WO2008057503A3 - Compositions including triciribine and taxanes and methods of use thereof - Google Patents
Compositions including triciribine and taxanes and methods of use thereof Download PDFInfo
- Publication number
- WO2008057503A3 WO2008057503A3 PCT/US2007/023309 US2007023309W WO2008057503A3 WO 2008057503 A3 WO2008057503 A3 WO 2008057503A3 US 2007023309 W US2007023309 W US 2007023309W WO 2008057503 A3 WO2008057503 A3 WO 2008057503A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- taxanes
- methods
- compositions including
- including triciribine
- triciribine
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
This application relates to combination therapies including triciribine and related compounds and taxanes and compositions with reduced toxicity for the treatment and prevention of tumors, cancer, and other disorders associated with abnormal cell proliferation.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07867363A EP2182939A2 (en) | 2006-11-06 | 2007-11-06 | Compositions including triciribine and taxanes and methods of use thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US85678306P | 2006-11-06 | 2006-11-06 | |
US60/856,783 | 2006-11-06 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008057503A2 WO2008057503A2 (en) | 2008-05-15 |
WO2008057503A3 true WO2008057503A3 (en) | 2008-09-04 |
Family
ID=39304748
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/023309 WO2008057503A2 (en) | 2006-11-06 | 2007-11-06 | Compositions including triciribine and taxanes and methods of use thereof |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP2182939A2 (en) |
WO (1) | WO2008057503A2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2415831A1 (en) † | 2010-08-06 | 2012-02-08 | Borealis AG | Heterophasic propylene copolymer with excellent impact/stiffness balance |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005094322A2 (en) * | 2004-03-29 | 2005-10-13 | University Of South Florida | Effective treatment of tumors and cancer with triciribine and related compounds |
WO2005110477A2 (en) * | 2004-04-09 | 2005-11-24 | University Of South Florida | Combination therapies for cancer and proliferative angiopathies |
WO2008060581A2 (en) * | 2006-11-15 | 2008-05-22 | University Of South Florida | Compositions including triciribine and trastuzumab and methods of use thereof |
US20080131526A1 (en) * | 2006-10-04 | 2008-06-05 | University Of South Florida | Akt sensitization of cancer cells |
WO2008070100A1 (en) * | 2006-12-05 | 2008-06-12 | University Of South Florida | Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof |
-
2007
- 2007-11-06 EP EP07867363A patent/EP2182939A2/en not_active Withdrawn
- 2007-11-06 WO PCT/US2007/023309 patent/WO2008057503A2/en active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005094322A2 (en) * | 2004-03-29 | 2005-10-13 | University Of South Florida | Effective treatment of tumors and cancer with triciribine and related compounds |
WO2005110477A2 (en) * | 2004-04-09 | 2005-11-24 | University Of South Florida | Combination therapies for cancer and proliferative angiopathies |
US20080131526A1 (en) * | 2006-10-04 | 2008-06-05 | University Of South Florida | Akt sensitization of cancer cells |
WO2008060581A2 (en) * | 2006-11-15 | 2008-05-22 | University Of South Florida | Compositions including triciribine and trastuzumab and methods of use thereof |
WO2008070100A1 (en) * | 2006-12-05 | 2008-06-12 | University Of South Florida | Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof |
Non-Patent Citations (3)
Title |
---|
BELLACOSA A ET AL: "Activation of AKT kinases in cancer: Implications for therapeutic targeting", ADVANCES IN CANCER RESEARCH 2005 US, vol. 94, no. 1 SUPPL., 2005, pages 29 - 86, XP008093755, ISSN: 0065-230X * |
LI Q: "Recent progress in the discovery of Akt inhibitors as anticancer agents", EXPERT OPINION ON THERAPEUTIC PATENTS 2007 GB, vol. 17, no. 9, 2007, pages 1077 - 1130, XP002472827, ISSN: 1354-3776 * |
YANG L ET AL: "ATK/PROTEIN KINASE B SIGNALING INHIBITOR-2, A SELECTIVE SMALL MOLECULE INHIBITOR OF AKT SIGNALING WITH ANTITUMOR ACTIVITY IN CANCER CELLS OVEREXPRESSING AKT", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, vol. 64, no. 13, 1 July 2004 (2004-07-01), pages 4394 - 4399, XP009075866, ISSN: 0008-5472 * |
Also Published As
Publication number | Publication date |
---|---|
WO2008057503A2 (en) | 2008-05-15 |
EP2182939A2 (en) | 2010-05-12 |
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