NO20081564L - Kinaseinhibitorer - Google Patents

Kinaseinhibitorer

Info

Publication number
NO20081564L
NO20081564L NO20081564A NO20081564A NO20081564L NO 20081564 L NO20081564 L NO 20081564L NO 20081564 A NO20081564 A NO 20081564A NO 20081564 A NO20081564 A NO 20081564A NO 20081564 L NO20081564 L NO 20081564L
Authority
NO
Norway
Prior art keywords
biohydrolysable
kinase inhibitors
solvate
arthritis
hydrate
Prior art date
Application number
NO20081564A
Other languages
English (en)
Norwegian (no)
Inventor
Stephen W Kaldor
Jeffrey A Stafford
Michael B Wallace
Jason W Brown
Sanjib Das
Qing Dong
Xianchang Gong
Bheema R Paraselli
Yan Liu
Nicholas Scorah
Original Assignee
Takeda San Diego Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda San Diego Inc filed Critical Takeda San Diego Inc
Publication of NO20081564L publication Critical patent/NO20081564L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO20081564A 2005-10-07 2008-03-31 Kinaseinhibitorer NO20081564L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72461905P 2005-10-07 2005-10-07
PCT/US2006/039667 WO2007044779A1 (fr) 2005-10-07 2006-10-10 Inhibiteurs de kinase

Publications (1)

Publication Number Publication Date
NO20081564L true NO20081564L (no) 2008-07-02

Family

ID=37622078

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20081564A NO20081564L (no) 2005-10-07 2008-03-31 Kinaseinhibitorer

Country Status (29)

Country Link
US (2) US8119655B2 (fr)
EP (2) EP2133349B1 (fr)
JP (1) JP5150878B2 (fr)
KR (1) KR20080051153A (fr)
CN (1) CN101356172B (fr)
AT (1) ATE495173T1 (fr)
AU (1) AU2006302135B2 (fr)
BR (1) BRPI0616950A2 (fr)
CA (1) CA2624610A1 (fr)
CR (1) CR9886A (fr)
CY (1) CY1111346T1 (fr)
DE (1) DE602006019651D1 (fr)
DK (1) DK2133349T3 (fr)
EA (1) EA015902B1 (fr)
ES (1) ES2358006T3 (fr)
GE (1) GEP20125368B (fr)
HK (1) HK1138842A1 (fr)
HR (1) HRP20110220T1 (fr)
IL (1) IL190306A0 (fr)
MA (1) MA29796B1 (fr)
MY (1) MY146989A (fr)
NO (1) NO20081564L (fr)
NZ (1) NZ566866A (fr)
PL (1) PL2133349T3 (fr)
PT (1) PT2133349E (fr)
RS (1) RS51897B (fr)
SI (1) SI2133349T1 (fr)
WO (1) WO2007044779A1 (fr)
ZA (1) ZA200802820B (fr)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006044687A2 (fr) 2004-10-15 2006-04-27 Takeda San Diego, Inc. Inhibiteurs de kinase
EP1926735A1 (fr) 2005-09-22 2008-06-04 Incyte Corporation Inhibiteurs tetracycliques de janus kinases
US8119655B2 (en) * 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
JP2010500961A (ja) * 2006-08-02 2010-01-14 武田薬品工業株式会社 α−カルボリン誘導体およびその製造方法
CA2666138A1 (fr) * 2006-10-09 2008-05-08 Takeda Pharmaceutical Company Limited Inhibiteurs de kinases
EP2223925A1 (fr) * 2006-10-09 2010-09-01 Takeda Pharmaceutical Company Limited Inhibiteurs de kinase
GEP20135728B (en) * 2006-10-09 2013-01-25 Takeda Pharmaceuticals Co Kinase inhibitors
WO2008079965A1 (fr) * 2006-12-22 2008-07-03 Incyte Corporation Hétérocycles substitués servant d'inhibiteurs de janus kinases
WO2009004329A1 (fr) 2007-07-02 2009-01-08 Cancer Research Technology Limited 9h-pyrimido[4,5-b]indoles, 9h-pyrido[4',3':4,5]pyrrolo[2,3-d]pyridines, et 9h-1,3,6,9-tétraaza-fluorènes en tant qu'inhibiteurs de la fonction kinase chk1
MX2010009513A (es) * 2008-02-28 2010-09-22 Takeda Pharmaceutical Composicion farmaceutica.
US20090312288A1 (en) * 2008-04-16 2009-12-17 Takeda Pharmaceutical Company Limited Kinase inhibitors
WO2009129259A2 (fr) * 2008-04-16 2009-10-22 Takeda Pharmaceutical Company Limited Polymorphes de 5-(3-(éthylsulfonyl)phényl)-3,8-diméthyl-n-(1-méthylpipéridin-4-yl)-9h-pyrido[2,3-b]indole-7-carboxamide et procédés d'utilisation associés
US20090270442A1 (en) * 2008-04-16 2009-10-29 Takeda Pharmaceutical Company Limited Polymorphs of hydrochloride salt of 5-(3-(ethylsulfonyl)phenyl)-3,8-dimethyl-n-(1-methylpiperidin-4-yl)-9h-pyrido[2,3-b]indole-7-carboxamide and methods of use therefor
CN102119163A (zh) 2008-06-11 2011-07-06 健泰科生物技术公司 二氮杂咔唑和使用方法
BRPI0909957A2 (pt) 2008-06-11 2016-04-19 Genentech Inc "composto, composição farmacêutica, método de inibir o crescimento anormal de células ou de tratar um distúrbio hiperproliferativo em um mamífero, método de tratamento do câncer em um mamífero"
AR072084A1 (es) * 2008-06-12 2010-08-04 Sanofi Aventis Derivados de azacarbolinas, su preparacion y su utilizacion terapeutica como inhibidores de las quinasas pim
DE102008052943A1 (de) 2008-10-23 2010-04-29 Merck Patent Gmbh Azaindolderivate
JP2012512871A (ja) * 2008-12-18 2012-06-07 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 三環式アザインドール
FR2950891B1 (fr) * 2009-10-06 2012-11-09 Sanofi Aventis Derives d'azacarbolines 9h-pyrrolo[2,3-b:5,4-c']dipyridine, leur preparation et leur utilisation therapeutique
FR2943674B1 (fr) * 2009-03-24 2013-02-22 Sanofi Aventis Derives d'azacarbolines,leur preparation et leur utilisation therapeutique
CA2756152A1 (fr) * 2009-03-24 2010-09-30 Sanofi Derives d'azacarbolines 9h-pyrrolo[2,3-b:5,4-c']dipyridine, leur preparation et leur utilisation therapeutique
FR2953837B1 (fr) * 2009-12-10 2012-03-09 Sanofi Aventis Derives 9h-pyridino[3,4-b]indole disubstitues, leur preparation et leur utilisation therapeutique
FR2953838B1 (fr) * 2009-12-10 2012-02-24 Sanofi Aventis Derives de 9h-beta-carboline (ou 9h-pyridino[3,4-b]indole) trisubstitues, leur preparation et leur utilisation therapeutique
US20110183938A1 (en) 2009-12-16 2011-07-28 Genentech, Inc. 1,7-diazacarbazoles and methods of use
CN102372707B (zh) * 2010-08-16 2015-08-19 上海药明康德新药开发有限公司 6-甲基-4-溴-1,6-二氢吡咯[2,3-c]吡啶-7-酮的合成方法
RU2641693C2 (ru) 2011-11-09 2018-01-22 Кансер Ресёрч Текнолоджи Лимитед Соединения 5-(пиридин-2-иламино)-пиразин-2-карбонитрила и их терапевтическое применение
PL2855448T3 (pl) 2012-05-15 2017-09-29 Cancer Research Technology Ltd 5-[[4-[[morfolino-2-ilo]metyloamino]-5-(trifluorometylo)-2-pirydylo]amino]pirazyno-2-karbonitryl i jego zastosowanie terapeutyczne
PL2810931T3 (pl) 2013-06-06 2018-09-28 Solvay Sa Sposób otrzymywania halogenowanych bezwodników kwasów karboksylowych
AR103598A1 (es) 2015-02-02 2017-05-24 Forma Therapeutics Inc Ácidos bicíclicos[4,6,0]hidroxámicos como inhibidores de hdac
JP6668362B2 (ja) 2015-02-02 2020-03-18 フォーマ セラピューティクス，インコーポレイテッド Ｈｄａｃ阻害薬としての３−アルキル−４−アミド−二環式［４，５，０］ヒドロキサム酸
WO2016187767A1 (fr) * 2015-05-25 2016-12-01 Hutchison Medipharma Limited Compositions pharmaceutiques et utilisation de celles-ci
US10555935B2 (en) 2016-06-17 2020-02-11 Forma Therapeutics, Inc. 2-spiro-5- and 6-hydroxamic acid indanes as HDAC inhibitors
EP3762368B1 (fr) 2018-03-08 2022-01-26 Incyte Corporation Composés d'aminopyrazine diol utilisés comme inhibiteurs de pi3k-y
BR112020022373A2 (pt) 2018-05-04 2021-02-02 Incyte Corporation sais de um inibidor de fgfr
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors
AU2019320773A1 (en) 2018-08-14 2021-03-04 Osteoqc Inc. Fluoro β-carboline compounds
SG11202101151SA (en) * 2018-08-14 2021-03-30 Osteoqc Inc Pyrrolo - dipyridine compounds
US11773093B1 (en) 2023-01-19 2023-10-03 King Faisal University N-(pyrimido[2,3-b]indol-7-yl)acetamide compounds as antibacterial agents

Family Cites Families (302)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB828847A (en) 1956-12-14 1960-02-24 Ilford Ltd Improvements in or relating to cyanine dyes
FR1242962A (fr) 1959-08-25 1960-10-07 Kodak Pathe Nouveau procédé pour la préparation de colorants sensibilisateurs de la série des cyanines et des mérocyanines et produits obtenus
GB1268773A (en) 1968-03-15 1972-03-29 Glaxo Lab Ltd NOVEL alpha-CARBOLINE DERIVATIVES, THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME
US3710795A (en) 1970-09-29 1973-01-16 Alza Corp Drug-delivery device with stretched, rate-controlling membrane
US4044126A (en) 1972-04-20 1977-08-23 Allen & Hanburys Limited Steroidal aerosol compositions and process for the preparation thereof
GB1429184A (en) 1972-04-20 1976-03-24 Allen & Hanburys Ltd Physically anti-inflammatory steroids for use in aerosols
USRE28819E (en) 1972-12-08 1976-05-18 Syntex (U.S.A.) Inc. Dialkylated glycol compositions and medicament preparations containing same
GB2013703B (en) * 1978-01-25 1982-06-03 Bayer Ag Heterocyclic dyestuffs
DE2844606A1 (de) 1978-10-13 1980-04-24 Bayer Ag Heterocyclische farbstoffe
US4410545A (en) 1981-02-13 1983-10-18 Syntex (U.S.A.) Inc. Carbonate diester solutions of PGE-type compounds
US4328245A (en) 1981-02-13 1982-05-04 Syntex (U.S.A.) Inc. Carbonate diester solutions of PGE-type compounds
US4358603A (en) 1981-04-16 1982-11-09 Syntex (U.S.A.) Inc. Acetal stabilized prostaglandin compositions
US4409239A (en) 1982-01-21 1983-10-11 Syntex (U.S.A.) Inc. Propylene glycol diester solutions of PGE-type compounds
GB9222253D0 (en) * 1992-10-23 1992-12-09 Celltech Ltd Chemical compounds
GB9304920D0 (en) * 1993-03-10 1993-04-28 Celltech Ltd Chemical compounds
CZ1598A3 (cs) * 1995-07-06 1998-04-15 Novartis Ag Pyrrolopyrimidiny a způsoby jejich přípravy
US7119174B2 (en) 1995-12-18 2006-10-10 Sugen, Inc. Diagnosis and treatment of AUR1 and/or AUR2 related disorders
EP0868519B1 (fr) 1995-12-18 2006-01-11 Sugen, Inc. Diagnostic et traitement de troubles lies aux aur-1 et aur-2
US6716575B2 (en) * 1995-12-18 2004-04-06 Sugen, Inc. Diagnosis and treatment of AUR1 and/or AUR2 related disorders
GB9707800D0 (en) 1996-05-06 1997-06-04 Zeneca Ltd Chemical compounds
ES2194213T3 (es) * 1996-08-09 2003-11-16 Boehringer Ingelheim Pharma Beta-carbolinas-4- sustituidas en calidad de inmunomoduladores.
GB9622363D0 (en) 1996-10-28 1997-01-08 Celltech Therapeutics Ltd Chemical compounds
GB9625184D0 (en) * 1996-12-04 1997-01-22 Celltech Therapeutics Ltd Chemical compounds
EP0946523A1 (fr) 1996-12-23 1999-10-06 Celltech Therapeutics Limited Derives polycyclique fondus de 2-aminopyrimidine, leur preparation et leur utilisation comme inhibiteurs de proteine tyrosine-kinase
GB9705361D0 (en) 1997-03-14 1997-04-30 Celltech Therapeutics Ltd Chemical compounds
ATE342971T1 (de) * 1997-08-15 2006-11-15 Univ Hiroshima Den zellzyklus regulierende proteine
ES2289791T3 (es) 1997-08-22 2008-02-01 Astrazeneca Ab Derivados de oxindolilquinazolina como inhibidores de la angiogenesis.
US7462605B2 (en) * 1998-01-23 2008-12-09 Celmed Oncology (Usa), Inc. Phosphoramidate compounds and methods of use
US6143480A (en) 1998-09-03 2000-11-07 Fuji Photo Film Co., Ltd. Leuco dye and image recording medium containing the same
US6706491B1 (en) * 1999-04-09 2004-03-16 The Board Of Trustees Of The University Of Illinois Reagents and methods for identifying and modulating expression of genes regulated by p21
US20050113460A1 (en) * 1999-04-30 2005-05-26 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
US6982265B1 (en) 1999-05-21 2006-01-03 Bristol Myers Squibb Company Pyrrolotriazine inhibitors of kinases
EP1203013A4 (fr) 1999-07-21 2004-10-13 Univ Massachusetts Polypeptides bloquant la kinase et leurs utilisations
US6787545B1 (en) 1999-08-23 2004-09-07 Shiongi & Co., Ltd. Pyrrolotriazine derivatives having spla2-inhibitory activities
GB9922173D0 (en) 1999-09-21 1999-11-17 Zeneca Ltd Chemical compounds
ES2334879T3 (es) 1999-09-21 2010-03-17 Astrazeneca Ab Derivados de quinazolina y su uso como productos farmaceuticos.
EP1218356A1 (fr) 1999-09-21 2002-07-03 AstraZeneca AB Composes de quinazoline et compositions pharmaceutiques comprenant lesdits composes
GB9922171D0 (en) 1999-09-21 1999-11-17 Zeneca Ltd Chemical compounds
DE60039059D1 (de) 1999-10-07 2008-07-10 Amgen Inc Triazin-kinase-hemmer
US6455525B1 (en) 1999-11-04 2002-09-24 Cephalon, Inc. Heterocyclic substituted pyrazolones
CZ301750B6 (cs) 1999-12-24 2010-06-09 Aventis Pharma Limited Bicyklický pyrrolový derivát, jeho použití pri výrobe léciva, farmaceutická kompozice tento derivát obsahující a pro použití pri lécení
US6977259B2 (en) * 2000-01-28 2005-12-20 Astrazeneca Ab Quinoline derivatives and their use as aurora 2 kinase inhibitors
JP4783532B2 (ja) * 2000-02-05 2011-09-28 バーテックス ファーマシューティカルズ インコーポレイテッド Ｅｒｋのインヒビターとして有用なピラゾール組成物
IL145756A0 (en) * 2000-02-05 2002-07-25 Vertex Pharma Pyrazole derivatives and pharmaceutical compositions containing the same
EP1134221A1 (fr) 2000-03-15 2001-09-19 Aventis Pharma Deutschland GmbH Bêta-carbolines substituées comme inhibiteurs de lkB kinase
EP1209158A1 (fr) 2000-11-18 2002-05-29 Aventis Pharma Deutschland GmbH Bêta-carbolines subtituées
HUP0300894A3 (en) * 2000-03-15 2008-05-28 Sanofi Aventis Deutschland Substituted beta-carbolines, process for their preparation, pharmaceutical compositions containing them and their use
JP2001294772A (ja) 2000-04-10 2001-10-23 Fuji Photo Film Co Ltd 着色組成物、インクジェット用インク及びインクジェット記録方法
JP2001302667A (ja) * 2000-04-28 2001-10-31 Bayer Ag イミダゾピリミジン誘導体およびトリアゾロピリミジン誘導体
US6555329B2 (en) * 2000-06-09 2003-04-29 Boehringer Ingelheim International Gmbh Method for identifying compounds altering higher-order chromatin-dependent chromosome stability
US6335342B1 (en) 2000-06-19 2002-01-01 Pharmacia & Upjohn S.P.A. Azaindole derivatives, process for their preparation, and their use as antitumor agents
DE60133897D1 (de) 2000-06-28 2008-06-19 Astrazeneca Ab Substituierte chinazolin-derivate und deren verwendung als aurora-2-kinase inhibitoren
WO2002006280A2 (fr) 2000-07-13 2002-01-24 Millennium Pharamaceuticals, Inc. Inhibiteurs du facteur xa
US20050009876A1 (en) * 2000-07-31 2005-01-13 Bhagwat Shripad S. Indazole compounds, compositions thereof and methods of treatment therewith
ES2349762T3 (es) 2000-08-10 2011-01-11 Pfizer Italia S.R.L. Biciclo-pirazoles activos como inhibidores de quinasas, procedimientos para su preparación y composiciones farmacéuticas que los comprenden.
US6352858B1 (en) * 2000-09-11 2002-03-05 Isis Pharmaceuticals, Inc. Antisense modulation of BTAK expression
US6613776B2 (en) * 2000-09-15 2003-09-02 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
US6660731B2 (en) * 2000-09-15 2003-12-09 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
MXPA03002294A (es) 2000-09-15 2005-09-08 Vertex Pharma Compuestos de pirazol utiles como inhibidores de proteina cinasa.
US6610677B2 (en) * 2000-09-15 2003-08-26 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
US7473691B2 (en) * 2000-09-15 2009-01-06 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
JP2004517840A (ja) 2000-11-27 2004-06-17 フアルマシア・イタリア・エツセ・ピー・アー フェニルアセトアミド−ピラゾール誘導体およびそれの抗腫瘍薬としての使用
US6455559B1 (en) 2001-07-19 2002-09-24 Pharmacia Italia S.P.A. Phenylacetamido-pyrazole derivatives, process for their preparation and their use as antitumor agents
UA74221C2 (uk) 2000-11-28 2005-11-15 Пфайзер Продактс Інк. Солі ізотіазол-4-карбоксаміду та їх використання як антигіперпроліферативних агентів
FR2818278B1 (fr) 2000-12-20 2003-02-28 Sod Conseils Rech Applic Inhibiteurs de kinases dependantes des cyclines (cdk) et de la glycogene synthase kinase-3 (gsk-3)
AU2002225096B8 (en) * 2000-12-20 2006-07-27 Ipsen Pharma S.A.S. Cyclin-dependent kinase (CDK) and glycogen synthase kinase-3 (GSK-3) inhibitors
EP1345922B1 (fr) * 2000-12-21 2006-05-31 Vertex Pharmaceuticals Incorporated Composes de pyrazole utilises comme inhibiteurs de la proteine kinase
GB0102687D0 (en) 2001-02-02 2001-03-21 Pharmacia & Upjohn Spa Oxazolyl-pyrazole derivatives active as kinase inhibitors,process for their preparation and pharmaceutical compositions comprising them
MY130778A (en) * 2001-02-09 2007-07-31 Vertex Pharma Heterocyclic inhibitiors of erk2 and uses thereof
US6864255B2 (en) 2001-04-11 2005-03-08 Amgen Inc. Substituted triazinyl amide derivatives and methods of use
WO2002092089A1 (fr) * 2001-05-14 2002-11-21 Pfizer Products Inc. Sels de tartrate de 5,8,14-triazatetracyclo[10.3.1.02,11.04,9]-hexadeca-2(11),3,5,7,9-pentaene
EP1396490A1 (fr) 2001-05-24 2004-03-10 Yamanouchi Pharmaceutical Co. Ltd. Derives de 3-quinoleine-2-(1h)-ylideneindoline-2-one
AU2002310187A1 (en) 2001-05-30 2002-12-09 Lg Biomedical Institute Inhibitors of protein kinase for the treatment of disease
MXPA03010961A (es) * 2001-05-31 2004-02-27 Vertex Pharma Compuestos de tiazol utiles como inhibidores de proteinas cinasas.
DE60214703T2 (de) 2001-06-01 2007-09-13 Vertex Pharmaceuticals Inc., Cambridge Thiazolverbindungen, die sich als inhibitoren von proteinkinasen eignen
GB0115109D0 (en) 2001-06-21 2001-08-15 Aventis Pharma Ltd Chemical compounds
EP1404799A1 (fr) 2001-06-22 2004-04-07 The Procter & Gamble Company Compositions d'entretien de textiles pour systemes fluides lipophiles
GB0115393D0 (en) 2001-06-23 2001-08-15 Aventis Pharma Ltd Chemical compounds
ATE345341T1 (de) 2001-07-19 2006-12-15 Pfizer Italia Srl Phenylacetamido-thiazole verbindungen, verfahren zu ihren herstellung und ihre anwendung als antitumor mittel
US20040235867A1 (en) 2001-07-24 2004-11-25 Bilodeau Mark T. Tyrosine kinase inhibitors
US6872533B2 (en) * 2001-07-27 2005-03-29 The Regents Of The University Of California STK15 (STK6) gene polymorphism and methods of determining cancer risk
US6916798B2 (en) * 2001-08-03 2005-07-12 Vertex Pharmaceuticals Incorporated Inhibitors of GSK-3 and uses thereof
WO2003013517A1 (fr) * 2001-08-06 2003-02-20 Pharmacia Italia S.P.A. Dérivés d'aminoisoxazole agissant comme inhibiteurs de la kinase
US20030073692A1 (en) * 2001-08-07 2003-04-17 Pharmacia & Upjohn S.P.A. Amino-phthalazinone derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions containing them
WO2003020276A1 (fr) 2001-08-30 2003-03-13 Merck & Co., Inc. Inhibiteurs de tyrosine kinase
US6806272B2 (en) 2001-09-04 2004-10-19 Boehringer Ingelheim Pharma Kg Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
US6849653B2 (en) * 2001-09-19 2005-02-01 Pharmacia Corporation Substituted pyrazolyl benzenesulfamide compounds for the treatment of inflammation
CA2460942A1 (fr) 2001-09-19 2003-03-27 Pharmacia Corporation Composes de pyrazolyle substitues destines au traitement de l'inflammation
EP1427707A1 (fr) 2001-09-19 2004-06-16 Pharmacia Corporation Composes d'indazole substitues destines au traitement de l'inflammation
CA2460939C (fr) * 2001-09-19 2008-07-29 Pharmacia Corporation Composes de pyrazolyl substitues pour le traitement de l'inflammation
EP1432416B1 (fr) 2001-09-26 2011-01-19 Pfizer Italia S.r.l. Derives d'aminoindazole agissant comme inhibiteurs de la kinase, procede de production et compositions pharmaceutiques les contenant
GB0124299D0 (en) 2001-10-10 2001-11-28 Astrazeneca Ab Crystal structure of enzyme and uses thereof
ATE407678T1 (de) 2001-10-17 2008-09-15 Boehringer Ingelheim Pharma Pyrimidinderivate, arzneimittel enthaltend diese verbindungen, deren verwendung und verfahren zu ihrer herstellung
US20040010027A1 (en) * 2001-12-17 2004-01-15 Pharmacia & Upjohn Spa Hydroxphenyl-pyrazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical comositions comprising them
SE0104340D0 (sv) 2001-12-20 2001-12-20 Astrazeneca Ab New compounds
MXPA04006260A (es) * 2001-12-24 2005-03-31 Astrazeneca Ab Derivados de quinazolina sustituidos como inhibidores de cinasas aurora.
IL162734A0 (en) 2002-02-01 2005-11-20 Ariad Gene Therapeutics Inc Phosphorus-containing compounds & uses thereof
FR2836914B1 (fr) * 2002-03-11 2008-03-14 Aventis Pharma Sa Indazoles substitues, compositions les contenant, procede de fabrication et utilisation
EP1485100B1 (fr) 2002-03-15 2010-05-05 Vertex Pharmaceuticals Incorporated Azinylaminoazoles utilises comme inhibiteurs de proteine kinases
ES2289279T3 (es) * 2002-03-15 2008-02-01 Vertex Pharmaceuticals Incorporated Composiciones utiles como inhibidores de proteinquinasas.
AU2003218215A1 (en) * 2002-03-15 2003-09-29 Vertex Pharmaceuticals, Inc. Azolylaminoazines as inhibitors of protein kinases
WO2003078426A1 (fr) 2002-03-15 2003-09-25 Vertex Pharmaceuticals, Inc. Azolylaminoazines en tant qu'inhibiteurs de proteines kinases
SE0200979D0 (sv) 2002-03-28 2002-03-28 Astrazeneca Ab New compounds
AU2003230802B2 (en) 2002-04-08 2007-08-09 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
AU2003244978A1 (en) 2002-04-15 2003-10-27 Inserm Methods to identify anti-tumoral agents inhibiting rasgap / aurora kinase interactions
AU2003237121A1 (en) 2002-04-26 2003-11-10 Vertex Pharmaceuticals Incorporated Pyrrole derivatives as inhibitors of erk2 and uses thereof
DE60331329D1 (de) 2002-05-01 2010-04-01 Vertex Pharma Kristallstruktur des aurora-2 proteins und dessen bindungstaschen
EP1506176B1 (fr) 2002-05-17 2013-04-24 Pfizer Italia S.r.l. Derives d'aminoindazole agissant comme inhibiteurs de kinase, methode d'obtention et compositions pharmaceutiques les renfermant
US20050239780A1 (en) * 2002-05-31 2005-10-27 Akira Suga Tetrahydropyran derivative
US6989451B2 (en) * 2002-06-04 2006-01-24 Valeant Research & Development Heterocyclic compounds and uses thereof
FR2840905B1 (fr) 2002-06-12 2006-07-07 Centre Nat Rech Scient Anticorps monoclonal anti-aurora-a, son procede d'obtention, et ses utilisations dans le diagnostic et le traitement des cancers
WO2003107002A1 (fr) 2002-06-12 2003-12-24 株式会社アクシアバイオサイエンス Polyubiquitination catalysee par une proteine chfr de aurora kinase a et aurora kinase b
CA2486215A1 (fr) 2002-06-14 2003-12-24 Merck & Co., Inc. Inhibiteurs de kinesine mitotique
MY141867A (en) 2002-06-20 2010-07-16 Vertex Pharma Substituted pyrimidines useful as protein kinase inhibitors
WO2004005283A1 (fr) 2002-07-09 2004-01-15 Vertex Pharmaceuticals Incorporated Imidazoles, oxazoles et thiazoles presentant des activites d'inhibition des proteines kinases
WO2004006838A2 (fr) 2002-07-15 2004-01-22 Sugen, Inc. Nouvelles kinases
DE60320560T2 (de) 2002-07-17 2008-12-11 Pfizer Italia S.R.L. Heterobicyclische pyrazolderivate als kinaseinhibitoren
EP1530573B1 (fr) 2002-07-25 2008-03-19 Pfizer Italia S.r.l. Inhibiteurs de kinases a base de derives de pyrazoles heterocycliques condenses
MXPA05000945A (es) 2002-07-25 2005-05-16 Pharmacia Italia Spa Biciclo-pirazoles activos como inhibidores de la cinasa, procedimientos para su preparacion y composiciones farmaceuticas que los contienen.
AU2003244632A1 (en) 2002-07-25 2004-02-25 Pharmacia Italia S.P.A. Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
EP1546117A2 (fr) * 2002-08-14 2005-06-29 Vertex Pharmaceuticals Incorporated Inhibiteurs de la proteine kinase et leurs utilisations
KR20050057520A (ko) * 2002-09-23 2005-06-16 쉐링 코포레이션 사이클린 의존성 키나제 억제제로서의 이미다조피라진
WO2004035577A2 (fr) 2002-10-16 2004-04-29 Gilead Sciences, Inc. Composes tricycliques pre-organises inhibiteurs d'integrase
AU2003286711A1 (en) 2002-10-25 2004-05-13 Vertex Pharmaceuticals Incorporated Indazolinone compositions useful as kinase inhibitors
US20040102360A1 (en) * 2002-10-30 2004-05-27 Barnett Stanley F. Combination therapy
GB0226583D0 (en) 2002-11-14 2002-12-18 Cyclacel Ltd Compounds
US6909001B2 (en) 2002-12-12 2005-06-21 Pharmacia Corporation Method of making tricyclic aminocyanopyridine compounds
UA81790C2 (uk) 2002-12-19 2008-02-11 Фармация Италия С.П.А. Заміщені піролопіразольні похідні як інгібітори кінази
WO2004056812A1 (fr) 2002-12-23 2004-07-08 Astrazeneca Ab Derives de 4-(pyridin-4-ylamino)-quinazoline utilises comme agents anticancereux
AU2003290322A1 (en) 2002-12-24 2004-07-22 Astrazeneca Ab Quinazoline compounds
AU2003294142A1 (en) 2002-12-24 2004-07-22 Astrazeneca Ab Therapeutic quinazoline derivatives
ATE438644T1 (de) 2002-12-24 2009-08-15 Astrazeneca Ab Chinazolinderivate
CL2004000016A1 (es) 2003-01-21 2005-04-15 Wyeth Corp Compuesto derivado de cloruro de 4-amino-2-butenoilo o una sal farmaceuticamente aceptable del mismo; procedimiento para preparar dicho compuesto, util como intermediario en la sintesis de compuestos inhibidores de proteina quinasa tirosina.
DE602004022633D1 (de) 2003-01-30 2009-10-01 Boehringer Ingelheim Pharma 2,4-diaminopyrimidinderivate, die sich als inhibitoren von pkc-theta eignen
WO2004070062A2 (fr) 2003-02-04 2004-08-19 Wyeth Compositions et techniques de diagnostic et de traitement de cancers
US8404690B2 (en) 2003-02-14 2013-03-26 Merck Serono Sa Piperazine-2-carboxamide derivatives
MXPA05008688A (es) 2003-02-17 2005-10-05 Pharmacia Italia Spa Derivados tetraciclicos de pirazol como inhibidores de la cinasa, procedimiento para su preparacion y composiciones farmaceuticas que los comprenden.
CN101200457A (zh) 2003-02-26 2008-06-18 贝林格尔英格海姆法玛两合公司 二氢蝶啶酮、其制法及作为药物制剂的用途
US6861422B2 (en) * 2003-02-26 2005-03-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
WO2006018628A1 (fr) 2003-03-07 2006-02-23 Astrazeneca Ab Enantiomeres de pyrimidones fusionnes selectionnes et utilisations dans le traitement et la prevention du cancer
MXPA05009719A (es) 2003-03-11 2005-10-18 Pharmacia Italia Spa Derivados de biciclo-pirazol activos como inhibidores de cinasa, procedimiento para su preparacion y composiciones farmaceuticas que los comprenden.
DE602004024374D1 (de) 2003-03-13 2010-01-14 Vertex Pharma Zusammensetzungen zur verwendung als protein-kinase-inhibitoren
WO2004087056A2 (fr) 2003-03-28 2004-10-14 Scios Inc. Inhibiteurs bi-cycliques a base de pyrimidine de tgf$g(b)
EP1608652A1 (fr) 2003-03-31 2005-12-28 Vernalis (Cambridge) Limited Composes pyrazolopyrimidines et leur utilisation en medecine
WO2004090106A2 (fr) 2003-04-04 2004-10-21 Vertex Pharmaceuticals Incorporated Structures cristallines de complexes proteiques humains de la pim-1 kinase et poches de liaison de ces structures, et leurs utilisations dans la conception de medicaments
OA13115A (en) * 2003-04-09 2006-11-10 Millenium Pharmaceuticals Inc Beta-carbolines useful for treating inflammatory disease.
PT1620429E (pt) * 2003-04-11 2009-04-28 Glenmark Pharmaceuticals Sa Novos compostos heterocíclicos úteis para o tratamento de perturbações inflamatórias e alérgicas: processo para a sua preparação e composições farmacêuticas que os contêm
CN1809557B (zh) 2003-04-16 2012-07-04 阿斯利康(瑞典)有限公司 化合物
ATE446752T1 (de) 2003-04-24 2009-11-15 Merck & Co Inc Hemmer der akt aktivität
US7304063B2 (en) 2003-04-24 2007-12-04 Merck & Co., Inc. Inhibitors of Akt activity
CA2522430A1 (fr) 2003-04-24 2004-11-11 Merck & Co., Inc. Inhibiteurs de l'activite akt
ATE512957T1 (de) 2003-04-24 2011-07-15 Merck Sharp & Dohme Hemmer der akt aktivität
US20040242559A1 (en) 2003-04-25 2004-12-02 Aventis Pharma S.A. Novel indole derivatives, preparation thereof as medicinal products and pharmaceutical compositions, and especially as KDR inhibitors
MXPA05011741A (es) 2003-05-01 2006-05-12 Univ Michigan Composiciones y metodos que se relacionan con compuestos y objetivos novedosos de los mismos.
ES2350837T3 (es) 2003-05-01 2011-01-27 Bristol-Myers Squibb Company Compuestos de pirazol-amida sustituidos con arilo útiles como inhibidores de quinasas.
WO2005000200A2 (fr) 2003-05-09 2005-01-06 Sugen, Inc. Nouvelles kinases
OA13170A (en) 2003-05-22 2006-12-13 Pharmacia Italia Spa Pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors.
US7345046B2 (en) * 2003-05-30 2008-03-18 Chiron Corporation Heteroaryl-fused pyrimidinyl compounds as anticancer agents
DE602004015108D1 (de) 2003-06-02 2008-08-28 Astrazeneca Ab (3-((chinazolin-4-yl)amino)-1h-pyrazol-1-yl)acetamid derivate und verwandte verbindungen als aurora kinase inhibitoren zur behandlung von proliferativen erkrankungen wie krebs
TW200505452A (en) 2003-06-17 2005-02-16 Astrazeneca Ab Chemical compounds
EP1636225B1 (fr) * 2003-06-20 2010-02-24 Novartis Vaccines and Diagnostics, Inc. Composes de pyridino 1,2-a pyrimidin-4-one servant d'agents anticancereux
US20050065171A1 (en) * 2003-06-25 2005-03-24 Shakespeare William C. Substituted purine derivatives
GB0315657D0 (en) 2003-07-03 2003-08-13 Astex Technology Ltd Pharmaceutical compounds
WO2005002571A1 (fr) 2003-07-03 2005-01-13 Cambridge University Technical Services Ltd Utilisation d'inhibiteurs des aurora kinases pour reduire la resistance des cellules cancereuses
DK1641775T3 (da) 2003-07-03 2009-04-20 Euro Celtique Sa 2-pyridinalkynderivater, der er anvendelige til behandling af smerter
TWI372050B (en) 2003-07-03 2012-09-11 Astex Therapeutics Ltd (morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles
US20050032869A1 (en) 2003-07-08 2005-02-10 Pharmacia Italia S.P.A. Pyrazolyl-indole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
GB0315966D0 (en) 2003-07-08 2003-08-13 Cyclacel Ltd Compounds
US7141568B2 (en) * 2003-07-09 2006-11-28 Pfizer Italia S.R.L. Pyrrolo[3,4-c]pyrazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
EP1648900A4 (fr) 2003-07-11 2010-02-10 Ariad Pharma Inc Macrocycles contenant du phosphore
CN100549014C (zh) 2003-07-16 2009-10-14 詹森药业有限公司 作为糖原合酶激酶3抑制剂的三唑并嘧啶衍生物
JP2009514782A (ja) 2003-07-16 2009-04-09 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ グリコーゲン合成酵素キナーゼ３阻害剤としてのトリアゾロピリミジン誘導体
ES2337150T3 (es) 2003-07-21 2010-04-21 Merck Serono Sa Alquinilaril carboxamidas.
US20050137220A1 (en) * 2003-07-23 2005-06-23 Pharmacia Corporation Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors
UA84710C2 (ru) 2003-07-24 2008-11-25 Евро-Селтик С.А. Пиперидиновые производные, фармацевтическая композиция, которая их содержит, и способ лечения
US20050026984A1 (en) * 2003-07-29 2005-02-03 Aventis Pharma S.A. Substituted thieno [2,3-c] pyrazoles and their use as medicinal products
US7619059B2 (en) 2003-07-29 2009-11-17 Life Technologies Corporation Bimolecular optical probes
AU2004261484A1 (en) 2003-07-30 2005-02-10 Cyclacel Limited 2-aminophenyl-4-phenylpyrimidines as kinase inhibitors
BRPI0412351A (pt) 2003-07-30 2006-09-05 Cyclacel Ltd derivados e piridilamino-pirimidina como inibidores de proteìna quinase
US7094791B2 (en) 2003-07-31 2006-08-22 Avalon Pharmaceuticals, Inc. Derivatives of 3-hydroxy-pyrrole-2,4-dicarboxylic acid and uses thereof
US20050043346A1 (en) * 2003-08-08 2005-02-24 Pharmacia Italia S.P.A. Pyridylpyrrole derivatives active as kinase inhibitors
US7279575B2 (en) * 2003-08-08 2007-10-09 Pfizer Italia S.R.L. Pyrimidylpyrrole derivatives active as kinase inhibitors
JP2007512230A (ja) 2003-08-20 2007-05-17 バーテックス　ファーマシューティカルズ　インコーポレイテッド プロテインキナーゼ阻害剤として有用な（４−アミノ−１，２，５−オキサジアゾール−４−イル）−ヘテロ芳香族化合物
TWI339206B (en) 2003-09-04 2011-03-21 Vertex Pharma Compositions useful as inhibitors of protein kinases
AU2004272306A1 (en) 2003-09-12 2005-03-24 Merck Serono Sa Benzimidazole acetonitriles
US20080234263A1 (en) 2003-09-16 2008-09-25 Laurent Francois Andre Hennequin Quinazoline Derivatives
SI1667991T1 (sl) 2003-09-16 2008-10-31 Astrazeneca Ab Kinazolinski derivati kot inhibitorji tirozin kinaze
MXPA06002962A (es) 2003-09-16 2006-06-14 Astrazeneca Ab Derivados de quinazolina.
EP1670422A4 (fr) 2003-09-17 2007-08-01 Sunesis Pharmaceuticals Inc Identification d'inhibiteurs de kinase
CA2539320A1 (fr) 2003-09-17 2005-03-31 Icos Corporation Utilisation d'inhibiteurs de la chk1 pour lutter contre la proliferation cellulaire
ATE433974T1 (de) 2003-09-19 2009-07-15 Gilead Sciences Inc Azachinolinolphosphonatverbindungen als integraseinhibitoren
US20050085531A1 (en) * 2003-10-03 2005-04-21 Hodge Carl N. Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof
DE602004005881T2 (de) 2003-10-14 2008-01-17 Pharmacia Corp. Substituierte pyrazinonverbindungen zur behandlung von entzündungen
CN1897950A (zh) 2003-10-14 2007-01-17 惠氏公司 稠合芳基和杂芳基衍生物及其使用方法
DK1678166T3 (da) 2003-10-14 2009-11-09 Univ Arizona State Proteinkinaseinhibitorer
DE602004022187D1 (de) 2003-10-17 2009-09-03 Astrazeneca Ab 4-(pyrazol-3-ylamino)pyrimidinderivate zur verwendung bei der behandlung von krebs
WO2005037797A1 (fr) 2003-10-21 2005-04-28 Pharmacia Corporation Composes d'uree de pyrazole substituee utiles dans le traitement d'inflammations
CA2542880A1 (fr) 2003-10-21 2005-05-12 Cyclacel Limited Composes de pyrimidin-4-yl-3, 4-thione et leur utilisation a des fins therapeutiques
BRPI0415678A (pt) 2003-10-23 2006-12-19 Pharmacia Corp compostos de pirimidina para o tratamento de inflamação
WO2005044270A1 (fr) 2003-11-04 2005-05-19 4Sc Ag Derives de l'oxadiazolopyrazine utilises comme composes pharmaceutiquement actifs
DK1692113T3 (en) 2003-11-14 2018-01-08 Lorus Therapeutics Inc ARYLIMIDAZOLES AND USE THEREOF AS ANTICANCES
MY141220A (en) 2003-11-17 2010-03-31 Astrazeneca Ab Pyrazole derivatives as inhibitors of receptor tyrosine kinases
JP2007521331A (ja) * 2003-11-19 2007-08-02 シグナル ファーマシューティカルズ，エルエルシー 複数キナーゼの標的化による疾患及び障害の治療方法
FR2864084B1 (fr) 2003-12-17 2006-02-10 Aventis Pharma Sa Nouveaux derives organophosphores des indazoles et leur utilisation comme medicaments
EP1713814A1 (fr) 2003-12-17 2006-10-25 SGX Pharmaceuticals, Inc. Composes a fusion pyrazolo bicycliques utilises comme modulateurs de proteine kinases
GB0330043D0 (en) 2003-12-24 2004-01-28 Pharmacia Italia Spa Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions comprising them
GB0330042D0 (en) 2003-12-24 2004-01-28 Pharmacia Italia Spa Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions them
WO2005071419A2 (fr) 2004-01-16 2005-08-04 Ipsogen Etablissement de profils d'expression de proteines et prognose du cancer du sein
EP1706404A2 (fr) 2004-01-23 2006-10-04 Chiron Corporation Composes de tetrahydrocarboline comme agents anticancereux
TW200526204A (en) 2004-02-03 2005-08-16 Pharmacia Italia Spa 1h-thieno[2,3-c]pyrazole derivatives useful as kinase inhibitors
FR2865934B1 (fr) 2004-02-05 2006-05-05 Sanofi Synthelabo Utilisation de derives d'indolizine 1,2,3 substitues, inhibiteurs des fgfs, pour la preparation de medicaments utiles pour le traitement de maladies liees a une angiogenese pathologique choroidienne
GB0402653D0 (en) 2004-02-06 2004-03-10 Cyclacel Ltd Compounds
AR047969A1 (es) * 2004-02-25 2006-03-15 Schering Corp Pirazolotriazinas como inhibidores de quinasa
WO2005097758A1 (fr) 2004-03-26 2005-10-20 Amphora Discovery Corporation Composes et compositions a base de triazoles et leurs applications
RU2403252C2 (ru) 2004-03-30 2010-11-10 Вертекс Фармасьютикалз Инкорпорейтед Азаиндолы, полезные в качестве ингибиторов jak и других протеинкиназ
BRPI0509580A (pt) 2004-03-30 2007-11-27 Pfizer Prod Inc combinações de inibidores de transdução de sinal
FR2868421B1 (fr) * 2004-04-01 2008-08-01 Aventis Pharma Sa Nouveaux benzothiazoles et leur utilisation comme medicaments
US20050250829A1 (en) 2004-04-23 2005-11-10 Takeda San Diego, Inc. Kinase inhibitors
AU2005249380C1 (en) 2004-04-23 2012-09-20 Exelixis, Inc. Kinase modulators and methods of use
TW200538453A (en) 2004-04-26 2005-12-01 Bristol Myers Squibb Co Bicyclic heterocycles as kinase inhibitors
WO2005105777A1 (fr) 2004-05-05 2005-11-10 Pharmacia & Upjohn Company Llc Composes d'amide a substitution de thiophene pour le traitement de l'inflammation.
WO2005113494A2 (fr) 2004-05-07 2005-12-01 Amgen Inc. Modulateurs de proteines kinases et procede d'utilisation
BRPI0511139B8 (pt) 2004-05-14 2021-05-25 Millennium Pharm Inc compostos que inibem quinase aurora e composição farmacêutica contendo os mesmos
WO2005118544A2 (fr) 2004-05-18 2005-12-15 Rigel Pharmaceuticals, Inc. Composes pyrimidinediamines a substitution cycloalkyle et leurs utilisations
EP1598343A1 (fr) 2004-05-19 2005-11-23 Boehringer Ingelheim International GmbH Dérivés de 2-arylaminopyrimidines comme des inhibiteurs de PLK
JPWO2005113550A1 (ja) 2004-05-20 2008-03-27 三菱ウェルファーマ株式会社 アミノピリミジン誘導体及びその医薬としての用途
ATE404536T1 (de) 2004-05-21 2008-08-15 Novartis Vaccines & Diagnostic Substituierte chinolinderivate als inhibitoren von mitotischem kinesin
AU2005249446A1 (en) 2004-05-27 2005-12-15 Vertex Pharmaceuticals Incorporated Biomarkers for monitoring inhibition of IMPDH pathway
US20070254877A1 (en) 2004-06-02 2007-11-01 Takada Pharmaceutical Company Limited Indole Derivative and Use for Treatment of Cancer
CA2569404A1 (fr) 2004-06-04 2005-12-22 Amphora Discovery Corporation Composes a base de quinoleine et d'isoquinoleine presentant une activite d'inhibition d'enzymes utilisant de l'atp et compositions et utilisations de ceux-ci
JP2008501677A (ja) 2004-06-04 2008-01-24 ファイザー・プロダクツ・インク 異常な細胞増殖を治療する方法
FR2871158A1 (fr) 2004-06-04 2005-12-09 Aventis Pharma Sa Indazoles substitues, compositions les contenant, procede de fabrication et utilisation
WO2005123672A2 (fr) 2004-06-14 2005-12-29 Takeda San Diego, Inc. Inhibiteurs de kinase
EP1761506A1 (fr) 2004-06-15 2007-03-14 AstraZeneca AB Quinazolones substitues en tant qu'agents anticancereux
EP1765789B1 (fr) 2004-06-18 2013-02-27 Novartis AG Derives de n-(1-(1-benzyl-4-phenyl-1h-imidazol-2-yl)-2,2-dymethylpropyl) benzamide et composes associes comme inhibiteurs de la proteine kinesine fuseau (ksp) pour le traitement du cancer
DE102004029784A1 (de) 2004-06-21 2006-01-05 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel
MXPA06015147A (es) 2004-06-23 2007-03-26 Irm Llc Compuestos y composiciones como inhibidores de la proteincinasa.
WO2006000589A1 (fr) 2004-06-28 2006-01-05 Altana Pharma Ag Pyrimidines 4,6-disubstituees et leur utilisation comme inhibiteurs des proteines kinases
US7253167B2 (en) 2004-06-30 2007-08-07 Bristol-Myers Squibb Company Tricyclic-heteroaryl compounds useful as kinase inhibitors
TW200616974A (en) 2004-07-01 2006-06-01 Astrazeneca Ab Chemical compounds
JP2008505089A (ja) 2004-07-01 2008-02-21 メルク　エンド　カムパニー　インコーポレーテッド 有糸分裂キネシン阻害剤
CA2571824A1 (fr) 2004-07-01 2006-01-19 Merck & Co., Inc. Inhibiteurs de kinesine mitotique
WO2006003440A1 (fr) 2004-07-05 2006-01-12 Astex Therapeutics Limited Pyrazoles 3,4-disubstitutes servant d'inhibiteurs de kinases cyclines dependantes (cdk), ou de kinases aurora ou de glycogene syntases 3 (gsk-3)
CA2571937A1 (fr) 2004-07-08 2006-02-09 Boehringer Ingelheim Pharmaceuticals, Inc. Derives de pyrimidine utiles comme inhibiteurs de la pkc-theta
EP1768956A1 (fr) 2004-07-12 2007-04-04 Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. Derives amide en tant qu'inhibiteurs d'histone deacetylase
EP1768955A1 (fr) 2004-07-12 2007-04-04 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Derives amidiques inhibiteurs de l'histone deacetylase
SG156650A1 (en) 2004-07-16 2009-11-26 Sunesis Pharmaceuticals Inc Thienopyrimidines useful as aurora kinase inhibitors
DE102004034623A1 (de) 2004-07-16 2006-02-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue 6-Formyl-tetrahydropteridine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
WO2006012624A2 (fr) 2004-07-21 2006-02-02 The Regents Of The University Of California Agents de reticulation fondes sur un mecanisme
JP2008506759A (ja) 2004-07-22 2008-03-06 アストラゼネカ アクチボラグ 癌の処置および予防に有用な縮合ピリミドン類
EP1781647A2 (fr) 2004-07-22 2007-05-09 Astex Therapeutics Limited Derives de thiazole et isothiazole comme inhibiteurs de proteine kinases
JP2008508303A (ja) 2004-07-27 2008-03-21 エスジーエックス ファーマシューティカルズ、インコーポレイテッド ピロロ−ピリジンキナーゼモジュレーター
WO2006015312A2 (fr) 2004-07-30 2006-02-09 Rosetta Inpharmatics Llc Pronostic de patients atteints d'un cancer du sein
JP2008508358A (ja) 2004-08-02 2008-03-21 オーエスアイ・ファーマスーティカルズ・インコーポレーテッド アリール−アミノ置換ピロロピリミジンマルチキナーゼ阻害化合物
WO2006017549A2 (fr) 2004-08-03 2006-02-16 Vertex Pharmaceuticals Incoporated Analyse de kinases à base de cellules
WO2006023083A1 (fr) 2004-08-12 2006-03-02 Merck & Co., Inc. Inhibiteurs de kinesine mitotiques
US7410988B2 (en) 2004-08-13 2008-08-12 Genentech, Inc. 2-Amido-thiazole-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof
WO2006023931A2 (fr) 2004-08-18 2006-03-02 Takeda San Diego, Inc. Inhibiteurs de kinase
JP2008510013A (ja) 2004-08-18 2008-04-03 メルク エンド カムパニー インコーポレーテッド 有糸分裂キネシン阻害剤
AU2005277587A1 (en) 2004-08-18 2006-03-02 Merck Sharp & Dohme Corp. Mitotic kinesin inhibitors
US7521457B2 (en) 2004-08-20 2009-04-21 Boehringer Ingelheim International Gmbh Pyrimidines as PLK inhibitors
AU2005290081B2 (en) 2004-08-23 2010-12-02 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
JP2008510770A (ja) * 2004-08-26 2008-04-10 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｐｌｋ阻害剤としての新規プテリジノン
JP2008510771A (ja) * 2004-08-27 2008-04-10 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ジヒドロプテリジノン、その製造方法および医薬薬剤としてのその使用
MY191349A (en) 2004-08-27 2022-06-17 Bayer Pharmaceuticals Corp New pharmaceutical compositions for the treatment of hyper-proliferative disorders
EP1786265A4 (fr) 2004-08-30 2009-08-19 Smithkline Beecham Corp Nouvelles compositions et procedes de traitement
GB0419416D0 (en) 2004-09-01 2004-10-06 Inst Of Ex Botany Ascr 4-Arylazo-3,5-Diamino-Pyrazole compounds and use thereof
MX2007002433A (es) 2004-09-01 2007-05-04 Astrazeneca Ab Derivados de quinazolinona y su uso como inhibidores de b-raf.
AR050926A1 (es) 2004-09-03 2006-12-06 Astrazeneca Ab Derivados de benzamida como inhibidores de la histonadesacetilasa(hdac)
TW200624431A (en) 2004-09-24 2006-07-16 Hoffmann La Roche Phthalazinone derivatives, their manufacture and use as pharmaceutical agents
WO2006036883A2 (fr) 2004-09-24 2006-04-06 Janssen Pharmaceutica, N.V. Inhibiteurs imidazo{4,5-b}pyrazinone de proteines kinases
US20060069101A1 (en) 2004-09-27 2006-03-30 Kim Kyoung S Prodrugs of protein tyrosine kinase inhibitors
CA2581375A1 (fr) 2004-09-27 2006-04-06 Kosan Biosciences Incorporated Inhibiteurs de kinases specifiques
EP1799684B1 (fr) 2004-10-04 2014-12-03 Millennium Pharmaceuticals, Inc. Composés à base de lactame utiles en tant qu'inhibiteurs de la protéine kinase
FR2876377B1 (fr) 2004-10-11 2007-03-16 Univ Claude Bernard Lyon Nouveaux derives de 9h-pyrido[2,3-b]indole, leur procede de preparation, ainsi que les compositions pharmaceutiques contenant de tels composes
NZ554017A (en) 2004-10-12 2010-06-25 Astrazeneca Ab [(Quinazolin-4-yloxy)phenyl]acetamide derivatives
JP2008516939A (ja) 2004-10-15 2008-05-22 アストラゼネカ アクチボラグ 化学化合物
US7855205B2 (en) 2004-10-29 2010-12-21 Janssen Pharmaceutica Nv Pyrimidinyl substituted fused-pyrrolyl compounds useful in treating kinase disorders
EP1813609B1 (fr) 2004-10-29 2013-06-19 Msd K.K. Nouveaux derives d'aminopyridine presentant un effet inhibiteur selectif d'aurora-a
EP2316835A1 (fr) 2004-11-22 2011-05-04 Vertex Pharmceuticals Incorporated Pyrrolopyrazines et pyrazolopyrazines utilisable comme inhibiteurs de proteines-kinases
GB0427917D0 (en) 2004-12-21 2005-01-26 Astrazeneca Ab Chemical compounds
ITPI20040099A1 (it) 2004-12-24 2005-03-24 Maurizio Pacini Sistema di realizzazione di tappeto erboso mediante micro-plantule preradicate
AU2005321091B2 (en) 2004-12-30 2012-04-12 Astex Therapeutics Limited Pyrazole compounds that modulate the activity of CDK, GSK and Aurora kinases
WO2006070192A1 (fr) 2004-12-30 2006-07-06 Astex Therapeutics Limited Derives de thiazole et isothiazole modulant l’activite des kinases cdk, gsk et aurora
WO2006070198A1 (fr) 2004-12-30 2006-07-06 Astex Therapeutics Limited Derives pyrazoliques modulant l'activite des kinases cdk, gsk et aurora
GB0500492D0 (en) 2005-01-11 2005-02-16 Cyclacel Ltd Compound
FR2882751B1 (fr) 2005-03-04 2007-09-14 Aventis Pharma Sa Hydrazinocarbonyl-thieno[2,3-c]pyrazoles, procede de preparation, compositions les contenant et utilisation
GB0504474D0 (en) 2005-03-04 2005-04-13 Astrazeneca Ab Chemical compounds
GB0504475D0 (en) 2005-03-04 2005-04-13 Astrazeneca Ab Chemical compounds
FR2884821B1 (fr) 2005-04-26 2007-07-06 Aventis Pharma Sa Pyrrolopyridines substitues, compositions les contenant, procede de fabrication et utilisation
GB0509227D0 (en) 2005-05-05 2005-06-15 Chroma Therapeutics Ltd Intracellular enzyme inhibitors
GB0509224D0 (en) 2005-05-05 2005-06-15 Chroma Therapeutics Ltd Inhibitors of intracellular enzymatic activity
GB0509223D0 (en) 2005-05-05 2005-06-15 Chroma Therapeutics Ltd Enzyme inhibitors
WO2006130673A1 (fr) 2005-05-31 2006-12-07 Janssen Pharmaceutica, N.V. 3-benzoimidazolyl-pyrazolopyridines utilisees pour traiter des troubles dont la mediation est assuree par des kinases
WO2006131552A1 (fr) 2005-06-09 2006-12-14 Boehringer Ingelheim International Gmbh Alpha-carbolines comme inhibiteurs de cdk-1
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
JP2010500961A (ja) * 2006-08-02 2010-01-14 武田薬品工業株式会社 α−カルボリン誘導体およびその製造方法
EP2223925A1 (fr) * 2006-10-09 2010-09-01 Takeda Pharmaceutical Company Limited Inhibiteurs de kinase
GEP20135728B (en) * 2006-10-09 2013-01-25 Takeda Pharmaceuticals Co Kinase inhibitors
EP2081930A2 (fr) 2006-10-09 2009-07-29 Takeda San Diego, Inc. Inhibiteurs de kinases
CA2666138A1 (fr) 2006-10-09 2008-05-08 Takeda Pharmaceutical Company Limited Inhibiteurs de kinases
US20090312288A1 (en) * 2008-04-16 2009-12-17 Takeda Pharmaceutical Company Limited Kinase inhibitors

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EP2133349B1 (fr) 2011-01-12
JP5150878B2 (ja) 2013-02-27
AU2006302135A1 (en) 2007-04-19
CA2624610A1 (fr) 2007-04-19
HK1138842A1 (en) 2010-09-03
US20070117816A1 (en) 2007-05-24
EA200800725A1 (ru) 2009-02-27
DE602006019651D1 (de) 2011-02-24
CN101356172B (zh) 2012-06-13
ES2358006T3 (es) 2011-05-04
SI2133349T1 (sl) 2011-05-31
HRP20110220T1 (hr) 2011-04-30
CR9886A (es) 2008-08-01
CY1111346T1 (el) 2015-08-05
US8119655B2 (en) 2012-02-21
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NZ566866A (en) 2011-12-22
ATE495173T1 (de) 2011-01-15
CN101356172A (zh) 2009-01-28
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MA29796B1 (fr) 2008-09-01
PL2133349T3 (pl) 2011-08-31
PT2133349E (pt) 2011-03-17
EP1931669A1 (fr) 2008-06-18
US20100190816A1 (en) 2010-07-29
JP2009511503A (ja) 2009-03-19
AU2006302135A2 (en) 2009-12-17
US8318939B2 (en) 2012-11-27
MY146989A (en) 2012-10-15
WO2007044779A1 (fr) 2007-04-19
KR20080051153A (ko) 2008-06-10
RS51897B (en) 2012-02-29
ZA200802820B (en) 2010-02-24
EA015902B1 (ru) 2011-12-30
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BRPI0616950A2 (pt) 2009-11-24
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