NO326620B1 - Beenzotiazepinderivater samt anvendelse og fremgangsmate for fremstilling derav og farmasoytisk preparat - Google Patents
Beenzotiazepinderivater samt anvendelse og fremgangsmate for fremstilling derav og farmasoytisk preparat Download PDFInfo
- Publication number
- NO326620B1 NO326620B1 NO20032829A NO20032829A NO326620B1 NO 326620 B1 NO326620 B1 NO 326620B1 NO 20032829 A NO20032829 A NO 20032829A NO 20032829 A NO20032829 A NO 20032829A NO 326620 B1 NO326620 B1 NO 326620B1
- Authority
- NO
- Norway
- Prior art keywords
- phenyl
- formula
- benzothiazepine
- dioxo
- tetrahydro
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 251
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- 239000001257 hydrogen Substances 0.000 claims description 78
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- 239000012453 solvate Substances 0.000 claims description 72
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 51
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- 238000006243 chemical reaction Methods 0.000 claims description 42
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 41
- -1 carboxy, sulfo, phosphono Chemical group 0.000 claims description 38
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 32
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 29
- 125000000217 alkyl group Chemical group 0.000 claims description 28
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 27
- 125000001424 substituent group Chemical group 0.000 claims description 24
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 22
- 238000011282 treatment Methods 0.000 claims description 22
- 229910052736 halogen Inorganic materials 0.000 claims description 21
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 17
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- CLZISMQKJZCZDN-UHFFFAOYSA-N [benzotriazol-1-yloxy(dimethylamino)methylidene]-dimethylazanium Chemical compound C1=CC=C2N(OC(N(C)C)=[N+](C)C)N=NC2=C1 CLZISMQKJZCZDN-UHFFFAOYSA-N 0.000 description 37
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Obesity (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Communicable Diseases (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0004811A SE0004811D0 (sv) | 2000-12-21 | 2000-12-21 | Chemical compounds |
| GB0112592A GB0112592D0 (en) | 2001-05-24 | 2001-05-24 | Chemical compounds |
| PCT/GB2001/005554 WO2002050051A1 (en) | 2000-12-21 | 2001-12-17 | Chemical compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20032829D0 NO20032829D0 (no) | 2003-06-20 |
| NO20032829L NO20032829L (no) | 2003-08-15 |
| NO326620B1 true NO326620B1 (no) | 2009-01-19 |
Family
ID=26246111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20032829A NO326620B1 (no) | 2000-12-21 | 2003-06-20 | Beenzotiazepinderivater samt anvendelse og fremgangsmate for fremstilling derav og farmasoytisk preparat |
Country Status (33)
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| EP (1) | EP1345918B1 (ru) |
| JP (2) | JP3665055B2 (ru) |
| KR (1) | KR100882342B1 (ru) |
| CN (1) | CN1268618C (ru) |
| AR (1) | AR035723A1 (ru) |
| AT (1) | ATE360008T1 (ru) |
| AU (2) | AU2222802A (ru) |
| BG (1) | BG66342B1 (ru) |
| BR (1) | BRPI0116397B8 (ru) |
| CA (1) | CA2431461C (ru) |
| CY (1) | CY1106664T1 (ru) |
| CZ (1) | CZ305032B6 (ru) |
| DE (1) | DE60127997T2 (ru) |
| DK (1) | DK1345918T3 (ru) |
| EE (1) | EE05158B1 (ru) |
| EG (1) | EG26979A (ru) |
| ES (1) | ES2284587T3 (ru) |
| HK (1) | HK1056732A1 (ru) |
| HU (1) | HU229050B1 (ru) |
| IL (2) | IL156341A0 (ru) |
| IS (1) | IS2833B (ru) |
| MX (1) | MXPA03005637A (ru) |
| MY (1) | MY137508A (ru) |
| NO (1) | NO326620B1 (ru) |
| NZ (1) | NZ526562A (ru) |
| PL (1) | PL219847B1 (ru) |
| PT (1) | PT1345918E (ru) |
| RU (1) | RU2302414C2 (ru) |
| SA (1) | SA02220610B1 (ru) |
| SI (1) | SI1345918T1 (ru) |
| SK (1) | SK287059B6 (ru) |
| WO (1) | WO2002050051A1 (ru) |
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| GB0121622D0 (en) * | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
| GB0121621D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
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| SE0104333D0 (sv) | 2001-12-19 | 2001-12-19 | Astrazeneca Ab | Therapeutic agents |
| GB0201850D0 (en) * | 2002-01-26 | 2002-03-13 | Astrazeneca Ab | Therapeutic treatment |
| GB0209467D0 (en) * | 2002-04-25 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
| GB0213669D0 (en) * | 2002-06-14 | 2002-07-24 | Astrazeneca Ab | Chemical compounds |
| ES2299702T3 (es) | 2002-06-20 | 2008-06-01 | Astrazeneca Ab | Derivados de acido benzoico orto-sustituidos para el tratamiento de la resistencia a la insulina. |
| GB0304194D0 (en) * | 2003-02-25 | 2003-03-26 | Astrazeneca Ab | Chemical compounds |
| GB0307918D0 (en) * | 2003-04-05 | 2003-05-14 | Astrazeneca Ab | Therapeutic use |
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| US20020183307A1 (en) | 2000-07-26 | 2002-12-05 | Tremont Samuel J. | Novel 1,4-benzothiazephine and 1,5-benzothiazepine compounds as inhibitors of apical sodium co-dependent bile acid transport and taurocholate uptake |
| SE0003766D0 (sv) | 2000-10-18 | 2000-10-18 | Astrazeneca Ab | Novel formulation |
| WO2002053548A1 (en) | 2000-12-27 | 2002-07-11 | Banyu Pharmaceutical Co.,Ltd. | Benzothiazepine derivatives |
| GB0121337D0 (en) | 2001-09-04 | 2001-10-24 | Astrazeneca Ab | Chemical compounds |
| GB0121621D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
| GB0121622D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
| NZ531796A (en) | 2001-09-08 | 2005-10-28 | Astrazeneca Ab | Benzothiazepine and benzothiadiazepine derivatives with ileal bile acid transport (ibat) inhibitory activity for the treatment of hyperlipidaemia |
| GB0201850D0 (en) | 2002-01-26 | 2002-03-13 | Astrazeneca Ab | Therapeutic treatment |
| GB0209467D0 (en) | 2002-04-25 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
| GB0213669D0 (en) | 2002-06-14 | 2002-07-24 | Astrazeneca Ab | Chemical compounds |
| GB0216321D0 (en) | 2002-07-13 | 2002-08-21 | Astrazeneca Ab | Therapeutic treatment |
| GB0304194D0 (en) | 2003-02-25 | 2003-03-26 | Astrazeneca Ab | Chemical compounds |
| GB0307918D0 (en) | 2003-04-05 | 2003-05-14 | Astrazeneca Ab | Therapeutic use |
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