US6228879B1
(en)
*
|
1997-10-16 |
2001-05-08 |
The Children's Medical Center |
Methods and compositions for inhibition of angiogenesis
|
US6429221B1
(en)
|
1994-12-30 |
2002-08-06 |
Celgene Corporation |
Substituted imides
|
HU228769B1
(en)
*
|
1996-07-24 |
2013-05-28 |
Celgene Corp |
Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha
|
US5635517B1
(en)
*
|
1996-07-24 |
1999-06-29 |
Celgene Corp |
Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines
|
US7629360B2
(en)
*
|
1999-05-07 |
2009-12-08 |
Celgene Corporation |
Methods for the treatment of cachexia and graft v. host disease
|
US6458810B1
(en)
|
2000-11-14 |
2002-10-01 |
George Muller |
Pharmaceutically active isoindoline derivatives
|
AU2002253795B2
(en)
*
|
2000-11-30 |
2007-02-01 |
The Children's Medical Center Corporation |
Synthesis of 4-Amino-Thalidomide enantiomers
|
US20030045552A1
(en)
*
|
2000-12-27 |
2003-03-06 |
Robarge Michael J. |
Isoindole-imide compounds, compositions, and uses thereof
|
DE10137163A1
(de)
*
|
2001-07-30 |
2003-02-13 |
Bayer Ag |
Substituierte Isoindole und ihre Verwendung
|
CA2457319C
(en)
*
|
2001-08-06 |
2011-07-05 |
The Children's Medical Center Corporation |
Synthesis and anti-tumor activity of nitrogen substituted thalidomide analogs
|
EP1475632B1
(en)
*
|
2002-02-14 |
2013-05-22 |
Ajinomoto Co., Inc. |
Method of analyzing aminofunctional compound and analytical reagent
|
US7498171B2
(en)
|
2002-04-12 |
2009-03-03 |
Anthrogenesis Corporation |
Modulation of stem and progenitor cell differentiation, assays, and uses thereof
|
MXPA04009996A
(es)
*
|
2002-04-12 |
2005-07-01 |
Celgene Corp |
Metodos para la identificacion de moduladores de la angiogenesis, compuestos descubiertos por los mismos, y metodos de tratamiento usando los compuestos.
|
NZ572388A
(en)
|
2002-05-17 |
2010-05-28 |
Celgene Corp |
Methods and compositions using immunomodulatory compounds for treatment and management of cancers and other diseases
|
AU2006202316B2
(en)
*
|
2002-05-17 |
2008-04-10 |
Celgene Corporation |
Methods and compositions using immunomodulatory compounds for treatment and management of cancers and other diseases
|
US7323479B2
(en)
|
2002-05-17 |
2008-01-29 |
Celgene Corporation |
Methods for treatment and management of brain cancer using 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline
|
USRE48890E1
(en)
|
2002-05-17 |
2022-01-11 |
Celgene Corporation |
Methods for treating multiple myeloma with 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione after stem cell transplantation
|
US7968569B2
(en)
|
2002-05-17 |
2011-06-28 |
Celgene Corporation |
Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione
|
US7393862B2
(en)
*
|
2002-05-17 |
2008-07-01 |
Celgene Corporation |
Method using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of certain leukemias
|
US8404717B2
(en)
*
|
2002-10-15 |
2013-03-26 |
Celgene Corporation |
Methods of treating myelodysplastic syndromes using lenalidomide
|
US11116782B2
(en)
|
2002-10-15 |
2021-09-14 |
Celgene Corporation |
Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine
|
US8404716B2
(en)
*
|
2002-10-15 |
2013-03-26 |
Celgene Corporation |
Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine
|
EP1900369A1
(en)
|
2002-10-15 |
2008-03-19 |
Celgene Corporation |
Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of myelodysplastic syndromes
|
US7189740B2
(en)
*
|
2002-10-15 |
2007-03-13 |
Celgene Corporation |
Methods of using 3-(4-amino-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myelodysplastic syndromes
|
US20050203142A1
(en)
*
|
2002-10-24 |
2005-09-15 |
Zeldis Jerome B. |
Methods of using and compositions comprising immunomodulatory compounds for treatment, modification and management of pain
|
EP1556044A2
(en)
*
|
2002-10-24 |
2005-07-27 |
Celgene Corporation |
Methods of using and compositions comprising immunomodulatory compounds for treatment, modification and management of pain
|
US8034831B2
(en)
|
2002-11-06 |
2011-10-11 |
Celgene Corporation |
Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies
|
US7563810B2
(en)
*
|
2002-11-06 |
2009-07-21 |
Celgene Corporation |
Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases
|
BR0316695A
(pt)
*
|
2002-11-26 |
2005-10-18 |
Anthrogenesis Corp |
Unidade citoterapêutica, kit para tratamento, método de tratamento de uma enfermidade, biblioteca de unidades citoterapêuticas e método de tratamento de um paciente
|
EP1615878B1
(en)
*
|
2003-01-14 |
2012-04-04 |
Cytokinetics, Inc. |
Compounds, compositions and methods of treatment for heart failure
|
BRPI0407427A
(pt)
*
|
2003-02-13 |
2006-01-24 |
Anthrogenesis Corp |
Método para tratar um paciente e para tratar a mielodisplasia
|
US7320992B2
(en)
*
|
2003-08-25 |
2008-01-22 |
Amgen Inc. |
Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use
|
UA83504C2
(en)
|
2003-09-04 |
2008-07-25 |
Селджин Корпорейшн |
Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione
|
US7973057B2
(en)
*
|
2003-09-17 |
2011-07-05 |
The United States Of America As Represented By The Department Of Health And Human Services |
Thalidomide analogs
|
US8952895B2
(en)
|
2011-06-03 |
2015-02-10 |
Apple Inc. |
Motion-based device operations
|
US7612096B2
(en)
*
|
2003-10-23 |
2009-11-03 |
Celgene Corporation |
Methods for treatment, modification and management of radiculopathy using 1-oxo-2-(2,6-dioxopiperidin-3yl)-4-aminoisoindoline
|
KR20060124607A
(ko)
*
|
2003-11-06 |
2006-12-05 |
셀진 코포레이션 |
암 및 그 밖의 질환의 치료 및 관리를 위하여탈리도마이드를 사용하는 방법 및 조성물
|
US20050100529A1
(en)
*
|
2003-11-06 |
2005-05-12 |
Zeldis Jerome B. |
Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of asbestos-related diseases and disorders
|
BRPI0417186A
(pt)
*
|
2003-12-02 |
2007-03-06 |
Celgene Corp |
método de tratamento de um indivìduo tendo uma hemoglobinopatia ou uma anemia, de modulação da diferenciação de uma célula-tronco ou precursora de cd34+ para uma linhagem de eritróides, e, composição farmacêutica
|
US20050143344A1
(en)
*
|
2003-12-30 |
2005-06-30 |
Zeldis Jerome B. |
Methods and compositions using immunomodulatory compounds for the treatment and management of central nervous system disorders or diseases
|
ZA200607799B
(en)
|
2004-03-22 |
2008-06-25 |
Celgene Corp |
Methods of using and compositions comprising immuno-modulatory compounds for the treatment and management of skin diseases or disorders
|
US20050222209A1
(en)
*
|
2004-04-01 |
2005-10-06 |
Zeldis Jerome B |
Methods and compositions for the treatment, prevention or management of dysfunctional sleep and dysfunctional sleep associated with disease
|
KR101164696B1
(ko)
*
|
2004-04-14 |
2012-07-11 |
셀진 코포레이션 |
골수이형성 증후군의 치료 및 관리를 위한 면역조절화합물의 사용 방법 및 상기 화합물을 포함하는 조성물
|
WO2005105088A2
(en)
*
|
2004-04-23 |
2005-11-10 |
Celgene Corporation |
Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of pulmonary hypertension
|
JP2005336157A
(ja)
*
|
2004-04-30 |
2005-12-08 |
Arigen Inc |
光学活性サリドマイドおよびその誘導体の製造法
|
CA2565447A1
(en)
*
|
2004-05-05 |
2005-12-01 |
Celgene Corporation |
Method of using and compositions comprising immunomodulatory compounds for the treatment and management of myeloproliferative diseases
|
JP5080970B2
(ja)
*
|
2004-06-17 |
2012-11-21 |
サイトキネティクス・インコーポレーテッド |
心疾患を治療するための置換尿素誘導体
|
US7176222B2
(en)
|
2004-07-27 |
2007-02-13 |
Cytokinetics, Inc. |
Syntheses of ureas
|
EP1797068B1
(en)
*
|
2004-09-03 |
2013-10-09 |
Celgene Corporation |
Processes for the preparation of substituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines
|
AU2005302523A1
(en)
*
|
2004-10-28 |
2006-05-11 |
Celgene Corporation |
Methods and compositions using PDE4 modulators for treatment and management of central nervous system injury
|
BRPI0517481A
(pt)
*
|
2004-11-12 |
2008-10-14 |
Celgene Corp |
método para tratar, controlar ou evitar uma doença ou distúrbio parasìtico protozoário, e, composição farmacêutica
|
WO2006058008A1
(en)
*
|
2004-11-23 |
2006-06-01 |
Celgene Corporation |
Methods and compositions using immunomodulatory compounds for treatment and management of central nervous system injury
|
US20060270707A1
(en)
*
|
2005-05-24 |
2006-11-30 |
Zeldis Jerome B |
Methods and compositions using 4-[(cyclopropanecarbonylamino)methyl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione for the treatment or prevention of cutaneous lupus
|
AU2006265019B2
(en)
*
|
2005-06-30 |
2011-10-13 |
Celgene Corporation |
Processes for the preparation of 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione compounds
|
KR20080026198A
(ko)
*
|
2005-06-30 |
2008-03-24 |
안트로제네시스 코포레이션 |
태반 유도된 콜라겐 바이오패브릭을 사용한 고막의 복원
|
WO2007009061A2
(en)
*
|
2005-07-13 |
2007-01-18 |
Anthrogenesis Corporation |
Ocular plug formed from placenta derived collagen biofabric
|
EP1919500A2
(en)
*
|
2005-07-13 |
2008-05-14 |
Anthrogenesis Corporation |
Treatment of leg ulcers using placenta derived collagen biofabric
|
US7538223B2
(en)
|
2005-08-04 |
2009-05-26 |
Cytokinetics, Inc. |
Compounds, compositions and methods
|
WO2007027527A2
(en)
*
|
2005-08-31 |
2007-03-08 |
Celgene Corporation |
Isoindole-imide compounds and compositions comprising and methods of using the same
|
EP1928492B1
(en)
|
2005-09-01 |
2011-02-23 |
Celgene Corporation |
Immunological uses of immunodulatory compounds for vaccine and anti-infections disease therapy
|
US20070066512A1
(en)
*
|
2005-09-12 |
2007-03-22 |
Dominique Verhelle |
Methods and compositions using immunomodulatory compounds for the treatment of disorders associated with low plasma leptin levels
|
CN1939922B
(zh)
*
|
2005-09-27 |
2010-10-13 |
天津和美生物技术有限公司 |
可抑制细胞释放肿瘤坏死因子的5H-噻吩[3,4-c]吡咯-4,6-二酮衍生物
|
PE20110020A1
(es)
|
2005-10-13 |
2011-01-31 |
Anthrogenesis Corp |
Inmunomodulacion mediante el uso de celulas madres de la placenta
|
US7825120B2
(en)
*
|
2005-12-15 |
2010-11-02 |
Cytokinetics, Inc. |
Certain substituted ((piperazin-1-ylmethyl)benzyl)ureas
|
EP1959960B1
(en)
*
|
2005-12-15 |
2013-04-10 |
Cytokinetics, Inc. |
Certain chemical entities, compositions and methods
|
US20070208000A1
(en)
*
|
2005-12-15 |
2007-09-06 |
Morgan Bradley P |
Certain chemical entities, compositions and methods
|
WO2007075377A2
(en)
*
|
2005-12-15 |
2007-07-05 |
Cytokinetics, Inc. |
Certain chemical entities, compositions and methods
|
US7718657B2
(en)
*
|
2005-12-16 |
2010-05-18 |
Cytokinetics, Inc. |
Certain indanyl urea modulators of the cardiac sarcomere
|
JP5178526B2
(ja)
*
|
2005-12-19 |
2013-04-10 |
サイトキネティクス・インコーポレーテッド |
化合物、組成物および方法
|
CN101374941A
(zh)
|
2005-12-29 |
2009-02-25 |
人类起源公司 |
采集和保存胎盘干细胞的改良组合物及其使用方法
|
US20070155791A1
(en)
*
|
2005-12-29 |
2007-07-05 |
Zeldis Jerome B |
Methods for treating cutaneous lupus using aminoisoindoline compounds
|
KR20200123283A
(ko)
*
|
2005-12-29 |
2020-10-28 |
안트로제네시스 코포레이션 |
태반 줄기 세포 집단
|
WO2007092569A1
(en)
*
|
2006-02-07 |
2007-08-16 |
Battelle Memorial Institute |
Esters of 5 -hydroxymethylfurfural and methods for their preparation
|
WO2007136640A2
(en)
*
|
2006-05-16 |
2007-11-29 |
Celgene Corporation |
Processes for the preparation of substituted 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
|
TW200806625A
(en)
*
|
2006-05-26 |
2008-02-01 |
Astrazeneca Ab |
Therapeutic compounds
|
EP2049119A2
(en)
*
|
2006-06-29 |
2009-04-22 |
Astex Therapeutics Limited |
Pharmaceutical combinations of 1-cyclopropyl-3-[3-(5-morphoolin-4-ylmethyl-1h-benzoimidazol-2-yl)-1h-1-pyrazol-4-yl]-urea
|
CL2007002218A1
(es)
*
|
2006-08-03 |
2008-03-14 |
Celgene Corp Soc Organizada Ba |
Uso de 3-(4-amino-1-oxo-1,3-dihidro-isoindol-2-il)-piperidina 2,6-diona para la preparacion de un medicamento util para el tratamiento de linfoma de celula de capa.
|
US7993918B2
(en)
|
2006-08-04 |
2011-08-09 |
Anthrogenesis Corporation |
Tumor suppression using placental stem cells
|
WO2008021391A1
(en)
*
|
2006-08-15 |
2008-02-21 |
Anthrogenesis Corporation |
Umbilical cord biomaterial for medical use
|
RU2448101C2
(ru)
*
|
2006-08-30 |
2012-04-20 |
Селджин Корпорейшн |
5-замещенные изоиндолиновые соединения
|
US8877780B2
(en)
*
|
2006-08-30 |
2014-11-04 |
Celgene Corporation |
5-substituted isoindoline compounds
|
CA2660806C
(en)
*
|
2006-08-30 |
2015-06-16 |
Celgene Corporation |
5-substituted isoindoline compounds
|
EP2076260B1
(en)
*
|
2006-09-15 |
2011-03-23 |
Celgene Corporation |
N-methylaminomethyl isoindole compounds and compositions comprising and methods of using the same
|
US20080131522A1
(en)
*
|
2006-10-03 |
2008-06-05 |
Qing Liu |
Use of placental biomaterial for ocular surgery
|
US8071135B2
(en)
|
2006-10-04 |
2011-12-06 |
Anthrogenesis Corporation |
Placental tissue compositions
|
MX2009003588A
(es)
|
2006-10-06 |
2009-05-28 |
Anthrogenesis Corp |
Composiciones de colageno placentario (telopeptido), natural.
|
US10494607B2
(en)
*
|
2007-02-12 |
2019-12-03 |
Celularity, Inc. |
CD34+,CD45−placental stem cell-enriched cell populations
|
KR20150039214A
(ko)
|
2007-02-12 |
2015-04-09 |
안트로제네시스 코포레이션 |
태반 줄기세포를 이용한 염증 질환의 치료
|
JP2010522170A
(ja)
*
|
2007-03-20 |
2010-07-01 |
セルジーン コーポレイション |
4’−o−置換イソインドリン誘導体および該誘導体を含有する組成物およびその使用方法
|
US20100172830A1
(en)
*
|
2007-03-29 |
2010-07-08 |
Cellx Inc. |
Extraembryonic Tissue cells and method of use thereof
|
WO2009020590A1
(en)
|
2007-08-07 |
2009-02-12 |
Celgene Corporation |
Methods for treating lymphomas in certain patient populations and screening patients for said therapy
|
KR101645311B1
(ko)
*
|
2007-09-26 |
2016-08-03 |
안트로제네시스 코포레이션 |
인간 태반 관류액으로부터의 혈관형성 세포
|
CN104211684A
(zh)
|
2007-09-26 |
2014-12-17 |
细胞基因公司 |
6-、7-或8-取代的喹唑啉酮衍生物、含有它的组合物及其使用方法
|
ES2530995T3
(es)
*
|
2007-09-28 |
2015-03-09 |
Anthrogenesis Corp |
Supresión de tumor usando perfusato placentario humano y células asesinas naturales intermediarias que provienen de placenta humana
|
MX2010005018A
(es)
*
|
2007-11-07 |
2010-05-27 |
Anthrogenesis Corp |
Tratamiento de complicaciones de nacimiento prematuro.
|
EP2219627A2
(en)
*
|
2007-11-08 |
2010-08-25 |
Celgene Corporation |
Use of immunomodulatory compounds for the treatment of disorders associated with endothelial dysfunction
|
WO2009073146A2
(en)
*
|
2007-11-29 |
2009-06-11 |
Celgene Corporation |
Use of immunomodulatory compounds for the treatment of transverse myelitis, multiple sclerosis, and other disorders
|
WO2009085234A2
(en)
*
|
2007-12-20 |
2009-07-09 |
Signal Pharmaceuticals, Inc. |
Use of micro-rna as a biomarker of immunomodulatory drug activity
|
JP2011510983A
(ja)
*
|
2008-01-29 |
2011-04-07 |
セルジーン コーポレイション |
Cd59のレベルを調節するための、免疫調節化合物を使用する方法
|
WO2009105256A2
(en)
*
|
2008-02-20 |
2009-08-27 |
Celgene Corporation |
Method of treating cancer by administering an immunomodulatory compound in combination with a cd40 antibody or cd40 ligand
|
US8828376B2
(en)
*
|
2008-08-20 |
2014-09-09 |
Anthrogenesis Corporation |
Treatment of stroke using isolated placental cells
|
RU2662676C1
(ru)
*
|
2008-08-20 |
2018-07-26 |
Антродженезис Корпорейшн |
Улучшенная клеточная композиция и способы ее получения
|
MX2011001992A
(es)
*
|
2008-08-22 |
2011-03-29 |
Anthrogenesis Corp |
Metodos y composiciones para el tratamiento de defectos oseos con poblaciones de celulas placentarias.
|
NZ592425A
(en)
|
2008-10-29 |
2013-04-26 |
Celgene Corp |
Isoindoline compounds for use in the treatment of cancer
|
KR20110086176A
(ko)
*
|
2008-11-19 |
2011-07-27 |
안트로제네시스 코포레이션 |
양막 유래 부착성 세포
|
RU2732240C2
(ru)
*
|
2008-11-21 |
2020-09-14 |
Антродженезис Корпорейшн |
Лечение заболеваний, расстройств или патологических состояний легких с использованием плацентарных клеток
|
WO2010077686A1
(en)
*
|
2008-12-08 |
2010-07-08 |
Sirtris Pharmaceuticals, Inc. |
Isoindolinone and related analogs as sirtuin modulators
|
PT2411506T
(pt)
|
2009-03-25 |
2019-03-19 |
Celularity Inc |
Supressão de tumores usando células assassinas naturais intermédias derivadas de placenta humana e compostos imunomoduladores
|
US20120134969A1
(en)
|
2009-05-25 |
2012-05-31 |
Hiroshi Handa |
Pharmaceutical composition containing nuclear factor involved in proliferation and differentiation of central neuronal cells
|
CN101580501B
(zh)
*
|
2009-06-01 |
2011-03-09 |
南京卡文迪许生物工程技术有限公司 |
3-(取代二氢异吲哚酮-2-基)-2,6-哌啶二酮的合成方法及其中间体
|
EP2521543B1
(en)
|
2010-01-05 |
2016-04-13 |
Celgene Corporation |
A combination of an immunomodulatory compound and an artemisinin derivative for treating cancer
|
DK3284818T3
(da)
*
|
2010-01-26 |
2022-06-20 |
Celularity Inc |
Behandling af knoglerelateret kræft ved hjælp af placenta stamceller
|
EP2536706B1
(en)
|
2010-02-11 |
2017-06-14 |
Celgene Corporation |
Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same
|
EP2555769B1
(en)
|
2010-04-07 |
2022-01-12 |
Amgen (Europe) GmbH |
Methods for treating respiratory viral infection
|
DK2556145T3
(en)
|
2010-04-07 |
2016-11-07 |
Anthrogenesis Corp |
Angiogenesis using placental stem cells
|
NZ602798A
(en)
|
2010-04-08 |
2014-10-31 |
Anthrogenesis Corp |
Treatment of sarcoidosis using placental stem cells
|
NZ605505A
(en)
|
2010-07-13 |
2015-02-27 |
Anthrogenesis Corp |
Methods of generating natural killer cells
|
US20140031325A1
(en)
|
2010-12-06 |
2014-01-30 |
Celgene Corporation |
Combination therapy with lenalidomide and a cdk inhibitor for treating multiple myeloma
|
AU2011352036A1
(en)
|
2010-12-31 |
2013-07-18 |
Anthrogenesis Corporation |
Enhancement of placental stem cell potency using modulatory RNA molecules
|
CA3037184C
(en)
|
2011-03-11 |
2021-04-06 |
Celgene Corporation |
Solid forms of 3-(5-amino-2-methyl-4-oxo-4h-quinazolin-3-yl)-piperidine-2,6-dione, and their pharmaceutical compositions and uses
|
EP2699091B1
(en)
|
2011-03-28 |
2017-06-21 |
DeuteRx, LLC |
2',6'-dioxo-3'-deutero-piperdin-3-yl-isoindoline compounds
|
EP2699909A1
(en)
|
2011-04-18 |
2014-02-26 |
Celgene Corporation |
Biomarkers for the treatment of multiple myeloma
|
MX353482B
(es)
|
2011-04-29 |
2018-01-16 |
Celgene Corp |
Metodos para el tratamiento del cancer y enfermedades inflamatorias utilizando cereblon como predictor.
|
CA2837871C
(en)
|
2011-06-01 |
2021-12-07 |
Anthrogenesis Corporation |
Treatment of pain using placental stem cells
|
US8927725B2
(en)
|
2011-12-02 |
2015-01-06 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Thio compounds
|
CA2874936A1
(en)
|
2012-06-06 |
2013-12-12 |
Bionor Immuno As |
Vaccine
|
EP3904875A1
(en)
|
2012-06-29 |
2021-11-03 |
Celgene Corporation |
Methods for determining drug efficacy using ikzf3 (aiolos)
|
US9587281B2
(en)
|
2012-08-14 |
2017-03-07 |
Celgene Corporation |
Cereblon isoforms and their use as biomarkers for therapeutic treatment
|
AU2013204922B2
(en)
|
2012-12-20 |
2015-05-14 |
Celgene Corporation |
Chimeric antigen receptors
|
US9540340B2
(en)
|
2013-01-14 |
2017-01-10 |
Deuterx, Llc |
3-(5-substituted-4-oxoquinazolin-3(4H)-yl)-3-deutero-piperidine-2,6-dione derivatives and compositions comprising and methods of using the same
|
JP2016506968A
(ja)
|
2013-02-05 |
2016-03-07 |
アントフロゲネシス コーポレーション |
胎盤由来のナチュラルキラー細胞
|
EP2968334A4
(en)
|
2013-03-14 |
2016-08-03 |
Deuterx Llc |
3- (SUBSTITIERTES-4-OXO-quinazolin-3 (4H) -yl) -3-deutero-PIPERIDINE-2,6-DIONE DERIVATIVES
|
CA2907397C
(en)
|
2013-03-15 |
2022-11-22 |
Anthrogenesis Corporation |
Modified t lymphocytes
|
WO2015007337A1
(en)
|
2013-07-19 |
2015-01-22 |
Bionor Immuno As |
Method for the vaccination against hiv
|
CN103421061A
(zh)
*
|
2013-08-14 |
2013-12-04 |
中国药科大学 |
来那度胺衍生物、其制法及其医药用途
|
CN103396397A
(zh)
*
|
2013-08-14 |
2013-11-20 |
中国人民解放军军事医学科学院毒物药物研究所 |
来那度胺衍生物及其作为药物的用途
|
US9969687B2
(en)
*
|
2013-12-23 |
2018-05-15 |
Norgine B.V. |
Compounds useful as CCR9 modulators
|
JP6778114B2
(ja)
*
|
2014-04-14 |
2020-10-28 |
アルビナス・オペレーションズ・インコーポレイテッドArvinas Operations, Inc. |
イミド系タンパク質分解モジュレーター及び関連する使用方法
|
WO2015200795A1
(en)
|
2014-06-27 |
2015-12-30 |
Celgene Corporation |
Compositions and methods for inducing conformational changes in cereblon other e3 ubiquitin ligases
|
JP2017523166A
(ja)
|
2014-07-11 |
2017-08-17 |
ビオノール イミュノ エーエスBionor Immuno As |
ヒト免疫不全ウイルスi(hiv)の病理学的影響を減少及び/若しくは遅延させるか又は後天性免疫不全症候群(aids)を発症するリスクを低減させる方法
|
CA2958867A1
(en)
|
2014-08-22 |
2016-02-25 |
Anjan THAKURTA |
Methods of treating multiple myeloma with immunomodulatory compounds in combination with antibodies
|
CN105566290B
(zh)
|
2014-10-30 |
2020-05-22 |
康朴生物医药技术(上海)有限公司 |
异吲哚啉衍生物、其中间体、制备方法、药物组合物及应用
|
JP6815318B2
(ja)
*
|
2014-12-23 |
2021-01-20 |
ダナ−ファーバー キャンサー インスティテュート,インコーポレイテッド |
二官能性分子によって標的化タンパク質分解を誘導する方法
|
US9694084B2
(en)
|
2014-12-23 |
2017-07-04 |
Dana-Farber Cancer Institute, Inc. |
Methods to induce targeted protein degradation through bifunctional molecules
|
KR20220029783A
(ko)
|
2015-01-20 |
2022-03-08 |
아비나스 오퍼레이션스, 인코포레이티드 |
안드로겐 수용체의 표적화된 분해를 위한 화합물 및 방법
|
US20170327469A1
(en)
|
2015-01-20 |
2017-11-16 |
Arvinas, Inc. |
Compounds and methods for the targeted degradation of androgen receptor
|
JP2018515603A
(ja)
|
2015-05-04 |
2018-06-14 |
ビオノル・イムノ・アクシェセルスカプBionor Immuno AS |
Hivワクチン用の投薬レジメン
|
EP3302482A4
(en)
|
2015-06-05 |
2018-12-19 |
Arvinas, Inc. |
Tank-binding kinase-1 protacs and associated methods of use
|
EP3313818B1
(en)
|
2015-06-26 |
2023-11-08 |
Celgene Corporation |
Methods for the treatment of kaposi's sarcoma or kshv-induced lymphoma using immunomodulatory compounds, and uses of biomarkers
|
US9809603B1
(en)
|
2015-08-18 |
2017-11-07 |
Deuterx, Llc |
Deuterium-enriched isoindolinonyl-piperidinonyl conjugates and oxoquinazolin-3(4H)-yl-piperidinonyl conjugates and methods of treating medical disorders using same
|
WO2017030814A1
(en)
|
2015-08-19 |
2017-02-23 |
Arvinas, Inc. |
Compounds and methods for the targeted degradation of bromodomain-containing proteins
|
ES2963446T3
(es)
*
|
2015-09-29 |
2024-03-27 |
Kangpu Biopharmaceuticals Ltd |
Composición farmacéutica y aplicación de la misma
|
WO2017117118A1
(en)
|
2015-12-28 |
2017-07-06 |
Celgene Corporation |
Compositions and methods for inducing conformational changes in cereblon and other e3 ubiquitin ligases
|
US10759808B2
(en)
|
2016-04-06 |
2020-09-01 |
The Regents Of The University Of Michigan |
Monofunctional intermediates for ligand-dependent target protein degradation
|
CN113788818A
(zh)
*
|
2016-04-06 |
2021-12-14 |
密执安大学评议会 |
Mdm2蛋白质降解剂
|
MX2018012379A
(es)
*
|
2016-04-12 |
2019-07-04 |
Univ Michigan Regents |
Degradadores de proteinas de bromodominio y dominioextraterminal (bet).
|
EP3455218A4
(en)
|
2016-05-10 |
2019-12-18 |
C4 Therapeutics, Inc. |
C3 CARBON-BASED GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN REDUCTION
|
WO2017197055A1
(en)
|
2016-05-10 |
2017-11-16 |
C4 Therapeutics, Inc. |
Heterocyclic degronimers for target protein degradation
|
CN109562113A
(zh)
|
2016-05-10 |
2019-04-02 |
C4医药公司 |
用于靶蛋白降解的螺环降解决定子体
|
CN110506039A
(zh)
|
2016-10-11 |
2019-11-26 |
阿尔维纳斯股份有限公司 |
用于雄激素受体靶向降解的化合物和方法
|
IL304982A
(en)
|
2016-11-01 |
2023-10-01 |
Arvinas Operations Inc |
PROTACS Targeted Tau-Protein and Related Methods of Use
|
EP3548483A4
(en)
|
2016-12-01 |
2020-06-10 |
Arvinas Operations, Inc. |
TETRAHYDRONAPHTHALINE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS AN ESTROGEN RECEPTOR-DEGRADING AGENT
|
MX2019006285A
(es)
|
2016-12-03 |
2019-12-16 |
Juno Therapeutics Inc |
Metodos para modulacion de celulas cart-t.
|
MA46963A
(fr)
|
2016-12-03 |
2019-10-09 |
Juno Therapeutics Inc |
Méthodes pour déterminer le dosage de céllules car-t
|
WO2018108147A1
(zh)
|
2016-12-16 |
2018-06-21 |
康朴生物医药技术(上海)有限公司 |
一种组合、其应用及治疗方法
|
KR102564201B1
(ko)
|
2016-12-23 |
2023-08-07 |
아비나스 오퍼레이션스, 인코포레이티드 |
급속 진행성 섬유육종 폴리펩티드의 표적화 분해를 위한 화합물 및 방법
|
EP3559006A4
(en)
|
2016-12-23 |
2021-03-03 |
Arvinas Operations, Inc. |
COMPOUNDS AND METHODS FOR TARGETED DEGRADATION OF FETAL LIVER KINASE POLYPEPTIDES
|
AU2017382406A1
(en)
|
2016-12-23 |
2019-04-18 |
Arvinas Operations, Inc. |
EGFR proteolysis targeting chimeric molecules and associated methods of use
|
US11191741B2
(en)
|
2016-12-24 |
2021-12-07 |
Arvinas Operations, Inc. |
Compounds and methods for the targeted degradation of enhancer of zeste homolog 2 polypeptide
|
JP7266526B6
(ja)
|
2017-01-26 |
2024-02-15 |
アルビナス・オペレーションズ・インコーポレイテッド |
エストロゲン受容体タンパク質分解性の調節因子およびその関連方法
|
CN110248662B
(zh)
*
|
2017-02-13 |
2022-08-16 |
康朴生物医药技术(上海)有限公司 |
一种治疗前列腺癌的组合、药物组合物及治疗方法
|
IL310031A
(en)
|
2017-05-01 |
2024-03-01 |
Juno Therapeutics Inc |
A combination of cellular therapy and an immune modulatory compound
|
US10093647B1
(en)
|
2017-05-26 |
2018-10-09 |
Celgene Corporation |
Crystalline 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione dihydrate, compositions and methods of use thereof
|
AU2018275894A1
(en)
|
2017-06-02 |
2019-12-12 |
Juno Therapeutics, Inc. |
Articles of manufacture and methods for treatment using adoptive cell therapy
|
CN110769822A
(zh)
|
2017-06-20 |
2020-02-07 |
C4医药公司 |
用于蛋白降解的n/o-连接的降解决定子和降解决定子体
|
JP2020526194A
(ja)
|
2017-06-29 |
2020-08-31 |
ジュノー セラピューティクス インコーポレイテッド |
免疫療法薬と関連する毒性を評価するためのマウスモデル
|
CN109422751B
(zh)
*
|
2017-09-03 |
2022-04-22 |
上海美志医药科技有限公司 |
一类具有降解酪氨酸蛋白激酶jak3活性的化合物
|
EP3679026A1
(en)
|
2017-09-04 |
2020-07-15 |
C4 Therapeutics, Inc. |
Glutarimide
|
CN111315735B
(zh)
|
2017-09-04 |
2024-03-08 |
C4医药公司 |
二氢苯并咪唑酮
|
WO2019043208A1
(en)
|
2017-09-04 |
2019-03-07 |
F. Hoffmann-La Roche Ag |
DIHYDROQUINOLINONES
|
US10093648B1
(en)
|
2017-09-22 |
2018-10-09 |
Celgene Corporation |
Crystalline 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione hemihydrate, compositions and methods of use thereof
|
US10093649B1
(en)
|
2017-09-22 |
2018-10-09 |
Celgene Corporation |
Crystalline 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione monohydrate, compositions and methods of use thereof
|
US20200246393A1
(en)
|
2017-09-28 |
2020-08-06 |
Celularity, Inc. |
Tumor suppression using human placenta-derived intermediate natural killer (pink) cells in combination with an antibody
|
EP3703688A2
(en)
|
2017-11-01 |
2020-09-09 |
Juno Therapeutics, Inc. |
Antibodies and chimeric antigen receptors specific for b-cell maturation antigen
|
WO2019089858A2
(en)
|
2017-11-01 |
2019-05-09 |
Juno Therapeutics, Inc. |
Methods of assessing or monitoring a response to a cell therapy
|
WO2019099868A2
(en)
|
2017-11-16 |
2019-05-23 |
C4 Therapeutics, Inc. |
Degraders and degrons for targeted protein degradation
|
WO2019099926A1
(en)
|
2017-11-17 |
2019-05-23 |
Arvinas, Inc. |
Compounds and methods for the targeted degradation of interleukin-1 receptor-associated kinase 4 polypeptides
|
EP3716980A1
(en)
|
2017-12-01 |
2020-10-07 |
Juno Therapeutics, Inc. |
Methods for dosing and for modulation of genetically engineered cells
|
EP3724225A1
(en)
|
2017-12-15 |
2020-10-21 |
Juno Therapeutics, Inc. |
Anti-cct5 binding molecules and methods of use thereof
|
US11299485B2
(en)
|
2018-01-25 |
2022-04-12 |
Fujimoto Co., Ltd. |
Thiophene derivative and use thereof
|
JP2021512153A
(ja)
|
2018-01-26 |
2021-05-13 |
イエール ユニバーシティ |
タンパク質分解のイミド系モジュレーターおよび使用方法
|
JP2021514193A
(ja)
|
2018-02-21 |
2021-06-10 |
セルジーン コーポレイション |
Bcma結合抗体及びその使用
|
JP2021519337A
(ja)
|
2018-03-26 |
2021-08-10 |
シー4 セラピューティクス, インコーポレイテッド |
Ikarosの分解のためのセレブロン結合剤
|
AU2019249231B2
(en)
|
2018-04-04 |
2022-04-21 |
Arvinas Operations, Inc. |
Modulators of proteolysis and associated methods of use
|
CN112312904A
(zh)
|
2018-04-16 |
2021-02-02 |
C4医药公司 |
螺环化合物
|
RS64663B1
(sr)
*
|
2018-04-23 |
2023-11-30 |
Celgene Corp |
Supstituisana jedinjenja 4-aminoizoindolin-1,3-diona i njihova upotreba u lečenju limfoma
|
EP3578561A1
(en)
|
2018-06-04 |
2019-12-11 |
F. Hoffmann-La Roche AG |
Spiro compounds
|
US11530219B2
(en)
|
2018-06-29 |
2022-12-20 |
Dana-Farber Cancer Institute, Inc. |
Ligands to cereblon (CRBN)
|
WO2020051235A1
(en)
*
|
2018-09-04 |
2020-03-12 |
C4 Therapeutics, Inc. |
Compounds for the degradation of brd9 or mth1
|
CA3117978A1
(en)
|
2018-11-08 |
2020-05-14 |
Juno Therapeutics, Inc. |
Methods and combinations for treatment and t cell modulation
|
JP2022507267A
(ja)
*
|
2018-11-13 |
2022-01-18 |
バイオセリックス, インコーポレイテッド |
置換イソインドリノン
|
AU2019381827A1
(en)
|
2018-11-16 |
2021-06-10 |
Juno Therapeutics, Inc. |
Methods of dosing engineered T cells for the treatment of B cell malignancies
|
CN109293631B
(zh)
*
|
2018-11-30 |
2020-05-08 |
常州制药厂有限公司 |
3-氨基-n-(2,6-二氧代-3-哌啶基)-邻苯二甲酰亚胺化合物的制备方法
|
AU2019387497A1
(en)
|
2018-11-30 |
2021-06-24 |
Juno Therapeutics, Inc. |
Methods for treatment using adoptive cell therapy
|
PE20212198A1
(es)
|
2019-01-29 |
2021-11-16 |
Juno Therapeutics Inc |
Anticuerpos y receptores quimericos de antigenos especificos para receptor 1 huerfano tipo receptor tirosina-cinasa (ror1)
|
US20230248696A1
(en)
*
|
2019-05-03 |
2023-08-10 |
Dynamic Biologics Inc. |
Lenalidomide prodrugs, polymeric conjugates, and formulations thereof, and their uses for the treatment of multiple myeloma
|
TW202110818A
(zh)
*
|
2019-05-24 |
2021-03-16 |
美商拜歐斯瑞克斯公司 |
靶向蛋白質之化合物及其醫藥組合物以及其治療應用
|
EP4041231A1
(en)
*
|
2019-10-09 |
2022-08-17 |
Monte Rosa Therapeutics AG |
Isoindolinone compounds
|
MX2022005839A
(es)
|
2019-11-19 |
2022-06-09 |
Bristol Myers Squibb Co |
Compuestos utiles como inhibidores de la proteina helios.
|
KR20220119094A
(ko)
|
2019-12-19 |
2022-08-26 |
아비나스 오퍼레이션스, 인코포레이티드 |
안드로겐 수용체의 표적화된 분해를 위한 화합물 및 방법
|
MX2023008296A
(es)
|
2021-01-13 |
2023-09-29 |
Monte Rosa Therapeutics Inc |
Compuestos de isoindolinona.
|
CN112876414B
(zh)
*
|
2021-01-29 |
2022-09-09 |
河南大学 |
一种基于多胺修饰的萘酰亚胺缀合物、其制备方法及应用
|
WO2022200857A1
(en)
*
|
2021-03-22 |
2022-09-29 |
Monte Rosa Therapeutics Ag |
Pharmaceutical compositions for use in the prevention and treatment of a disease or disorder caused by or associated with one or more premature termination codons
|
JP2024515243A
(ja)
|
2021-04-06 |
2024-04-08 |
ブリストル-マイヤーズ スクイブ カンパニー |
ピリジニル置換されたオキソイソインドリン化合物
|
WO2022236339A1
(en)
*
|
2021-05-07 |
2022-11-10 |
Kymera Therapeutics, Inc. |
Deuterated irak degraders and uses thereof
|
CN115504963A
(zh)
*
|
2021-06-22 |
2022-12-23 |
苏州开拓药业股份有限公司 |
一种c-Myc蛋白降解剂
|
WO2023081224A1
(en)
*
|
2021-11-03 |
2023-05-11 |
St. Jude Children's Research Hospital, Inc. |
Substituted n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4- yl)methyl)benzamide analogs as modulators of cereblon protein
|
CN114656374A
(zh)
*
|
2022-02-22 |
2022-06-24 |
营口兴福化工有限公司 |
2,4-二氯-3-氰基-5-氟苯甲酸合成方法
|
WO2023250400A1
(en)
|
2022-06-22 |
2023-12-28 |
Juno Therapeutics, Inc. |
Treatment methods for second line therapy of cd19-targeted car t cells
|
KR20240001072A
(ko)
*
|
2022-06-24 |
2024-01-03 |
주식회사 아이비스바이오 |
신규한 포말리도마이드 유도체 및 이의 제조방법
|
US11957759B1
(en)
|
2022-09-07 |
2024-04-16 |
Arvinas Operations, Inc. |
Rapidly accelerated fibrosarcoma (RAF) degrading compounds and associated methods of use
|
WO2024097905A1
(en)
|
2022-11-02 |
2024-05-10 |
Celgene Corporation |
Methods of treatment with t cell therapy and immunomodulatory agent maintenance therapy
|
WO2024101763A1
(ko)
*
|
2022-11-08 |
2024-05-16 |
주식회사 온코드바이오 |
아릴시클로알킬아마이드 구조를 갖는 이소인돌리논 유도체 및 이의 용도
|