MX2009010132A - Analogos de pirazolopirimidina y su uso como inhibidores de cinasa mtor y cinasa pi3. - Google Patents

Analogos de pirazolopirimidina y su uso como inhibidores de cinasa mtor y cinasa pi3.

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Publication number
MX2009010132A
MX2009010132A MX2009010132A MX2009010132A MX2009010132A MX 2009010132 A MX2009010132 A MX 2009010132A MX 2009010132 A MX2009010132 A MX 2009010132A MX 2009010132 A MX2009010132 A MX 2009010132A MX 2009010132 A MX2009010132 A MX 2009010132A
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MX
Mexico
Prior art keywords
kinase
pyrazolopyrimidine
mtor
analogs
pyrazolopyrimidine analogs
Prior art date
Application number
MX2009010132A
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English (en)
Inventor
Semiramis Ayral-Kaloustian
Arie Zask
Derek Cecil Cole
Ker Yu
Pawel Wojciech Nowak
Joshua Kaplan
Matthew Gregory Bursavich
Jeroen Verheijen
Kevin J Curran
David Malwitz
David James Richard
Mark Lefever
Original Assignee
Wyeth Corp
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Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of MX2009010132A publication Critical patent/MX2009010132A/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A—HUMAN NECESSITIES
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P19/00—Drugs for skeletal disorders
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
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    • A61P3/00—Drugs for disorders of the metabolism
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
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  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente invención se refiere a Análogo e Pirazolopirimidina, métodos para elaborar Análogos de Pirazolopirimidina, composiciones que comprenden un Análogo de Pirazolopirimidina, y métodos para tratar trastornos relacionados con mTOR que comprende administrar a un sujeto en necesidad de este una cantidad efectiva de un Análogo de Pirazolopirimidina. La invención también se relaciona con tratar trastornos relacionados con PI3K que comprenden administrar a un sujeto en necesidad de este una cantidad efectiva de un Análogo de Pirazolopirimidina.
MX2009010132A 2007-03-21 2008-03-19 Analogos de pirazolopirimidina y su uso como inhibidores de cinasa mtor y cinasa pi3. MX2009010132A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91930107P 2007-03-21 2007-03-21
PCT/US2008/057467 WO2008115974A2 (en) 2007-03-21 2008-03-19 Pyrazolopyrimidine analogs and their use as mtor kinase and pi3 kinase inhibitors

Publications (1)

Publication Number Publication Date
MX2009010132A true MX2009010132A (es) 2009-10-12

Family

ID=39766744

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009010132A MX2009010132A (es) 2007-03-21 2008-03-19 Analogos de pirazolopirimidina y su uso como inhibidores de cinasa mtor y cinasa pi3.

Country Status (13)

Country Link
US (1) US20080234262A1 (es)
EP (1) EP2078021A2 (es)
JP (1) JP2010522195A (es)
CN (1) CN101675051A (es)
AR (1) AR065812A1 (es)
AU (1) AU2008228964A1 (es)
BR (1) BRPI0809239A2 (es)
CA (1) CA2681501A1 (es)
CL (1) CL2008000815A1 (es)
MX (1) MX2009010132A (es)
PE (1) PE20081888A1 (es)
TW (1) TW200900404A (es)
WO (1) WO2008115974A2 (es)

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