BRPI0409032A - método para a produção de micropartìculas à base de emulsão - Google Patents

método para a produção de micropartìculas à base de emulsão

Info

Publication number
BRPI0409032A
BRPI0409032A BRPI0409032-2A BRPI0409032A BRPI0409032A BR PI0409032 A BRPI0409032 A BR PI0409032A BR PI0409032 A BRPI0409032 A BR PI0409032A BR PI0409032 A BRPI0409032 A BR PI0409032A
Authority
BR
Brazil
Prior art keywords
emulsion
production
based microparticles
vessel
methods
Prior art date
Application number
BRPI0409032-2A
Other languages
English (en)
Inventor
Ehud Zeigerson
Original Assignee
Pr Pharmaceuticals
Ehud Zeigerson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pr Pharmaceuticals, Ehud Zeigerson filed Critical Pr Pharmaceuticals
Publication of BRPI0409032A publication Critical patent/BRPI0409032A/pt

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
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    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/06—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a liquid medium
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    • C08J3/12—Powdering or granulating
    • C08J3/14—Powdering or granulating by precipitation from solutions

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Polymers & Plastics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Dispersion Chemistry (AREA)
  • Cardiology (AREA)
  • Toxicology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Anesthesiology (AREA)

Abstract

"MéTODOS E APARELHO PARA PREPARAçãO E PRODUçãO DE MICROPARTìCULAS à BASE DE EMULSãO". Para a produção de micropartículas á base de emulsão que contêm um agente biológico ou químico, sendo que o aparelho compreende um vaso; material de compactação situado dentro de tal vaso, e também pode compreender um material que pode ser inserido em ambas as extremidades do dito vaso para encerrar o material de compactação; em uma realização particular, o aparelho é de leito compactado; os métodos incluem a produção de micropartículas à base de emulsão que contêm um agente biológico ou químico; a utilidade da presente invenção é que os aparelhos e os métodos da presente invenção propiciam uma produção não turbulenta de baixo cisalhamento de micropartículas à base de emulsão que resulta em uma distribuição de tamanho de partícula estreita reproduzível, que pode ser utilizada com volumes grandes e pequenos que podem ser convenientemente escalonados para cima enquanto propiciam propriedades de emulsão previsíveis.
BRPI0409032-2A 2003-04-10 2004-04-12 método para a produção de micropartìculas à base de emulsão BRPI0409032A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46186003P 2003-04-10 2003-04-10
PCT/US2004/011485 WO2005003180A2 (en) 2003-04-10 2004-04-12 A method for the production of emulsion-based micro particles

Publications (1)

Publication Number Publication Date
BRPI0409032A true BRPI0409032A (pt) 2006-05-02

Family

ID=33563700

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0409032-2A BRPI0409032A (pt) 2003-04-10 2004-04-12 método para a produção de micropartìculas à base de emulsão

Country Status (10)

Country Link
US (2) US8916196B2 (pt)
EP (2) EP2548550A1 (pt)
JP (3) JP2007515392A (pt)
CN (2) CN101410174B (pt)
AU (1) AU2004253853B2 (pt)
BR (1) BRPI0409032A (pt)
CA (1) CA2516107C (pt)
ES (1) ES2427092T3 (pt)
PT (1) PT1615959E (pt)
WO (1) WO2005003180A2 (pt)

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