MX361916B - Inhibidores de mtor cinasa para indicadores de oncología y enfermedades asociadas con la trayectoria mtor/pi3k/akt. - Google Patents
Inhibidores de mtor cinasa para indicadores de oncología y enfermedades asociadas con la trayectoria mtor/pi3k/akt.Info
- Publication number
- MX361916B MX361916B MX2014000653A MX2014000653A MX361916B MX 361916 B MX361916 B MX 361916B MX 2014000653 A MX2014000653 A MX 2014000653A MX 2014000653 A MX2014000653 A MX 2014000653A MX 361916 B MX361916 B MX 361916B
- Authority
- MX
- Mexico
- Prior art keywords
- mtor
- kinase inhibitors
- diseases associated
- akt pathway
- oncology indications
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 101150097381 Mtor gene Proteins 0.000 title 1
- 239000003628 mammalian target of rapamycin inhibitor Substances 0.000 title 1
- 230000037361 pathway Effects 0.000 title 1
- -1 Heteroaryl Compound Chemical class 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 230000001900 immune effect Effects 0.000 abstract 1
- 230000004968 inflammatory condition Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
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- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Gastroenterology & Hepatology (AREA)
- Otolaryngology (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- Endocrinology (AREA)
Abstract
En la presente se proporcionan Compuestos Heteroarilo que tienen la siguiente estructura: R2 N (I) o (II) donde R1-R4 son como se definen en la presente, composiciones que comprenden una cantidad efectiva de un Compuesto Heteroarilo y métodos para tratar o prevenir cáncer, padecimientos inflamatorios, padecimientos inmunológicos, enfermedades neurodegenerativas, diabetes, obesidad, trastornos neurológicos, enfermedades relacionadas con la edad, o padecimientos cardiovasculares, que comprenden administrar una cantidad efectiva de un Compuesto Heteroarilo a un paciente que lo necesita.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10862708P | 2008-10-27 | 2008-10-27 | |
PCT/US2009/062143 WO2010062571A1 (en) | 2008-10-27 | 2009-10-27 | Mtor kinase inhibitors for oncology indications and diseases associated with the mtor/p13k/akt pathway |
Publications (1)
Publication Number | Publication Date |
---|---|
MX361916B true MX361916B (es) | 2018-12-19 |
Family
ID=41490345
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014000653A MX361916B (es) | 2008-10-27 | 2009-10-27 | Inhibidores de mtor cinasa para indicadores de oncología y enfermedades asociadas con la trayectoria mtor/pi3k/akt. |
MX2011004401A MX2011004401A (es) | 2008-10-27 | 2009-10-27 | Inhibidores de mtor cinasa para indicadores de oncologia y enfermedades asociadas con la trayectoria mtor/pi3k/akt. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2011004401A MX2011004401A (es) | 2008-10-27 | 2009-10-27 | Inhibidores de mtor cinasa para indicadores de oncologia y enfermedades asociadas con la trayectoria mtor/pi3k/akt. |
Country Status (35)
Country | Link |
---|---|
US (10) | US8110578B2 (es) |
EP (5) | EP2740732B1 (es) |
JP (3) | JP5689420B2 (es) |
KR (2) | KR101815604B1 (es) |
CN (3) | CN104725384B (es) |
AR (2) | AR073995A1 (es) |
AU (1) | AU2009320137C1 (es) |
BR (1) | BRPI0920254A2 (es) |
CA (1) | CA2740975C (es) |
CO (1) | CO6501147A2 (es) |
CR (1) | CR20110223A (es) |
CY (2) | CY1117272T1 (es) |
DK (2) | DK2740733T3 (es) |
EC (1) | ECSP11011084A (es) |
ES (4) | ES2562803T3 (es) |
HK (3) | HK1154858A1 (es) |
HR (2) | HRP20160084T1 (es) |
HU (1) | HUE026834T2 (es) |
IL (1) | IL212440A (es) |
LT (1) | LT2740732T (es) |
MX (2) | MX361916B (es) |
MY (1) | MY159235A (es) |
NI (1) | NI201100080A (es) |
NZ (4) | NZ708183A (es) |
PE (3) | PE20141197A1 (es) |
PL (2) | PL2740733T3 (es) |
PT (1) | PT2740732T (es) |
RU (2) | RU2692796C2 (es) |
SG (3) | SG2014006852A (es) |
SI (2) | SI2740732T1 (es) |
SM (1) | SMT201600089B (es) |
TW (3) | TWI605047B (es) |
UA (1) | UA108601C2 (es) |
WO (1) | WO2010062571A1 (es) |
ZA (1) | ZA201102813B (es) |
Families Citing this family (119)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
MX2010012703A (es) | 2008-05-21 | 2010-12-21 | Ariad Pharma Inc | Derivados fosforosos como inhibidores de cinasa. |
US8110578B2 (en) * | 2008-10-27 | 2012-02-07 | Signal Pharmaceuticals, Llc | Pyrazino[2,3-b]pyrazine mTOR kinase inhibitors for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway |
WO2010056311A1 (en) | 2008-11-12 | 2010-05-20 | Ariad Pharmaceuticals, Inc. | Pyrazinopyrazines and derivatives as kinase inhibitors |
DE102009043260A1 (de) | 2009-09-28 | 2011-04-28 | Merck Patent Gmbh | Pyridinyl-imidazolonderivate |
MX341704B (es) * | 2009-10-26 | 2016-08-31 | Signal Pharm Llc | Métodos de síntesis y purificación de compuestos de heteroarilo. |
NZ601581A (en) * | 2010-02-03 | 2014-03-28 | Signal Pharm Llc | Identification of lkb1 mutation as a predictive biomarker for sensitivity to tor kinase inhibitors |
US20110275699A1 (en) * | 2010-03-16 | 2011-11-10 | University Of California | Treatment For Obesity And Diabetes |
US20120028972A1 (en) * | 2010-07-30 | 2012-02-02 | Lilly Wong | Biomarker assays for detecting or measuring inhibition of tor kinase activity |
PT2675451E (pt) * | 2011-02-18 | 2015-10-16 | Incyte Corp | Terapia de combinação com inibidores mtor/jak |
WO2012122405A2 (en) * | 2011-03-08 | 2012-09-13 | The Trustees Of Columbia University In The City Of New York | Screening assays using stem cells and stem cell-derived neurons from mouse models of alzheimer's disease |
AU2012250517B2 (en) | 2011-05-04 | 2016-05-19 | Takeda Pharmaceutical Company Limited | Compounds for inhibiting cell proliferation in EGFR-driven cancers |
MX2014001246A (es) * | 2011-08-03 | 2014-06-11 | Signal Pharm Llc | Identificación del perfil de la expresión génica como biomarcador predictivo del estatus de lkb1. |
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