GB1397073A - 1,2,4-oxadizoles - Google Patents
1,2,4-oxadizolesInfo
- Publication number
- GB1397073A GB1397073A GB1583871A GB1583871A GB1397073A GB 1397073 A GB1397073 A GB 1397073A GB 1583871 A GB1583871 A GB 1583871A GB 1583871 A GB1583871 A GB 1583871A GB 1397073 A GB1397073 A GB 1397073A
- Authority
- GB
- United Kingdom
- Prior art keywords
- carbamoyl group
- araliphatic
- conr
- cycloaliphatic
- defined above
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicinal Preparation (AREA)
Abstract
1397073 Antibacterial &c medicines GLAXO LABORATORIES LTD 18 May 1972 [19 May 1971] 15838/71 Heading A5B [Also in Division C2] Pharmaceutical preparations having, in particular, antimicrobial activity, including antiviral, antiparasitic and antibacterial activities, contain (I) as active ingredient where R<SP>6</SP> represents R, where R represents a hydrogen atom or an aliphatic, cycloaliphatic, araliphatic, aryl or heterocyclic group; or a carbamoyl group of the formula -CONR<SP>1</SP>R<SP>2</SP> where R<SP>1</SP> and R<SP>2</SP>, which may be the same or different, represent hydrogen atoms or alkyl, alkenyl or alkynyl groups (or such groups substituted by a hydroxy group) or cycloaliphatic, araliphatic or aryl groups, or, together with the intervening nitrogen atom, represent a heterocydic ring; and R<SP>7</SP> represents R, Where R is as defined above, or a carbamoyl group of the formula -CONR<SP>3</SP>R<SP>4</SP>, where R<SP>3</SP> and R<SP>4</SP> are as defined above for R<SP>1</SP> and R<SP>2</SP>; provided that at least one of R<SP>6</SP> and R<SP>7</SP> is an N-substituted carbamoyl group. Administration is e.g. orally, topically, rectally, parentally or intravaginally. Other compounding ingredients may be, e.g. anti-inflammatory agents such as steriods, e.g. betamethasone-21-phosphate or antibiotics such as tetracycline and neomycin sulphate. The examples describe the preparations of tablets, capsules, eye drops (aqueous and oily) and ointments and nasal sprays.
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1583871A GB1397073A (en) | 1971-05-19 | 1971-05-19 | 1,2,4-oxadizoles |
DE19722224338 DE2224338A1 (en) | 1971-05-19 | 1972-05-18 | Oxadiazole derivatives |
BE783653A BE783653A (en) | 1971-05-19 | 1972-05-18 | NEW DERIVATIVES OF 1,2,4-OXADIAZOLE AND PHARMACEUTICAL COMPOSITIONS, WHICH CONTAIN THEM |
FR7217790A FR2138079B1 (en) | 1971-05-19 | 1972-05-18 | |
NL7206759A NL7206759A (en) | 1971-05-19 | 1972-05-18 | |
ZA723387A ZA723387B (en) | 1971-05-19 | 1972-05-18 | New oxadiazole derivatives,processes for the preparation thereof and pharmaceutical composition containing the same |
US05/415,342 US3991067A (en) | 1971-05-19 | 1973-11-13 | Mono- or disubstituted 1,2,4,oxadiazoles which are substituted by at least 1-N-substituted carbamoyl group |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1583871A GB1397073A (en) | 1971-05-19 | 1971-05-19 | 1,2,4-oxadizoles |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1397073A true GB1397073A (en) | 1975-06-11 |
Family
ID=10066433
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1583871A Expired GB1397073A (en) | 1971-05-19 | 1971-05-19 | 1,2,4-oxadizoles |
Country Status (6)
Country | Link |
---|---|
BE (1) | BE783653A (en) |
DE (1) | DE2224338A1 (en) |
FR (1) | FR2138079B1 (en) |
GB (1) | GB1397073A (en) |
NL (1) | NL7206759A (en) |
ZA (1) | ZA723387B (en) |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996016080A1 (en) * | 1994-11-21 | 1996-05-30 | Cortech, Inc. | Human neutrophil elastase inhibitors |
US5998379A (en) * | 1994-11-21 | 1999-12-07 | Cortech Inc. | Serine protease inhibitors-proline analogs |
US6001813A (en) * | 1994-11-21 | 1999-12-14 | Cortech Inc. | Val-pro containing α-keto oxadiazoles as serine protease inhibitors |
US6001814A (en) * | 1994-11-21 | 1999-12-14 | Cortech Inc. | Serine protease inhibitors |
US6001811A (en) * | 1994-11-21 | 1999-12-14 | Cortech Inc. | Serine protease inhibitors--N-substituted derivatives |
US6015791A (en) * | 1994-11-21 | 2000-01-18 | Cortech Inc. | Serine protease inhibitors-cycloheptane derivatives |
US6100238A (en) * | 1994-11-21 | 2000-08-08 | Cortech Inc. | Indole and tetrahydroisoquinoline containing Alpha-keto oxadiazoles as serine protease inhibitors |
US6150334A (en) * | 1994-11-21 | 2000-11-21 | Cortech, Inc. | Serine protease inhibitors-tripeptoid analogs |
US6159938A (en) * | 1994-11-21 | 2000-12-12 | Cortech, Inc. | Serine protease inhibitors comprising α-keto heterocycles |
US6548638B2 (en) | 1998-06-03 | 2003-04-15 | Cortech, Inc. | Peptoid and nonpeptoid containing α-keto oxadiazoles as serine protease inhibitors |
US6608175B2 (en) | 1994-11-21 | 2003-08-19 | Cortech, Inc. | Serine protease inhibitors |
US6656910B2 (en) | 1997-12-04 | 2003-12-02 | Cortech, Inc. | Serine protease inhibitors |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8207205B2 (en) | 2008-04-21 | 2012-06-26 | Institute For Oneworld Health | Compounds, compositions and methods comprising oxadiazole derivatives |
US8343976B2 (en) | 2009-04-20 | 2013-01-01 | Institute For Oneworld Health | Compounds, compositions and methods comprising pyrazole derivatives |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1357733A (en) * | 1970-07-28 | 1974-06-26 | Glaxo Lab Ltd | 1,2,4-oxadiazole derivatives |
-
1971
- 1971-05-19 GB GB1583871A patent/GB1397073A/en not_active Expired
-
1972
- 1972-05-18 DE DE19722224338 patent/DE2224338A1/en active Pending
- 1972-05-18 ZA ZA723387A patent/ZA723387B/en unknown
- 1972-05-18 BE BE783653A patent/BE783653A/en unknown
- 1972-05-18 NL NL7206759A patent/NL7206759A/xx unknown
- 1972-05-18 FR FR7217790A patent/FR2138079B1/fr not_active Expired
Cited By (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6001814A (en) * | 1994-11-21 | 1999-12-14 | Cortech Inc. | Serine protease inhibitors |
US5861380A (en) * | 1994-11-21 | 1999-01-19 | Cortech, Inc. | Serine protease inhibitors-keto and di-keto containing ring systems |
WO1996016080A1 (en) * | 1994-11-21 | 1996-05-30 | Cortech, Inc. | Human neutrophil elastase inhibitors |
US6015791A (en) * | 1994-11-21 | 2000-01-18 | Cortech Inc. | Serine protease inhibitors-cycloheptane derivatives |
US6001811A (en) * | 1994-11-21 | 1999-12-14 | Cortech Inc. | Serine protease inhibitors--N-substituted derivatives |
US5869455A (en) * | 1994-11-21 | 1999-02-09 | Cortech, Inc. | Serine protease inhibitors-N-substituted derivatives |
US5874585A (en) * | 1994-11-21 | 1999-02-23 | Cortech, Inc. | Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase |
US5891852A (en) * | 1994-11-21 | 1999-04-06 | Cortech, Inc. | Serine protease inhibitors-cycloheptane derivatives |
US5998379A (en) * | 1994-11-21 | 1999-12-07 | Cortech Inc. | Serine protease inhibitors-proline analogs |
US6001813A (en) * | 1994-11-21 | 1999-12-14 | Cortech Inc. | Val-pro containing α-keto oxadiazoles as serine protease inhibitors |
US5801148A (en) * | 1994-11-21 | 1998-09-01 | Cortech, Inc. | Serine protease inhibitors-proline analogs |
US5618792A (en) * | 1994-11-21 | 1997-04-08 | Cortech, Inc. | Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase |
US5807829A (en) * | 1994-11-21 | 1998-09-15 | Cortech, Inc. | Serine protease inhibitor--tripeptoid analogs |
US6037325A (en) * | 1994-11-21 | 2000-03-14 | Cortech, Inc. | Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase |
US6100238A (en) * | 1994-11-21 | 2000-08-08 | Cortech Inc. | Indole and tetrahydroisoquinoline containing Alpha-keto oxadiazoles as serine protease inhibitors |
US6150334A (en) * | 1994-11-21 | 2000-11-21 | Cortech, Inc. | Serine protease inhibitors-tripeptoid analogs |
US6159938A (en) * | 1994-11-21 | 2000-12-12 | Cortech, Inc. | Serine protease inhibitors comprising α-keto heterocycles |
US6656911B2 (en) | 1994-11-21 | 2003-12-02 | Cortech, Inc. | Serine protease inhibitors |
US6608175B2 (en) | 1994-11-21 | 2003-08-19 | Cortech, Inc. | Serine protease inhibitors |
US6656910B2 (en) | 1997-12-04 | 2003-12-02 | Cortech, Inc. | Serine protease inhibitors |
US6548638B2 (en) | 1998-06-03 | 2003-04-15 | Cortech, Inc. | Peptoid and nonpeptoid containing α-keto oxadiazoles as serine protease inhibitors |
Also Published As
Publication number | Publication date |
---|---|
ZA723387B (en) | 1974-01-30 |
FR2138079A1 (en) | 1972-12-29 |
NL7206759A (en) | 1972-11-21 |
BE783653A (en) | 1972-11-20 |
DE2224338A1 (en) | 1972-11-30 |
FR2138079B1 (en) | 1975-12-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PLNP | Patent lapsed through nonpayment of renewal fees |