IE32706B1 - Novel alpha-carboline derivatives,the preparation thereof and compositions containing the same - Google Patents

Novel alpha-carboline derivatives,the preparation thereof and compositions containing the same

Info

Publication number
IE32706B1
IE32706B1 IE33969A IE33969A IE32706B1 IE 32706 B1 IE32706 B1 IE 32706B1 IE 33969 A IE33969 A IE 33969A IE 33969 A IE33969 A IE 33969A IE 32706 B1 IE32706 B1 IE 32706B1
Authority
IE
Ireland
Prior art keywords
compositions
substituted
carboline
araliphatic
lotions
Prior art date
Application number
IE33969A
Other versions
IE32706L (en
Original Assignee
Glaxo Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Lab Ltd filed Critical Glaxo Lab Ltd
Publication of IE32706L publication Critical patent/IE32706L/en
Publication of IE32706B1 publication Critical patent/IE32706B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1,268,773. Antiviral compositions. GLAXO LABORATORIES Ltd. 14 March, 1969 [15 March, 1968], No. 12732/68. Heading A5B. [Also in Division C2[ Pharmaceutical or veterinary compositions having antiviral activity comprise, as active ingredient, at least one 4-substituted α-carboline derivative of the general formula wherein R is a hydrogen atom or a substituted or unsubstituted aliphatic, araliphatic, aromatic or acyl group, X is a halogen atom or the residue of a nucleophile and in which the nucleus may be further substituted by aliphatic, araliphatic, aromatic, carboxy, carboxylic acid ester, acylamino, hydroxy, acyloxy, ether, nitro, amino or sulphonic acid groups or halogen atoms, or physiologically compatible salt thereof, together with at least one pharmaceutical or veterinary carrier or excipient and/or other medicinal agents, e.g. anti-inflammatory agents such as steroids (e.g. betamethasone-21- phosphate) or antibiotics such as tetracycline. The compositions may be administered orally, topically, rectally, intravaginally or parenterally in the form of tablets, capsules, lozenges, chewing gum, medicated sweets, solutions, suspensions, syrups, elixirs, emulsions, granules for reconstitution before use, liquid sprays, powder insufflations, nasal drops or ointments, throat paints, gargles, opthalmic preparations and collyria, skin paints, lotions, creams, ointments, dusting powders, medicated dressings, eye drops and lotions, aerosols, suppositories, pessaries or injectable preparations. The compound 4-diethylaminoethylamino-9 methyl-α-carboline additionally shows antimycoplasma activity. [GB1268773A]
IE33969A 1968-03-15 1969-03-14 Novel alpha-carboline derivatives,the preparation thereof and compositions containing the same IE32706B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1273268A GB1268773A (en) 1968-03-15 1968-03-15 NOVEL alpha-CARBOLINE DERIVATIVES, THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME

Publications (2)

Publication Number Publication Date
IE32706L IE32706L (en) 1969-09-15
IE32706B1 true IE32706B1 (en) 1973-10-31

Family

ID=10010080

Family Applications (1)

Application Number Title Priority Date Filing Date
IE33969A IE32706B1 (en) 1968-03-15 1969-03-14 Novel alpha-carboline derivatives,the preparation thereof and compositions containing the same

Country Status (9)

Country Link
AT (2) AT305277B (en)
BE (1) BE729854A (en)
CH (1) CH529155A (en)
DE (1) DE1913124A1 (en)
FR (1) FR2004000A1 (en)
GB (1) GB1268773A (en)
IE (1) IE32706B1 (en)
NL (1) NL6903974A (en)
SE (1) SE370399B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4952584A (en) * 1986-01-11 1990-08-28 Beecham Group P.L.C. 9H-pyrido[2,B-8]indole-3-carboxylic acid ester compounds having useful pharmaceutical activity
GB8600651D0 (en) * 1986-01-11 1986-02-19 Beecham Group Plc Compounds
US6147085A (en) * 1999-04-01 2000-11-14 Neurogen Corporation Aminoalkyl substituted 9H-pyridino[2,3-b] indole and 9H-pyrimidino[4,5-b] indole derivatives
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
US20100120717A1 (en) 2006-10-09 2010-05-13 Brown Jason W Kinase inhibitors
EP2161271A1 (en) * 2008-09-08 2010-03-10 Università Degli Studi Di Milano - Bicocca Alpha-carboline inhibitors of NMP-ALK, RET, and Bcr-Abl
CA2960101C (en) 2014-09-05 2024-05-21 Allosteros Therapeutics, Inc. Substituted carboline derivative and compositions thereof useful as camkii inhibitors

Also Published As

Publication number Publication date
SE370399B (en) 1974-10-14
GB1268773A (en) 1972-03-29
IE32706L (en) 1969-09-15
FR2004000A1 (en) 1969-11-14
BE729854A (en) 1969-09-15
NL6903974A (en) 1969-09-17
CH529155A (en) 1972-10-15
DE1913124A1 (en) 1969-10-02
AT306713B (en) 1973-04-25
AT305277B (en) 1973-02-26

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