GB1268773A - NOVEL alpha-CARBOLINE DERIVATIVES, THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME - Google Patents
NOVEL alpha-CARBOLINE DERIVATIVES, THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAMEInfo
- Publication number
- GB1268773A GB1268773A GB1273268A GB1273268A GB1268773A GB 1268773 A GB1268773 A GB 1268773A GB 1273268 A GB1273268 A GB 1273268A GB 1273268 A GB1273268 A GB 1273268A GB 1268773 A GB1268773 A GB 1268773A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compositions
- substituted
- araliphatic
- carboline
- lotions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1,268,773. Antiviral compositions. GLAXO LABORATORIES Ltd. 14 March, 1969 [15 March, 1968], No. 12732/68. Heading A5B. [Also in Division C2[ Pharmaceutical or veterinary compositions having antiviral activity comprise, as active ingredient, at least one 4-substituted α-carboline derivative of the general formula wherein R is a hydrogen atom or a substituted or unsubstituted aliphatic, araliphatic, aromatic or acyl group, X is a halogen atom or the residue of a nucleophile and in which the nucleus may be further substituted by aliphatic, araliphatic, aromatic, carboxy, carboxylic acid ester, acylamino, hydroxy, acyloxy, ether, nitro, amino or sulphonic acid groups or halogen atoms, or physiologically compatible salt thereof, together with at least one pharmaceutical or veterinary carrier or excipient and/or other medicinal agents, e.g. anti-inflammatory agents such as steroids (e.g. betamethasone-21- phosphate) or antibiotics such as tetracycline. The compositions may be administered orally, topically, rectally, intravaginally or parenterally in the form of tablets, capsules, lozenges, chewing gum, medicated sweets, solutions, suspensions, syrups, elixirs, emulsions, granules for reconstitution before use, liquid sprays, powder insufflations, nasal drops or ointments, throat paints, gargles, opthalmic preparations and collyria, skin paints, lotions, creams, ointments, dusting powders, medicated dressings, eye drops and lotions, aerosols, suppositories, pessaries or injectable preparations. The compound 4-diethylaminoethylamino-9 methyl-α-carboline additionally shows antimycoplasma activity.
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1273268A GB1268773A (en) | 1968-03-15 | 1968-03-15 | NOVEL alpha-CARBOLINE DERIVATIVES, THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME |
IE33969A IE32706B1 (en) | 1968-03-15 | 1969-03-14 | Novel alpha-carboline derivatives,the preparation thereof and compositions containing the same |
DE19691913124 DE1913124A1 (en) | 1968-03-15 | 1969-03-14 | Alpha carbolines and their method of manufacture |
NL6903974A NL6903974A (en) | 1968-03-15 | 1969-03-14 | |
BE729854D BE729854A (en) | 1968-03-15 | 1969-03-14 | |
AT736571A AT306713B (en) | 1968-03-15 | 1969-03-14 | Process for the production of new α-carbolines and their salts |
FR6907281A FR2004000A1 (en) | 1968-03-15 | 1969-03-14 | |
AT253269A AT305277B (en) | 1968-03-15 | 1969-03-14 | Process for the production of new α-carbolines and their salts |
SE360469A SE370399B (en) | 1968-03-15 | 1969-03-14 | |
CH962672A CH530409A (en) | 1968-03-15 | 1969-03-14 | Alpha-carbolines antiviral agents |
CH390069A CH529155A (en) | 1968-03-15 | 1969-03-14 | Process for the preparation of virostatically effective new α-carbolines |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1273268A GB1268773A (en) | 1968-03-15 | 1968-03-15 | NOVEL alpha-CARBOLINE DERIVATIVES, THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1268773A true GB1268773A (en) | 1972-03-29 |
Family
ID=10010080
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1273268A Expired GB1268773A (en) | 1968-03-15 | 1968-03-15 | NOVEL alpha-CARBOLINE DERIVATIVES, THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME |
Country Status (9)
Country | Link |
---|---|
AT (2) | AT306713B (en) |
BE (1) | BE729854A (en) |
CH (1) | CH529155A (en) |
DE (1) | DE1913124A1 (en) |
FR (1) | FR2004000A1 (en) |
GB (1) | GB1268773A (en) |
IE (1) | IE32706B1 (en) |
NL (1) | NL6903974A (en) |
SE (1) | SE370399B (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0249301A1 (en) * | 1986-01-11 | 1987-12-16 | Beecham Group Plc | Pyrido[2,3-b]indoles |
US4952584A (en) * | 1986-01-11 | 1990-08-28 | Beecham Group P.L.C. | 9H-pyrido[2,B-8]indole-3-carboxylic acid ester compounds having useful pharmaceutical activity |
US6147085A (en) * | 1999-04-01 | 2000-11-14 | Neurogen Corporation | Aminoalkyl substituted 9H-pyridino[2,3-b] indole and 9H-pyrimidino[4,5-b] indole derivatives |
EP2161271A1 (en) * | 2008-09-08 | 2010-03-10 | Università Degli Studi Di Milano - Bicocca | Alpha-carboline inhibitors of NMP-ALK, RET, and Bcr-Abl |
US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
US8278450B2 (en) | 2007-04-18 | 2012-10-02 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
WO2016037106A1 (en) * | 2014-09-05 | 2016-03-10 | Allosteros Therapeutics, Inc | CaMKII INHIBITORS AND USES THEREOF |
-
1968
- 1968-03-15 GB GB1273268A patent/GB1268773A/en not_active Expired
-
1969
- 1969-03-14 DE DE19691913124 patent/DE1913124A1/en active Pending
- 1969-03-14 AT AT736571A patent/AT306713B/en not_active IP Right Cessation
- 1969-03-14 FR FR6907281A patent/FR2004000A1/fr not_active Withdrawn
- 1969-03-14 CH CH390069A patent/CH529155A/en not_active IP Right Cessation
- 1969-03-14 AT AT253269A patent/AT305277B/en not_active IP Right Cessation
- 1969-03-14 SE SE360469A patent/SE370399B/xx unknown
- 1969-03-14 IE IE33969A patent/IE32706B1/en unknown
- 1969-03-14 BE BE729854D patent/BE729854A/xx unknown
- 1969-03-14 NL NL6903974A patent/NL6903974A/xx unknown
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4952584A (en) * | 1986-01-11 | 1990-08-28 | Beecham Group P.L.C. | 9H-pyrido[2,B-8]indole-3-carboxylic acid ester compounds having useful pharmaceutical activity |
EP0249301A1 (en) * | 1986-01-11 | 1987-12-16 | Beecham Group Plc | Pyrido[2,3-b]indoles |
US6147085A (en) * | 1999-04-01 | 2000-11-14 | Neurogen Corporation | Aminoalkyl substituted 9H-pyridino[2,3-b] indole and 9H-pyrimidino[4,5-b] indole derivatives |
US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
US8278450B2 (en) | 2007-04-18 | 2012-10-02 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
EP2161271A1 (en) * | 2008-09-08 | 2010-03-10 | Università Degli Studi Di Milano - Bicocca | Alpha-carboline inhibitors of NMP-ALK, RET, and Bcr-Abl |
JP2012501984A (en) * | 2008-09-08 | 2012-01-26 | ウニヴェルシダ’デリ ストゥディ ディ ミラノ−ビコッカ | Α-carboline inhibitors of NPM-ALK, RET and BCR-ABL |
CN102203092A (en) * | 2008-09-08 | 2011-09-28 | 米兰-比科卡大学 | Alfa-carboline inhibitors of npm-alk, ret, and bcr-abl |
US8895744B2 (en) | 2008-09-08 | 2014-11-25 | Universita' Degli Studi Di Milano-Bicocca | Alfa-carboline inhibitors of NPM-ALK, RET, and Bcr-Abl |
WO2016037106A1 (en) * | 2014-09-05 | 2016-03-10 | Allosteros Therapeutics, Inc | CaMKII INHIBITORS AND USES THEREOF |
CN107074856A (en) * | 2014-09-05 | 2017-08-18 | 阿略斯泰罗斯医疗公司 | CaMKII inhibitor and application thereof |
US10759792B2 (en) | 2014-09-05 | 2020-09-01 | The Johns Hopkins University | CaMKII inhibitors and uses thereof |
US11325908B2 (en) | 2014-09-05 | 2022-05-10 | The Johns Hopkins University | CaMKII inhibitors and uses thereof |
Also Published As
Publication number | Publication date |
---|---|
BE729854A (en) | 1969-09-15 |
NL6903974A (en) | 1969-09-17 |
AT306713B (en) | 1973-04-25 |
AT305277B (en) | 1973-02-26 |
IE32706L (en) | 1969-09-15 |
SE370399B (en) | 1974-10-14 |
FR2004000A1 (en) | 1969-11-14 |
CH529155A (en) | 1972-10-15 |
IE32706B1 (en) | 1973-10-31 |
DE1913124A1 (en) | 1969-10-02 |
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