GB1351437A - N-substituted amino acids having antiviral anti-inflammatory or anti-tumour activity - Google Patents

N-substituted amino acids having antiviral anti-inflammatory or anti-tumour activity

Info

Publication number
GB1351437A
GB1351437A GB3874872A GB3874872A GB1351437A GB 1351437 A GB1351437 A GB 1351437A GB 3874872 A GB3874872 A GB 3874872A GB 3874872 A GB3874872 A GB 3874872A GB 1351437 A GB1351437 A GB 1351437A
Authority
GB
United Kingdom
Prior art keywords
inflammatory
amino acids
naphthylaminomethyl
isoleucine
phenylalanine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3874872A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP6325171A external-priority patent/JPS5313626B2/ja
Priority claimed from JP6325071A external-priority patent/JPS5218176B2/ja
Priority claimed from JP6325271A external-priority patent/JPS4828612A/ja
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Publication of GB1351437A publication Critical patent/GB1351437A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes

Abstract

1351437 Medicines comprising amino acid derivatives AJINOMOTO CO INC 18 Aug 1972 [19 Aug 1971 (3)] 38748/72 Heading A5B [Also in Division C2] A therapeutic composition suitable for oral or parenteral administration comprises a pharmaceutical carrier and as the active ingredient novel N-#-naphthylaminomethyl-leucine, N-#- naphthylaminomethyl urethane, N-furfurylaminomethyl-phenylalanine, . N-furfuryl-4-nitrophenylalanine, N- 2 -fluorenesulphonylmethionine, N-2-fluorenesulphonyl-phenylalanine, N- ethylcarbanunomethyl-isoleucine, N-#-naphthylaminiomethyl-threonine; N-9-fluorenylacetylphenylalanine, N-myristoyl-isoleucine or N-#- naphthalenesulphpnyl-tryptophan. or a pharmaceutically acceptable salt thereof. The above composition may be in a unit dosage form and in this form the invention also includes a therapeutic composition comprising a pharmaceutical carrier and as the active ingredient N-benzylvaline, N-lauroyl-leucine' or N-propionylvaline or. a pharmaceutically acceptable salt thereof. The compositions are useful for combatting infection with influenza virus, as anti-inflammatory agents or as anti-tumour agents.
GB3874872A 1971-08-19 1972-08-10 N-substituted amino acids having antiviral anti-inflammatory or anti-tumour activity Expired GB1351437A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP6325171A JPS5313626B2 (en) 1971-08-19 1971-08-19
JP6325071A JPS5218176B2 (en) 1971-08-19 1971-08-19
JP6325271A JPS4828612A (en) 1971-08-19 1971-08-19

Publications (1)

Publication Number Publication Date
GB1351437A true GB1351437A (en) 1974-05-01

Family

ID=27298102

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3874872A Expired GB1351437A (en) 1971-08-19 1972-08-10 N-substituted amino acids having antiviral anti-inflammatory or anti-tumour activity

Country Status (4)

Country Link
DE (1) DE2236876C3 (en)
FR (1) FR2150803B1 (en)
GB (1) GB1351437A (en)
NL (1) NL7211361A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4416820A (en) 1981-01-14 1983-11-22 Takeda Chemical Industries, Ltd. Indole derivatives and a method for production of peptides

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2508444A1 (en) * 1981-06-29 1982-12-31 Irceba Analgesic and anti:inflammatory sulphonyl-tryptophan(s) - prepd. from tryptophan and aryl-sulphonyl-halide
AU736347B2 (en) * 1996-09-04 2001-07-26 Warner-Lambert Company Compounds for and a method of inhibiting matrix metalloproteinases
WO1999059574A1 (en) * 1998-05-21 1999-11-25 Magainin Pharmaceuticals, Inc. A method for stimulation of defensin production by exposure to isoleucin
DE10112882A1 (en) * 2001-03-15 2002-09-19 Max Delbrueck Centrum Selective cytostatic treatment of serotonin-producing tumors, using non-toxic tryptophan derivatives, e.g. 7-hydroxytryptophan, which are enzymatically converted into specific toxins in the tumor cells
DE10321759B4 (en) * 2003-05-15 2006-04-27 Henkel Kgaa Process for spray-drying free-flowing recyclables

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4416820A (en) 1981-01-14 1983-11-22 Takeda Chemical Industries, Ltd. Indole derivatives and a method for production of peptides

Also Published As

Publication number Publication date
DE2236876B2 (en) 1980-06-04
DE2236876A1 (en) 1973-03-01
NL7211361A (en) 1973-02-21
FR2150803B1 (en) 1975-10-17
FR2150803A1 (en) 1973-04-13
DE2236876C3 (en) 1981-02-12

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee