GB1268773A - NOVEL alpha-CARBOLINE DERIVATIVES, THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME - Google Patents

NOVEL alpha-CARBOLINE DERIVATIVES, THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME

Info

Publication number
GB1268773A
GB1268773A GB1273268A GB1273268A GB1268773A GB 1268773 A GB1268773 A GB 1268773A GB 1273268 A GB1273268 A GB 1273268A GB 1273268 A GB1273268 A GB 1273268A GB 1268773 A GB1268773 A GB 1268773A
Authority
GB
United Kingdom
Prior art keywords
compositions
substituted
araliphatic
carboline
lotions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1273268A
Inventor
Joseph Elks
Godfrey Basil Webb
Gordon Ian Gregory
John Derek Cocker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Laboratories Ltd
Original Assignee
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Laboratories Ltd filed Critical Glaxo Laboratories Ltd
Priority to GB1273268A priority Critical patent/GB1268773A/en
Priority to IE33969A priority patent/IE32706B1/en
Priority to DE19691913124 priority patent/DE1913124A1/en
Priority to NL6903974A priority patent/NL6903974A/xx
Priority to BE729854D priority patent/BE729854A/xx
Priority to AT736571A priority patent/AT306713B/en
Priority to FR6907281A priority patent/FR2004000A1/fr
Priority to AT253269A priority patent/AT305277B/en
Priority to SE360469A priority patent/SE370399B/xx
Priority to CH962672A priority patent/CH530409A/en
Priority to CH390069A priority patent/CH529155A/en
Publication of GB1268773A publication Critical patent/GB1268773A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1,268,773. Antiviral compositions. GLAXO LABORATORIES Ltd. 14 March, 1969 [15 March, 1968], No. 12732/68. Heading A5B. [Also in Division C2[ Pharmaceutical or veterinary compositions having antiviral activity comprise, as active ingredient, at least one 4-substituted α-carboline derivative of the general formula wherein R is a hydrogen atom or a substituted or unsubstituted aliphatic, araliphatic, aromatic or acyl group, X is a halogen atom or the residue of a nucleophile and in which the nucleus may be further substituted by aliphatic, araliphatic, aromatic, carboxy, carboxylic acid ester, acylamino, hydroxy, acyloxy, ether, nitro, amino or sulphonic acid groups or halogen atoms, or physiologically compatible salt thereof, together with at least one pharmaceutical or veterinary carrier or excipient and/or other medicinal agents, e.g. anti-inflammatory agents such as steroids (e.g. betamethasone-21- phosphate) or antibiotics such as tetracycline. The compositions may be administered orally, topically, rectally, intravaginally or parenterally in the form of tablets, capsules, lozenges, chewing gum, medicated sweets, solutions, suspensions, syrups, elixirs, emulsions, granules for reconstitution before use, liquid sprays, powder insufflations, nasal drops or ointments, throat paints, gargles, opthalmic preparations and collyria, skin paints, lotions, creams, ointments, dusting powders, medicated dressings, eye drops and lotions, aerosols, suppositories, pessaries or injectable preparations. The compound 4-diethylaminoethylamino-9 methyl-α-carboline additionally shows antimycoplasma activity.
GB1273268A 1968-03-15 1968-03-15 NOVEL alpha-CARBOLINE DERIVATIVES, THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME Expired GB1268773A (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
GB1273268A GB1268773A (en) 1968-03-15 1968-03-15 NOVEL alpha-CARBOLINE DERIVATIVES, THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME
IE33969A IE32706B1 (en) 1968-03-15 1969-03-14 Novel alpha-carboline derivatives,the preparation thereof and compositions containing the same
DE19691913124 DE1913124A1 (en) 1968-03-15 1969-03-14 Alpha carbolines and their method of manufacture
NL6903974A NL6903974A (en) 1968-03-15 1969-03-14
BE729854D BE729854A (en) 1968-03-15 1969-03-14
AT736571A AT306713B (en) 1968-03-15 1969-03-14 Process for the production of new α-carbolines and their salts
FR6907281A FR2004000A1 (en) 1968-03-15 1969-03-14
AT253269A AT305277B (en) 1968-03-15 1969-03-14 Process for the production of new α-carbolines and their salts
SE360469A SE370399B (en) 1968-03-15 1969-03-14
CH962672A CH530409A (en) 1968-03-15 1969-03-14 Alpha-carbolines antiviral agents
CH390069A CH529155A (en) 1968-03-15 1969-03-14 Process for the preparation of virostatically effective new α-carbolines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1273268A GB1268773A (en) 1968-03-15 1968-03-15 NOVEL alpha-CARBOLINE DERIVATIVES, THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME

Publications (1)

Publication Number Publication Date
GB1268773A true GB1268773A (en) 1972-03-29

Family

ID=10010080

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1273268A Expired GB1268773A (en) 1968-03-15 1968-03-15 NOVEL alpha-CARBOLINE DERIVATIVES, THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME

Country Status (9)

Country Link
AT (2) AT306713B (en)
BE (1) BE729854A (en)
CH (1) CH529155A (en)
DE (1) DE1913124A1 (en)
FR (1) FR2004000A1 (en)
GB (1) GB1268773A (en)
IE (1) IE32706B1 (en)
NL (1) NL6903974A (en)
SE (1) SE370399B (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0249301A1 (en) * 1986-01-11 1987-12-16 Beecham Group Plc Pyrido[2,3-b]indoles
US4952584A (en) * 1986-01-11 1990-08-28 Beecham Group P.L.C. 9H-pyrido[2,B-8]indole-3-carboxylic acid ester compounds having useful pharmaceutical activity
US6147085A (en) * 1999-04-01 2000-11-14 Neurogen Corporation Aminoalkyl substituted 9H-pyridino[2,3-b] indole and 9H-pyrimidino[4,5-b] indole derivatives
EP2161271A1 (en) * 2008-09-08 2010-03-10 Università Degli Studi Di Milano - Bicocca Alpha-carboline inhibitors of NMP-ALK, RET, and Bcr-Abl
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
US8278450B2 (en) 2007-04-18 2012-10-02 Takeda Pharmaceutical Company Limited Kinase inhibitors
WO2016037106A1 (en) * 2014-09-05 2016-03-10 Allosteros Therapeutics, Inc CaMKII INHIBITORS AND USES THEREOF

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4952584A (en) * 1986-01-11 1990-08-28 Beecham Group P.L.C. 9H-pyrido[2,B-8]indole-3-carboxylic acid ester compounds having useful pharmaceutical activity
EP0249301A1 (en) * 1986-01-11 1987-12-16 Beecham Group Plc Pyrido[2,3-b]indoles
US6147085A (en) * 1999-04-01 2000-11-14 Neurogen Corporation Aminoalkyl substituted 9H-pyridino[2,3-b] indole and 9H-pyrimidino[4,5-b] indole derivatives
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
US8278450B2 (en) 2007-04-18 2012-10-02 Takeda Pharmaceutical Company Limited Kinase inhibitors
EP2161271A1 (en) * 2008-09-08 2010-03-10 Università Degli Studi Di Milano - Bicocca Alpha-carboline inhibitors of NMP-ALK, RET, and Bcr-Abl
JP2012501984A (en) * 2008-09-08 2012-01-26 ウニヴェルシダ’デリ ストゥディ ディ ミラノ−ビコッカ Α-carboline inhibitors of NPM-ALK, RET and BCR-ABL
CN102203092A (en) * 2008-09-08 2011-09-28 米兰-比科卡大学 Alfa-carboline inhibitors of npm-alk, ret, and bcr-abl
US8895744B2 (en) 2008-09-08 2014-11-25 Universita' Degli Studi Di Milano-Bicocca Alfa-carboline inhibitors of NPM-ALK, RET, and Bcr-Abl
WO2016037106A1 (en) * 2014-09-05 2016-03-10 Allosteros Therapeutics, Inc CaMKII INHIBITORS AND USES THEREOF
CN107074856A (en) * 2014-09-05 2017-08-18 阿略斯泰罗斯医疗公司 CaMKII inhibitor and application thereof
US10759792B2 (en) 2014-09-05 2020-09-01 The Johns Hopkins University CaMKII inhibitors and uses thereof
US11325908B2 (en) 2014-09-05 2022-05-10 The Johns Hopkins University CaMKII inhibitors and uses thereof

Also Published As

Publication number Publication date
BE729854A (en) 1969-09-15
NL6903974A (en) 1969-09-17
AT306713B (en) 1973-04-25
AT305277B (en) 1973-02-26
IE32706L (en) 1969-09-15
SE370399B (en) 1974-10-14
FR2004000A1 (en) 1969-11-14
CH529155A (en) 1972-10-15
IE32706B1 (en) 1973-10-31
DE1913124A1 (en) 1969-10-02

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