1997-04-22 Eurand America, Incorporated Procedure for encapsulating chlorpheniramine
US7033608B1 (en) 1995-05-22 2006-04-25 The United States Of America As Represented By The Secretary Of The Army “Burst-free” sustained release poly-(lactide/glycolide) microspheres
US6902743B1 (en) 1995-05-22 2005-06-07 The United States Of America As Represented By The Secretary Of The Army Therapeutic treatment and prevention of infections with a bioactive material(s) encapuslated within a biodegradable-bio-compatable polymeric matrix
US5883103A (en) * 1995-06-07 1999-03-16 Shire Laboratories Inc. Oral acyclovir delivery
US5879712A (en) 1995-06-07 1999-03-09 Sri International Method for producing drug-loaded microparticles and an ICAM-1 dosage form so produced
EP0778768B1 (en) 1995-06-09 2004-05-26 Euroceltique S.A. Formulations and methods for providing prolonged local anesthesia
US6248720B1 (en) 1996-07-03 2001-06-19 Brown University Research Foundation Method for gene therapy using nucleic acid loaded polymeric microparticles
CA2227287A1 (en) 1995-07-21 1997-02-06 Brown University Research Foundation A method for gene therapy using nucleic acid loaded polymeric microparticles
US6143211A (en) * 1995-07-21 2000-11-07 Brown University Foundation Process for preparing microparticles through phase inversion phenomena
US5766629A (en) 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
ATE192334T1 (de) † 1995-11-09 2000-05-15 Microbiological Res Authority Mikroverkapselte dna zur impfung und gentherapie
US6270795B1 (en) 1995-11-09 2001-08-07 Microbiological Research Authority Method of making microencapsulated DNA for vaccination and gene therapy
GB9709900D0 (en) 1997-05-15 1997-07-09 Microbiological Res Authority Microencapsulated DNA for vaccination and gene therapy
JPH09169610A (ja) * 1995-12-20 1997-06-30 Sumitomo Chem Co Ltd マイクロカプセル化された有害生物防除剤組成物
US5955143A (en) * 1995-12-21 1999-09-21 Drexel University Hollow polymer microcapsules and method of producing the same
US5792477A (en) 1996-05-07 1998-08-11 Alkermes Controlled Therapeutics, Inc. Ii Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent
US6652837B1 (en) 1996-05-24 2003-11-25 Massachusetts Institute Of Technology Preparation of novel particles for inhalation
US20020052310A1 (en) * 1997-09-15 2002-05-02 Massachusetts Institute Of Technology The Penn State Research Foundation Particles for inhalation having sustained release properties
US5985309A (en) * 1996-05-24 1999-11-16 Massachusetts Institute Of Technology Preparation of particles for inhalation
US5874064A (en) * 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
WO1997049391A1 (en) 1996-06-24 1997-12-31 Euro-Celtique, S.A. Methods for providing safe local anesthesia
US6046187A (en) 1996-09-16 2000-04-04 Children's Medical Center Corporation Formulations and methods for providing prolonged local anesthesia
IL119938A (en) * 1996-12-30 2005-08-31 Yissum Res Dev Co Peptides capable of eliciting protective immunity against toxic shock induced by pyrogenic exotoxins or of antagonizing toxin-mediated activation of t cells
US7060277B2 (en) * 1996-12-30 2006-06-13 Yissum Research Development Company Of The Hebrew University Of Jerusalem Broad spectrum antagonists and vaccines directed against pyrogenic exotoxins
US5783567A (en) * 1997-01-22 1998-07-21 Pangaea Pharmaceuticals, Inc. Microparticles for delivery of nucleic acid
US20020182258A1 (en) * 1997-01-22 2002-12-05 Zycos Inc., A Delaware Corporation Microparticles for delivery of nucleic acid
US5945126A (en) * 1997-02-13 1999-08-31 Oakwood Laboratories L.L.C. Continuous microsphere process
ATE278397T1 (de) 1997-03-31 2004-10-15 Boston Scient Ltd Verwendung von cytoskelettinhibitoren zur vorbeugung der restenose
IL129951A0 (en) * 1997-07-02 2000-02-29 Euro Celtique Sa Prolonged anesthesia in joints and body spaces
KR100380856B1 (ko) * 1997-07-19 2003-10-10 주식회사 엘지화학 카본블랙의고분자에의한피낭화방법
DK0942780T3 (da) * 1997-09-09 2003-10-27 Lyotropic Therapeutics Inc Overtrukne partikler, fremgangsmåder til fremstilling deraf og anvendelse deraf
US7052678B2 (en) 1997-09-15 2006-05-30 Massachusetts Institute Of Technology Particles for inhalation having sustained release properties
SE512663C2 (sv) * 1997-10-23 2000-04-17 Biogram Ab Inkapslingsförfarande för aktiv substans i en bionedbrytbar polymer
FR2771824A1 (fr) * 1997-12-01 1999-06-04 Eastman Kodak Co Utilisation de microvesicules contenant un developpateur des halogenures d'argent pour former une image photographique
US6197229B1 (en) * 1997-12-12 2001-03-06 Massachusetts Institute Of Technology Method for high supercoiled DNA content microspheres
US20020147143A1 (en) 1998-03-18 2002-10-10 Corixa Corporation Compositions and methods for the therapy and diagnosis of lung cancer
WO1999051748A2 (en) 1998-04-07 1999-10-14 Corixa Corporation Fusion proteins of mycobacterium tuberculosis antigens and their uses
GB9810236D0 (en) 1998-05-13 1998-07-08 Microbiological Res Authority Improvements relating to encapsulation of bioactive agents
US6406719B1 (en) 1998-05-13 2002-06-18 Microbiological Research Authority Encapsulation of bioactive agents
EP1096957A1 (en) 1998-06-18 2001-05-09 Johns Hopkins University School of Medicine Methods and reagents for intramuscular delivery of nucleic acids
US6916490B1 (en) 1998-07-23 2005-07-12 UAB Research Center Controlled release of bioactive substances
US6264991B1 (en) 1998-08-18 2001-07-24 Southern Research Institute Compositions and methods for treating intracellular infections
US6956021B1 (en) 1998-08-25 2005-10-18 Advanced Inhalation Research, Inc. Stable spray-dried protein formulations
US20030235557A1 (en) 1998-09-30 2003-12-25 Corixa Corporation Compositions and methods for WT1 specific immunotherapy
US6270802B1 (en) 1998-10-28 2001-08-07 Oakwood Laboratories L.L.C. Method and apparatus for formulating microspheres and microcapsules
US20040009535A1 (en) 1998-11-27 2004-01-15 Celltech R&D, Inc. Compositions and methods for increasing bone mineralization
US6194006B1 (en) 1998-12-30 2001-02-27 Alkermes Controlled Therapeutics Inc. Ii Preparation of microparticles having a selected release profile
US6498153B1 (en) 1998-12-31 2002-12-24 Akzo Nobel N.V. Extended release growth promoting two component composition
US6204308B1 (en) 1999-03-01 2001-03-20 Novartis Ag Organic compounds
US6306425B1 (en) 1999-04-09 2001-10-23 Southern Research Institute Injectable naltrexone microsphere compositions and their use in reducing consumption of heroin and alcohol
EP1044683A1 (en) * 1999-04-15 2000-10-18 Debio Recherche Pharmaceutique S.A. One-step dispersion method for the microencapsulation of water soluble substances
US6291013B1 (en) 1999-05-03 2001-09-18 Southern Biosystems, Inc. Emulsion-based processes for making microparticles
US6387986B1 (en) * 1999-06-24 2002-05-14 Ahmad Moradi-Araghi Compositions and processes for oil field applications
US6749835B1 (en) 1999-08-25 2004-06-15 Advanced Inhalation Research, Inc. Formulation for spray-drying large porous particles
US20010036481A1 (en) * 1999-08-25 2001-11-01 Advanced Inhalation Research, Inc. Modulation of release from dry powder formulations
WO2001013891A2 (en) * 1999-08-25 2001-03-01 Advanced Inhalation Research, Inc. Modulation of release from dry powder formulations
US7678364B2 (en) 1999-08-25 2010-03-16 Alkermes, Inc. Particles for inhalation having sustained release properties
ATE280579T1 (de) 1999-08-27 2004-11-15 Southern Res Inst Injizierbare buprenorphinhaltige mikrosphärenzusammensetzungen und ihre verwendung zur reduktion von heroin- und alkoholkonsum
US6458387B1 (en) * 1999-10-18 2002-10-01 Epic Therapeutics, Inc. Sustained release microspheres
US6331317B1 (en) 1999-11-12 2001-12-18 Alkermes Controlled Therapeutics Ii Inc. Apparatus and method for preparing microparticles
US6495166B1 (en) 1999-11-12 2002-12-17 Alkermes Controlled Therapeutics Inc. Apparatus and method for preparing microparticles using in-line solvent extraction
US6705757B2 (en) * 1999-11-12 2004-03-16 Alkermes Controlled Therapeutics, Inc. Ii Method and apparatus for preparing microparticles using in-line solvent extraction
US7838037B2 (en) * 1999-11-17 2010-11-23 Tagra Biotechnologies Ltd. Method of microencapsulation
US20050037086A1 (en) * 1999-11-19 2005-02-17 Zycos Inc., A Delaware Corporation Continuous-flow method for preparing microparticles
AU1956401A (en) * 1999-12-10 2001-06-18 Microban Products Company Antimicrobial synthetic ion exchange resins
US7029700B2 (en) * 2000-01-14 2006-04-18 Brown University Research Foundation Micronized freeze-dried particles
DK1265915T3 (da) 2000-02-23 2011-02-14 Glaxosmithkline Biolog Sa Nye forbindelser
US7250267B2 (en) * 2000-03-14 2007-07-31 Trustees Of Tufts College Cross-reactive sensors
AU2001257359A1 (en) 2000-04-27 2001-11-07 Verion Inc. Zero order release and temperature-controlled microcapsules and process for the preparation thereof
CN1189159C (zh) 2000-05-05 2005-02-16 欧莱雅 含水溶性美容活性组分水性核的微胶囊及含其的组合物
US6264987B1 (en) * 2000-05-19 2001-07-24 Alkermes Controlled Therapeutics Inc. Ii Method for preparing microparticles having a selected polymer molecular weight
US6495164B1 (en) 2000-05-25 2002-12-17 Alkermes Controlled Therapeutics, Inc. I Preparation of injectable suspensions having improved injectability
CA2410052A1 (en) * 2000-06-02 2001-12-13 Zycos Inc. Delivery systems for bioactive agents
WO2002000174A2 (en) 2000-06-28 2002-01-03 Corixa Corporation Compositions and methods for the therapy and diagnosis of lung cancer
EP1299087A1 (en) * 2000-07-07 2003-04-09 Corixa Corporation Microspheres and adjuvants for dna vaccine delivery
ATE377048T1 (de) * 2000-09-06 2007-11-15 Ap Pharma Inc Abbaubare polyacetal-polymere
JP4955899B2 (ja) 2000-09-06 2012-06-20 アップルトン ペーパーズ インコーポレイテッド インシツマイクロカプセル化された接着剤
US6824822B2 (en) * 2001-08-31 2004-11-30 Alkermes Controlled Therapeutics Inc. Ii Residual solvent extraction method and microparticles produced thereby
JP2004509739A (ja) 2000-09-27 2004-04-02 ベリオン　インコーポレイテッド 即時水溶解性カプセルおよびその製法
US6962716B1 (en) * 2000-09-27 2005-11-08 Board Of Regents, The University Of Texas System Compositions and methods for biodegradable microspheres as carriers of bioactive substances
US6471995B1 (en) 2000-09-27 2002-10-29 Alkermes Controlled Therapeutics, Inc. Ii Apparatus and method for preparing microparticles using liquid-liquid extraction
SE517421C2 (sv) 2000-10-06 2002-06-04 Bioglan Ab Mikropartiklar, lämpade för parenteral administration, väsentligen bestående av stärkelse med minst 85 % amylopektin och med reducerad molekylvikt, samt framställning därav
SE517422C2 (sv) * 2000-10-06 2002-06-04 Bioglan Ab Farmaceutiskt acceptabel stärkelse
CA2424896A1 (en) 2000-10-06 2002-04-11 Jagotec Ag A controlled-release, parenterally administrable microparticle preparation
ES2326209T3 (es) 2000-10-27 2009-10-05 Baxter Healthcare S.A. Produccion de microesferas.
ATE537845T1 (de) * 2000-10-31 2012-01-15 Pr Pharmaceuticals Inc Verfahren zur herstellung von formulierungen zur verbesserten abgabe von bioaktiven molekülen
SE518007C2 (sv) 2000-11-16 2002-08-13 Bioglan Ab Förfarande för framställning av mikropartiklar
SE518008C2 (sv) * 2000-11-16 2002-08-13 Bioglan Ab Parenteralt administrerbara mikropartiklar och förfarande för framställning av desamma
US20020114843A1 (en) * 2000-12-27 2002-08-22 Ramstack J. Michael Preparation of microparticles having improved flowability
AU2002230993B2 (en) * 2000-12-29 2006-02-02 Alkermes, Inc. Particles for inhalation having sustained release properties
US20020141946A1 (en) * 2000-12-29 2002-10-03 Advanced Inhalation Research, Inc. Particles for inhalation having rapid release properties
US20070142325A1 (en) * 2001-01-08 2007-06-21 Gustavsson Nils O Starch
US20020142047A1 (en) * 2001-01-19 2002-10-03 Johnson Mark E. Microsphere delivery of mucin peptides
WO2002058670A1 (en) * 2001-01-25 2002-08-01 Euroceltique S.A. Local anesthetic, and method of use
WO2002089747A2 (en) 2001-05-09 2002-11-14 Corixa Corporation Compositions and methods for the therapy and diagnosis of prostate cancer
US20030152630A1 (en) * 2001-05-11 2003-08-14 Ng Steven Y. PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers
US6590059B2 (en) 2001-05-11 2003-07-08 Ap Pharma, Inc. Bioerodible polyorthoesters from dioxolane-based diketene acetals
US6730772B2 (en) 2001-06-22 2004-05-04 Venkatram P. Shastri Degradable polymers from derivatized ring-opened epoxides
CA2452382A1 (en) * 2001-07-10 2003-01-23 Corixa Corporation Compositions and methods for delivery of proteins and adjuvants encapsulated in microspheres
CA2456806C (en) * 2001-08-08 2011-10-18 Brown University Research Foundation Methods for micronization of hydrophobic drugs
US20080026068A1 (en) * 2001-08-16 2008-01-31 Baxter Healthcare S.A. Pulmonary delivery of spherical insulin microparticles
US20030064033A1 (en) * 2001-08-16 2003-04-03 Brown Larry R. Propellant-based microparticle formulations
US7105181B2 (en) * 2001-10-05 2006-09-12 Jagotec, Ag Microparticles
US6524606B1 (en) * 2001-11-16 2003-02-25 Ap Pharma, Inc. Bioerodible polyorthoesters containing amine groups
AU2002346472A1 (en) * 2001-11-20 2003-06-10 Advanced Inhalation Research, Inc. Particulate compositions for improving solubility of poorly soluble agents
AU2002352836B2 (en) * 2001-11-20 2005-09-29 Alkermes, Inc. Improved particulate compositions for pulmonary delivery
WO2003049701A2 (en) * 2001-12-10 2003-06-19 Spherics, Inc. Methods and products useful in the formation and isolation of microparticles
AU2002365279B2 (en) 2001-12-17 2009-08-13 Corixa Corporation Compositions and methods for the therapy and diagnosis of inflammatory bowel disease
US20060286356A1 (en) * 2002-02-27 2006-12-21 Thomas Toby R Web materials with active agent
US20050220375A1 (en) * 2002-02-27 2005-10-06 Thomas Toby R Pakages with active agents
US7497623B2 (en) * 2002-02-27 2009-03-03 Pactiv Corporation Packages with active agents
SE0201599D0 (sv) * 2002-03-21 2002-05-30 Skyepharma Ab Microparticles
US7157102B1 (en) 2002-05-31 2007-01-02 Biotek, Inc. Multi-layered microcapsules and method of preparing same
US7041320B1 (en) 2002-05-31 2006-05-09 Biotek, Inc. High drug loaded injectable microparticle compositions and methods of treating opioid drug dependence
US20040047835A1 (en) * 2002-09-06 2004-03-11 Cell Therapeutics, Inc. Combinatorial drug therapy using polymer drug conjugates
US7544657B2 (en) * 2002-10-02 2009-06-09 Zealand Pharma A/S Stabilized Exendin-4 compounds
US6800663B2 (en) * 2002-10-18 2004-10-05 Alkermes Controlled Therapeutics Inc. Ii, Crosslinked hydrogel copolymers
US20040097419A1 (en) * 2002-11-19 2004-05-20 Holger Petersen Organic compounds
US7691296B2 (en) * 2002-11-25 2010-04-06 Amorepacific Corporation Method for stabilizing active components using polyol/polymer microcapsule, and cosmetic composition containing the microcapsule
BRPI0409032A (pt) * 2003-04-10 2006-05-02 Pr Pharmaceuticals método para a produção de micropartìculas à base de emulsão
US20070207211A1 (en) * 2003-04-10 2007-09-06 Pr Pharmaceuticals, Inc. Emulsion-based microparticles and methods for the production thereof
US7622269B2 (en) * 2004-03-19 2009-11-24 Tyratech, Inc. Methods of screening tyramine- and octopamine-expressing cells for compounds and compositions having potential insect control activity
US20060263403A1 (en) * 2003-04-24 2006-11-23 Essam Enan Compositions and methods for controlling insects involving the tyramine receptor
JP2007502860A (ja) * 2003-04-24 2007-02-15 ヴァンダービルト ユニバースィティ 昆虫を防除するための組成物及び方法
US20040224030A1 (en) * 2003-05-06 2004-11-11 Shastri Venkatram R. Microsphere delivery systems
US7578916B2 (en) * 2004-05-25 2009-08-25 Applied Biosystems, Llc Emulsions of ionic liquids
ES2586401T3 (es) 2003-06-16 2016-10-14 Ucb Pharma S.A. Anticuerpos específicos para la esclerostina y métodos para aumentar la mineralización ósea
US7101617B2 (en) * 2003-07-10 2006-09-05 Motorola, Inc. Silicone dispensing with a conformal film
US8871269B2 (en) * 2003-07-15 2014-10-28 Evonik Corporation Method for the preparation of controlled release formulations
JP2007531701A (ja) * 2003-07-18 2007-11-08 バクスター・インターナショナル・インコーポレイテッド 制御された相分離により調製される小球状粒子の作製方法、使用および組成物
US20050142205A1 (en) * 2003-07-18 2005-06-30 Julia Rashba-Step Methods for encapsulating small spherical particles prepared by controlled phase separation
US8343513B2 (en) 2003-07-18 2013-01-01 Oakwood Laboratories, Llc Prevention of molecular weight reduction of the polymer, impurity formation and gelling in polymer compositions
US20070092452A1 (en) * 2003-07-18 2007-04-26 Julia Rashba-Step Methods for fabrication, uses, compositions of inhalable spherical particles
CA2532874A1 (en) * 2003-07-22 2005-02-03 Baxter International Inc. Small spherical particles of low molecular weight organic molecules and methods of preparation and use thereof
CA2533592C (en) * 2003-07-23 2015-11-10 Pr Pharmaceuticals, Inc. Controlled release compositions
US20050245541A1 (en) * 2004-03-19 2005-11-03 Elliot Ehrich Methods for treating alcoholism
US20080226704A1 (en) * 2004-03-23 2008-09-18 Makoto Kigoshi Method of Producing Coated Fine Particles
EP2409707B8 (en) 2004-04-15 2015-05-06 Alkermes Pharma Ireland Limited Polymer-based sustained release device
US7919499B2 (en) * 2004-04-22 2011-04-05 Alkermes, Inc. Naltrexone long acting formulations and methods of use
US20050260272A1 (en) * 2004-05-05 2005-11-24 Alkermes Controlled Therapeutics, Inc. Method of forming microparticles that include a bisphosphonate and a polymer
ES2313350T3 (es) * 2004-05-12 2009-03-01 Baxter International Inc. Microesferas de acido nucleico, produccion y suministro de las mismas.
US8728525B2 (en) * 2004-05-12 2014-05-20 Baxter International Inc. Protein microspheres retaining pharmacokinetic and pharmacodynamic properties
MXPA06012992A (es) 2004-05-12 2007-02-12 Baxter Int Microesferas que comprenden proteina y que muestran inyectabilidad en altas concentraciones de este agente.
DK1758558T3 (da) * 2004-05-12 2014-01-20 Baxter Int Oligonukleotidholdige mikrokugler samt deres anvendelse til fremstilling af et medikament til behandling af diabetes type 1
US7740861B2 (en) 2004-06-16 2010-06-22 University Of Massachusetts Drug delivery product and methods
CA2575988C (en) 2004-08-04 2014-02-18 Brookwood Pharmaceuticals, Inc. Methods for manufacturing delivery devices and devices thereof
MX2007001563A (es) * 2004-08-04 2008-03-05 Johnson & Johnson Composicion para liberacion sostenida de farmaco que demuestra un patron de liberacion ascendente del orden cero, metodos para la elaboracion de dicha composicion.
CN101052383B (zh) 2004-09-17 2013-01-30 马萨诸塞大学 用于溶酶体酶缺乏症的组合物和其用途
US20060073208A1 (en) * 2004-10-01 2006-04-06 Allergan, Inc. Cosmetic neurotoxin compositions and methods
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
JP4975731B2 (ja) 2005-03-25 2012-07-11 アップルトン ペーパーズ インコーポレイテッド 接着固定可能な包装資材
AU2006241145B2 (en) * 2005-04-27 2011-04-28 Baxter Healthcare S. A. Surface-modified microparticles and methods of forming and using the same
WO2006127454A2 (en) * 2005-05-23 2006-11-30 Appleton Papers Inc. Oil-in-water capsule manufacture process and microcapsules produced by such process
US7678847B2 (en) * 2005-07-22 2010-03-16 Appleton Papers Inc. Encapsulated structural adhesive
US9693967B2 (en) * 2005-09-07 2017-07-04 Southwest Research Institute Biodegradable microparticle pharmaceutical formulations exhibiting improved released rates
US20090099031A1 (en) * 2005-09-27 2009-04-16 Stemmer Willem P Genetic package and uses thereof
US7846445B2 (en) * 2005-09-27 2010-12-07 Amunix Operating, Inc. Methods for production of unstructured recombinant polymers and uses thereof
US7855279B2 (en) * 2005-09-27 2010-12-21 Amunix Operating, Inc. Unstructured recombinant polymers and uses thereof
US20070191272A1 (en) * 2005-09-27 2007-08-16 Stemmer Willem P Proteinaceous pharmaceuticals and uses thereof
EP1948245B1 (en) * 2005-10-24 2011-10-05 University of Massachusetts Compositions and their uses for gene therapy of bone conditions
US20070138671A1 (en) * 2005-12-15 2007-06-21 Anastasiou Theodore J Encapsulated active material with reduced formaldehyde potential
US20070190127A1 (en) 2005-12-30 2007-08-16 Mingdong Zhou Extended release of neuregulin for improved cardiac function
JP5524610B2 (ja) 2006-04-07 2014-06-18 ザ リサーチ ファウンデーション オブ ステイト ユニバーシティー オブ ニューヨーク トランスコバラミン受容体ポリペプチド、核酸およびその調節因子、ならびに細胞の増殖の調節ならびにガンおよびコバラミン欠損症の処置に使用する関連方法
CN100385063C (zh) * 2006-04-25 2008-04-30 中原工学院 具有持久抗菌芳香效果的纺织品纳米后整理试剂及其制作工艺
US7959940B2 (en) * 2006-05-30 2011-06-14 Advanced Cardiovascular Systems, Inc. Polymer-bioceramic composite implantable medical devices
US20070282434A1 (en) * 2006-05-30 2007-12-06 Yunbing Wang Copolymer-bioceramic composite implantable medical devices
US20070281031A1 (en) * 2006-06-01 2007-12-06 Guohan Yang Microparticles and methods for production thereof
EP2043620B1 (en) 2006-06-27 2017-05-03 Tyratech, Inc. Compositions for use in treating a parasitic infections in a mammalian subject
BRPI0714350B1 (pt) * 2006-07-17 2017-03-07 Tyratech Inc composições e métodos para controle de insentos
AU2007281737B2 (en) * 2006-08-04 2013-09-19 Baxter Healthcare S.A. Microsphere-based composition for preventing and/or reversing new-onset autoimmune diabetes
EP2359808B1 (en) 2006-08-09 2013-05-22 Intarcia Therapeutics, Inc Osmotic delivery systems and piston assemblies
WO2008060786A2 (en) * 2006-10-06 2008-05-22 Baxter International Inc. Microencapsules containing surface-modified microparticles and methods of forming and using the same
MX2009007637A (es) * 2007-01-16 2009-09-28 Tyratech Inc Composiciones y metodos para control de pestes.
US20080233199A1 (en) * 2007-03-22 2008-09-25 Alkermes, Inc. Coacervation Process
EP2157967B1 (en) 2007-04-23 2013-01-16 Intarcia Therapeutics, Inc Suspension formulations of insulinotropic peptides and uses thereof
JP2010530293A (ja) * 2007-05-21 2010-09-09 フイルメニツヒ ソシエテ アノニム 大きいコアセルベート化カプセル
US10092524B2 (en) 2008-06-11 2018-10-09 Edge Therapeutics, Inc. Compositions and their use to treat complications of aneurysmal subarachnoid hemorrhage
US8425591B1 (en) 2007-06-11 2013-04-23 Abbott Cardiovascular Systems Inc. Methods of forming polymer-bioceramic composite medical devices with bioceramic particles
US9364432B2 (en) 2007-06-11 2016-06-14 Edge Therapeutics, Inc. Intraventricular drug delivery system for improving outcome after a brain injury affecting cerebral blood flow
US20080317865A1 (en) * 2007-06-20 2008-12-25 Alkermes, Inc. Quench liquids and washing systems for production of microparticles
KR20100058541A (ko) * 2007-08-15 2010-06-03 아뮤닉스 인코포레이티드 생물학적 활성 폴리펩티드의 특성을 변경하기 위한 조성물 및 방법
JP2011517279A (ja) * 2007-10-29 2011-06-02 ユニバーシティ オブ マサチューセッツ 核酸（ｓｉＲＮＡ）送達用の酵母細胞壁粒子（ＹＣＷＰ）多層状ナノ粒子
JP2011503183A (ja) * 2007-11-13 2011-01-27 サーモディクス ファーマシューティカルズ， インコーポレイテッド 薬物送達のプラットホームとしての粘稠なターポリマー
US8619257B2 (en) 2007-12-13 2013-12-31 Kimberley-Clark Worldwide, Inc. Recombinant bacteriophage for detection of nosocomial infection
ES2718612T3 (es) 2007-12-20 2019-07-03 Evonik Corp Procedimiento para preparar micropartículas que tienen un bajo volumen de disolvente residual
ES2900339T3 (es) * 2007-12-27 2022-03-16 Tyratech Inc Composiciones antiparasitarias sinérgicas y procedimientos de selección
WO2009085083A1 (en) * 2007-12-28 2009-07-09 Dow Global Technologies Inc. Phase compensation film comprising polymer nanoparticles imbibed with liquid crystal material
WO2009085082A1 (en) * 2007-12-28 2009-07-09 Dow Global Technologies Inc. Small scale functional materials
CA2726861C (en) 2008-02-13 2014-05-27 Intarcia Therapeutics, Inc. Devices, formulations, and methods for delivery of multiple beneficial agents
US8133861B2 (en) * 2008-02-29 2012-03-13 Alseres Pharmaceuticals, Inc. Systemic purine administration: modulating axonal outgrowth of central nervous system neurons
US20090274906A1 (en) * 2008-05-01 2009-11-05 Appleton Papers Inc. Particle with low permeance wall
US8071214B2 (en) * 2008-05-01 2011-12-06 Appleton Papers Inc. Particle with selected permeance wall
US8067089B2 (en) * 2008-05-01 2011-11-29 Appleton Papers Inc. Cationic microcapsule particles
CA2723192A1 (en) * 2008-05-07 2009-11-12 Surmodics, Inc. Delivery of nucleic acid complexes from particles
US8815818B2 (en) 2008-07-18 2014-08-26 Rxi Pharmaceuticals Corporation Phagocytic cell delivery of RNAI
US8323685B2 (en) * 2008-08-20 2012-12-04 Baxter International Inc. Methods of processing compositions containing microparticles
US8367427B2 (en) * 2008-08-20 2013-02-05 Baxter International Inc. Methods of processing compositions containing microparticles
US8323615B2 (en) * 2008-08-20 2012-12-04 Baxter International Inc. Methods of processing multi-phasic dispersions
US20100047292A1 (en) * 2008-08-20 2010-02-25 Baxter International Inc. Methods of processing microparticles and compositions produced thereby
EP2334288B1 (en) * 2008-09-18 2021-05-19 Evonik Corporation Microencapsulation process with solvent and salt
US8796443B2 (en) 2008-09-22 2014-08-05 Rxi Pharmaceuticals Corporation Reduced size self-delivering RNAi compounds
LT2349324T (lt) 2008-10-17 2017-12-27 Sanofi-Aventis Deutschland Gmbh Insulino ir glp-1 agonisto derinys
WO2010057215A1 (en) * 2008-11-17 2010-05-20 Wayne State University Engineering porous particles of water soluble therapeutics for pressurized metered-dose inhaler formulations
US20100168807A1 (en) * 2008-12-23 2010-07-01 Burton Kevin W Bioactive terpolymer compositions and methods of making and using same
US8951546B2 (en) * 2008-12-23 2015-02-10 Surmodics Pharmaceuticals, Inc. Flexible implantable composites and implants comprising same
EP2395982B1 (en) 2008-12-23 2014-10-22 Surmodics Pharmaceuticals, Inc. An implantable composite comprising a tacky biocompatible polymer film and a releasable bioactive agent
US9415197B2 (en) * 2008-12-23 2016-08-16 Surmodics, Inc. Implantable suction cup composites and implants comprising same
US9480643B2 (en) 2008-12-23 2016-11-01 Surmodics Pharmaceuticals, Inc. Implantable composites and implants comprising same
US8974808B2 (en) 2008-12-23 2015-03-10 Surmodics, Inc. Elastic implantable composites and implants comprising same
US9493774B2 (en) 2009-01-05 2016-11-15 Rxi Pharmaceuticals Corporation Inhibition of PCSK9 through RNAi
JP2012515791A (ja) * 2009-01-23 2012-07-12 サーモディクス ファーマシューティカルズ， インコーポレイテッド ポリマー混成物由来の放出制御システム
US20100216948A1 (en) * 2009-01-23 2010-08-26 Tipton Arthur J Polymer mixtures comprising polymers having different non-repeating units and methods for making and using same
US20100189800A1 (en) * 2009-01-23 2010-07-29 Peter Markland Continous double emulsion process for making microparticles
US20100196436A1 (en) * 2009-01-30 2010-08-05 Gooberman Lance L Implants containing disulfiram and an anti-inflammatory agent
ES2730800T3 (es) * 2009-02-03 2019-11-12 Amunix Pharmaceuticals Inc Polipéptidos recombinantes extendidos y composiciones que comprenden los mismos
WO2010114770A1 (en) * 2009-03-30 2010-10-07 Cerulean Pharma Inc. Polymer-agent conjugates, particles, compositions, and related methods of use
US8455098B2 (en) * 2009-04-07 2013-06-04 Appleton Papers Inc. Encapsulated solid hydrophilic particles
US8791093B2 (en) * 2009-05-29 2014-07-29 Lance L. Gooberman Pharmaceutical delivery systems for treatment of substance abuse and other addictions
AU2010290131C1 (en) 2009-08-24 2015-12-03 Amunix Operating Inc. Coagulation factor VII compositions and methods of making and using same
EP3323423B1 (en) 2009-09-28 2020-06-17 Intarcia Therapeutics, Inc Rapid establishment and/or termination of substantial steady-state drug delivery
IN2012DN03361A (no) * 2009-10-01 2015-10-23 Evonik Degussa Corp
AU2010313456A1 (en) 2009-10-30 2012-05-17 Ntf Therapeutics, Inc. Improved neurturin molecules
ES2534191T3 (es) 2009-11-13 2015-04-20 Sanofi-Aventis Deutschland Gmbh Composición farmacéutica que comprende un agonista de GLP-1, una insulina y metionina
PL2498801T3 (pl) 2009-11-13 2018-08-31 Sanofi Aventis Deutschland Kompozycja farmaceutyczna zawierająca desPro<sup>36</sup>eksendyno-4(1-39)-Lys6-NH2 i metioninę
WO2011084141A2 (en) * 2009-12-21 2011-07-14 Appleton Papers Inc. Hydrophilic liquid encapsulates
US20110207653A1 (en) * 2009-12-21 2011-08-25 Adrian Raiche Microparticle Encapsulated Thiol-Containing Polypeptides Together with a Redox Reagent
ES2764971T3 (es) * 2009-12-22 2020-06-05 Evonik Corp Proceso basado en emulsión para la preparación de micropartículas y conjunto de cabezal de trabajo para su uso con el mismo
WO2011119995A2 (en) 2010-03-26 2011-09-29 Cerulean Pharma Inc. Formulations and methods of use
US9743688B2 (en) 2010-03-26 2017-08-29 Philip Morris Usa Inc. Emulsion/colloid mediated flavor encapsulation and delivery with tobacco-derived lipids
US9186642B2 (en) 2010-04-28 2015-11-17 The Procter & Gamble Company Delivery particle
US9993793B2 (en) 2010-04-28 2018-06-12 The Procter & Gamble Company Delivery particles
US20110269657A1 (en) 2010-04-28 2011-11-03 Jiten Odhavji Dihora Delivery particles
US20110319473A1 (en) 2010-06-29 2011-12-29 Surmodics, Inc. Compositions and methods for enhancement of nucleic acid delivery
ES2614181T3 (es) 2010-08-14 2017-05-30 University Of Massachusetts Partícula de pared celular de levadura para suministro de nanopartículas direccionadas al receptor
EP2605799A4 (en) * 2010-08-20 2014-02-26 Cerulean Pharma Inc CONJUGATES, PARTICLES, COMPOSITIONS AND RELATED METHODS
WO2012030819A1 (en) 2010-08-30 2012-03-08 Surmodics Pharmaceuticals, Inc. Terpolymers as pressure-sensitive adhesives
HUE031181T2 (en) 2010-08-30 2017-06-28 Sanofi Aventis Deutschland Use of AVE0010 for the manufacture of a medicament for the treatment of type 2 diabetes
EP2621473A2 (en) 2010-09-30 2013-08-07 Evonik Corporation Method for removing residual organic solvent from microparticles
JP2013538855A (ja) 2010-09-30 2013-10-17 エボニック コーポレイション 低い残留有機溶剤の微粒子を製造するためのエマルション法
US8901092B2 (en) 2010-12-29 2014-12-02 Surmodics, Inc. Functionalized polysaccharides for active agent delivery
CN105997890A (zh) 2011-02-11 2016-10-12 优势医疗公司 用于改善患有蛛网膜下腔出血的人的预后的组合物和方法
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
CN103458858B (zh) 2011-04-07 2016-04-27 宝洁公司 具有增强的聚丙烯酸酯微胶囊的沉积的洗发剂组合物
MX2013010980A (es) 2011-04-07 2013-10-30 Procter & Gamble Composiciones de limpieza personal con deposito mejorado de microcapsulas de poliacrilato.
CN103458871B (zh) 2011-04-07 2015-05-13 宝洁公司 具有增强的聚丙烯酸酯微胶囊的沉积的调理剂组合物
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
WO2012164480A1 (en) * 2011-05-30 2012-12-06 National Institute Of Immunology A vaccine composition capable of inducing memory antibody response from single point immunization
MX2013013627A (es) 2011-06-21 2014-04-25 Oncofactor Corp Composiciones y metodos para la terapia y diagnostico de cancer.
CN108079281A (zh) 2011-08-29 2018-05-29 赛诺菲-安万特德国有限公司 用于2型糖尿病患者中的血糖控制的药物组合
AR087744A1 (es) 2011-09-01 2014-04-16 Sanofi Aventis Deutschland Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa
EP2776451B1 (en) 2011-11-11 2018-07-18 Fred Hutchinson Cancer Research Center Cyclin a1-targeted t-cell immunotherapy for cancer
SI3564260T1 (sl) 2012-02-15 2023-02-28 Bioverativ Therapeutics Inc. Sestavki faktorja VIII in postopki njegove izdelave in uporabe
CA2864126A1 (en) 2012-02-15 2013-08-22 Biogen Idec Ma Inc. Recombinant factor viii proteins
US20130260040A1 (en) * 2012-02-28 2013-10-03 Neil Werde Microencapsulated catnip oil and methods of using the same
US9408419B2 (en) 2012-03-23 2016-08-09 Victoria's Secret Store Brand Management, Inc. Moisturizing fabric material, use thereof in moisturizing bras, and method of manufacture
US9399019B2 (en) 2012-05-09 2016-07-26 Evonik Corporation Polymorph compositions, methods of making, and uses thereof
US10064836B2 (en) 2012-08-03 2018-09-04 Tyratech, Inc. Antiparasitic compositions and methods
RU2015121799A (ru) 2012-11-09 2017-01-10 Эвоник Корпорейшн Способы сушки для регулировки свойств микрочастиц
TWI780236B (zh) 2013-02-04 2022-10-11 法商賽諾菲公司 胰島素類似物及/或胰島素衍生物之穩定化醫藥調配物
EP3033097B1 (en) 2013-08-14 2021-03-10 Bioverativ Therapeutics Inc. Factor viii-xten fusions and uses thereof
SG11201604708VA (en) 2014-01-09 2016-07-28 Sanofi Sa Stabilized glycerol free pharmaceutical formulations of insulin analogues and/or insulin derivatives
CN114939156A (zh) 2014-01-09 2022-08-26 赛诺菲 门冬胰岛素的稳定化药物制剂
KR20160104724A (ko) 2014-01-09 2016-09-05 사노피 인슐린 유사체 및/또는 인슐린 유도체의 안정화된 약제학적 제형
WO2015150942A2 (en) 2014-03-29 2015-10-08 The WOCKHARDT LIMITED Improved process for preparing microparticles
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
US9950039B2 (en) 2014-12-12 2018-04-24 Sanofi-Aventis Deutschland Gmbh Insulin glargine/lixisenatide fixed ratio formulation
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
MA44390A (fr) 2015-06-03 2019-01-23 Intarcia Therapeutics Inc Systèmes de mise en place et de retrait d'implant
CN108472337B (zh) 2015-08-03 2022-11-25 比奥贝拉蒂治疗公司 因子ix融合蛋白以及其制备和使用方法
WO2017074995A1 (en) 2015-10-27 2017-05-04 Encapsys, Llc Encapsulation
BG112154A (bg) 2015-11-19 2017-05-31 СОФИЙСКИ УНИВЕРСИТЕТ "Св. Кл. Охридски" Метод за получаване на течни, полутечни и твърди органични частици с контролирана форма и/или размер
AU2017223606A1 (en) 2016-02-23 2018-09-13 Biodelivery Sciences International, Inc. Sustained release buprenorphine microspheres (SRBM) and methods of use thereof
SG11201810102SA (en) 2016-05-16 2018-12-28 Intarcia Therapeutics Inc Glucagon-receptor selective polypeptides and methods of use thereof
WO2017199123A1 (en) 2016-05-17 2017-11-23 Ecole Polytechnique Federale De Lausanne (Epfl) Device and methods for shell phase removal of core-shell capsules
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
CN110225762A (zh) 2017-01-03 2019-09-10 因塔西亚制药公司 包括glp-1受体激动剂的连续施用和药物的共同施用的方法
EP3574061B1 (en) 2017-01-27 2021-11-10 Encapsys, LLC Encapsulates
GB201710973D0 (en) 2017-07-07 2017-08-23 Avacta Life Sciences Ltd Scaffold proteins
WO2019236669A1 (en) * 2018-06-08 2019-12-12 The United States Of America, As Represented By The Secretary Of Agriculture Compositions containing microencapsulated organic compounds
WO2019240568A1 (es) 2018-06-14 2019-12-19 Centro De Investigación En Química Aplicada Método de obtención de partículas porosas mediante un proceso híbrido de pulverización por secado-enfriamiento
US11260359B2 (en) 2019-01-11 2022-03-01 Encapsys, Llc Incorporation of chitosan in microcapsule wall
US20210047425A1 (en) 2019-08-12 2021-02-18 Purinomia Biotech, Inc. Methods and compositions for promoting and potentiating t-cell mediated immune responses through adcc targeting of cd39 expressing cells
WO2021074695A1 (en) 2019-10-16 2021-04-22 Avacta Life Sciences Limited PD-L1 INHIBITOR - TGFβ INHIBITOR BISPECIFIC DRUG MOIETIES.
WO2022234003A1 (en) 2021-05-07 2022-11-10 Avacta Life Sciences Limited Cd33 binding polypeptides with stefin a protein
TW202334196A (zh) 2021-10-07 2023-09-01 英商阿法克塔生命科學有限公司 Pd-l1結合多肽
TW202332694A (zh) 2021-10-07 2023-08-16 英商阿凡克塔生命科學公司 血清半衰期延長之ｐｄ－ｌ１結合多肽
WO2023218243A1 (en) 2022-05-12 2023-11-16 Avacta Life Sciences Limited Lag-3/pd-l1 binding fusion proteins
US20240147990A1 (en) 2022-10-21 2024-05-09 Encapsys, Llc Delivery Particles Based On Amine-Thiol-Ene Conjugates and Derivatives

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4572869A (en) * 1967-04-20 1986-02-25 Ppg Industries, Inc. Microcapsular opacifiers and method for their production
US3644963A (en) * 1969-07-24 1972-02-29 Federico Terranova Procedure for the removal of the bones from hams and similar cuts of meat
US3664963A (en) * 1969-10-22 1972-05-23 Balchem Corp Encapsulation process
US3780195A (en) * 1969-10-22 1973-12-18 Balchem Corp Encapsulation process
DE2059494B2 (de) * 1970-12-03 1972-03-16 Licentia Gmbh Biegsamer hohlleiter
US3790497A (en) * 1971-11-24 1974-02-05 Mitsubishi Rayon Co Method for producing water containing microcapsules
JPS528795B2 (no) * 1971-12-30 1977-03-11
US4089800A (en) * 1975-04-04 1978-05-16 Ppg Industries, Inc. Method of preparing microcapsules
JPS528795A (en) * 1975-07-10 1977-01-22 Kyocera Corp Selective indication circuit
DE2930248A1 (de) * 1979-07-26 1981-02-12 Bayer Ag Verfahren zur herstellung von mikrokapseln
US4933105A (en) * 1980-06-13 1990-06-12 Sandoz Pharm. Corp. Process for preparation of microspheres
US4389330A (en) * 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
US4675189A (en) * 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
US4637905A (en) * 1982-03-04 1987-01-20 Batelle Development Corporation Process of preparing microcapsules of lactides or lactide copolymers with glycolides and/or ε-caprolactones
JPS6048923A (ja) * 1983-08-25 1985-03-16 Mitsui Toatsu Chem Inc 微小粒子の製造方法
JPS60100516A (ja) * 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
US4818542A (en) * 1983-11-14 1989-04-04 The University Of Kentucky Research Foundation Porous microspheres for drug delivery and methods for making same
CA1287459C (en) * 1986-10-01 1991-08-13 Mukesh Jain Process for the preparation of hollow microspheres
US5075109A (en) * 1986-10-24 1991-12-24 Southern Research Institute Method of potentiating an immune response
JPS63122620A (ja) * 1986-11-12 1988-05-26 Sanraku Inc ポリ乳酸マイクロスフエア及びその製造方法
FR2608942B1 (fr) * 1986-12-31 1991-01-11 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanocapsules
FR2608988B1 (fr) * 1986-12-31 1991-01-11 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanoparticules
US4897268A (en) * 1987-08-03 1990-01-30 Southern Research Institute Drug delivery system and method of making the same

Also Published As

Publication number Publication date
EP0471036B2 (en) 2004-06-23
IL94296A (en) 1995-10-31
NO302683B1 (no) 1998-04-14
US5407609A (en) 1995-04-18
IL94296A0 (en) 1991-03-10
EP0471036A4 (en) 1992-03-18
JP2582186B2 (ja) 1997-02-19
KR0162660B1 (en) 1998-11-16
DE69024953D1 (de) 1996-02-29
CA2050911A1 (en) 1990-11-05
NZ233570A (en) 1992-12-23
FI103183B (fi) 1999-05-14
ES2084698T5 (es) 2005-03-01
HK30897A (en) 1997-03-21
WO1990013361A1 (en) 1990-11-15
FI103183B1 (fi) 1999-05-14
KR920700762A (ko) 1992-08-10
DK0471036T3 (da) 1996-05-28
ZA903411B (en) 1991-02-27
IE69313B1 (en) 1996-09-04
EP0471036A1 (en) 1992-02-19
IE901616L (en) 1990-11-04
DE69024953T2 (de) 1996-08-14
AU5741590A (en) 1990-11-29
JPH04505454A (ja) 1992-09-24
CA2050911C (en) 1997-07-15
NO914292D0 (no) 1991-11-01
ES2084698T3 (es) 1996-05-16
MX20594A (es) 1994-03-31
GR1000614B (el) 1992-08-31
EP0471036B1 (en) 1996-01-17
FI915129A0 (fi) 1991-10-30
DE69024953T3 (de) 2005-01-27
GR900100330A (en) 1991-10-10
DK0471036T4 (da) 2004-07-19
CN1047223A (zh) 1990-11-28
ATE133087T1 (de) 1996-02-15

Similar Documents

Publication Publication Date Title
NO914292L (no) Forbedret innkapslingsprosess, samt produkter fra denne prosess
SE8105897L (sv) Sett for mikroinkapsling
ES2084171T3 (es) Sustitutivos de grasas y metodo de preparar microglobulos organicos.
ES523834A0 (es) Metodo y dispositivo para la formacion de fieltro de fibras que contienen un producto adicional.
AU3155571A (en) Process of facilitating the separation of oil from an oil-in-water liquid emulsion system
NZ235401A (en) Introducing a pharmaceutical substance into a container having a pressurised propellant therein
ATE12458T1 (de) Verfahren zum fuellen von hartkapseln mit pharmazeutischen produkten, die phospholipide enthalten und bei zimmertemperatur hochviskos sind.
FR2253615A1 (no)
CA920079A (en) Process for separating or breaking an emulsified mixture of liquid hydrocarbon, insoluble fluid and finely divided solid material
ZA773814B (en) A method of preparing a stable suspension of micronized solid particles in the oil phase of an oil-in-water emulsion such as a pigmented stain
DE3171100D1 (en) Process for separation of products containing propolis and products containing propolis
NZ220959A (en) Process for the production of emulsion explosive in solid cartridge form, and apparatus
ES2021345B3 (es) Metodo para la separacion y recuperacion de un material granulado de una suspension viscosa que contiene dicho material, y aparato para llevar a cabo dicho metodo.
NL149485B (nl) Werkwijze voor de bereiding van 5h-dibenzo (a,d) cyclohepteen-5-carbonamiden en 10, 11-dihydro-5h-dibenzo (a,d)-cyclohepteen-5-carbonamiden, een werkwijze voor de bereiding van een geneesmiddel met anti-aritmische en anti-hypertensieve werking, alsmede een dergelijk geneesmiddel.
IT8120873A0 (it) Metodo per formare su un supporto quale un crosta di pelle un rivestimento finemente rugoso di elevata trasparenza e brillantezza,apparecchiatura per attuare tale metodo e manufatti cosi&#39; ottenuti.
NL187974C (nl) O-gesubstitueerde oximderivaten, werkwijze voor de bereiding daarvan, alsmede farmaceutische preparaten, die dergelijke verbindingen bevatten.
JPS52110708A (en) Method of oil expression and apparatus for it
JPS545389A (en) Double checking method for good product
Duby ELECTROMETALLURGY, ARTICLE FROM ANNUAL REVIEW OF EXTRACTIVE AND PROCESS METALLURGY
BR7410065A (pt) Composicao de materia de mistura emulsificada e processo para recuperacao de petroleo de um reservatorio subterrane
JPS52138751A (en) Method and apparatus of crush clearance regulation
JPS57191313A (en) Method of making feather into down
IT1196911B (it) Apparecchiatura per l&#39;estrazione dei prosciutti cotti e simili dagli stampi
NL178251C (nl) 5-gesubstitueerde picolinezuren en derivaten daarvan met bloeddruk verlagende werking, werkwijze voor de bereiding daarvan en preparaten die ze bevatten.
NL177210C (nl) Anti-arritmische n,n&#39;-bis-(fenylcarbamoylmethyl)amidinen, werkwijze voor het bereiden daarvan en farmaceutische preparaten die deze stoffen bevatten.

Legal Events

Date Code Title Description
MK1K Patent expired