NO329193B1 - Paramyksovirus cDNA for fremstilling av medikamenter mot Newcastle-Disease hos fjaerfe. - Google Patents
Paramyksovirus cDNA for fremstilling av medikamenter mot Newcastle-Disease hos fjaerfe. Download PDFInfo
- Publication number
- NO329193B1 NO329193B1 NO20006406A NO20006406A NO329193B1 NO 329193 B1 NO329193 B1 NO 329193B1 NO 20006406 A NO20006406 A NO 20006406A NO 20006406 A NO20006406 A NO 20006406A NO 329193 B1 NO329193 B1 NO 329193B1
- Authority
- NO
- Norway
- Prior art keywords
- ndv
- cdna
- virus
- protein
- cells
- Prior art date
Links
- 239000002299 complementary DNA Substances 0.000 title claims description 109
- 208000010359 Newcastle Disease Diseases 0.000 title description 16
- 238000002360 preparation method Methods 0.000 title description 2
- 241001494479 Pecora Species 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 241000700605 Viruses Species 0.000 claims description 132
- 108090000623 proteins and genes Proteins 0.000 claims description 122
- 229960005486 vaccine Drugs 0.000 claims description 108
- 208000015181 infectious disease Diseases 0.000 claims description 88
- 101710133291 Hemagglutinin-neuraminidase Proteins 0.000 claims description 74
- 241000271566 Aves Species 0.000 claims description 66
- 102000004169 proteins and genes Human genes 0.000 claims description 63
- 230000002458 infectious effect Effects 0.000 claims description 62
- 238000000034 method Methods 0.000 claims description 59
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims description 38
- 108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 claims description 36
- 238000003776 cleavage reaction Methods 0.000 claims description 32
- 230000007017 scission Effects 0.000 claims description 32
- 241000711404 Avian avulavirus 1 Species 0.000 claims description 30
- 239000003550 marker Substances 0.000 claims description 27
- 244000144977 poultry Species 0.000 claims description 22
- 235000013594 poultry meat Nutrition 0.000 claims description 22
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims description 19
- 241000287828 Gallus gallus Species 0.000 claims description 19
- 229960000458 allantoin Drugs 0.000 claims description 19
- 241001465754 Metazoa Species 0.000 claims description 18
- 108090001074 Nucleocapsid Proteins Proteins 0.000 claims description 18
- 108091005804 Peptidases Proteins 0.000 claims description 18
- 239000004365 Protease Substances 0.000 claims description 18
- 235000013330 chicken meat Nutrition 0.000 claims description 17
- 150000007523 nucleic acids Chemical group 0.000 claims description 17
- 230000003612 virological effect Effects 0.000 claims description 17
- 230000004048 modification Effects 0.000 claims description 16
- 238000012986 modification Methods 0.000 claims description 16
- 239000000427 antigen Substances 0.000 claims description 14
- 108091007433 antigens Proteins 0.000 claims description 14
- 102000036639 antigens Human genes 0.000 claims description 14
- 230000037430 deletion Effects 0.000 claims description 13
- 238000012217 deletion Methods 0.000 claims description 13
- 230000002797 proteolythic effect Effects 0.000 claims description 13
- 102000039446 nucleic acids Human genes 0.000 claims description 11
- 108020004707 nucleic acids Proteins 0.000 claims description 11
- 244000052769 pathogen Species 0.000 claims description 11
- 230000004927 fusion Effects 0.000 claims description 9
- 238000004519 manufacturing process Methods 0.000 claims description 9
- 108010067390 Viral Proteins Proteins 0.000 claims description 8
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 7
- 230000003308 immunostimulating effect Effects 0.000 claims description 7
- 239000001963 growth medium Substances 0.000 claims description 5
- 230000001717 pathogenic effect Effects 0.000 claims description 5
- 230000003362 replicative effect Effects 0.000 claims description 5
- 108060003393 Granulin Proteins 0.000 claims description 4
- 230000037431 insertion Effects 0.000 claims description 4
- 238000003780 insertion Methods 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- 230000035772 mutation Effects 0.000 claims description 4
- 108020001507 fusion proteins Proteins 0.000 claims description 3
- 102000037865 fusion proteins Human genes 0.000 claims description 3
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 2
- 210000004027 cell Anatomy 0.000 description 144
- 239000013612 plasmid Substances 0.000 description 139
- 239000012634 fragment Substances 0.000 description 81
- 238000003752 polymerase chain reaction Methods 0.000 description 80
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 51
- 230000035897 transcription Effects 0.000 description 39
- 238000013518 transcription Methods 0.000 description 39
- 230000014509 gene expression Effects 0.000 description 37
- 108020004414 DNA Proteins 0.000 description 35
- 239000002773 nucleotide Substances 0.000 description 29
- 125000003729 nucleotide group Chemical group 0.000 description 29
- 201000010099 disease Diseases 0.000 description 26
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 26
- 230000010076 replication Effects 0.000 description 26
- 238000002255 vaccination Methods 0.000 description 26
- 238000010367 cloning Methods 0.000 description 25
- 101710137500 T7 RNA polymerase Proteins 0.000 description 23
- 235000013601 eggs Nutrition 0.000 description 23
- 230000001018 virulence Effects 0.000 description 21
- 238000012360 testing method Methods 0.000 description 20
- 238000006243 chemical reaction Methods 0.000 description 19
- 238000001727 in vivo Methods 0.000 description 17
- 239000000203 mixture Substances 0.000 description 17
- 101000988651 Homo sapiens Humanin-like 1 Proteins 0.000 description 16
- 230000029087 digestion Effects 0.000 description 16
- 239000013598 vector Substances 0.000 description 16
- 241001493169 Avian avulavirus 2 Species 0.000 description 14
- 101150008820 HN gene Proteins 0.000 description 14
- 239000002609 medium Substances 0.000 description 14
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 13
- 239000012530 fluid Substances 0.000 description 13
- 239000000463 material Substances 0.000 description 13
- 102100038132 Endogenous retrovirus group K member 6 Pro protein Human genes 0.000 description 12
- 230000035931 haemagglutination Effects 0.000 description 12
- 235000019419 proteases Nutrition 0.000 description 12
- 238000010839 reverse transcription Methods 0.000 description 12
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 description 11
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 description 11
- 108091027544 Subgenomic mRNA Proteins 0.000 description 11
- 239000002245 particle Substances 0.000 description 11
- 230000007918 pathogenicity Effects 0.000 description 11
- 239000000047 product Substances 0.000 description 11
- 238000012163 sequencing technique Methods 0.000 description 11
- 238000001890 transfection Methods 0.000 description 11
- 101001065501 Escherichia phage MS2 Lysis protein Proteins 0.000 description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 10
- 101150062031 L gene Proteins 0.000 description 10
- 125000003275 alpha amino acid group Chemical class 0.000 description 10
- 230000001419 dependent effect Effects 0.000 description 10
- 238000000338 in vitro Methods 0.000 description 10
- 239000006228 supernatant Substances 0.000 description 10
- 230000015572 biosynthetic process Effects 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- 241000272517 Anseriformes Species 0.000 description 8
- 101710085938 Matrix protein Proteins 0.000 description 8
- 101710127721 Membrane protein Proteins 0.000 description 8
- 108010019653 Pwo polymerase Proteins 0.000 description 8
- 238000010276 construction Methods 0.000 description 8
- 238000002474 experimental method Methods 0.000 description 8
- 229940031551 inactivated vaccine Drugs 0.000 description 8
- 238000003757 reverse transcription PCR Methods 0.000 description 8
- 108020004635 Complementary DNA Proteins 0.000 description 7
- 108091034117 Oligonucleotide Proteins 0.000 description 7
- 101710086015 RNA ligase Proteins 0.000 description 7
- 108020000999 Viral RNA Proteins 0.000 description 7
- 230000005875 antibody response Effects 0.000 description 7
- 238000003556 assay Methods 0.000 description 7
- 241001493065 dsRNA viruses Species 0.000 description 7
- 230000036039 immunity Effects 0.000 description 7
- 238000011534 incubation Methods 0.000 description 7
- 210000002345 respiratory system Anatomy 0.000 description 7
- 230000000405 serological effect Effects 0.000 description 7
- 241000272201 Columbiformes Species 0.000 description 6
- 102000012410 DNA Ligases Human genes 0.000 description 6
- 108010061982 DNA Ligases Proteins 0.000 description 6
- 102000004190 Enzymes Human genes 0.000 description 6
- 108090000790 Enzymes Proteins 0.000 description 6
- 101150034814 F gene Proteins 0.000 description 6
- 241000700662 Fowlpox virus Species 0.000 description 6
- 241000724709 Hepatitis delta virus Species 0.000 description 6
- 101710181008 P protein Proteins 0.000 description 6
- 241000286209 Phasianidae Species 0.000 description 6
- 101710177166 Phosphoprotein Proteins 0.000 description 6
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 6
- 150000001413 amino acids Chemical group 0.000 description 6
- 230000008901 benefit Effects 0.000 description 6
- 210000000170 cell membrane Anatomy 0.000 description 6
- 210000001035 gastrointestinal tract Anatomy 0.000 description 6
- 230000005764 inhibitory process Effects 0.000 description 6
- 108020004999 messenger RNA Proteins 0.000 description 6
- 230000036961 partial effect Effects 0.000 description 6
- 108091035707 Consensus sequence Proteins 0.000 description 5
- 108090000626 DNA-directed RNA polymerases Proteins 0.000 description 5
- 102000004163 DNA-directed RNA polymerases Human genes 0.000 description 5
- 241000588724 Escherichia coli Species 0.000 description 5
- 241000712003 Human respirovirus 3 Species 0.000 description 5
- 101100473971 Mus musculus Pdcd11 gene Proteins 0.000 description 5
- 206010028980 Neoplasm Diseases 0.000 description 5
- 101100030133 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) SEC53 gene Proteins 0.000 description 5
- 230000009471 action Effects 0.000 description 5
- 230000003115 biocidal effect Effects 0.000 description 5
- 239000007795 chemical reaction product Substances 0.000 description 5
- 230000000295 complement effect Effects 0.000 description 5
- 238000011161 development Methods 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 5
- 210000003743 erythrocyte Anatomy 0.000 description 5
- 230000001900 immune effect Effects 0.000 description 5
- 230000000241 respiratory effect Effects 0.000 description 5
- 208000023504 respiratory system disease Diseases 0.000 description 5
- 210000002966 serum Anatomy 0.000 description 5
- 238000001228 spectrum Methods 0.000 description 5
- 238000003786 synthesis reaction Methods 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 4
- 102000053642 Catalytic RNA Human genes 0.000 description 4
- 108090000994 Catalytic RNA Proteins 0.000 description 4
- 102000019034 Chemokines Human genes 0.000 description 4
- 108010012236 Chemokines Proteins 0.000 description 4
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
- 108010017826 DNA Polymerase I Proteins 0.000 description 4
- 102000004594 DNA Polymerase I Human genes 0.000 description 4
- 238000002965 ELISA Methods 0.000 description 4
- 241000282414 Homo sapiens Species 0.000 description 4
- 208000002979 Influenza in Birds Diseases 0.000 description 4
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 4
- 241000711408 Murine respirovirus Species 0.000 description 4
- 102000035195 Peptidases Human genes 0.000 description 4
- 230000000890 antigenic effect Effects 0.000 description 4
- 230000002238 attenuated effect Effects 0.000 description 4
- 239000003651 drinking water Substances 0.000 description 4
- 235000020188 drinking water Nutrition 0.000 description 4
- 244000144992 flock Species 0.000 description 4
- 238000012239 gene modification Methods 0.000 description 4
- 230000002068 genetic effect Effects 0.000 description 4
- 230000005017 genetic modification Effects 0.000 description 4
- 235000013617 genetically modified food Nutrition 0.000 description 4
- 230000005847 immunogenicity Effects 0.000 description 4
- 231100000518 lethal Toxicity 0.000 description 4
- 230000001665 lethal effect Effects 0.000 description 4
- 230000033001 locomotion Effects 0.000 description 4
- 230000003472 neutralizing effect Effects 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 239000011541 reaction mixture Substances 0.000 description 4
- 230000004044 response Effects 0.000 description 4
- 230000002441 reversible effect Effects 0.000 description 4
- 108091092562 ribozyme Proteins 0.000 description 4
- 238000011282 treatment Methods 0.000 description 4
- 210000002845 virion Anatomy 0.000 description 4
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 3
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 3
- 241001135673 Avian avulavirus 4 Species 0.000 description 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- 241000701832 Enterobacteria phage T3 Species 0.000 description 3
- 241000701047 Gallid alphaherpesvirus 2 Species 0.000 description 3
- 208000037262 Hepatitis delta Diseases 0.000 description 3
- 101001081170 Homo sapiens Humanin-like 12 Proteins 0.000 description 3
- 102100027737 Humanin-like 12 Human genes 0.000 description 3
- 102100034349 Integrase Human genes 0.000 description 3
- 241001559185 Mammalian rubulavirus 5 Species 0.000 description 3
- 108700008625 Reporter Genes Proteins 0.000 description 3
- 241001559173 Simian rubulavirus Species 0.000 description 3
- 108010008038 Synthetic Vaccines Proteins 0.000 description 3
- 239000000443 aerosol Substances 0.000 description 3
- 230000003321 amplification Effects 0.000 description 3
- 230000034303 cell budding Effects 0.000 description 3
- 238000012512 characterization method Methods 0.000 description 3
- 229960005091 chloramphenicol Drugs 0.000 description 3
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 3
- 238000012761 co-transfection Methods 0.000 description 3
- 238000002405 diagnostic procedure Methods 0.000 description 3
- 230000004069 differentiation Effects 0.000 description 3
- 230000008030 elimination Effects 0.000 description 3
- 238000003379 elimination reaction Methods 0.000 description 3
- 230000008029 eradication Effects 0.000 description 3
- 208000029570 hepatitis D virus infection Diseases 0.000 description 3
- 244000144980 herd Species 0.000 description 3
- 230000003053 immunization Effects 0.000 description 3
- 230000006698 induction Effects 0.000 description 3
- 238000011081 inoculation Methods 0.000 description 3
- 230000003993 interaction Effects 0.000 description 3
- 238000002955 isolation Methods 0.000 description 3
- 230000008774 maternal effect Effects 0.000 description 3
- 231100000350 mutagenesis Toxicity 0.000 description 3
- 238000002703 mutagenesis Methods 0.000 description 3
- 238000006386 neutralization reaction Methods 0.000 description 3
- 238000003199 nucleic acid amplification method Methods 0.000 description 3
- 239000002243 precursor Substances 0.000 description 3
- 230000006337 proteolytic cleavage Effects 0.000 description 3
- 238000000746 purification Methods 0.000 description 3
- 229940124551 recombinant vaccine Drugs 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 230000005030 transcription termination Effects 0.000 description 3
- 210000004881 tumor cell Anatomy 0.000 description 3
- BHELIUBJHYAEDK-OAIUPTLZSA-N Aspoxicillin Chemical compound C1([C@H](C(=O)N[C@@H]2C(N3[C@H](C(C)(C)S[C@@H]32)C(O)=O)=O)NC(=O)[C@H](N)CC(=O)NC)=CC=C(O)C=C1 BHELIUBJHYAEDK-OAIUPTLZSA-N 0.000 description 2
- 241000713826 Avian leukosis virus Species 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
- 241000725585 Chicken anemia virus Species 0.000 description 2
- 102000053602 DNA Human genes 0.000 description 2
- 238000009007 Diagnostic Kit Methods 0.000 description 2
- 239000006145 Eagle's minimal essential medium Substances 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- 208000000666 Fowlpox Diseases 0.000 description 2
- 241000701063 Gallid alphaherpesvirus 1 Species 0.000 description 2
- 108090000288 Glycoproteins Proteins 0.000 description 2
- 102000003886 Glycoproteins Human genes 0.000 description 2
- 108091080980 Hepatitis delta virus ribozyme Proteins 0.000 description 2
- 241000711450 Infectious bronchitis virus Species 0.000 description 2
- 241000702626 Infectious bursal disease virus Species 0.000 description 2
- 102000014150 Interferons Human genes 0.000 description 2
- 108010050904 Interferons Proteins 0.000 description 2
- 235000019687 Lamb Nutrition 0.000 description 2
- 241000712079 Measles morbillivirus Species 0.000 description 2
- 102100039364 Metalloproteinase inhibitor 1 Human genes 0.000 description 2
- 101150118742 NP gene Proteins 0.000 description 2
- 101100065137 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) prt-1 gene Proteins 0.000 description 2
- 101150084044 P gene Proteins 0.000 description 2
- 238000009004 PCR Kit Methods 0.000 description 2
- 241000711504 Paramyxoviridae Species 0.000 description 2
- 241000711502 Paramyxovirinae Species 0.000 description 2
- 241000711798 Rabies lyssavirus Species 0.000 description 2
- 241000711897 Rinderpest morbillivirus Species 0.000 description 2
- 238000012300 Sequence Analysis Methods 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 108091081024 Start codon Proteins 0.000 description 2
- 210000001744 T-lymphocyte Anatomy 0.000 description 2
- 102100038126 Tenascin Human genes 0.000 description 2
- 108010008125 Tenascin Proteins 0.000 description 2
- 108010003533 Viral Envelope Proteins Proteins 0.000 description 2
- 230000010530 Virus Neutralization Effects 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 206010064097 avian influenza Diseases 0.000 description 2
- 230000008827 biological function Effects 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 210000004899 c-terminal region Anatomy 0.000 description 2
- 230000007910 cell fusion Effects 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000004186 co-expression Effects 0.000 description 2
- 238000012258 culturing Methods 0.000 description 2
- 210000000805 cytoplasm Anatomy 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- FFYPMLJYZAEMQB-UHFFFAOYSA-N diethyl pyrocarbonate Chemical compound CCOC(=O)OC(=O)OCC FFYPMLJYZAEMQB-UHFFFAOYSA-N 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 239000013604 expression vector Substances 0.000 description 2
- 239000012894 fetal calf serum Substances 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 230000028993 immune response Effects 0.000 description 2
- 238000002649 immunization Methods 0.000 description 2
- 230000002163 immunogen Effects 0.000 description 2
- 230000000977 initiatory effect Effects 0.000 description 2
- 229940047124 interferons Drugs 0.000 description 2
- 208000028774 intestinal disease Diseases 0.000 description 2
- 229930027917 kanamycin Natural products 0.000 description 2
- 229960000318 kanamycin Drugs 0.000 description 2
- SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 description 2
- 229930182823 kanamycin A Natural products 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 230000002147 killing effect Effects 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 229910001629 magnesium chloride Inorganic materials 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000001404 mediated effect Effects 0.000 description 2
- 210000004779 membrane envelope Anatomy 0.000 description 2
- 239000013642 negative control Substances 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 230000004983 pleiotropic effect Effects 0.000 description 2
- 230000003389 potentiating effect Effects 0.000 description 2
- 235000013613 poultry product Nutrition 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 230000001915 proofreading effect Effects 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 230000009257 reactivity Effects 0.000 description 2
- 238000012552 review Methods 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 230000007480 spreading Effects 0.000 description 2
- 238000003892 spreading Methods 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- 230000002103 transcriptional effect Effects 0.000 description 2
- 230000010474 transient expression Effects 0.000 description 2
- 238000013519 translation Methods 0.000 description 2
- 241000701447 unidentified baculovirus Species 0.000 description 2
- 230000029812 viral genome replication Effects 0.000 description 2
- 230000009385 viral infection Effects 0.000 description 2
- 229960004854 viral vaccine Drugs 0.000 description 2
- RNAMYOYQYRYFQY-UHFFFAOYSA-N 2-(4,4-difluoropiperidin-1-yl)-6-methoxy-n-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine Chemical compound N1=C(N2CCC(F)(F)CC2)N=C2C=C(OCCCN3CCCC3)C(OC)=CC2=C1NC1CCN(C(C)C)CC1 RNAMYOYQYRYFQY-UHFFFAOYSA-N 0.000 description 1
- 208000010543 22q11.2 deletion syndrome Diseases 0.000 description 1
- ZKRFOXLVOKTUTA-KQYNXXCUSA-N 9-(5-phosphoribofuranosyl)-6-mercaptopurine Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]1N1C(NC=NC2=S)=C2N=C1 ZKRFOXLVOKTUTA-KQYNXXCUSA-N 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 241000588813 Alcaligenes faecalis Species 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 241000228197 Aspergillus flavus Species 0.000 description 1
- 241001225321 Aspergillus fumigatus Species 0.000 description 1
- 241000588851 Bordetella avium Species 0.000 description 1
- 241000589875 Campylobacter jejuni Species 0.000 description 1
- 101800001299 Cerebellin Proteins 0.000 description 1
- 102000001327 Chemokine CCL5 Human genes 0.000 description 1
- 108010055166 Chemokine CCL5 Proteins 0.000 description 1
- 241000710777 Classical swine fever virus Species 0.000 description 1
- 108091026890 Coding region Proteins 0.000 description 1
- 108020004705 Codon Proteins 0.000 description 1
- 208000003322 Coinfection Diseases 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 101800000414 Corticotropin Proteins 0.000 description 1
- 239000000055 Corticotropin-Releasing Hormone Substances 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 108010067770 Endopeptidase K Proteins 0.000 description 1
- 102000009025 Endorphins Human genes 0.000 description 1
- 108010049140 Endorphins Proteins 0.000 description 1
- 101710121417 Envelope glycoprotein Proteins 0.000 description 1
- 101710091045 Envelope protein Proteins 0.000 description 1
- 108700039887 Essential Genes Proteins 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 101000669513 Homo sapiens Metalloproteinase inhibitor 1 Proteins 0.000 description 1
- 101000635799 Homo sapiens Run domain Beclin-1-interacting and cysteine-rich domain-containing protein Proteins 0.000 description 1
- 241000701024 Human betaherpesvirus 5 Species 0.000 description 1
- 241000711920 Human orthopneumovirus Species 0.000 description 1
- 241001559187 Human rubulavirus 2 Species 0.000 description 1
- 102100029068 Humanin-like 4 Human genes 0.000 description 1
- 238000012404 In vitro experiment Methods 0.000 description 1
- 102100034353 Integrase Human genes 0.000 description 1
- 101710125507 Integrase/recombinase Proteins 0.000 description 1
- 108010002352 Interleukin-1 Proteins 0.000 description 1
- 108090001005 Interleukin-6 Proteins 0.000 description 1
- 108020004684 Internal Ribosome Entry Sites Proteins 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- 108700018351 Major Histocompatibility Complex Proteins 0.000 description 1
- 208000006758 Marek Disease Diseases 0.000 description 1
- 108050006599 Metalloproteinase inhibitor 1 Proteins 0.000 description 1
- 241000711513 Mononegavirales Species 0.000 description 1
- 241000712045 Morbillivirus Species 0.000 description 1
- 241000711386 Mumps virus Species 0.000 description 1
- 241000699660 Mus musculus Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 241000204022 Mycoplasma gallisepticum Species 0.000 description 1
- 241000202967 Mycoplasma iowae Species 0.000 description 1
- 102000005348 Neuraminidase Human genes 0.000 description 1
- 108010006232 Neuraminidase Proteins 0.000 description 1
- 102100029438 Nitric oxide synthase, inducible Human genes 0.000 description 1
- 101710089543 Nitric oxide synthase, inducible Proteins 0.000 description 1
- 108091092724 Noncoding DNA Proteins 0.000 description 1
- 102000011931 Nucleoproteins Human genes 0.000 description 1
- 108010061100 Nucleoproteins Proteins 0.000 description 1
- 241000337007 Oceania Species 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 208000002606 Paramyxoviridae Infections Diseases 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 108010089430 Phosphoproteins Proteins 0.000 description 1
- 102000007982 Phosphoproteins Human genes 0.000 description 1
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 1
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 1
- 206010035148 Plague Diseases 0.000 description 1
- 241000711902 Pneumovirus Species 0.000 description 1
- 108010021757 Polynucleotide 5'-Hydroxyl-Kinase Proteins 0.000 description 1
- 102000008422 Polynucleotide 5'-hydroxyl-kinase Human genes 0.000 description 1
- 102100027467 Pro-opiomelanocortin Human genes 0.000 description 1
- 102000029301 Protein S Human genes 0.000 description 1
- 229940096437 Protein S Drugs 0.000 description 1
- 101710188315 Protein X Proteins 0.000 description 1
- 238000010357 RNA editing Methods 0.000 description 1
- 230000026279 RNA modification Effects 0.000 description 1
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 description 1
- 108020004511 Recombinant DNA Proteins 0.000 description 1
- 208000035415 Reinfection Diseases 0.000 description 1
- 241000702263 Reovirus sp. Species 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 241001478225 Riemerella Species 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 241001533467 Rubulavirus Species 0.000 description 1
- 102100030852 Run domain Beclin-1-interacting and cysteine-rich domain-containing protein Human genes 0.000 description 1
- 101100285899 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) SSE2 gene Proteins 0.000 description 1
- 241001354013 Salmonella enterica subsp. enterica serovar Enteritidis Species 0.000 description 1
- 108020004682 Single-Stranded DNA Proteins 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- 101710167605 Spike glycoprotein Proteins 0.000 description 1
- 241000271567 Struthioniformes Species 0.000 description 1
- 101800001271 Surface protein Proteins 0.000 description 1
- 108091008874 T cell receptors Proteins 0.000 description 1
- 230000005867 T cell response Effects 0.000 description 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 description 1
- 108010006785 Taq Polymerase Proteins 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
- 102100040247 Tumor necrosis factor Human genes 0.000 description 1
- 206010046865 Vaccinia virus infection Diseases 0.000 description 1
- 241000711975 Vesicular stomatitis virus Species 0.000 description 1
- 241001672648 Vieira Species 0.000 description 1
- 206010058874 Viraemia Diseases 0.000 description 1
- 108020005202 Viral DNA Proteins 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 238000012387 aerosolization Methods 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 238000000246 agarose gel electrophoresis Methods 0.000 description 1
- 230000004520 agglutination Effects 0.000 description 1
- 229940005347 alcaligenes faecalis Drugs 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000118 anti-neoplastic effect Effects 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- VEZXCJBBBCKRPI-UHFFFAOYSA-N beta-propiolactone Chemical compound O=C1CCO1 VEZXCJBBBCKRPI-UHFFFAOYSA-N 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 201000006824 bubonic plague Diseases 0.000 description 1
- 238000010804 cDNA synthesis Methods 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 229940030156 cell vaccine Drugs 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 210000003837 chick embryo Anatomy 0.000 description 1
- 230000001886 ciliary effect Effects 0.000 description 1
- GVPFVAHMJGGAJG-UHFFFAOYSA-L cobalt dichloride Chemical compound [Cl-].[Cl-].[Co+2] GVPFVAHMJGGAJG-UHFFFAOYSA-L 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000010668 complexation reaction Methods 0.000 description 1
- IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 description 1
- 229960000258 corticotropin Drugs 0.000 description 1
- 239000012228 culture supernatant Substances 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 108010030074 endodeoxyribonuclease MluI Proteins 0.000 description 1
- 108010078428 env Gene Products Proteins 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 229940023064 escherichia coli Drugs 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 239000012737 fresh medium Substances 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 230000001894 hemadsorption Effects 0.000 description 1
- 238000010211 hemagglutination inhibition (HI) assay Methods 0.000 description 1
- 230000002008 hemorrhagic effect Effects 0.000 description 1
- 235000010299 hexamethylene tetramine Nutrition 0.000 description 1
- 239000004312 hexamethylene tetramine Substances 0.000 description 1
- VKYKSIONXSXAKP-UHFFFAOYSA-N hexamethylenetetramine Chemical compound C1N(C2)CN3CN1CN2C3 VKYKSIONXSXAKP-UHFFFAOYSA-N 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 230000028996 humoral immune response Effects 0.000 description 1
- 230000004727 humoral immunity Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 230000003903 intestinal lesions Effects 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 239000010985 leather Substances 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 229940124590 live attenuated vaccine Drugs 0.000 description 1
- 229940023012 live-attenuated vaccine Drugs 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000006166 lysate Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000034217 membrane fusion Effects 0.000 description 1
- 230000001617 migratory effect Effects 0.000 description 1
- 102000035118 modified proteins Human genes 0.000 description 1
- 108091005573 modified proteins Proteins 0.000 description 1
- 231100000219 mutagenic Toxicity 0.000 description 1
- 230000003505 mutagenic effect Effects 0.000 description 1
- 230000000926 neurological effect Effects 0.000 description 1
- 230000002276 neurotropic effect Effects 0.000 description 1
- 238000011580 nude mouse model Methods 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 229960005030 other vaccine in atc Drugs 0.000 description 1
- 108700010867 paramyxovirus proteins Proteins 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N phenylalanine group Chemical group N[C@@H](CC1=CC=CC=C1)C(=O)O COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
- IZRPKIZLIFYYKR-UHFFFAOYSA-N phenyltoloxamine Chemical compound CN(C)CCOC1=CC=CC=C1CC1=CC=CC=C1 IZRPKIZLIFYYKR-UHFFFAOYSA-N 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000001323 posttranslational effect Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 229960000380 propiolactone Drugs 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 238000010188 recombinant method Methods 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 108091008146 restriction endonucleases Proteins 0.000 description 1
- 238000012770 revaccination Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 238000003307 slaughter Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000010415 tropism Effects 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 230000001810 trypsinlike Effects 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 241001529453 unidentified herpesvirus Species 0.000 description 1
- 208000007089 vaccinia Diseases 0.000 description 1
- 230000006490 viral transcription Effects 0.000 description 1
- 230000003253 viricidal effect Effects 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
- C12N2760/18122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
- C12N2760/18141—Use of virus, viral particle or viral elements as a vector
- C12N2760/18143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98202054A EP0974660A1 (en) | 1998-06-19 | 1998-06-19 | Newcastle disease virus infectious clones, vaccines and diagnostic assays |
| PCT/NL1999/000377 WO1999066045A1 (en) | 1998-06-19 | 1999-06-17 | Newcastle disease virus infectious clones, vaccines and diagnostic assays |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20006406D0 NO20006406D0 (no) | 2000-12-15 |
| NO20006406L NO20006406L (no) | 2001-02-19 |
| NO329193B1 true NO329193B1 (no) | 2010-09-13 |
Family
ID=8233832
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20006406A NO329193B1 (no) | 1998-06-19 | 2000-12-15 | Paramyksovirus cDNA for fremstilling av medikamenter mot Newcastle-Disease hos fjaerfe. |
Country Status (28)
| Country | Link |
|---|---|
| US (3) | US6719979B2 (uk) |
| EP (2) | EP0974660A1 (uk) |
| JP (3) | JP2002518012A (uk) |
| KR (1) | KR20010053000A (uk) |
| CN (2) | CN1314942A (uk) |
| AR (1) | AR020091A1 (uk) |
| AT (1) | ATE367442T1 (uk) |
| AU (1) | AU754844B2 (uk) |
| BR (1) | BR9911383A (uk) |
| CA (1) | CA2334165A1 (uk) |
| CZ (1) | CZ300760B6 (uk) |
| DE (1) | DE69936585T2 (uk) |
| DK (1) | DK1088077T3 (uk) |
| EA (1) | EA004796B1 (uk) |
| ES (1) | ES2291029T3 (uk) |
| HR (1) | HRP20010042B1 (uk) |
| HU (1) | HUP0102429A3 (uk) |
| ID (1) | ID27343A (uk) |
| IL (2) | IL140381A0 (uk) |
| NO (1) | NO329193B1 (uk) |
| NZ (1) | NZ508982A (uk) |
| PL (1) | PL197722B1 (uk) |
| PT (1) | PT1088077E (uk) |
| SI (1) | SI1088077T1 (uk) |
| TR (1) | TR200100350T2 (uk) |
| UA (1) | UA77146C2 (uk) |
| WO (1) | WO1999066045A1 (uk) |
| ZA (1) | ZA200100241B (uk) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0974660A1 (en) | 1998-06-19 | 2000-01-26 | Stichting Instituut voor Dierhouderij en Diergezondheid (ID-DLO) | Newcastle disease virus infectious clones, vaccines and diagnostic assays |
| US6146642A (en) * | 1998-09-14 | 2000-11-14 | Mount Sinai School Of Medicine, Of The City University Of New York | Recombinant new castle disease virus RNA expression systems and vaccines |
| US10383936B2 (en) * | 1999-05-05 | 2019-08-20 | University Of Maryland, College Park | Infectious laryngotracheitis virus (ILTV) vaccine using recombinant newcastle disease virus vector |
| US7244558B1 (en) * | 1999-05-05 | 2007-07-17 | University Of Maryland | Production of novel Newcastle disease virus strains from cDNAs and improved live attenuated Newcastle disease vaccines |
| EP1074614B1 (en) * | 1999-07-27 | 2004-07-07 | Akzo Nobel N.V. | A recombinant Newcastle disease virus for in ovo vaccination |
| CA2312626A1 (en) * | 1999-07-27 | 2001-01-27 | Akzo Nobel N.V. | A recombinant newcastle disease virus as an embryo vaccine |
| US6921535B2 (en) | 2000-06-23 | 2005-07-26 | Akzo Nobel N.V. | Attenuated Bovine Respiratory Syncytial virus |
| CA2427578C (en) * | 2000-11-02 | 2011-09-06 | Akzo Nobel N.V. | A recombinant newcastle disease virus nucleoprotein mutant as a marker vaccine |
| KR100437888B1 (ko) * | 2001-07-30 | 2004-07-03 | 주식회사 인트론바이오테크놀로지 | 뉴캐슬병 바이러스 검출용 프라이머 및 상기 프라이머를이용한 뉴캐슬병 바이러스 검출, 병원성 및 유전형 조사방법 |
| IL145397A0 (en) * | 2001-09-12 | 2002-06-30 | Yissum Res Dev Co | Compositions and methods for treatment of cancer |
| US7615209B2 (en) | 2001-09-12 | 2009-11-10 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Compositions of NDV and methods of use thereof for treatment of cancer |
| ATE307606T1 (de) * | 2001-10-04 | 2005-11-15 | Ct Voor Onderzoek In Diergenee | Abgeschwächter mutantenstamm eines virus der newcastle-krankheit für eine in ovo impfung und dessen benutzung |
| JP2005518209A (ja) * | 2002-02-21 | 2005-06-23 | マウント シナイ スクール オブ メディシン | 組換えマイナス鎖ウイルスｒｎａ発現系およびワクチン |
| TW200502402A (en) * | 2002-12-06 | 2005-01-16 | Wyeth Corp | Escape mutants of newcastle disease virus as marker vaccines |
| AU2004235813B2 (en) | 2003-05-05 | 2010-07-29 | Boyce Thompson Institute For Plant Research | Vectors and cells for preparing immunoprotective compositions derived from transgenic plants |
| EP1635772A4 (en) * | 2003-05-05 | 2008-02-13 | Dow Agrosciences Llc | STERILE IMMUNOPROPHYLACTIC AND THERAPEUTIC COMPOSITIONS DERIVED FROM TRANSGENIC VEGETABLE CELLS AND METHODS OF PRODUCTION THEREOF |
| DE602004028736D1 (de) | 2003-06-20 | 2010-09-30 | Microbix Biosystems Inc | Verbesserungen bei der virusproduktion |
| US7527638B2 (en) | 2003-12-16 | 2009-05-05 | Depuy Spine, Inc. | Methods and devices for minimally invasive spinal fixation element placement |
| MY146476A (en) | 2004-06-24 | 2012-08-15 | Boehringer Ingelheim Vetmed | Method of diagnosing lawsonia intracellularis |
| GB0423681D0 (en) * | 2004-10-26 | 2004-11-24 | Sec Dep For Environment Food & | Vaccine and nucleic acids |
| NZ581958A (en) | 2004-11-12 | 2011-01-28 | Bayer Schering Pharma Ag | Recombinant newcastle disease virus comprising a transgene encoding a prodrug-converting enzyme or protease for use in the treatment of cancer |
| US7871626B2 (en) | 2005-08-04 | 2011-01-18 | St. Jude Children's Research Hospital | Modified influenza virus for monitoring and improving vaccine efficiency |
| US7951384B2 (en) * | 2005-08-05 | 2011-05-31 | University Of Massachusetts | Virus-like particles as vaccines for paramyxovirus |
| US9216212B2 (en) * | 2005-08-05 | 2015-12-22 | University Of Massachusetts | Virus-like particles as vaccines for paramyxovirus |
| HUE037460T2 (hu) | 2005-12-02 | 2018-08-28 | Icahn School Med Mount Sinai | Nem-natív felületi fehérjéket prezentáló kiméra Newcastle disease vírusok és alkalmazásuk |
| MX2008011728A (es) * | 2006-03-15 | 2008-12-10 | Intervet Int Bv | Virus de enfermedad de newcastle recombinante que expresa hemaglutinina h5 de virus de influenza aviar. |
| KR20080103602A (ko) * | 2006-03-15 | 2008-11-27 | 인터벳 인터내셔널 비.브이. | 재조합 모노네가바이랄러스 바이러스 벡터 |
| KR100776398B1 (ko) * | 2006-03-23 | 2007-11-28 | 주식회사 고려비엔피 | 조류 ｈｎ 단백질의 에피토프 및 상기 변이 에피토프를포함하는 뉴캐슬병 바이러스 |
| KR100801180B1 (ko) * | 2006-09-26 | 2008-02-05 | 주식회사 고려비엔피 | 약독화된 재조합 뉴캐슬병 바이러스 및 이를 함유하는뉴캐슬병 백신 |
| KR100874256B1 (ko) | 2007-02-12 | 2008-12-16 | 대한민국 | 대장균 내독소 단백질 및 뉴캐슬병 바이러스뉴라미니데이즈 에피토프의 융합단백질 및 이의 용도 |
| KR100955502B1 (ko) * | 2007-11-30 | 2010-04-30 | 대한민국 | 병원성 뉴캐슬병 바이러스 항체와 특이적으로 반응하는펩타이드 및 그의 용도 |
| EP2085092A1 (en) | 2008-01-29 | 2009-08-05 | Bayer Schering Pharma Aktiengesellschaft | Attenuated oncolytic paramyxoviruses encoding avian cytokines |
| US7794714B2 (en) * | 2008-03-14 | 2010-09-14 | The United States Of America As Represented By The Secretary Of Agriculture | Newcastle disease virus monoclonal antibodies |
| US20090258035A1 (en) * | 2008-03-21 | 2009-10-15 | The United States Of America, As Represented By The Secretary Of Agriculture | Avian virus vaccines and uses thereof |
| MX2011005231A (es) * | 2008-11-19 | 2011-07-29 | Avi Mex S A De C V Lab | Vacuna recombinante de vector viral inactivado. |
| EP2987856B1 (en) | 2009-02-05 | 2018-07-25 | Icahn School of Medicine at Mount Sinai | Chimeric newcastle disease viruses and uses thereof |
| PT3210622T (pt) * | 2009-08-21 | 2021-03-03 | Univ Georgia | Vacina recombinante contra o paramixovírus aviário e método de preparação e utilização da mesma |
| US20110110975A1 (en) * | 2009-11-06 | 2011-05-12 | Streck, Inc. | Inactivated virus compositions and methods of preparing such compositions |
| ATE539148T1 (de) | 2009-11-30 | 2012-01-15 | United Cancer Res Inst | Neuer klon des geflügelpestvirus, herstellung und anwendung bei der medizinischen behandlung von krebs |
| WO2012151391A2 (en) | 2011-05-04 | 2012-11-08 | Streck, Inc. | Inactivated virus compositions and methods of preparing such compositions |
| CA2853379C (en) | 2011-10-27 | 2020-11-24 | Wellstat Ophthalmics Corporation | Vectors encoding rod-derived cone viability factor |
| CA2857025C (en) | 2011-11-30 | 2021-08-03 | Merial Limited | Recombinant hvt vectors expressing antigens of avian pathogens and uses thereof |
| KR101374192B1 (ko) * | 2011-12-21 | 2014-03-14 | 대한민국 | 제4형 조류파라믹소바이러스 ｈｎ 단백질 및 이를 포함하는 ｈｉ법 검사용 항원진단액 |
| NZ711946A (en) | 2013-03-14 | 2020-05-29 | Icahn School Med Mount Sinai | Newcastle disease viruses and uses thereof |
| CN104059942B (zh) * | 2013-03-20 | 2016-12-28 | 湖北省农业科学院畜牧兽医研究所 | 新城疫病毒耐热活疫苗载体系统及其应用 |
| US20140341950A1 (en) * | 2013-05-15 | 2014-11-20 | University Of Georgia Research Foundation, Inc. | Recombinant avian paramyxovirus vaccine and method for making and using thereof |
| CN107073099B (zh) | 2014-02-27 | 2022-09-27 | 默沙东公司 | 用于治疗癌症的联合方法 |
| WO2017087550A1 (en) | 2015-11-16 | 2017-05-26 | Georgia State University Research Foundation, Inc. | Tunable vaccine platform against pathogens of the paramyxovirus family |
| US10063211B2 (en) * | 2016-02-03 | 2018-08-28 | Qualcomm Incorporated | Compact bypass and decoupling structure for millimeter-wave circuits |
| SG11201806567WA (en) | 2016-02-03 | 2018-08-30 | Cg Discovery Inc | Compositions of influenza hemagglutinin with heterologous epitopes and/or altered maturation cleavage sites |
| US10196616B2 (en) | 2017-02-15 | 2019-02-05 | The United States Of America, As Represented By The Secretary Of Agriculture | Altered avian virus for in-ovo inoculation and methods of use thereof |
| JOP20190256A1 (ar) | 2017-05-12 | 2019-10-28 | Icahn School Med Mount Sinai | فيروسات داء نيوكاسل واستخداماتها |
| JP2021514609A (ja) * | 2018-02-28 | 2021-06-17 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ウイルス混入物質を同定するためのシステムおよび方法 |
| US20200297787A1 (en) * | 2018-07-13 | 2020-09-24 | Icahn School Of Medicine At Mount Sinai | Apmv and uses thereof for the treatment of cancer |
| CN109735552A (zh) * | 2019-02-27 | 2019-05-10 | 苏州世诺生物技术有限公司 | 禽新城疫病毒新型基因工程亚单位疫苗 |
| CN110018304A (zh) * | 2019-05-15 | 2019-07-16 | 河南省农业科学院 | 一种新城疫抗体阻断检测试纸 |
| CN110240635B (zh) * | 2019-06-10 | 2022-04-22 | 华中农业大学 | 检测新城疫病毒抗体的多肽及其elisa检测试剂盒 |
| CN110257562A (zh) * | 2019-07-31 | 2019-09-20 | 河北农业大学 | 一种raa-lfd检测鸡传染性喉气管炎病毒的引物和探针组合及其应用 |
| US11334671B2 (en) | 2019-10-14 | 2022-05-17 | International Business Machines Corporation | Adding adversarial robustness to trained machine learning models |
| KR102154796B1 (ko) * | 2019-10-18 | 2020-09-22 | 주식회사 바이오포아 | 변이 뉴캣슬병 바이러스 및 상기 바이러스를 이용한 조류 백신 |
| CN110938711A (zh) * | 2019-12-20 | 2020-03-31 | 河北农业大学 | 一种检测鸡传染性喉气管炎病毒的实时荧光raa引物和探针、试剂盒及其使用方法 |
| CN111334528B (zh) * | 2020-03-20 | 2022-02-18 | 山东农业大学 | 水貂肠炎细小病毒全基因组感染性克隆及其构建方法和应用 |
| CN112048484A (zh) * | 2020-07-27 | 2020-12-08 | 华南农业大学 | 一株表达传染性法氏囊强毒株vp2蛋白的基因ⅶ型新城疫重组病毒和疫苗 |
| CN114214338B (zh) * | 2021-08-26 | 2023-02-03 | 扬州大学 | 猪源piv5全长感染性克隆及其制备方法和应用 |
| US20240342313A1 (en) | 2023-03-30 | 2024-10-17 | Pharma Cinq, Llc | Vector encoding rod-derived cone viability factor and human igk signal sequence |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU602875B2 (en) * | 1985-12-18 | 1990-11-01 | British Technology Group Limited | Newcastle disease virus gene clones |
| PT702085E (pt) * | 1994-07-18 | 2004-04-30 | Karl Klaus Conzelmann | Virus de arn de cadeia negativa nao segmentada infeccioso recombinante |
| WO1996040880A1 (en) * | 1995-06-07 | 1996-12-19 | Syntro Corporation | Recombinant fowlpox viruses and uses thereof |
| ATE181112T1 (de) * | 1995-08-09 | 1999-06-15 | Schweiz Serum & Impfinst | Dem genom von minussträngigen rna-viren entsprechende cdna und verfahren zur herstellung von infektiösen minussträngigen rna-viren |
| EP0839912A1 (en) * | 1996-10-30 | 1998-05-06 | Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) | Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof |
| EP0974660A1 (en) | 1998-06-19 | 2000-01-26 | Stichting Instituut voor Dierhouderij en Diergezondheid (ID-DLO) | Newcastle disease virus infectious clones, vaccines and diagnostic assays |
| US6146642A (en) | 1998-09-14 | 2000-11-14 | Mount Sinai School Of Medicine, Of The City University Of New York | Recombinant new castle disease virus RNA expression systems and vaccines |
-
1998
- 1998-06-19 EP EP98202054A patent/EP0974660A1/en not_active Withdrawn
-
1999
- 1999-06-17 IL IL14038199A patent/IL140381A0/xx active IP Right Grant
- 1999-06-17 ID IDW20010146A patent/ID27343A/id unknown
- 1999-06-17 PL PL348300A patent/PL197722B1/pl not_active IP Right Cessation
- 1999-06-17 JP JP2000554854A patent/JP2002518012A/ja not_active Withdrawn
- 1999-06-17 CZ CZ20004707A patent/CZ300760B6/cs not_active IP Right Cessation
- 1999-06-17 BR BR9911383-0A patent/BR9911383A/pt not_active IP Right Cessation
- 1999-06-17 TR TR2001/00350T patent/TR200100350T2/xx unknown
- 1999-06-17 AT AT99926984T patent/ATE367442T1/de active
- 1999-06-17 SI SI9930990T patent/SI1088077T1/sl unknown
- 1999-06-17 CA CA002334165A patent/CA2334165A1/en not_active Abandoned
- 1999-06-17 PT PT99926984T patent/PT1088077E/pt unknown
- 1999-06-17 KR KR1020007014397A patent/KR20010053000A/ko not_active Application Discontinuation
- 1999-06-17 EA EA200100057A patent/EA004796B1/ru not_active IP Right Cessation
- 1999-06-17 ES ES99926984T patent/ES2291029T3/es not_active Expired - Lifetime
- 1999-06-17 CN CN99809714A patent/CN1314942A/zh active Pending
- 1999-06-17 HU HU0102429A patent/HUP0102429A3/hu unknown
- 1999-06-17 EP EP99926984A patent/EP1088077B2/en not_active Expired - Lifetime
- 1999-06-17 WO PCT/NL1999/000377 patent/WO1999066045A1/en active IP Right Grant
- 1999-06-17 NZ NZ508982A patent/NZ508982A/en unknown
- 1999-06-17 CN CNA2008100921449A patent/CN101275142A/zh active Pending
- 1999-06-17 DK DK99926984T patent/DK1088077T3/da active
- 1999-06-17 UA UA2001010408A patent/UA77146C2/uk unknown
- 1999-06-17 AU AU43991/99A patent/AU754844B2/en not_active Ceased
- 1999-06-17 DE DE69936585T patent/DE69936585T2/de not_active Expired - Lifetime
- 1999-06-18 AR ARP990102948A patent/AR020091A1/es not_active Application Discontinuation
-
2000
- 2000-12-15 NO NO20006406A patent/NO329193B1/no not_active IP Right Cessation
- 2000-12-18 IL IL140381A patent/IL140381A/en not_active IP Right Cessation
- 2000-12-19 US US09/741,744 patent/US6719979B2/en not_active Expired - Fee Related
-
2001
- 2001-01-09 ZA ZA2001/00241A patent/ZA200100241B/en unknown
- 2001-01-15 HR HR20010042A patent/HRP20010042B1/xx not_active IP Right Cessation
-
2004
- 2004-02-26 US US10/788,232 patent/US7332169B2/en not_active Expired - Fee Related
- 2004-04-15 US US10/824,782 patent/US7547442B2/en not_active Expired - Fee Related
-
2005
- 2005-12-01 JP JP2005347888A patent/JP2006141398A/ja active Pending
-
2009
- 2009-02-04 JP JP2009023349A patent/JP2009261387A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US7547442B2 (en) | Newcastle disease virus infectious clones, vaccines and new diagnostic assays | |
| Kumar et al. | Evaluation of the Newcastle disease virus F and HN proteins in protective immunity by using a recombinant avian paramyxovirus type 3 vector in chickens | |
| US9476033B2 (en) | Recombinant newcastle disease viruses useful as vaccines or vaccine vectors | |
| MXPA01002656A (es) | Sistema de expresion del rna de virus de la enfermedad de newcastle, recombinante y vacunas. | |
| MX2014011754A (es) | Virus del herpes aviar recombinantes multivalentes y vacunas para inmunizar especies aviares. | |
| CA2427578C (en) | A recombinant newcastle disease virus nucleoprotein mutant as a marker vaccine | |
| JP2009203242A (ja) | インビボ（ｉｎｖｉｖｏ）マルチプルｄｎａワクチンと多価ｄｎａワクチン | |
| RU2441070C2 (ru) | Рекомбинантный вирус болезни ньюкастла, экспрессирующий н5 гемаглютинин вируса птичьего гриппа (avian ineluenza) | |
| AU775514B2 (en) | A recombinant Newcastle Disease virus as an embryo vaccine | |
| MXPA00012787A (en) | Newcastle disease virus infectious clones, vaccines and diagnostic assays | |
| Liu | Generating a new vaccine for protecting poultry from Newcastle disease and controlling viral shedding | |
| Elbehairy | Development of Avian Paramyxovirus Vectored Vaccines |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |