PT2411506T - Supressão de tumores usando células assassinas naturais intermédias derivadas de placenta humana e compostos imunomoduladores - Google Patents

Supressão de tumores usando células assassinas naturais intermédias derivadas de placenta humana e compostos imunomoduladores

Info

Publication number
PT2411506T
PT2411506T PT10722830T PT10722830T PT2411506T PT 2411506 T PT2411506 T PT 2411506T PT 10722830 T PT10722830 T PT 10722830T PT 10722830 T PT10722830 T PT 10722830T PT 2411506 T PT2411506 T PT 2411506T
Authority
PT
Portugal
Prior art keywords
natural killer
killer cells
human placenta
tumor suppression
immunomodulatory compounds
Prior art date
Application number
PT10722830T
Other languages
English (en)
Inventor
Zhang Xiaokui
Kang Lin
Heidaran Mohammad
Jasko Steven
Zeitlin Andy
Pal Ajai
J Hariri Robert
Original Assignee
Celularity Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celularity Inc filed Critical Celularity Inc
Publication of PT2411506T publication Critical patent/PT2411506T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/50—Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4613—Natural-killer cells [NK or NK-T]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Mycology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Reproductive Health (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pregnancy & Childbirth (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PT10722830T 2009-03-25 2010-03-26 Supressão de tumores usando células assassinas naturais intermédias derivadas de placenta humana e compostos imunomoduladores PT2411506T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16344909P 2009-03-25 2009-03-25

Publications (1)

Publication Number Publication Date
PT2411506T true PT2411506T (pt) 2019-03-19

Family

ID=42315196

Family Applications (1)

Application Number Title Priority Date Filing Date
PT10722830T PT2411506T (pt) 2009-03-25 2010-03-26 Supressão de tumores usando células assassinas naturais intermédias derivadas de placenta humana e compostos imunomoduladores

Country Status (12)

Country Link
EP (2) EP2411506B1 (pt)
AU (1) AU2010229711B2 (pt)
CA (2) CA2756594C (pt)
DK (1) DK2411506T3 (pt)
ES (1) ES2713524T3 (pt)
IL (2) IL215228A (pt)
NZ (1) NZ595440A (pt)
PL (1) PL2411506T3 (pt)
PT (1) PT2411506T (pt)
RU (2) RU2742171C2 (pt)
WO (1) WO2010111631A1 (pt)
ZA (2) ZA201106982B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2203176T1 (sl) 2007-09-28 2015-04-30 Anthrogenesis Corporation Tumorska supresija z uporabo humanega perfuzata placente in intermediarnih naravnih celic ubijalk, pridobljenih iz humane placente
KR20210063457A (ko) 2010-07-13 2021-06-01 안트로제네시스 코포레이션 천연 킬러 세포의 생성 방법
EP2953635A4 (en) * 2013-02-05 2016-10-26 Anthrogenesis Corp NATURAL KILLER CELLS FROM PLAZENTA
US9931332B2 (en) * 2014-07-30 2018-04-03 University Of Southern California Compositions and methods for treating primary effusion lymphoma
EP4034567A4 (en) * 2019-09-23 2023-07-05 Neonc Technologies, Inc. PHARMACEUTICAL COMPOSITIONS COMPRISING POH DERIVATIVES
US20220000919A1 (en) * 2020-01-29 2022-01-06 Celularity Inc. Placental derived natural killer cells for treatment of coronavirus infections
EP4180049A1 (en) * 2021-11-16 2023-05-17 Ostravska univerzita Therapeutic composition for cancer treatment
WO2024100203A1 (en) * 2022-11-10 2024-05-16 Onk Therapeutics Limited Combined therapies using immunomodulating drugs

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US5190556A (en) 1991-03-19 1993-03-02 O.B. Tech, Inc. Cord cutter sampler
US5552267A (en) 1992-04-03 1996-09-03 The Trustees Of Columbia University In The City Of New York Solution for prolonged organ preservation
US5698579A (en) 1993-07-02 1997-12-16 Celgene Corporation Cyclic amides
US5372581A (en) 1993-07-21 1994-12-13 Minneapolis Children's Services Corporation Method and apparatus for placental blood collection
US5798368A (en) 1996-08-22 1998-08-25 Celgene Corporation Tetrasubstituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines and method of reducing TNFα levels
HU228769B1 (en) 1996-07-24 2013-05-28 Celgene Corp Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha
US6281230B1 (en) 1996-07-24 2001-08-28 Celgene Corporation Isoindolines, method of use, and pharmaceutical compositions
US5635517B1 (en) 1996-07-24 1999-06-29 Celgene Corp Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines
ES2339425T3 (es) 1996-07-24 2010-05-20 Celgene Corporation 2-(2,6-dioxopiperidin-3-il)-ftalimidas y -1-oxoisoindolinas sustituidas y procedimiento para reducir los niveles de tnf-alfa.
EP1361210B1 (en) 1996-08-12 2008-12-24 Celgene Corporation Novel immunotherapeutic agents and their use in the reduction of cytokine levels
ATE323756T1 (de) * 1997-04-30 2006-05-15 Hans Klingemann Natürliche killerzelllinien und verfahren zu ihrer verwendung
US5955476A (en) 1997-11-18 1999-09-21 Celgene Corporation Substituted 2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing inflammatory cytokine levels
US5874448A (en) 1997-11-18 1999-02-23 Celgene Corporation Substituted 2-(2,6 dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing TNFα levels
CZ299253B6 (cs) 1998-03-16 2008-05-28 Celgene Corporation Isoindolinový derivát, jeho použití pro výrobu léciva a farmaceutická kompozice tento derivát obsahující
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KR100696408B1 (ko) 1999-04-16 2007-03-19 더블유엠. 마쉬 라이스 유니버시티 폴리(에틸렌글리콜)과 가교결합을 이룬 폴리(프로필렌푸마레이트)
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Also Published As

Publication number Publication date
EP3489352A1 (en) 2019-05-29
RU2018102205A (ru) 2019-02-22
ZA201504633B (en) 2020-12-23
DK2411506T3 (en) 2019-03-04
RU2011142911A (ru) 2013-04-27
WO2010111631A1 (en) 2010-09-30
AU2010229711B2 (en) 2015-06-04
EP2411506B1 (en) 2018-11-07
CA2756594A1 (en) 2010-09-30
CA2756594C (en) 2021-03-23
AU2010229711A1 (en) 2011-10-27
PL2411506T3 (pl) 2019-07-31
IL215228A (en) 2016-11-30
NZ595440A (en) 2014-05-30
RU2018102205A3 (pt) 2019-02-22
IL215228A0 (en) 2011-12-29
RU2642988C2 (ru) 2018-01-29
RU2742171C2 (ru) 2021-02-02
IL248842A0 (en) 2017-01-31
CA3110964A1 (en) 2010-09-30
ES2713524T3 (es) 2019-05-22
EP2411506A1 (en) 2012-02-01
ZA201106982B (en) 2016-08-31

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