ES2194213T3 - Beta-carbolinas-4- sustituidas en calidad de inmunomoduladores. - Google Patents
Beta-carbolinas-4- sustituidas en calidad de inmunomoduladores.Info
- Publication number
- ES2194213T3 ES2194213T3 ES97938122T ES97938122T ES2194213T3 ES 2194213 T3 ES2194213 T3 ES 2194213T3 ES 97938122 T ES97938122 T ES 97938122T ES 97938122 T ES97938122 T ES 97938122T ES 2194213 T3 ES2194213 T3 ES 2194213T3
- Authority
- ES
- Spain
- Prior art keywords
- replaced
- carbolins
- carbolinas
- immunomodulators
- beta
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002955 immunomodulating agent Substances 0.000 title abstract 2
- 229940121354 immunomodulator Drugs 0.000 title abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 230000004075 alteration Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002584 immunomodulator Effects 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
Abstract
LA INVENCION SE REFIERE A BE - CARBOLINAS SUSTITUIDAS EN POSICION 4 Y A ANALOGOS DE CARBOLINA, QUE INHIBEN LA ENTRADA DE CA 2+ Y LA PRODUCCION DE INTERLEUQUINA-2 (IL-2). LAS BE CARBOLINAS SUSTITUIDAS EN POSICION 4 Y LOS ANALOGOS DE BE CARBOLINA DE LA PRESENTE INVENCION SE REPRESENTAN MEDIANTE LA FORMULA (I), DONDE Q, N, R, R'', R'''' Y R 1 - R 4 SON TAL Y COMO SE LOS DEFINE EN LA DESCRIPCION. LA INVENCION SE REFIERE ASIMISMO A PROCEDIMIENTOS DE PRODUCCION DE BE - CARBOL INAS. DEBIDO A SUS PROPIEDADES INMUNOMODULADORAS SELECTIVAS, LOS COMPUESTOS Y COMPOSICIONES FARMACEUTICAS DE LA INVENCION, SON ESPECIALMENTE ADECUADOS PARA EVITAR Y TRATAR ALTERACIONES INMUNITARIAS, INCLUYENDO ENFERMEDADES AUTOINMUNES, ENFERMEDAD INFLAMATORIA, RECHAZO DE TRASPLANTE DE ORGANOS Y OTRAS ALTERACIONES ASOCIADAS CON LA RESPUESTA INMUNE MEDIADA POR IL-2.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2365096P | 1996-08-09 | 1996-08-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2194213T3 true ES2194213T3 (es) | 2003-11-16 |
Family
ID=21816410
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97938122T Expired - Lifetime ES2194213T3 (es) | 1996-08-09 | 1997-08-08 | Beta-carbolinas-4- sustituidas en calidad de inmunomoduladores. |
Country Status (10)
Country | Link |
---|---|
US (1) | US6093723A (es) |
EP (1) | EP0923581B1 (es) |
JP (1) | JP2000516231A (es) |
AT (1) | ATE240955T1 (es) |
CA (1) | CA2262796C (es) |
DE (1) | DE69722220T2 (es) |
DK (1) | DK0923581T3 (es) |
ES (1) | ES2194213T3 (es) |
PT (1) | PT923581E (es) |
WO (1) | WO1998006719A1 (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001047510A2 (en) * | 1999-12-29 | 2001-07-05 | Glaxo Group Limited | Methods and compositions related to modulators of annexin and cartilage homeostasis |
NZ521386A (en) * | 2000-03-15 | 2004-06-25 | Aventis Pharma Gmbh | Substituted beta-carbolines with lkB-kinase inhibiting activity |
EP1134221A1 (en) * | 2000-03-15 | 2001-09-19 | Aventis Pharma Deutschland GmbH | Substituted beta-carbolines as lkB kinase inhibitors |
US6379900B1 (en) | 2000-05-09 | 2002-04-30 | Conceptual Mindworks, Inc. | Compositions and methods of use of 8-nitroguanine |
US20030045541A1 (en) * | 2001-07-23 | 2003-03-06 | Christopher Bruckner | GABA-Receptor modulators with NMDA-Antagonistic activity |
EP1768662A2 (en) | 2004-06-24 | 2007-04-04 | Novartis Vaccines and Diagnostics, Inc. | Small molecule immunopotentiators and assays for their detection |
US8119655B2 (en) * | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
JP2012051804A (ja) * | 2008-12-26 | 2012-03-15 | Kyoto Univ | Eg5阻害剤 |
JP5320083B2 (ja) * | 2009-01-13 | 2013-10-23 | 坂元醸造株式会社 | 潰瘍性大腸炎治療薬 |
WO2010138685A1 (en) | 2009-05-27 | 2010-12-02 | Ptc Therapeutics, Inc. | Methods for treating prostate conditions |
CA2763479A1 (en) | 2009-05-27 | 2010-12-02 | Ptc Therapeutics, Inc. | Processes for the preparation of substituted tetrahydro beta-carbolines |
TWI574961B (zh) | 2009-05-27 | 2017-03-21 | Ptc治療公司 | 治療癌症及非腫瘤病症之方法 |
WO2010138652A1 (en) | 2009-05-27 | 2010-12-02 | Ptc Therapeutics, Inc. | Methods for treating kaposi sarcoma |
US10703722B2 (en) | 2010-04-27 | 2020-07-07 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
AU2011248579A1 (en) | 2010-04-27 | 2012-11-29 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
WO2011139489A2 (en) | 2010-04-27 | 2011-11-10 | Calcimedica Inc. | Compounds that modulate intracellular calcium |
US9079891B2 (en) | 2010-08-27 | 2015-07-14 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
KR101840313B1 (ko) * | 2011-02-14 | 2018-03-21 | 에스에프씨 주식회사 | 피리딘 유도체 화합물 및 이를 포함하는 유기전계발광소자 |
WO2012170931A2 (en) | 2011-06-10 | 2012-12-13 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
WO2013059677A1 (en) | 2011-10-19 | 2013-04-25 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
US8871778B2 (en) * | 2012-01-20 | 2014-10-28 | Genosco | Substituted pyrimidine compounds and their use as SYK inhibitors |
US9512116B2 (en) | 2012-10-12 | 2016-12-06 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
US10046002B2 (en) | 2013-08-02 | 2018-08-14 | Syntrix Biosystems Inc. | Method for treating cancer using chemokine antagonists |
US10561676B2 (en) | 2013-08-02 | 2020-02-18 | Syntrix Biosystems Inc. | Method for treating cancer using dual antagonists of CXCR1 and CXCR2 |
US8969365B2 (en) | 2013-08-02 | 2015-03-03 | Syntrix Biosystems, Inc. | Thiopyrimidinecarboxamides as CXCR1/2 modulators |
DK3778595T3 (da) | 2015-02-27 | 2021-10-18 | Calcimedica Inc | Pancreatitisbehandling |
EP3331525B1 (en) | 2015-08-07 | 2020-10-07 | Calcimedica, Inc. | Use of crac channel inhibitors for the treatment of stroke and traumatic brain injury |
EP3664803A4 (en) | 2017-08-01 | 2021-05-05 | PTC Therapeutics, Inc. | DHODH INHIBITOR FOR USE IN THE TREATMENT OF HEMATOLOGICAL CANCERS |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ194747A (en) * | 1979-08-29 | 1988-11-29 | Schering Ag | 9h-pyrido(3,4-b)indol-3-ylcarboxylic acid derivatives |
SU859889A1 (ru) * | 1980-01-17 | 1981-08-30 | Читинский Медицинский Институт | Способ количественного определени 1-метил-4-(N-метилпирролидил-1)- -карболин гидрохлорида |
DE3240514A1 (de) * | 1982-10-29 | 1984-05-03 | Schering AG, 1000 Berlin und 4709 Bergkamen | Ss-carboline, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
US5359078A (en) * | 1989-05-19 | 1994-10-25 | The United States Of America As Represented By The Department Of Health And Human Services | Signal transduction inhibitor compounds |
WO1991013627A1 (en) * | 1990-03-14 | 1991-09-19 | The Board Of Regents, The University Of Texas System | Tripterygium wilfordii hook f extracts and components thereof for immunosuppression |
DK0610744T3 (da) * | 1993-02-09 | 1999-07-19 | Bayer Ag | Sulfonamidaminomethylenderivater som immunosuppressive stoffer |
JPH07112918A (ja) * | 1993-10-15 | 1995-05-02 | Pola Chem Ind Inc | 育毛剤及びこれを含有する頭髪用化粧料 |
DE19502753A1 (de) * | 1995-01-23 | 1996-07-25 | Schering Ag | Neue 9H-Pyrido[3,4-b]indol-Derivate |
-
1997
- 1997-08-08 US US08/908,211 patent/US6093723A/en not_active Expired - Lifetime
- 1997-08-08 DE DE69722220T patent/DE69722220T2/de not_active Expired - Fee Related
- 1997-08-08 CA CA002262796A patent/CA2262796C/en not_active Expired - Fee Related
- 1997-08-08 ES ES97938122T patent/ES2194213T3/es not_active Expired - Lifetime
- 1997-08-08 DK DK97938122T patent/DK0923581T3/da active
- 1997-08-08 EP EP97938122A patent/EP0923581B1/en not_active Expired - Lifetime
- 1997-08-08 AT AT97938122T patent/ATE240955T1/de not_active IP Right Cessation
- 1997-08-08 JP JP10509821A patent/JP2000516231A/ja not_active Ceased
- 1997-08-08 PT PT97938122T patent/PT923581E/pt unknown
- 1997-08-08 WO PCT/US1997/013767 patent/WO1998006719A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
DE69722220D1 (de) | 2003-06-26 |
WO1998006719A1 (en) | 1998-02-19 |
JP2000516231A (ja) | 2000-12-05 |
ATE240955T1 (de) | 2003-06-15 |
PT923581E (pt) | 2003-10-31 |
US6093723A (en) | 2000-07-25 |
EP0923581A1 (en) | 1999-06-23 |
DE69722220T2 (de) | 2004-02-19 |
CA2262796A1 (en) | 1998-02-19 |
CA2262796C (en) | 2006-10-31 |
DK0923581T3 (da) | 2003-08-04 |
EP0923581B1 (en) | 2003-05-21 |
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