DK0923581T3 - 4-substituerede beta-carboliner som immunmodulatorer - Google Patents
4-substituerede beta-carboliner som immunmodulatorerInfo
- Publication number
- DK0923581T3 DK0923581T3 DK97938122T DK97938122T DK0923581T3 DK 0923581 T3 DK0923581 T3 DK 0923581T3 DK 97938122 T DK97938122 T DK 97938122T DK 97938122 T DK97938122 T DK 97938122T DK 0923581 T3 DK0923581 T3 DK 0923581T3
- Authority
- DK
- Denmark
- Prior art keywords
- carbolines
- beta
- substituted beta
- immune modulators
- substituted
- Prior art date
Links
- AIFRHYZBTHREPW-UHFFFAOYSA-N β-carboline Chemical class N1=CC=C2C3=CC=CC=C3NC2=C1 AIFRHYZBTHREPW-UHFFFAOYSA-N 0.000 title abstract 6
- 102000000588 Interleukin-2 Human genes 0.000 abstract 3
- 108010002350 Interleukin-2 Proteins 0.000 abstract 3
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 206010052779 Transplant rejections Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000002519 immonomodulatory effect Effects 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 208000026278 immune system disease Diseases 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000004941 influx Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2365096P | 1996-08-09 | 1996-08-09 | |
PCT/US1997/013767 WO1998006719A1 (en) | 1996-08-09 | 1997-08-08 | 4-substituted beta-carbolines as immunomodulators |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0923581T3 true DK0923581T3 (da) | 2003-08-04 |
Family
ID=21816410
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK97938122T DK0923581T3 (da) | 1996-08-09 | 1997-08-08 | 4-substituerede beta-carboliner som immunmodulatorer |
Country Status (10)
Country | Link |
---|---|
US (1) | US6093723A (da) |
EP (1) | EP0923581B1 (da) |
JP (1) | JP2000516231A (da) |
AT (1) | ATE240955T1 (da) |
CA (1) | CA2262796C (da) |
DE (1) | DE69722220T2 (da) |
DK (1) | DK0923581T3 (da) |
ES (1) | ES2194213T3 (da) |
PT (1) | PT923581E (da) |
WO (1) | WO1998006719A1 (da) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE280580T1 (de) * | 1999-12-29 | 2004-11-15 | Glaxo Group Ltd | Verwendung von annexin-modulatoren zur herstellung eines medikaments zur behandlung und/oder vorbeugung von arthritis und arthritischen erkrankungen |
NZ521386A (en) * | 2000-03-15 | 2004-06-25 | Aventis Pharma Gmbh | Substituted beta-carbolines with lkB-kinase inhibiting activity |
EP1134221A1 (en) * | 2000-03-15 | 2001-09-19 | Aventis Pharma Deutschland GmbH | Substituted beta-carbolines as lkB kinase inhibitors |
US6379900B1 (en) | 2000-05-09 | 2002-04-30 | Conceptual Mindworks, Inc. | Compositions and methods of use of 8-nitroguanine |
US20030045541A1 (en) * | 2001-07-23 | 2003-03-06 | Christopher Bruckner | GABA-Receptor modulators with NMDA-Antagonistic activity |
CA2571710A1 (en) | 2004-06-24 | 2006-11-02 | Nicholas Valiante | Small molecule immunopotentiators and assays for their detection |
US8119655B2 (en) * | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
JP2012051804A (ja) * | 2008-12-26 | 2012-03-15 | Kyoto Univ | Eg5阻害剤 |
JP5320083B2 (ja) * | 2009-01-13 | 2013-10-23 | 坂元醸造株式会社 | 潰瘍性大腸炎治療薬 |
MX348817B (es) | 2009-05-27 | 2017-06-30 | Ptc Therapeutics Inc | Metodos para tratar cancer y estados no neoplasicos. |
US8703726B2 (en) | 2009-05-27 | 2014-04-22 | Ptc Therapeutics, Inc. | Methods for treating prostate conditions |
WO2010138652A1 (en) | 2009-05-27 | 2010-12-02 | Ptc Therapeutics, Inc. | Methods for treating kaposi sarcoma |
JP2012528181A (ja) | 2009-05-27 | 2012-11-12 | ピーティーシー セラピューティクス,インコーポレーテッド | 置換テトラヒドロβ−カルボリンの製造方法 |
US10703722B2 (en) | 2010-04-27 | 2020-07-07 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
JP6112486B2 (ja) | 2010-04-27 | 2017-04-12 | カルシメディカ,インク. | 細胞内カルシウムを調節する化合物 |
EP2563759B1 (en) | 2010-04-27 | 2022-04-06 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
US9079891B2 (en) | 2010-08-27 | 2015-07-14 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
KR101840313B1 (ko) * | 2011-02-14 | 2018-03-21 | 에스에프씨 주식회사 | 피리딘 유도체 화합물 및 이를 포함하는 유기전계발광소자 |
WO2012170931A2 (en) | 2011-06-10 | 2012-12-13 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
US9856240B2 (en) | 2011-10-19 | 2018-01-02 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
EP2804861B1 (en) * | 2012-01-20 | 2018-02-28 | Genosco | Substituted pyrimidine compounds and their use as syk inhibitors |
US9512116B2 (en) | 2012-10-12 | 2016-12-06 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
US8969365B2 (en) | 2013-08-02 | 2015-03-03 | Syntrix Biosystems, Inc. | Thiopyrimidinecarboxamides as CXCR1/2 modulators |
US10561676B2 (en) | 2013-08-02 | 2020-02-18 | Syntrix Biosystems Inc. | Method for treating cancer using dual antagonists of CXCR1 and CXCR2 |
US10046002B2 (en) | 2013-08-02 | 2018-08-14 | Syntrix Biosystems Inc. | Method for treating cancer using chemokine antagonists |
CN114712513A (zh) | 2015-02-27 | 2022-07-08 | 钙医学公司 | 胰腺炎治疗 |
EP3331525B1 (en) | 2015-08-07 | 2020-10-07 | Calcimedica, Inc. | Use of crac channel inhibitors for the treatment of stroke and traumatic brain injury |
KR20200035292A (ko) | 2017-08-01 | 2020-04-02 | 피티씨 테라퓨틱스, 인크. | 혈액 암 치료에 사용하기 위한 dhodh 억제제 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ194747A (en) * | 1979-08-29 | 1988-11-29 | Schering Ag | 9h-pyrido(3,4-b)indol-3-ylcarboxylic acid derivatives |
SU859889A1 (ru) * | 1980-01-17 | 1981-08-30 | Читинский Медицинский Институт | Способ количественного определени 1-метил-4-(N-метилпирролидил-1)- -карболин гидрохлорида |
DE3240514A1 (de) * | 1982-10-29 | 1984-05-03 | Schering AG, 1000 Berlin und 4709 Bergkamen | Ss-carboline, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
US5359078A (en) * | 1989-05-19 | 1994-10-25 | The United States Of America As Represented By The Department Of Health And Human Services | Signal transduction inhibitor compounds |
AU7570191A (en) * | 1990-03-14 | 1991-10-10 | Board Of Regents, The University Of Texas System | Tripterygium wilfordii hook f extracts and components thereof for immunosuppression |
ES2124327T3 (es) * | 1993-02-09 | 1999-02-01 | Bayer Ag | Derivados de sulfonamida aminometileno como inmunosupresores. |
JPH07112918A (ja) * | 1993-10-15 | 1995-05-02 | Pola Chem Ind Inc | 育毛剤及びこれを含有する頭髪用化粧料 |
DE19502753A1 (de) * | 1995-01-23 | 1996-07-25 | Schering Ag | Neue 9H-Pyrido[3,4-b]indol-Derivate |
-
1997
- 1997-08-08 DK DK97938122T patent/DK0923581T3/da active
- 1997-08-08 DE DE69722220T patent/DE69722220T2/de not_active Expired - Fee Related
- 1997-08-08 PT PT97938122T patent/PT923581E/pt unknown
- 1997-08-08 CA CA002262796A patent/CA2262796C/en not_active Expired - Fee Related
- 1997-08-08 AT AT97938122T patent/ATE240955T1/de not_active IP Right Cessation
- 1997-08-08 JP JP10509821A patent/JP2000516231A/ja not_active Ceased
- 1997-08-08 WO PCT/US1997/013767 patent/WO1998006719A1/en active IP Right Grant
- 1997-08-08 ES ES97938122T patent/ES2194213T3/es not_active Expired - Lifetime
- 1997-08-08 EP EP97938122A patent/EP0923581B1/en not_active Expired - Lifetime
- 1997-08-08 US US08/908,211 patent/US6093723A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CA2262796A1 (en) | 1998-02-19 |
ATE240955T1 (de) | 2003-06-15 |
DE69722220D1 (de) | 2003-06-26 |
JP2000516231A (ja) | 2000-12-05 |
US6093723A (en) | 2000-07-25 |
CA2262796C (en) | 2006-10-31 |
WO1998006719A1 (en) | 1998-02-19 |
EP0923581A1 (en) | 1999-06-23 |
PT923581E (pt) | 2003-10-31 |
DE69722220T2 (de) | 2004-02-19 |
EP0923581B1 (en) | 2003-05-21 |
ES2194213T3 (es) | 2003-11-16 |
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