LT3813946T - Rapamicino analogai ir jų panaudojimas - Google Patents

Rapamicino analogai ir jų panaudojimas

Info

Publication number
LT3813946T
LT3813946T LTEPPCT/US2019/037507T LTUS2019037507T LT3813946T LT 3813946 T LT3813946 T LT 3813946T LT US2019037507 T LTUS2019037507 T LT US2019037507T LT 3813946 T LT3813946 T LT 3813946T
Authority
LT
Lithuania
Prior art keywords
rapamycin analogs
rapamycin
analogs
Prior art date
Application number
LTEPPCT/US2019/037507T
Other languages
English (en)
Inventor
Eddine Saiah
David O'neill
Seong Woo Anthony Kang
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of LT3813946T publication Critical patent/LT3813946T/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
LTEPPCT/US2019/037507T 2018-06-15 2019-06-17 Rapamicino analogai ir jų panaudojimas LT3813946T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862685666P 2018-06-15 2018-06-15
PCT/US2019/037507 WO2019241789A1 (en) 2018-06-15 2019-06-17 Rapamycin analogs and uses thereof

Publications (1)

Publication Number Publication Date
LT3813946T true LT3813946T (lt) 2024-07-10

Family

ID=68842366

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEPPCT/US2019/037507T LT3813946T (lt) 2018-06-15 2019-06-17 Rapamicino analogai ir jų panaudojimas

Country Status (16)

Country Link
US (3) US10980784B2 (lt)
EP (2) EP4302827A3 (lt)
JP (2) JP7382353B2 (lt)
KR (1) KR20210021534A (lt)
CN (2) CN117843659A (lt)
AU (1) AU2019286524A1 (lt)
BR (1) BR112020025283A2 (lt)
CA (1) CA3103282A1 (lt)
CO (1) CO2020015747A2 (lt)
EA (1) EA202092692A1 (lt)
FI (1) FI3813946T3 (lt)
IL (1) IL279329A (lt)
LT (1) LT3813946T (lt)
MX (1) MX2020013630A (lt)
SG (1) SG11202012447YA (lt)
WO (1) WO2019241789A1 (lt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7382353B2 (ja) 2018-06-15 2023-11-16 ヤンセン ファーマシューティカ エヌ．ベー． ラパマイシン類似体およびその使用
KR102643707B1 (ko) 2019-01-22 2024-03-04 에오비안 파마슈티컬스, 인크. Mtorc 조절제 및 이의 용도
EP4069223A4 (en) * 2019-12-05 2023-12-20 Janssen Pharmaceutica NV RAPAMYCIN ANALOGS AND THEIR USES
JP2023530778A (ja) 2020-03-27 2023-07-19 エオビアン ファーマシューティカルズ， インコーポレイテッド Ｍｔｏｒｃ１モジュレーターおよびその使用
EP4185590A2 (en) * 2020-07-21 2023-05-31 Aeovian Pharmaceuticals, Inc. Mtorc1 modulators and uses thereof
KR20230136625A (ko) * 2021-01-22 2023-09-26 얀센 파마슈티카 엔브이 라파마이신 유사체 및 이의 용도
CN115097046B (zh) * 2022-07-07 2023-09-26 国药集团川抗制药有限公司 一种分离雷帕霉素及其杂质的方法

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Also Published As

Publication number Publication date
CO2020015747A2 (es) 2020-12-21
JP2021528396A (ja) 2021-10-21
EA202092692A1 (ru) 2021-04-21
EP4302827A3 (en) 2024-03-13
US20210220339A1 (en) 2021-07-22
EP3813946A4 (en) 2022-06-01
MX2020013630A (es) 2021-04-28
AU2019286524A1 (en) 2021-01-07
KR20210021534A (ko) 2021-02-26
US20240173305A1 (en) 2024-05-30
WO2019241789A1 (en) 2019-12-19
EP4302827A2 (en) 2024-01-10
IL279329A (en) 2021-01-31
US20190388401A1 (en) 2019-12-26
CN117843659A (zh) 2024-04-09
CN112423843B (zh) 2023-11-28
US11944605B2 (en) 2024-04-02
FI3813946T3 (fi) 2024-06-25
SG11202012447YA (en) 2021-01-28
EP3813946A1 (en) 2021-05-05
US10980784B2 (en) 2021-04-20
EP3813946B1 (en) 2024-05-22
JP2024012524A (ja) 2024-01-30
BR112020025283A2 (pt) 2021-03-09
CA3103282A1 (en) 2019-12-19
CN112423843A (zh) 2021-02-26
JP7382353B2 (ja) 2023-11-16

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