BR112012031873A2 - antagonistas de ciclo-hexil-azetidinila do ccr2 - Google Patents

antagonistas de ciclo-hexil-azetidinila do ccr2

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Publication number
BR112012031873A2
BR112012031873A2 BR112012031873A BR112012031873A BR112012031873A2 BR 112012031873 A2 BR112012031873 A2 BR 112012031873A2 BR 112012031873 A BR112012031873 A BR 112012031873A BR 112012031873 A BR112012031873 A BR 112012031873A BR 112012031873 A2 BR112012031873 A2 BR 112012031873A2
Authority
BR
Brazil
Prior art keywords
ccr2
antagonists
cyclohexyl
syndrome
disorder
Prior art date
Application number
BR112012031873A
Other languages
English (en)
Inventor
James C Lanter
Nalin Subasinghe
Thomas P Markotan
Zhihua Sui
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BR112012031873A2 publication Critical patent/BR112012031873A2/pt

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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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Abstract

antagonistas de ciclo-hexil-azetidinila do ccr2. a presente invenção compreende composto da fórmula i. em que: r^ 1^,r^ 2^,r^ 4^, j, q e a são conforme definido no relatório descritivo. a invenção compreende, também, um método para previnir, tratar ou aliviar uma síndrome, distúrbio ou doença, sendo que a dita síndrome, distúrbio ou doença é diabetes tipo ii, obesidade e asma, a invenção compreende, também, um método de inibição de atividade de ccr2 em um mamífero através da administração de uma quantidade terapeuticamente eficaz de pelo menos um composto da fórmula i.
BR112012031873A 2010-06-17 2011-06-16 antagonistas de ciclo-hexil-azetidinila do ccr2 BR112012031873A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35566310P 2010-06-17 2010-06-17
PCT/US2011/040610 WO2011159854A1 (en) 2010-06-17 2011-06-16 Cyclohexyl-azetidinyl antagonists of ccr2

Publications (1)

Publication Number Publication Date
BR112012031873A2 true BR112012031873A2 (pt) 2016-11-08

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Application Number Title Priority Date Filing Date
BR112012031873A BR112012031873A2 (pt) 2010-06-17 2011-06-16 antagonistas de ciclo-hexil-azetidinila do ccr2

Country Status (13)

Country Link
US (2) US8518969B2 (pt)
EP (1) EP2582692B1 (pt)
JP (1) JP5936608B2 (pt)
KR (1) KR101743280B1 (pt)
CN (1) CN103097375B (pt)
AR (1) AR082016A1 (pt)
AU (1) AU2011268375B2 (pt)
BR (1) BR112012031873A2 (pt)
CA (1) CA2801934A1 (pt)
ES (1) ES2550312T3 (pt)
MX (1) MX2012014934A (pt)
TW (1) TW201204717A (pt)
WO (1) WO2011159854A1 (pt)

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JP5498571B2 (ja) 2009-04-30 2014-05-21 ミッドウェスタン ユニバーシティ センタキンを用いた新規の治療方法
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